WO1998015263A3 - A method for producing a microparticle - Google Patents

A method for producing a microparticle Download PDF

Info

Publication number
WO1998015263A3
WO1998015263A3 PCT/JP1997/003608 JP9703608W WO9815263A3 WO 1998015263 A3 WO1998015263 A3 WO 1998015263A3 JP 9703608 W JP9703608 W JP 9703608W WO 9815263 A3 WO9815263 A3 WO 9815263A3
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
microparticle
producing
pulverizing
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1997/003608
Other languages
French (fr)
Other versions
WO1998015263A2 (en
Inventor
Nobuyuki Takechi
Muneo Nonomura
Shigehiro Higuchi
Toshiharu Beppu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to AU45710/97A priority Critical patent/AU4571097A/en
Priority to CA002267930A priority patent/CA2267930A1/en
Priority to EP97944088A priority patent/EP0930874A2/en
Publication of WO1998015263A2 publication Critical patent/WO1998015263A2/en
Publication of WO1998015263A3 publication Critical patent/WO1998015263A3/en
Priority to US09/260,797 priority patent/US6022564A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/06—Selection or use of additives to aid disintegrating

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention provides a method for producing a microparticle which comprises pulverizing a solid preparation comprising a compound represented by formula (I), wherein ring A is an optionally substituted benzene ring; R is a hydrogen atom or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is -CH(OH)- or -CO-; k is 0 or 1; and n is 0, 1 or 2 or a pharmaceutically acceptable salt thereof and a biodegradable polymer of α-hydroxycarboxylic acid in the presence of a pulverizing auxiliary, which can provide microparticles which are less adhesive and involve less aggregation and are thus excellent in drug entrapment ratio and control of drug release in a desired particle size.
PCT/JP1997/003608 1996-10-09 1997-10-08 A method for producing a microparticle Ceased WO1998015263A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU45710/97A AU4571097A (en) 1996-10-09 1997-10-08 A method for producing a microparticle
CA002267930A CA2267930A1 (en) 1996-10-09 1997-10-08 A method for producing a microparticle
EP97944088A EP0930874A2 (en) 1996-10-09 1997-10-08 A method for producing a microparticle
US09/260,797 US6022564A (en) 1996-10-09 1999-03-01 Method for producing a microparticle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/268704 1996-10-09
JP26870496 1996-10-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/260,797 Continuation US6022564A (en) 1996-10-09 1999-03-01 Method for producing a microparticle

Publications (2)

Publication Number Publication Date
WO1998015263A2 WO1998015263A2 (en) 1998-04-16
WO1998015263A3 true WO1998015263A3 (en) 1998-06-11

Family

ID=17462219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/003608 Ceased WO1998015263A2 (en) 1996-10-09 1997-10-08 A method for producing a microparticle

Country Status (5)

Country Link
US (1) US6022564A (en)
EP (1) EP0930874A2 (en)
AU (1) AU4571097A (en)
CA (1) CA2267930A1 (en)
WO (1) WO1998015263A2 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
WO2001010463A1 (en) * 1999-08-05 2001-02-15 Takeda Chemical Industries, Ltd. Pastes with the sustained release of osteogenesis promoter
JP4075247B2 (en) * 1999-09-30 2008-04-16 Ｊｓｒ株式会社 Aqueous dispersion for chemical mechanical polishing
WO2002078673A1 (en) * 2001-03-29 2002-10-10 Takeda Chemical Industries, Ltd. Process for producing fine granulate drug
DE10118978A1 (en) * 2001-04-18 2002-10-31 Markus Miller Grinding aid-free grinding process with grinding additive
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US20030072731A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing starch or dextrin
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
CA2456806C (en) * 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US20030234304A1 (en) * 2002-06-20 2003-12-25 Weifang Miao Superfine powders and methods for manufacture of said powders
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
US20040105821A1 (en) * 2002-09-30 2004-06-03 Howard Bernstein Sustained release pharmaceutical formulation for inhalation
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US8691277B2 (en) 2004-09-21 2014-04-08 Shandong Luye Pharmaceutical Co., Ltd. Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof
US20070081972A1 (en) * 2005-09-30 2007-04-12 The University Of Iowa Research Foundation Polymer-based delivery system for immunotherapy of cancer
EP1978933A2 (en) * 2005-12-15 2008-10-15 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
CA2631493A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
DE102006029032A1 (en) * 2006-02-17 2007-08-23 Poly-An Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Apparatus, method and kit for detecting analytes in a sample
AU2007264418B2 (en) * 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
US7592009B2 (en) * 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2013121296A1 (en) 2012-02-15 2013-08-22 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2603520A4 (en) 2010-08-10 2014-02-19 Ecole Polytech THERAPEUTIC AGENTS BINDING TO ERYTHROCYTES
US9540428B2 (en) 2012-07-03 2017-01-10 Ecole Polytechnique Federale De Lausanne (Epfl) Extracellular matrix heparin-binding domains
US9879062B2 (en) 2012-07-03 2018-01-30 Ecole Polytechnique Federale De Lausanne Protein-binding peptide isolated from placenta growth factor
US20140141065A1 (en) 2012-11-19 2014-05-22 Discovery Genomics, Inc. Method to achieve extended expression of dna infused into liver
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
SG11201606761RA (en) 2014-02-21 2016-09-29 Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
EP3303585A4 (en) 2015-06-03 2018-10-31 Board of Regents of the University of Nebraska Dna editing using single-stranded dna
US20170050856A1 (en) * 2015-08-18 2017-02-23 Massachusetts Institute Of Technology Re-Dispersible Dry Graphene Powder
US10751367B2 (en) 2016-05-27 2020-08-25 Corning Incorporated Bioactive glass microspheres
US20170342383A1 (en) 2016-05-27 2017-11-30 Corning Incorporated Lithium disilicate glass-ceramic compositions and methods thereof
WO2018031771A1 (en) 2016-08-11 2018-02-15 University Of Iowa Research Foundation CATIONIC CaMKII INHIBITING NANOPARTICLES FOR THE TREATMENT OF ALLERGIC ASTHMA
JP2019533001A (en) * 2016-11-07 2019-11-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Instant release capsules based on heat melt extruded polyvinyl alcohol
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance
US11732029B2 (en) 2017-11-13 2023-08-22 The University Chicago Methods and compositions for the treatment of wounds
TWI794344B (en) 2017-11-28 2023-03-01 美商康寧公司 Chemically strengthened bioactive glass-ceramics
CN111417603B (en) 2017-11-28 2023-10-31 康宁股份有限公司 Bioactive Borate Glass and Methods
CN111433165A (en) 2017-11-28 2020-07-17 康宁股份有限公司 High liquidus viscosity bioactive glass
WO2019108556A1 (en) 2017-11-28 2019-06-06 Corning Incorporated Bioactive glass compositions and dentin hypersensitivity remediation
EP3790577A4 (en) 2018-05-09 2022-04-27 The University of Chicago COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE
JP2022552375A (en) 2019-10-15 2022-12-15 コーネル・ユニバーシティー Methods for modulating expression levels from gene therapy expression cassettes
JP2023500793A (en) 2019-10-16 2023-01-11 コーネル・ユニバーシティー Gene therapy method for Alzheimer's disease
WO2021086973A2 (en) 2019-10-28 2021-05-06 University Of Iowa Research Foundation Formulation for delivery of lubricin gene
EP4065600A1 (en) 2019-11-25 2022-10-05 Cornell University Apoe gene therapy
EP4138921A1 (en) 2020-04-23 2023-03-01 University Of Iowa Research Foundation Gper proteolytic targeting chimeras
WO2022040564A1 (en) 2020-08-21 2022-02-24 University Of Iowa Research Foundation Cationic nanoparticle adjuvants
WO2022047201A1 (en) 2020-08-27 2022-03-03 University Of Iowa Research Foundation Gene knock-out for treatment of glaucoma
WO2022125963A1 (en) 2020-12-11 2022-06-16 University Of Iowa Research Foundation Compositions comprising molecules for cystic fibrosis treatment
US20240238383A1 (en) 2021-05-21 2024-07-18 University Of Lowa Research Foundation Anti-oxidant containing particles and methods of use
US20240293322A1 (en) 2021-06-23 2024-09-05 University Of Iowa Research Foundation Sustained release formulations comprising a selective androgen receptor modulator
WO2024197165A1 (en) 2023-03-21 2024-09-26 University Of Iowa Research Foundation Broad spectrum antifungal keto-alkyl-pyridinium compounds
WO2024233783A1 (en) 2023-05-09 2024-11-14 Cornell University Expression cassette coding for vascular endothelial growth factor
WO2025213111A2 (en) 2024-04-05 2025-10-09 Cornell University Aav expression of mirna to suppress human apoe mrna

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376197A1 (en) * 1988-12-28 1990-07-04 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
GB2234169A (en) * 1989-07-28 1991-01-30 Debiopharm Sa A method for preparing a sustained release pharmaceutical peptide composition
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
WO1992016193A1 (en) * 1991-03-14 1992-10-01 Centre National De La Recherche Scientifique (Cnrs) Polylactic acid-based implant susceptible of bioresorption containing an antibiotic
EP0535937A1 (en) * 1991-10-01 1993-04-07 Takeda Chemical Industries, Ltd. Prolonged release microparticle preparation and production of the same
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376197A1 (en) * 1988-12-28 1990-07-04 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
GB2234169A (en) * 1989-07-28 1991-01-30 Debiopharm Sa A method for preparing a sustained release pharmaceutical peptide composition
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
WO1992016193A1 (en) * 1991-03-14 1992-10-01 Centre National De La Recherche Scientifique (Cnrs) Polylactic acid-based implant susceptible of bioresorption containing an antibiotic
EP0535937A1 (en) * 1991-10-01 1993-04-07 Takeda Chemical Industries, Ltd. Prolonged release microparticle preparation and production of the same
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use

Also Published As

Publication number Publication date
EP0930874A2 (en) 1999-07-28
WO1998015263A2 (en) 1998-04-16
US6022564A (en) 2000-02-08
AU4571097A (en) 1998-05-05
CA2267930A1 (en) 1998-04-16

Similar Documents

Publication Publication Date Title
WO1998015263A3 (en) A method for producing a microparticle
AU8586491A (en) Prolonged release preparation and polymers thereof
AU2930700A (en) Pyridine-imine polymerisation catalyst
AU2323897A (en) Cyclopropyl alkanoic acid derivatives
AU2910100A (en) Nanoparticulate, redispersible zinc oxide gels
AU2402692A (en) Anti-inflammatory analgesic plaster
CA2215281A1 (en) Improved synthesis of tyrosine-derived diphenol monomers
EP0664289A3 (en) Isoquinolines
TW329386B (en) Cough medicine
AU8142594A (en) Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP1103577A4 (en) Block copolymer composition, process for producing the same, and pressure-sensitive adhesive composition
AU2337197A (en) Cinnamic acid derivatives and their use as integrin antagonists
WO1999047497A3 (en) Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
AU8134198A (en) Encapsulation of active ingredients
MY114423A (en) Compositions and methods for inhibiting vinyl aromatic monomer polymerization
AU2545497A (en) Temporary wet strength polymers from oxidized reaction product of polyhydroxy polymer and 1,2-disubstituted carboxylic alkene
CA2243139A1 (en) Iron-based powder mixture for powder metallurgy and process for preparing the same
MXPA03007887A (en) Method to obtain microparticles containing a h[+] , k[+] -atp-ase inhibitor.
EP1640811A3 (en) Toner
SI0941068T1 (en) Controlled release microspheres
CA2302738A1 (en) Removable protective coating
EP1229390A4 (en) Positive type radiation-sensitive composition and process for producing pattern with the same
WO1995011682A3 (en) Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
WO1998051748A1 (en) Granulated powdery paint and process for producing the same
BR9612809A (en) Plastisol composition, process for preparing and using it, and a plasticized product produced from a plastisol composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE HU ID IL IS KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA US UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE HU ID IL IS KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA US UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09260797

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1997944088

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2267930

Country of ref document: CA

Ref country code: CA

Ref document number: 2267930

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1997944088

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1997944088

Country of ref document: EP