WO1998015825A3 - Matrices with memories in automated drug discovery and units therefor - Google Patents

Matrices with memories in automated drug discovery and units therefor Download PDF

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Publication number
WO1998015825A3
WO1998015825A3 PCT/US1997/015754 US9715754W WO9815825A3 WO 1998015825 A3 WO1998015825 A3 WO 1998015825A3 US 9715754 W US9715754 W US 9715754W WO 9815825 A3 WO9815825 A3 WO 9815825A3
Authority
WO
WIPO (PCT)
Prior art keywords
memories
automated
matrices
drug discovery
units
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/015754
Other languages
French (fr)
Other versions
WO1998015825A2 (en
Inventor
Michael Phillip Nova
John E Lillig
Kanchana Sanjaya G Karunaratne
Donald O'neil
William Ewing
Yozo Satoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Irori Inc
Original Assignee
Irori Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/912,998 external-priority patent/US6329139B1/en
Application filed by Irori Inc filed Critical Irori Inc
Priority to EP97912649A priority Critical patent/EP0931259B1/en
Priority to AU49767/97A priority patent/AU4976797A/en
Priority to DE69737025T priority patent/DE69737025D1/en
Priority to CA002267769A priority patent/CA2267769A1/en
Publication of WO1998015825A2 publication Critical patent/WO1998015825A2/en
Publication of WO1998015825A3 publication Critical patent/WO1998015825A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/02—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using elements whose operation depends upon chemical change
    • G11C13/025—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using elements whose operation depends upon chemical change using fullerenes, e.g. C60, or nanotubes, e.g. carbon or silicon nanotubes
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C2213/00—Indexing scheme relating to G11C13/00 for features not covered by this group
    • G11C2213/70—Resistive array aspects
    • G11C2213/81—Array wherein the array conductors, e.g. word lines, bit lines, are made of nanowires

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Abstract

Automated drug discovery protocols, or partially automated protocols, in which matrices-with-memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microreactors and microvessels, which contain memories, an automated or semi-automated synthesizer, a microreactor washer/dryer, a manual or automated cleaver for removing compounds from the matrix-with-memory microreactors, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodable during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
PCT/US1997/015754 1996-10-07 1997-10-07 Matrices with memories in automated drug discovery and units therefor Ceased WO1998015825A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97912649A EP0931259B1 (en) 1996-10-07 1997-10-07 System for synthesizing a library of compounds and use thereof
AU49767/97A AU4976797A (en) 1996-10-07 1997-10-07 Matrices with memories in automated drug discovery and units therefor
DE69737025T DE69737025D1 (en) 1996-10-07 1997-10-07 SYSTEM FOR SYNTHESIS OF A CONNECTION LIBRARY AND USE THEREOF
CA002267769A CA2267769A1 (en) 1996-10-07 1997-10-07 Matrices with memories in automated drug discovery and units therefor

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US72670396A 1996-10-07 1996-10-07
US08/726,703 1996-10-07
US74398496A 1996-10-28 1996-10-28
US08/743,984 1996-10-28
US74168596A 1996-10-31 1996-10-31
US08/741,685 1996-10-31
US85780097A 1997-01-22 1997-01-22
US78859497A 1997-01-22 1997-01-22
US08/788,594 1997-01-22
US08/857,800 1997-01-22
US82625397A 1997-03-27 1997-03-27
US08/826,253 1997-03-27
US08/912,998 US6329139B1 (en) 1995-04-25 1997-08-11 Automated sorting system for matrices with memory
US08/912,998 1997-08-11

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WO1998015825A2 WO1998015825A2 (en) 1998-04-16
WO1998015825A3 true WO1998015825A3 (en) 1998-07-30

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AT (1) ATE347101T1 (en)
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WO1998015825A2 (en) 1998-04-16
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AU4976797A (en) 1998-05-05
CA2267769A1 (en) 1998-04-16
EP0931259A2 (en) 1999-07-28

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