WO1998016149A3 - Enhanced breast imaging/biopsy system employing targeted ultrasound - Google Patents

Enhanced breast imaging/biopsy system employing targeted ultrasound Download PDF

Info

Publication number
WO1998016149A3
WO1998016149A3 PCT/US1997/018468 US9718468W WO9816149A3 WO 1998016149 A3 WO1998016149 A3 WO 1998016149A3 US 9718468 W US9718468 W US 9718468W WO 9816149 A3 WO9816149 A3 WO 9816149A3
Authority
WO
WIPO (PCT)
Prior art keywords
system employing
biopsy system
ray
breast imaging
ultrasound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/018468
Other languages
French (fr)
Other versions
WO1998016149A2 (en
Inventor
Morgan W Nields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fischer Imaging Corp
Original Assignee
Fischer Imaging Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fischer Imaging Corp filed Critical Fischer Imaging Corp
Priority to AU49009/97A priority Critical patent/AU4900997A/en
Priority to EP97911697A priority patent/EP0936889B8/en
Priority to DE69739947T priority patent/DE69739947D1/en
Publication of WO1998016149A2 publication Critical patent/WO1998016149A2/en
Publication of WO1998016149A3 publication Critical patent/WO1998016149A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/502—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of breast, i.e. mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/04—Positioning of patients; Tiltable beds or the like
    • A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
    • A61B6/0435—Supports, e.g. tables or beds, for the body or parts of the body with means for imaging suspended breasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4417—Constructional features of apparatus for radiation diagnosis related to combined acquisition of different diagnostic modalities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0825—Clinical applications for diagnosis of the breast, e.g. mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/40—Positioning of patients, e.g. means for holding or immobilising parts of the patient's body
    • A61B8/406—Positioning of patients, e.g. means for holding or immobilising parts of the patient's body using means for diagnosing suspended breasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4218—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by articulated arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B90/14—Fixators for body parts, e.g. skull clamps; Constructional details of fixators, e.g. pins
    • A61B90/17—Fixators for body parts, e.g. skull clamps; Constructional details of fixators, e.g. pins for soft tissue, e.g. breast-holding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/915—Ultrasound mammography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/916—Ultrasound 3-D imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Neurosurgery (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

The present invention provides for x-ray imaging (40), and ultrasound imaging (100) of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinative employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis/biopsy (50, 52) of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head (110), as well as targeted ultrasound imaging of a selected portion of the region from which x-ray images are obtained.
PCT/US1997/018468 1996-10-15 1997-10-14 Enhanced breast imaging/biopsy system employing targeted ultrasound Ceased WO1998016149A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU49009/97A AU4900997A (en) 1996-10-15 1997-10-14 Enhanced breast imaging/biopsy system employing targeted ultrasound
EP97911697A EP0936889B8 (en) 1996-10-15 1997-10-14 Enhanced breast imaging/biopsy system employing targeted ultrasound
DE69739947T DE69739947D1 (en) 1996-10-15 1997-10-14 ARRANGEMENT FOR IMAGING AND BIOPSYING THE MOM WITH FOCUSED ULTRASOUND

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/730,107 US5776062A (en) 1996-10-15 1996-10-15 Enhanced breast imaging/biopsy system employing targeted ultrasound
US08/730,107 1996-10-15

Publications (2)

Publication Number Publication Date
WO1998016149A2 WO1998016149A2 (en) 1998-04-23
WO1998016149A3 true WO1998016149A3 (en) 1998-10-22

Family

ID=24933944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018468 Ceased WO1998016149A2 (en) 1996-10-15 1997-10-14 Enhanced breast imaging/biopsy system employing targeted ultrasound

Country Status (5)

Country Link
US (3) US5776062A (en)
EP (1) EP0936889B8 (en)
AU (1) AU4900997A (en)
DE (1) DE69739947D1 (en)
WO (1) WO1998016149A2 (en)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5983123A (en) 1993-10-29 1999-11-09 United States Surgical Corporation Methods and apparatus for performing ultrasound and enhanced X-ray imaging
FR2751109B1 (en) * 1996-07-09 1998-10-09 Ge Medical Syst Sa PROCEDURE FOR LOCATING AN ELEMENT OF INTEREST CONTAINED IN A THREE-DIMENSIONAL OBJECT, IN PARTICULAR DURING AN EXAMINATION OF STEREOTAXIS IN MAMMOGRAPHY
CA2261782C (en) * 1996-08-15 2008-01-29 Life Imaging Systems Inc. System for performing percutaneous biopsy of the breast using three-dimensional ultrasonography
FR2754612B1 (en) * 1996-10-10 1998-11-20 Ge Medical Syst Sa SYSTEM FOR LOCATING DIGITAL IMAGE TAPE CASSETTES
US5776062A (en) * 1996-10-15 1998-07-07 Fischer Imaging Corporation Enhanced breast imaging/biopsy system employing targeted ultrasound
US6731966B1 (en) 1997-03-04 2004-05-04 Zachary S. Spigelman Systems and methods for targeting a lesion
DE19809460C1 (en) * 1998-03-06 1999-09-30 Siemens Ag Medical target device for breathing-compensated punction
WO2000009014A1 (en) * 1998-08-17 2000-02-24 Kari Richter Combined ultrasound-radiography apparatuses
US6574499B1 (en) 1998-11-25 2003-06-03 Xdata Corporation Mammography method and apparatus
AU2003203755B2 (en) * 1998-11-25 2005-04-28 Rubicor Medical, Inc. Breast Stabilization Devices and Imaging and Interventional Methods Using Same
EP1143845A4 (en) * 1998-11-25 2004-10-06 Fischer Imaging Corp USER INTERFACE SYSTEM FOR MAMMOGRAPHIC IMAGER
AU4694900A (en) * 1999-05-03 2000-11-17 Biotrack, Inc. Systems and methods for targeting a breast lesion
US6421454B1 (en) * 1999-05-27 2002-07-16 Litton Systems, Inc. Optical correlator assisted detection of calcifications for breast biopsy
US6396940B1 (en) 1999-05-27 2002-05-28 Litton Systems, Inc. Optical correlator based automated pathologic region of interest selector for integrated 3D ultrasound and digital mammography
US6512943B1 (en) 2000-05-22 2003-01-28 Wisconsin Alumni Research Foundation Combined ultrasound-radionuclide device for percutaneous ultrasound-guided biopsy and method of use
US6367104B1 (en) * 2000-07-07 2002-04-09 Medical Positioning, Inc. Patient support apparatus and method for performing decubitus breast biopsy
AU2001245159A1 (en) 2000-07-07 2002-01-21 Medical Positioning, Inc. Patient support apparatus and method for performing decubitus breast biopsy
US7940966B2 (en) * 2000-11-24 2011-05-10 U-Systems, Inc. Full-field breast image data processing and archiving
US7103205B2 (en) * 2000-11-24 2006-09-05 U-Systems, Inc. Breast cancer screening with ultrasound image overlays
US7597663B2 (en) 2000-11-24 2009-10-06 U-Systems, Inc. Adjunctive ultrasound processing and display for breast cancer screening
US7556602B2 (en) * 2000-11-24 2009-07-07 U-Systems, Inc. Breast cancer screening with adjunctive ultrasound mammography
US7615008B2 (en) * 2000-11-24 2009-11-10 U-Systems, Inc. Processing and displaying breast ultrasound information
US6678546B2 (en) * 2001-01-30 2004-01-13 Fischer Imaging Corporation Medical instrument guidance using stereo radiolocation
US6558337B2 (en) * 2001-04-17 2003-05-06 Wisconsin Alumni Research Foundation Positioner for medical devices such as biopsy needles
IL143060A0 (en) * 2001-05-09 2002-04-21 Sonnet Medical Ltd In Formatio Method and apparatus for breast imaging utilizing ultrasound
US6478739B1 (en) 2001-05-11 2002-11-12 The Procter & Gamble Company Ultrasonic breast examination system
US6491632B1 (en) * 2001-06-26 2002-12-10 Geoffrey L. Taylor Method and apparatus for photogrammetric orientation of ultrasound images
US20030045798A1 (en) * 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
WO2003032837A1 (en) * 2001-10-12 2003-04-24 University Of Florida Computer controlled guidance of a biopsy needle
US7609806B2 (en) 2004-10-18 2009-10-27 Hologic Inc. Mammography system and method employing offset compression paddles, automatic collimations, and retractable anti-scatter grid
EP1444873A2 (en) 2001-10-19 2004-08-11 Hologic, Inc. Mammography system and method employing offset compression paddles, automatic collimation, and retractable anti-scatter grid
US20030149364A1 (en) * 2002-02-01 2003-08-07 Ajay Kapur Methods, system and apparatus for digital imaging
US6971991B2 (en) * 2002-03-08 2005-12-06 Imperium, Inc. Apparatus for multimodal plane wave ultrasound imaging
US6882700B2 (en) * 2002-04-15 2005-04-19 General Electric Company Tomosynthesis X-ray mammogram system and method with automatic drive system
US6724856B2 (en) * 2002-04-15 2004-04-20 General Electric Company Reprojection and backprojection methods and algorithms for implementation thereof
US7783089B2 (en) * 2002-04-15 2010-08-24 General Electric Company Method and apparatus for providing mammographic image metrics to a clinician
US6707878B2 (en) 2002-04-15 2004-03-16 General Electric Company Generalized filtered back-projection reconstruction in digital tomosynthesis
US20030194050A1 (en) * 2002-04-15 2003-10-16 General Electric Company Multi modality X-ray and nuclear medicine mammography imaging system and method
US7218766B2 (en) * 2002-04-15 2007-05-15 General Electric Company Computer aided detection (CAD) for 3D digital mammography
US20030199753A1 (en) * 2002-04-23 2003-10-23 Ethicon Endo-Surgery MRI compatible biopsy device with detachable probe
US7826883B2 (en) * 2002-04-23 2010-11-02 Devicor Medical Products, Inc. Localization mechanism for an MRI compatible biopsy device
US6748047B2 (en) * 2002-05-15 2004-06-08 General Electric Company Scatter correction method for non-stationary X-ray acquisitions
EP1531730B1 (en) 2002-05-31 2012-01-18 U-Systems, Inc. Apparatus for acquiring ultrasound scans of a breast
US20040082856A1 (en) * 2002-07-16 2004-04-29 Alfred E. Mann Institute For Biomedical Engineering, University Of Southern California Support bra for ultrasonic breast scanner
US20040022447A1 (en) * 2002-07-31 2004-02-05 General Electric Company Method and system for image compression and decompression using span of interest of an imaging sequence
US7438692B2 (en) * 2002-10-18 2008-10-21 Mark Tsonton Localization mechanism for an MRI compatible biopsy device
US7963918B2 (en) * 2003-01-17 2011-06-21 Hee-Boong Park Apparatus for ultrasonic examination of deformable object
US8083678B2 (en) * 2003-04-16 2011-12-27 Eastern Virginia Medical School System, method and medium for acquiring and generating standardized operator independent ultrasound images of fetal, neonatal and adult organs
MXPA05011120A (en) * 2003-04-16 2005-12-15 Eastern Viriginai Medical Scho System and method for generating operator independent ultrasound images.
US6846289B2 (en) * 2003-06-06 2005-01-25 Fischer Imaging Corporation Integrated x-ray and ultrasound medical imaging system
US20050089205A1 (en) * 2003-10-23 2005-04-28 Ajay Kapur Systems and methods for viewing an abnormality in different kinds of images
US7313259B2 (en) * 2003-11-26 2007-12-25 General Electric Company Method, system and computer program product for multi-modality registration using virtual cursors
WO2005072636A1 (en) * 2004-01-23 2005-08-11 Traxyz Medical, Inc. Methods and apparatus for performing procedures on target locations in the body
DE102004034240A1 (en) * 2004-07-15 2006-02-16 Siemens Ag Medical imaging device
ES2253997B1 (en) * 2004-07-29 2007-07-16 Udiat Centre Diagnostic, S.A. DIGITAL SYSTEM TO PERFORM STEREOTAXIC BIOPSY.
US20060074287A1 (en) * 2004-09-30 2006-04-06 General Electric Company Systems, methods and apparatus for dual mammography image detection
WO2006043859A1 (en) * 2004-10-18 2006-04-27 Mobile Robotics Sweden Ab Robot for ultrasonic examination
US20060251301A1 (en) * 2004-11-02 2006-11-09 Mcnamara Michael P Jr Method and apparatus for determining correlation between spatial coordinates in breast
EP1816965B1 (en) 2004-11-26 2016-06-29 Hologic, Inc. Integrated multi-mode mammography/tomosynthesis x-ray system
US10026338B2 (en) 2004-11-30 2018-07-17 The Regents Of The University Of California Embedded motion sensing technology for integration within commercial ultrasound probes
US10726741B2 (en) 2004-11-30 2020-07-28 The Regents Of The University Of California System and method for converting handheld diagnostic ultrasound systems into ultrasound training systems
US11627944B2 (en) 2004-11-30 2023-04-18 The Regents Of The University Of California Ultrasound case builder system and method
DE102005039658B3 (en) * 2005-08-22 2007-07-19 Siemens Ag Laser device for a mammography device
US8303505B2 (en) * 2005-12-02 2012-11-06 Abbott Cardiovascular Systems Inc. Methods and apparatuses for image guided medical procedures
WO2007095330A2 (en) 2006-02-15 2007-08-23 Hologic Inc Breast biopsy and needle localization using tomosynthesis systems
US10561394B2 (en) * 2006-05-02 2020-02-18 U-Systems, Inc. Ultrasound scanning and ultrasound-assisted biopsy
US20070282221A1 (en) * 2006-06-02 2007-12-06 U-Systems, Inc. Ultrasound assisted and x-ray assisted biopsy devices
WO2008054279A1 (en) * 2006-10-31 2008-05-08 Xcounter Ab Imaging arrangement and system for imaging
SE530549C2 (en) * 2006-10-31 2008-07-08 Xcounter Ab System for imaging a breast through computed tomography
JP5481038B2 (en) 2007-04-05 2014-04-23 株式会社東芝 Ultrasound diagnostic apparatus, breast imaging system, and breast imaging program
US8133242B1 (en) 2007-04-27 2012-03-13 Q-Tech Medical Incorporated Image-guided extraluminal occlusion
US10201324B2 (en) 2007-05-04 2019-02-12 Delphinus Medical Technologies, Inc. Patient interface system
US8870771B2 (en) 2007-05-04 2014-10-28 Barbara Ann Karmanos Cancer Institute Method and apparatus for categorizing breast density and assessing cancer risk utilizing acoustic parameters
US8066644B2 (en) * 2007-05-17 2011-11-29 Vanderbilt University System, method and device for positioning a target located within soft tissue in a path of an instrument
US20090080604A1 (en) 2007-08-23 2009-03-26 Fischer Medical Technologies, Inc. Computed tomography breast imaging and biopsy system
WO2009050712A2 (en) * 2007-10-15 2009-04-23 Yissum Research Development Company Of The Hebrew Univercity Of Jerusalem Method, system and computer program product for tissue characterization
DE102008009967A1 (en) * 2008-02-20 2009-09-17 Siemens Aktiengesellschaft Mammography system and method for sonographic and radiographic examination of a breast
US8375054B2 (en) * 2008-04-03 2013-02-12 Siemens Aktiengesellschaft Findings navigator
US10603008B2 (en) * 2009-02-19 2020-03-31 Tessonics Corporation Ultrasonic device for assessment of internal tooth structure
JP5373450B2 (en) * 2009-03-31 2013-12-18 富士フイルム株式会社 Biopsy device and method of operating biopsy device
US8556815B2 (en) * 2009-05-20 2013-10-15 Laurent Pelissier Freehand ultrasound imaging systems and methods for guiding fine elongate instruments
US10039527B2 (en) 2009-05-20 2018-08-07 Analogic Canada Corporation Ultrasound systems incorporating spatial position sensors and associated methods
US10595954B2 (en) 2009-10-08 2020-03-24 Hologic, Inc. Needle breast biopsy system and method for use
JP5317933B2 (en) * 2009-11-17 2013-10-16 富士フイルム株式会社 Image display device and program thereof
US9579120B2 (en) 2010-01-29 2017-02-28 University Of Virginia Patent Foundation Ultrasound for locating anatomy or probe guidance
JP2013519455A (en) 2010-02-12 2013-05-30 デルフィヌス メディカル テクノロジーズ，インコーポレイテッド How to characterize a patient's tissue
US9144403B2 (en) 2010-02-12 2015-09-29 Delphinus Medical Technologies, Inc. Method of characterizing the pathological response of tissue to a treatment plan
US8211121B1 (en) 2010-03-06 2012-07-03 Q-Tech Medical Incorporated Methods and apparatus for image-guided extraluminal occlusion using clamping jaws
EP2577279A4 (en) * 2010-06-03 2015-01-14 Caperay Medical Pty Ltd Dual-modality scanning system for detecting breast cancer
WO2012071429A1 (en) 2010-11-26 2012-05-31 Hologic, Inc. User interface for medical image review workstation
AU2012225398B2 (en) 2011-03-08 2017-02-02 Hologic, Inc. System and method for dual energy and/or contrast enhanced breast imaging for screening, diagnosis and biopsy
DE102011006058A1 (en) * 2011-03-24 2012-09-27 Siemens Aktiengesellschaft Tomosynthesis device and method for its operation
EP2701607B1 (en) 2011-04-26 2020-09-16 University Of Virginia Patent Foundation Bone surface image reconstruction using ultrasound
US12042134B2 (en) 2011-09-16 2024-07-23 Hologic, Inc. Breast biopsy lateral arm system
EP2755559B1 (en) 2011-09-16 2020-03-25 Hologic, Inc. Breast biopsy lateral arm system
US11284869B2 (en) 2011-09-16 2022-03-29 Hologic, Inc. Breast biopsy lateral arm system
KR102109588B1 (en) 2011-11-27 2020-05-12 홀로직, 인크. Methods for processing, displaying and navigating breast tissue images
US9295449B2 (en) 2012-01-23 2016-03-29 Ultrasonix Medical Corporation Landmarks for ultrasound imaging
US8914925B2 (en) * 2012-02-08 2014-12-23 Wayne County Employees' Retirement System Mobile diagnostic assembly
ES2641456T3 (en) 2012-02-13 2017-11-10 Hologic, Inc. System and method for navigating a tomosynthesis stack using synthesized image data
WO2013173369A2 (en) * 2012-05-14 2013-11-21 Delphinus Medical Technologies, Inc. System and method for performing an image-guided biopsy
US9498182B2 (en) 2012-05-22 2016-11-22 Covidien Lp Systems and methods for planning and navigation
US9439622B2 (en) 2012-05-22 2016-09-13 Covidien Lp Surgical navigation system
US9439623B2 (en) 2012-05-22 2016-09-13 Covidien Lp Surgical planning system and navigation system
US9439627B2 (en) 2012-05-22 2016-09-13 Covidien Lp Planning system and navigation system for an ablation procedure
US8750568B2 (en) 2012-05-22 2014-06-10 Covidien Lp System and method for conformal ablation planning
US11631342B1 (en) 2012-05-25 2023-04-18 The Regents Of University Of California Embedded motion sensing technology for integration within commercial ultrasound probes
CN102697539B (en) * 2012-06-27 2016-04-27 青岛银泰医疗科技有限公司 A kind of novel three-dimensional Needle localization system
US20140073907A1 (en) 2012-09-12 2014-03-13 Convergent Life Sciences, Inc. System and method for image guided medical procedures
US9763641B2 (en) 2012-08-30 2017-09-19 Delphinus Medical Technologies, Inc. Method and system for imaging a volume of tissue with tissue boundary detection
RU2651877C2 (en) * 2012-09-13 2018-04-24 Конинклейке Филипс Н.В. Device for ultrasound visualization controlled by mobile display device, and ultrasound visualization system
CN104883975B (en) 2012-12-28 2019-04-05 皇家飞利浦有限公司 Real-time scene modeling combining 3D ultrasound and 2D X-ray images
US10123770B2 (en) 2013-03-13 2018-11-13 Delphinus Medical Technologies, Inc. Patient support system
US9271686B2 (en) 2013-03-14 2016-03-01 West Virginia University Endorectal prostate probe composed of a combined mini gamma camera and ultrasound sensor
US10568560B2 (en) 2013-03-14 2020-02-25 West Virginia University Endorectal prostate probe with combined PET and US modalities
CN105451657A (en) 2013-03-15 2016-03-30 霍罗吉克公司 Systems and methods including autofocus for navigating tomosynthesis stacks
AU2014233687B2 (en) 2013-03-15 2018-12-06 Hologic, Inc. Tomosynthesis-guided biopsy in prone
KR101656776B1 (en) * 2013-09-03 2016-09-12 삼성전자주식회사 Ultrasound diagnostic apparatus and operating method thereof
US10380919B2 (en) 2013-11-21 2019-08-13 SonoSim, Inc. System and method for extended spectrum ultrasound training using animate and inanimate training objects
ES2960537T3 (en) 2013-10-24 2024-03-05 Hologic Inc System and method for navigating an X-ray guided breast biopsy
JP6506769B2 (en) 2014-02-28 2019-04-24 ホロジック, インコーポレイテッドHologic, Inc. System and method for generating and displaying tomosynthesis image slabs
WO2015140782A1 (en) * 2014-03-18 2015-09-24 Doron Kwiat Biopsy method and clinic for imaging and biopsy
CN106470615B (en) * 2014-05-28 2021-01-15 通用电气公司 Biopsy method and related biopsy device
US10285667B2 (en) 2014-08-05 2019-05-14 Delphinus Medical Technologies, Inc. Method for generating an enhanced image of a volume of tissue
US9950194B2 (en) 2014-09-09 2018-04-24 Mevion Medical Systems, Inc. Patient positioning system
US9855014B2 (en) 2014-12-16 2018-01-02 General Electric Company Compression paddle for use in breast imaging
US9949719B2 (en) 2014-12-16 2018-04-24 General Electric Company Breast imaging method and system
US11600201B1 (en) 2015-06-30 2023-03-07 The Regents Of The University Of California System and method for converting handheld diagnostic ultrasound systems into ultrasound training systems
US10786224B2 (en) 2016-04-21 2020-09-29 Covidien Lp Biopsy devices and methods of use thereof
US10372876B2 (en) * 2017-01-20 2019-08-06 Agfa Healthcare Inc. System and method for providing breast image data
US10896628B2 (en) 2017-01-26 2021-01-19 SonoSim, Inc. System and method for multisensory psychomotor skill training
EP3600052A1 (en) 2017-03-30 2020-02-05 Hologic, Inc. System and method for targeted object enhancement to generate synthetic breast tissue images
US11399790B2 (en) 2017-03-30 2022-08-02 Hologic, Inc. System and method for hierarchical multi-level feature image synthesis and representation
WO2018183549A1 (en) 2017-03-30 2018-10-04 Hologic, Inc. System and method for synthesizing low-dimensional image data from high-dimensional image data using an object grid enhancement
EP3641635A4 (en) 2017-06-20 2021-04-07 Hologic, Inc. DYNAMIC SELF-LEARNING MEDICAL IMAGING PROCESS AND SYSTEM
DE102017210604A1 (en) * 2017-06-23 2018-12-27 Siemens Healthcare Gmbh Compression unit for a combined X-ray / ultrasound examination device
GB2566942B (en) * 2017-09-22 2020-06-03 Caperay Medical Pty Ltd Multimodal imaging system and method
EP3510930B1 (en) 2018-01-15 2021-07-14 Hologic, Inc. Automated and configurable magnification stand
US11331161B2 (en) 2018-03-23 2022-05-17 Covidien Lp Surgical assemblies facilitating tissue marking and methods of use thereof
EP3787514A4 (en) * 2018-04-30 2022-01-05 Memorial Sloan-Kettering Cancer Center Compression paddles for breast biopsies
US12121304B2 (en) 2018-05-04 2024-10-22 Hologic, Inc. Introducer and localization wire visualization
CA3091593A1 (en) 2018-05-04 2019-11-07 Hologic, Inc. Biopsy needle visualization
US11707329B2 (en) 2018-08-10 2023-07-25 Covidien Lp Systems and methods for ablation visualization
JP7441828B2 (en) 2018-09-24 2024-03-01 ホロジック， インコーポレイテッド Breast mapping and abnormal localization
JP7084291B2 (en) 2018-12-07 2022-06-14 富士フイルム株式会社 Tomosynthesis photography support equipment, methods and programs
US11810473B2 (en) 2019-01-29 2023-11-07 The Regents Of The University Of California Optical surface tracking for medical simulation
US11495142B2 (en) 2019-01-30 2022-11-08 The Regents Of The University Of California Ultrasound trainer with internal optical tracking
US11517294B2 (en) 2019-05-07 2022-12-06 Covidien Lp Biopsy devices and methods of use thereof
US11883206B2 (en) 2019-07-29 2024-01-30 Hologic, Inc. Personalized breast imaging system
EP4035176A1 (en) 2019-09-27 2022-08-03 Hologic, Inc. Ai system for predicting reading time and reading complexity for reviewing 2d/3d breast images
EP3832689A3 (en) 2019-12-05 2021-08-11 Hologic, Inc. Systems and methods for improved x-ray tube life
EP4125601B1 (en) 2020-03-27 2025-08-06 Hologic, Inc. Systems and methods for correlating regions of interest in multiple imaging modalities
US11481038B2 (en) 2020-03-27 2022-10-25 Hologic, Inc. Gesture recognition in controlling medical hardware or software
US11471118B2 (en) 2020-03-27 2022-10-18 Hologic, Inc. System and method for tracking x-ray tube focal spot position
JP7671776B2 (en) 2020-03-27 2025-05-02 ホロジック， インコーポレイテッド System and method for identifying regions of interest in multiple imaging modalities - Patents.com
KR102522627B1 (en) * 2020-09-17 2023-04-17 주식회사 제이시스메디칼 Ultrasonic medical instrument with adjusable focusing depth of ultrasonic wave generator
EP4214671A1 (en) 2020-09-18 2023-07-26 Hologic, Inc. Correlating regions of interest
US11013492B1 (en) * 2020-11-04 2021-05-25 Philip B. Kivitz Ultrasound sonographic imaging system and method
US20220164951A1 (en) 2020-11-20 2022-05-26 Hologic, Inc. Systems and methods for using ai to identify regions of interest in medical images
US12254586B2 (en) 2021-10-25 2025-03-18 Hologic, Inc. Auto-focus tool for multimodality image review
KR20240118765A (en) 2021-11-29 2024-08-05 홀로직, 인크. Systems and methods for correlating objects of interest
US12414217B2 (en) 2022-02-07 2025-09-09 Hologic, Inc. Systems and methods for adaptively controlling filament current in an X-ray tube
JP2025530679A (en) 2022-08-29 2025-09-17 ホロジック， インコーポレイテッド Systems and methods for lateral treatment of the breast
US12251257B2 (en) * 2022-10-19 2025-03-18 GE Precision Healthcare LLC System and method for analyzing breast support environment
JP2024128887A (en) * 2023-03-10 2024-09-24 富士フイルム株式会社 Control device, control method, and control program
USD1107232S1 (en) 2023-08-29 2025-12-23 Hologic, Inc. Lateral adapter for biopsy system
USD1107233S1 (en) 2023-08-29 2025-12-23 Hologic, Inc. Biopsy system and controller
USD1107231S1 (en) 2023-08-29 2025-12-23 Hologic, Inc. Biopsy system and lateral adapter
US12399923B1 (en) 2023-09-15 2025-08-26 Gabriele Nataneli Multi-modal enhancement of large language models without retraining
WO2026031072A1 (en) * 2024-08-08 2026-02-12 汕头市超声仪器研究所股份有限公司 Depth sensing method for x-ray image

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346717A (en) * 1979-09-07 1982-08-31 Siemens Aktiengesellschaft Device for punctuating internal body organs, vessels or the like
US5289520A (en) * 1991-11-27 1994-02-22 Lorad Corporation Stereotactic mammography imaging system with prone position examination table and CCD camera
US5398690A (en) * 1994-08-03 1995-03-21 Batten; Bobby G. Slaved biopsy device, analysis apparatus, and process
US5411026A (en) * 1993-10-08 1995-05-02 Nomos Corporation Method and apparatus for lesion position verification
US5447154A (en) * 1992-07-31 1995-09-05 Universite Joseph Fourier Method for determining the position of an organ
US5479927A (en) * 1993-10-29 1996-01-02 Neovision Corporation Methods and apparatus for performing sonomammography and enhanced x-ray imaging

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2707662A (en) * 1949-05-27 1955-05-03 Picker X Ray Corp Waite Mfg Tiltably X-ray table with extension panel
US3165630A (en) * 1961-06-13 1965-01-12 Polaroid Corp Table for holding and positioning a female subject and film during breast x-ray exposures
US3973126A (en) * 1975-07-31 1976-08-03 General Electric Company Mammography
US3963933A (en) * 1975-08-18 1976-06-15 General Electric Company Mammography fixture
US4051380A (en) * 1976-03-31 1977-09-27 Lasky Harold J Apparatus and method for supporting and positioning the body to facilitate radiographic mammography procedures
US4099880A (en) * 1976-08-11 1978-07-11 Tsutomu Kano Method and an apparatus for stereoscopic measurement utilizing a three-dimensional image
US4249539A (en) * 1979-02-09 1981-02-10 Technicare Corporation Ultrasound needle tip localization system
US4341120A (en) * 1979-11-09 1982-07-27 Diasonics Cardio/Imaging, Inc. Ultrasonic volume measuring system
US4485819A (en) * 1980-01-21 1984-12-04 Wolfgang Igl Mechanical accessory for commercially available compound apparatuses for echo mammography
EP0096039A1 (en) * 1981-12-14 1983-12-21 The Commonwealth Of Australia Apparatus for ultrasonic examination of deformable objects
JPS6041955A (en) * 1983-08-19 1985-03-05 株式会社東芝 Bed elevator apparatus for ct
US4576175A (en) * 1983-09-06 1986-03-18 Moshe Epstein Biopsy attachment for ultrasonic probe
SE8306243L (en) * 1983-11-14 1985-05-15 Cytex Medicinteknik Ab LOCATION METHODOLOGY
US4567896A (en) * 1984-01-20 1986-02-04 Elscint, Inc. Method and apparatus for calibrating a biopsy attachment for ultrasonic imaging apparatus
JPS60163643A (en) * 1984-02-07 1985-08-26 テルモ株式会社 Ultrasonic measuring method and apparatus
US4671292A (en) * 1985-04-30 1987-06-09 Dymax Corporation Concentric biopsy probe
US4618973A (en) * 1985-11-01 1986-10-21 Lasky Harold J Mammographic X-ray apparatus
US4791934A (en) * 1986-08-07 1988-12-20 Picker International, Inc. Computer tomography assisted stereotactic surgery system and method
SE459150B (en) * 1986-09-19 1989-06-12 Anders Wallner DEVICE FOR MAMMOGRAPHIC STEREOTACTIC PUNCTION OF PATHOLOGICAL CHANGES IN THE FEMALE BREAST
US4750487A (en) * 1986-11-24 1988-06-14 Zanetti Paul H Stereotactic frame
US4875478A (en) * 1987-04-10 1989-10-24 Chen Harry H Portable compression grid & needle holder
DE3883637D1 (en) * 1987-06-30 1993-10-07 Siemens Ag Biopsy device for an X-ray examination device.
US4869247A (en) * 1988-03-11 1989-09-26 The University Of Virginia Alumni Patents Foundation Video tumor fighting system
US4899756A (en) * 1988-07-18 1990-02-13 Sonek Jiri D Articulated needle guide for ultrasound imaging and method of using same
US5078142A (en) * 1989-11-21 1992-01-07 Fischer Imaging Corporation Precision mammographic needle biopsy system
US5240011A (en) * 1991-11-27 1993-08-31 Fischer Imaging Corporation Motorized biopsy needle positioner
US5415169A (en) * 1989-11-21 1995-05-16 Fischer Imaging Corporation Motorized mammographic biopsy apparatus
US5662109A (en) * 1990-12-14 1997-09-02 Hutson; William H. Method and system for multi-dimensional imaging and analysis for early detection of diseased tissue
US5409497A (en) * 1991-03-11 1995-04-25 Fischer Imaging Corporation Orbital aiming device for mammo biopsy
US5129911A (en) * 1991-03-11 1992-07-14 Siczek Bernard W Orbital aiming device
US5569266A (en) * 1991-03-11 1996-10-29 Fischer Imaging Corporation Magnetic resonance imaging device useful for guiding a medical instrument
DE4143540C2 (en) * 1991-10-24 1996-08-08 Siemens Ag Therapeutic assembly for treatment by acoustic irradiation
US5320111A (en) * 1992-02-07 1994-06-14 Livingston Products, Inc. Light beam locator and guide for a biopsy needle
DE4309597A1 (en) * 1993-03-22 1994-09-29 Kari Dr Richter Process for imaging a part of the human body
IL107523A (en) * 1993-11-07 2000-01-31 Ultraguide Ltd Articulated needle guide for ultrasound imaging and method of using same
JP2833456B2 (en) * 1993-11-22 1998-12-09 株式会社東芝 Insertable ultrasound system
US5526394A (en) * 1993-11-26 1996-06-11 Fischer Imaging Corporation Digital scan mammography apparatus
US5584292A (en) * 1994-10-31 1996-12-17 Grumman Aerospace Corporation Digital X-ray camera for precision mammographic needle biopsy system
US5660185A (en) * 1995-04-13 1997-08-26 Neovision Corporation Image-guided biopsy apparatus with enhanced imaging and methods
US5640956A (en) * 1995-06-07 1997-06-24 Neovision Corporation Methods and apparatus for correlating ultrasonic image data and radiographic image data
US5769086A (en) * 1995-12-06 1998-06-23 Biopsys Medical, Inc. Control system and method for automated biopsy device
US5776062A (en) * 1996-10-15 1998-07-07 Fischer Imaging Corporation Enhanced breast imaging/biopsy system employing targeted ultrasound
EP1143845A4 (en) * 1998-11-25 2004-10-06 Fischer Imaging Corp USER INTERFACE SYSTEM FOR MAMMOGRAPHIC IMAGER

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346717A (en) * 1979-09-07 1982-08-31 Siemens Aktiengesellschaft Device for punctuating internal body organs, vessels or the like
US5289520A (en) * 1991-11-27 1994-02-22 Lorad Corporation Stereotactic mammography imaging system with prone position examination table and CCD camera
US5447154A (en) * 1992-07-31 1995-09-05 Universite Joseph Fourier Method for determining the position of an organ
US5411026A (en) * 1993-10-08 1995-05-02 Nomos Corporation Method and apparatus for lesion position verification
US5479927A (en) * 1993-10-29 1996-01-02 Neovision Corporation Methods and apparatus for performing sonomammography and enhanced x-ray imaging
US5398690A (en) * 1994-08-03 1995-03-21 Batten; Bobby G. Slaved biopsy device, analysis apparatus, and process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0936889A4 *

Also Published As

Publication number Publication date
EP0936889B1 (en) 2010-07-28
DE69739947D1 (en) 2010-09-09
WO1998016149A2 (en) 1998-04-23
US5776062A (en) 1998-07-07
AU4900997A (en) 1998-05-11
EP0936889A4 (en) 1999-12-01
EP0936889B8 (en) 2010-11-24
EP0936889A2 (en) 1999-08-25
US6102866A (en) 2000-08-15
US20090143674A1 (en) 2009-06-04

Similar Documents

Publication Publication Date Title
WO2000051484A3 (en) User interface system for mammographic imager
EP0881506A3 (en) Three dimensional M-mode ultrasonic diagnostic imaging system
EP0797106A3 (en) Three dimensional medical ultrasonic diagnostic imaging of tissue texture and vasculature
CA2261782A1 (en) System for performing percutaneous biopsy of the breast using three-dimensional ultrasonography
EP0936889B8 (en) Enhanced breast imaging/biopsy system employing targeted ultrasound
IL125895A0 (en) The use of an image enhancing moiety in the preparation of bioactivated nmr or optical imaging contrat agent from a prodrug
WO1998038486A3 (en) Ultrasonic probe, system and method for two-dimensional imaging or dimensional reconstruction
EP0366387A3 (en) Obtaining three-dimensional images from tomographic data
WO1998058593A3 (en) Image guided surgery system
EP0844496A3 (en) Three dimensional ultrasonic diagnostic image rendering from tissue and flow images
AU7072898A (en) System for carrying out surgery, biopsy and ablation of a tumor or other physical anomaly
WO2001069282A3 (en) Spatially compounded three dimensional ultrasonic images
MXPA02011496A (en) Ultrasound apparatus and method for tissue resonance analysis.
WO2002000103A3 (en) Method and apparatus for tracking a medical instrument based on image registration
CA2112391A1 (en) Method and apparatus for removing artifacts from an ultrasonically generated image of a small cavity
AU6028299A (en) Method and system for tactile imaging for breast cancer examination and detection of prostate cancer
EP0857457A3 (en) Method and system for the fast determination of EKG waveform morphology
AU2001236592A1 (en) Methods for diagnosis of alzheimer's disease
HK1044882A1 (en) Systems and methods for targeting a breast lesion
IL121084A0 (en) Compositions and methods for diagnosis of tumors by X-ray imaging
WO2002044144A3 (en) Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
GB0130305D0 (en) Compounds for imaging alzheimers disease
Manchester Secondary cancer in an Anglo-Saxon female
FR2737845B1 (en) ENDOSCOPIC IMAGING DEVICE FOR THE EARLY DETECTION OF CANCEROUS OR PRE-CANCER SURFACE LESIONS
WO2002041776A8 (en) Ultrasound within mri scanners for guidance of mri pulse sequences

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

WWE Wipo information: entry into national phase

Ref document number: 1997911697

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 1997911697

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA