WO1998018930A3 - Streptococcus pneumoniae antigens and vaccines - Google Patents

Streptococcus pneumoniae antigens and vaccines Download PDF

Info

Publication number
WO1998018930A3
WO1998018930A3 PCT/US1997/019422 US9719422W WO9818930A3 WO 1998018930 A3 WO1998018930 A3 WO 1998018930A3 US 9719422 W US9719422 W US 9719422W WO 9818930 A3 WO9818930 A3 WO 9818930A3
Authority
WO
WIPO (PCT)
Prior art keywords
streptococcus pneumoniae
vaccines
relates
polypeptides
pneumoniae antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/019422
Other languages
French (fr)
Other versions
WO1998018930A2 (en
Inventor
Charles A Kunsch
Gil H Choi
L Sydnor Johnson
Alex Hromockyj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21851789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998018930(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP97946850.1A priority Critical patent/EP0942983B2/en
Priority to CA002269663A priority patent/CA2269663A1/en
Priority to DE69737125.5T priority patent/DE69737125T3/en
Priority to AU51945/98A priority patent/AU5194598A/en
Priority to ES97946850.1T priority patent/ES2277362T5/en
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Priority to DK97946850.1T priority patent/DK0942983T4/en
Priority to JP52066798A priority patent/JP4469026B2/en
Publication of WO1998018930A2 publication Critical patent/WO1998018930A2/en
Publication of WO1998018930A3 publication Critical patent/WO1998018930A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
PCT/US1997/019422 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines Ceased WO1998018930A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP52066798A JP4469026B2 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
CA002269663A CA2269663A1 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
DE69737125.5T DE69737125T3 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
AU51945/98A AU5194598A (en) 1996-10-31 1997-10-30 (streptococcus pneumoniae) antigens and vaccines
ES97946850.1T ES2277362T5 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
EP97946850.1A EP0942983B2 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
DK97946850.1T DK0942983T4 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2996096P 1996-10-31 1996-10-31
US60/029,960 1996-10-31

Publications (2)

Publication Number Publication Date
WO1998018930A2 WO1998018930A2 (en) 1998-05-07
WO1998018930A3 true WO1998018930A3 (en) 1998-10-08

Family

ID=21851789

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1997/019422 Ceased WO1998018930A2 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae antigens and vaccines
PCT/US1997/019588 Ceased WO1998018931A2 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae polynucleotides and sequences

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019588 Ceased WO1998018931A2 (en) 1996-10-31 1997-10-30 Streptococcus pneumoniae polynucleotides and sequences

Country Status (11)

Country Link
US (9) US6420135B1 (en)
EP (4) EP0942983B2 (en)
JP (6) JP4469026B2 (en)
AT (2) ATE479756T1 (en)
AU (6) AU6909098A (en)
CA (2) CA2271720A1 (en)
DE (2) DE69737125T3 (en)
DK (1) DK0942983T4 (en)
ES (2) ES2277362T5 (en)
PT (1) PT942983E (en)
WO (2) WO1998018930A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582731B2 (en) 1997-07-02 2009-09-01 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
KR101170203B1 (en) * 1998-12-23 2012-07-31 아이디 바이오메디칼 코포레이션 Novel Streptococcus antigens

Families Citing this family (337)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
JP2000506385A (en) * 1996-02-20 2000-05-30 スミスクライン・ビーチャム・コーポレイション New ERA
GB9608000D0 (en) * 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
GB9607991D0 (en) * 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
US5795758A (en) * 1997-04-18 1998-08-18 Smithkline Beecham Corporation DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae
US5834276A (en) * 1996-04-18 1998-11-10 Smithkline Beecham Corporation Asparaginyl TRNA synthetase polynucleotides of streptococcus
US5968777A (en) * 1996-04-18 1999-10-19 Smithkline Beecham Corporation DNA encoding seryl t-RNA synthetase
US6270999B1 (en) 1997-04-10 2001-08-07 Smithkline Beecham Corporation Compounds
GB9607993D0 (en) 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
JP2000509984A (en) * 1996-05-01 2000-08-08 スミスクライン・ビーチャム・コーポレイション New compound
JP2000512487A (en) * 1996-05-14 2000-09-26 スミスクライン・ビーチャム・コーポレイション New compound
US6165989A (en) * 1996-05-14 2000-12-26 Smithkline Beecham Corporation Era of Streptococcus pneumoniae
US5712108A (en) * 1996-05-29 1998-01-27 Eli Lilly And Company Peptidoglycan biosynthetic mure protein from streptocuccus pneumoniae
US5681694A (en) * 1996-06-18 1997-10-28 Eli Lilly And Company Murd protein method and kit for identification of inhibitors
EP0816502A3 (en) * 1996-07-03 1999-10-20 Smithkline Beecham Corporation Mur A-1, an UDP-N-acetylglucosamine enolpyruvyl-transferase from Streptococcus pneumoniae
GB9613907D0 (en) 1996-07-03 1996-09-04 Smithkline Beecham Plc Novel compounds
US5776733A (en) * 1996-07-25 1998-07-07 Eli Lilly And Company Biosynthetic gene DD1 from Streptococcus pneumoniae
US5691161A (en) * 1996-08-01 1997-11-25 Eli Lilly And Company Peptidoglycan biosynthetic mura protein from Streptococcus pneumoniae
US5858718A (en) * 1997-07-08 1999-01-12 Smithkline Beecham Corporation Pcr a
US6284878B1 (en) 1996-08-16 2001-09-04 Smithkline Beecham Corporation def1
US6165762A (en) * 1996-08-16 2000-12-26 Smithkline Beecham Corporation DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
GB9619071D0 (en) 1996-09-12 1996-10-23 Smithkline Beecham Plc Novel compounds
US5928895A (en) * 1996-09-24 1999-07-27 Smithkline Beecham Corporation IgA Fc binding protein
US5882871A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation Saliva binding protein
US5882896A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation M protein
US6225083B1 (en) * 1996-10-01 2001-05-01 Smithkline Beecham Corporation FtsL from Streptococcus pneumoniae
US5910414A (en) 1996-10-15 1999-06-08 Smithkline Beecham Corporation Topoisomerase I of streptococcus pneumoniae
US5789202A (en) * 1996-10-17 1998-08-04 Eli Lilly And Company DNA encoding a novel penicillin binding protein from streptococcus pneumoniae
US6096518A (en) * 1996-10-24 2000-08-01 Smithkline Beecham Corporation DNA encoding SPO/REL polypeptides of streptococcus
US6022710A (en) * 1996-10-25 2000-02-08 Smithkline Beecham Corporation Nucleic acid encoding greA from Streptococcus pneumoniae
US6887663B1 (en) * 1996-10-31 2005-05-03 Human Genome Sciences, Inc. Streptococcus pneumoniae SP036 polynucleotides
JP4469026B2 (en) * 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Streptococcus pneumoniae antigens and vaccines
US5821335A (en) * 1996-11-19 1998-10-13 Eli Lilly And Company Biosynthetic gene murg from streptococcus pneumoniae
US5786197A (en) * 1996-11-25 1998-07-28 Smithkline Beecham Corporation lep
US6287803B1 (en) * 1996-11-27 2001-09-11 Smithkline Beecham Corporation Polynucleotides encoding a novel era polypeptide
US5948645A (en) * 1996-12-04 1999-09-07 Eli Lilly And Company Biosynthetic gene muri from Streptococcus pneumoniae
CA2220850A1 (en) * 1997-01-21 1998-07-21 Smithkline Beecham Corporation Novel aroe
EP0863152A3 (en) * 1997-02-10 2000-04-19 Smithkline Beecham Corporation Streptococcus pneumoniae Def1 protein
EP0863205A1 (en) * 1997-02-10 1998-09-09 Smithkline Beecham Corporation Def2 protein from Streptococcus pneumoniae
US6110899A (en) * 1997-02-28 2000-08-29 Smithkline Beecham Corporation LICC of Streptococcus pneumoniae
US6228838B1 (en) 1997-02-28 2001-05-08 Smithkline Beecham Corporation LicD1 polypeptides
CA2230497A1 (en) * 1997-02-28 1998-08-28 Smithkline Beecham Corporation Novel lica
US5962295A (en) * 1997-02-28 1999-10-05 Smithkline Beecham Corporation LicB polypeptides from Streptococcus pneumoniae
DE19708537A1 (en) * 1997-03-03 1998-09-10 Biotechnolog Forschung Gmbh New surface protein (SpsA protein) from Streptococcus pneumoniae etc.
US6210940B1 (en) 1997-04-18 2001-04-03 Smithkline Beecham Corporation Compounds
US6074858A (en) * 1997-04-18 2000-06-13 Smithkline Beecham Corporation Cysteinyl TRNA synthetase from Streptococcus pneumoniae
US6676943B1 (en) 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
CN1253589A (en) * 1997-04-24 2000-05-17 美国明尼苏达州大学 Human complement C3-degrading proteinase from streptococcus pneumoniae
US5919664A (en) 1997-05-29 1999-07-06 Smithkline Beecham Corporation Peptide release factor, prfC (RF-3), a GTP-Binding protein
US6287836B1 (en) 1997-05-30 2001-09-11 Smithkline Beecham Corporation Histidine kinase from Streptococcus pneumoniae and compositions therecontaining
US6165992A (en) * 1997-05-30 2000-12-26 Smithkline Beecham Corporation Histidine kinase
US6165991A (en) * 1997-05-30 2000-12-26 Smithkline Beecham Corporation Sensor histidine kinase of Streptococcus pneumoniae
CA2233577A1 (en) * 1997-05-30 1998-11-30 Smithkline Beecham Corporation Histidine kinase
US5866365A (en) * 1997-06-05 1999-02-02 Smithkline Beecham Corporation RNC polynucleotides
US5882889A (en) * 1997-06-13 1999-03-16 Smithkline Beecham Corporation Response regulator in a two component signal transduction system
US6268172B1 (en) * 1997-06-20 2001-07-31 Smithkline Beecham Corporation Compounds
EP0885963A3 (en) * 1997-06-20 1999-12-29 Smithkline Beecham Corporation Compounds comprising polypeptides and polynucleotides of Streptococcus pneumoniae,said polypeptides being related by amino acid sequence homology to SapR from Streptococcus mutans polypeptide
US6140061A (en) * 1997-06-20 2000-10-31 Smithkline Beecham Corporation Response regulator
US6270991B1 (en) 1997-06-20 2001-08-07 Smithkline Beecham Corporation Histidine kinase
EP0891984A3 (en) 1997-06-20 2000-01-19 Smithkline Beecham Corporation Nucleic acid encoding streptococcus pneumoniae response regulator
EP0885965A3 (en) * 1997-06-20 2000-01-12 Smithkline Beecham Corporation Histidine kinase polypeptides
EP0885903A3 (en) * 1997-06-20 2000-01-19 Smithkline Beecham Corporation Nucleic acid encoding streptococcus pheumoniae response regulator
EP0885966A3 (en) * 1997-06-20 1999-12-29 Smithkline Beecham Corporation Novel compouds
US5866366A (en) * 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
CA2236441A1 (en) * 1997-07-01 1999-01-01 Smithkline Beecham Corporation Gida2
US6238882B1 (en) * 1997-07-01 2001-05-29 Smithkline Beecham Corporation GidA1
US7115731B1 (en) 1997-07-02 2006-10-03 sanofi pasteur limited/ sanofi pasteur limiteé Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
EP0890641A1 (en) * 1997-07-10 1999-01-13 Smithkline Beecham Corporation Novel IspA
EP0915159A1 (en) * 1997-07-17 1999-05-12 Smithkline Beecham Corporation Novel xanthine phosphoribosyl transferase
CA2237043A1 (en) * 1997-07-18 1999-01-18 Smithkline Beecham Corporation Response regulator
US5994101A (en) * 1997-07-18 1999-11-30 Smithkline Beecham Corporation DNA encoding gidA1 polypeptides
EP0894857A3 (en) * 1997-08-01 2001-09-26 Smithkline Beecham Corporation SecA gene from Streptococcus pneumoniae
US5840538A (en) * 1997-08-06 1998-11-24 Smithkline Beecham Corporation Lgt
EP0896061A3 (en) * 1997-08-08 2000-07-26 Smithkline Beecham Corporation RpoA gene from Staphylococcus aureus
US6197300B1 (en) * 1997-08-12 2001-03-06 Smithkline Beecham Corporation ftsZ
US5929045A (en) * 1997-08-12 1999-07-27 Smithkline Beecham Corporation Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae
US5888770A (en) * 1997-08-26 1999-03-30 Smithkline Beecham Corporation Spoiiie
US6072032A (en) * 1997-08-29 2000-06-06 Smithkline Beecham Corporation FtsY polypeptides from Streptococcus pneumoniae
US5882898A (en) * 1997-08-29 1999-03-16 Smithkline Beecham Corporation Streptococcus pneumoniae polynucleotides which encode folyl-polyglutamate synthetase (FPGS) polypeptides
US6225087B1 (en) * 1997-09-09 2001-05-01 Smithkline Beecham Corporation Response regulator
EP0902087A3 (en) * 1997-09-10 2000-03-15 SmithKline Beecham Corporation Histidine kinase
EP0913478A3 (en) * 1997-09-17 1999-12-29 Smithkline Beecham Corporation Histidine kinase from Streptococcus pneumoniae 0100993
US5866369A (en) * 1997-09-18 1999-02-02 Smithkline Beecham Corporation Amps
US5885804A (en) * 1997-09-18 1999-03-23 Smithkline Beecham Corporation PhoH
AU9510598A (en) * 1997-09-24 1999-04-12 American Cyanamid Company Human complement c3-degrading proteinase from (streptococcus pneumoniae)
EP0905249A3 (en) * 1997-09-25 1999-08-04 Smithkline Beecham Corporation Alcohol dehydrogenase
CA2244954A1 (en) * 1997-09-25 1999-03-25 Smithkline Beecham Corporation Murf
US6194170B1 (en) 1997-09-25 2001-02-27 Smithkline Beecham Corporation MurF of Streptococcus pneumoniae
US6121028A (en) * 1997-10-10 2000-09-19 Smithkline Beecham Corporation MurE
US6331411B1 (en) * 1997-10-14 2001-12-18 Smithkline Beecham Corporation TopA
EP0913479A3 (en) * 1997-10-27 2000-10-25 Smithkline Beecham Corporation Adenine glycosylase
US5861281A (en) * 1997-10-30 1999-01-19 Smithkline Beecham Corporation Lacc
US6165763A (en) * 1997-10-30 2000-12-26 Smithkline Beecham Corporation Ornithine carbamoyltransferase
EP0913480A3 (en) * 1997-11-03 2001-07-11 Smithkline Beecham Corporation Chorismate synthase
EP0964921A4 (en) * 1997-11-05 2002-01-23 Smithkline Beecham Corp Novel streptococcal ers
US20020058799A1 (en) * 1998-05-18 2002-05-16 Sanjoy Biswas Novel pth
WO1999035270A1 (en) * 1997-12-31 1999-07-15 Stressgen Biotechnologies Corporation Streptococcal heat shock proteins of the hsp60 family
KR20010033721A (en) * 1997-12-31 2001-04-25 밀레니엄 파머슈티컬스 인코퍼레이티드 Essential bacterial genes and their use
CA2321106C (en) 1998-02-20 2013-07-23 Biochem Pharma Inc. Group b streptococcus antigens
DE69942176D1 (en) * 1998-04-07 2010-05-06 Medimmune Llc CHOLINE-BINDING PROTEIN DERIVATIVES FROM PNEUMOCOKES AS A VACCINE
US6858706B2 (en) * 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
IL138939A0 (en) * 1998-04-07 2001-11-25 St Jude Childrens Res Hospital A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
GB9808350D0 (en) * 1998-04-22 1998-06-17 Glaxo Group Ltd Bacterial polypeptide family
GB9808363D0 (en) * 1998-04-22 1998-06-17 Glaxo Group Ltd Bacterial polypeptide family
US20010016200A1 (en) * 1998-04-23 2001-08-23 Briles David E. Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
EP1080181A4 (en) * 1998-05-18 2001-08-08 Smithkline Beecham Corp clpX OF STREPTOCOCCUS PNEUMONIAE
WO1999061452A2 (en) * 1998-05-28 1999-12-02 Smithkline Beecham Corporation acpS
US6660520B2 (en) 1998-06-05 2003-12-09 Smithkline Beecham Corporation Nrde
US6190881B1 (en) * 1998-06-05 2001-02-20 Smithkline Beecham Corporation Ribonucleotide diphosphate reductase, nrdF, of streptococcus pneumoniae
WO1999064610A1 (en) * 1998-06-11 1999-12-16 St. Jude Children's Research Hospital ZmpB, A NEW DETERMINANT OF VIRULENCE FOR STREPTOCOCCUS PNEUMONIAE, VACCINE DERIVED THEREFROM AND USES THEREOF
JP2002519055A (en) * 1998-07-02 2002-07-02 スミスクライン・ビーチャム・コーポレイション FTSZ multimeric proteins and uses thereof
EP1100879A1 (en) * 1998-07-24 2001-05-23 SmithKline Beecham Corporation Pneumococcal nrdg protein
EP1785486A3 (en) * 1998-07-27 2007-08-08 Sanofi Pasteur Limited Streptococcus pneumoniae proteins and nucleic acid molecules
US20030134407A1 (en) 1998-07-27 2003-07-17 Le Page Richard William Falla Nucleic acids and proteins from Streptococcus pneumoniae
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
EP1624064A3 (en) * 1998-07-27 2006-05-10 Microbial Technics Limited Nucleic acids and proteins from streptococcus pneumoniae
CN1318103A (en) * 1998-07-27 2001-10-17 微生物技术有限公司 Nucleic acids and proteins from streptococcus pneumoniae
WO2000006736A2 (en) * 1998-07-27 2000-02-10 Microbial Technics Limited Nucleic acids and proteins from group b streptococcus
EP1801218A3 (en) * 1998-07-27 2007-10-10 Sanofi Pasteur Limited Nucleic acids and proteins from streptococcus pneumoniae
US7098182B2 (en) 1998-07-27 2006-08-29 Microbial Technics Limited Nucleic acids and proteins from group B streptococcus
ATE361365T1 (en) * 1998-07-27 2007-05-15 Sanofi Pasteur Ltd STREPTOCOCCUS PNEUMONIAE PROTEINS AND NUCLEIC ACIDS
KR20010024603A (en) 1998-09-09 2001-03-26 밀레니엄 파머슈티컬스 인코퍼레이티드 Essential bacterial genes and their use
US6268177B1 (en) 1998-09-22 2001-07-31 Smithkline Beecham Corporation Isolated nucleic acid encoding nucleotide pyrophosphorylase
US6225457B1 (en) * 1998-09-23 2001-05-01 Smithkline Beecham Corporation murF2
EP1115875A1 (en) * 1998-09-24 2001-07-18 Regents Of The University Of Minnesota Human complement c3-degrading polypeptide from streptococcus pneumoniae
WO2000018797A1 (en) * 1998-09-28 2000-04-06 Smithkline Beecham Corporation Map
US20030082614A1 (en) * 2001-05-29 2003-05-01 Sanjoy Biswas Map
US6515119B1 (en) * 1998-09-30 2003-02-04 Millennium Pharmaceuticals, Inc. Use of S-ydcB and B-ydcB, essential bacterial genes
US6537774B1 (en) * 1998-10-14 2003-03-25 Smithkline Beecham Corporation UPS (undecaprenyl diphosphate synthase
US6255075B1 (en) * 1998-10-20 2001-07-03 Smithkline Beecham Corporation Bira
US6110685A (en) * 1998-10-28 2000-08-29 Smithkline Beecham Corporation infB
US6228625B1 (en) 1998-11-03 2001-05-08 Smithkline Beecham Corporation metK from Streptococcus pneumoniae
WO2000026359A1 (en) * 1998-11-04 2000-05-11 Smithkline Beecham Corporation ftsX
US6165764A (en) * 1998-11-09 2000-12-26 Smithkline Beecham Corporation Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae
US6277595B1 (en) * 1998-11-19 2001-08-21 Smithkline Beecham Corporation FabZ
WO2000029434A2 (en) * 1998-11-19 2000-05-25 St. Jude Children's Research Hospital PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, DIAGNOSTIC AND THERAPEUTIC USES THEREOF
US6495139B2 (en) * 1998-11-19 2002-12-17 St. Jude Children's Research Hospital Identification and characterization of novel pneumococcal choline binding protein, CBPG, and diagnostic and therapeutic uses thereof
EP1140157B1 (en) * 1998-12-21 2009-02-18 MedImmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
AU2004242430C1 (en) * 1998-12-21 2008-06-05 Med Immune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
CN101066447A (en) 1998-12-22 2007-11-07 微科学有限公司 Group b streptococcus proteins, and their use
CA2354843A1 (en) * 1998-12-22 2000-06-29 Microscience Limited Outer surface proteins, their genes, and their use
EP1950302B1 (en) 1998-12-23 2012-12-05 ID Biomedical Corporation of Quebec Streptococcus antigens
AU2005209689B2 (en) * 1998-12-23 2008-07-17 Id Biomedical Corporation Of Quebec Novel streptococcus antigens
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
US6340564B1 (en) * 1999-01-26 2002-01-22 Smithkline Beecham Corporation yhxB
WO2000044764A1 (en) * 1999-01-28 2000-08-03 Smithkline Beecham Corporation Mvd
US6346396B1 (en) * 1999-01-29 2002-02-12 Jianzhong Huang MurA
US6306633B1 (en) 1999-02-01 2001-10-23 Smithkline Beecham Corporation Polynucleotides encoding mevalonate kinase from Streptococcus pneumoniae
WO2000049033A1 (en) * 1999-02-17 2000-08-24 Smithkline Beecham Corporation yybQ
US6270762B1 (en) 1999-02-26 2001-08-07 Smithkline Beecham Corporation tdk
GB9906437D0 (en) * 1999-03-19 1999-05-12 Smithkline Beecham Biolog Vaccine
WO2000056884A1 (en) * 1999-03-24 2000-09-28 Smithkline Beecham Corporation pksG
US6130069A (en) * 1999-03-24 2000-10-10 Smithkline Beecham Corporation IspA from Streptococcus pneumoniae
WO2000056873A1 (en) * 1999-03-25 2000-09-28 Smithkline Beecham Corporation mvaA
CN1198932C (en) * 1999-03-26 2005-04-27 科特克斯(Om)有限公司 Streptococcus pneumoniae antigens
WO2000059514A1 (en) * 1999-04-02 2000-10-12 Smithkline Beecham Corporation Yeaz
EP1233780A4 (en) 1999-04-15 2004-09-22 Univ California IDENTIFICATION OF THE SORTASEGEN
US7101692B2 (en) 1999-04-15 2006-09-05 The Regents Of The University Of California Identification of sortase gene
US6326167B1 (en) * 1999-04-23 2001-12-04 Smithkline Beecham Corp. TktA from Streptococcus pneumoniae
WO2000065026A2 (en) * 1999-04-28 2000-11-02 Smithkline Beecham Corporation YycG
US6245542B1 (en) * 1999-05-06 2001-06-12 Smithkline Beecham Corporation tRNA methyltransferase from Streptococcus pneumoniae
WO2000070075A1 (en) * 1999-05-17 2000-11-23 Smithkline Beecham Corporation STREPTOCOCCUS PNEUMONIAE yerS
NZ515935A (en) 1999-05-19 2004-01-30 Chiron S Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis
US6177269B1 (en) * 1999-06-04 2001-01-23 Smithkline Beecham Corporation, aroA
JP2003501110A (en) * 1999-06-10 2003-01-14 メディミューン，インコーポレーテッド S. pneumoniae proteins and vaccines
US6887480B1 (en) 1999-06-10 2005-05-03 Medimmune, Inc. Streptococcus pneumoniae proteins and vaccines
US6869767B1 (en) * 1999-06-11 2005-03-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection
WO2000078785A1 (en) * 1999-06-22 2000-12-28 Smithkline Beecham Corporation lacA
US6511839B1 (en) * 1999-06-22 2003-01-28 Pan Fong Chan Fucose kinase
US6291230B1 (en) * 1999-06-23 2001-09-18 Smithkline Beecham Corporation Galk promoter
WO2000078784A1 (en) * 1999-06-23 2000-12-28 Smithkline Beecham Corporation treP
US6884614B1 (en) 1999-07-01 2005-04-26 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins
MXPA01012932A (en) * 1999-07-01 2002-07-30 Basf Ag Orynebacterium glutamicum.
WO2001007460A1 (en) * 1999-07-22 2001-02-01 Smithkline Beecham Corporation FucR
WO2001007463A1 (en) * 1999-07-22 2001-02-01 Smithkline Beecham Corporation Trer
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
US6277597B1 (en) * 1999-08-03 2001-08-21 Smithkline Beecham Corporation kdtB
EP1075841A1 (en) * 1999-08-13 2001-02-14 Erasmus Universiteit Rotterdam Pneumococcal vaccines
WO2001012649A1 (en) * 1999-08-18 2001-02-22 Smithkline Beecham Corporation Aga
US6168797B1 (en) * 1999-08-18 2001-01-02 Smithkline Beecham Corporation FabF
AU7076100A (en) * 1999-08-25 2001-03-19 Med Immune, Inc. Homologs of a pneumococcal protein and fragments for vaccines
US6833356B1 (en) 1999-08-25 2004-12-21 Medimmune, Inc. Pneumococcal protein homologs and fragments for vaccines
WO2001023403A1 (en) * 1999-09-27 2001-04-05 Smithkline Beecham Corporation ypga CLADE GENES
WO2001023599A1 (en) * 1999-09-28 2001-04-05 Smithkline Beecham Corporation Streptococcus pneumoniae ykqc
EP1246935B1 (en) * 1999-09-28 2013-08-14 Geneohm Sciences Canada Inc. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US6861516B1 (en) 1999-10-04 2005-03-01 Merck & Co., Inc. MraY gene and enzyme of pseudomonas aeruginosa
US6951729B1 (en) 1999-10-27 2005-10-04 Affinium Pharmaceuticals, Inc. High throughput screening method for biological agents affecting fatty acid biosynthesis
WO2001048208A2 (en) * 1999-12-23 2001-07-05 Vmax Limited Streptococcus pyogenes virulence genes and proteins and their use
WO2001049721A2 (en) * 1999-12-30 2001-07-12 Bristol-Myers Squibb Company Bacterial genes and proteins that are essential for cell viability and their uses
EP1130091A3 (en) * 2000-03-01 2001-11-14 Message Pharmaceuticals, Inc. Bacterial RNaseP Proteins and their use in identifying antibacterial compounds
FR2807764B1 (en) * 2000-04-18 2004-09-10 Agronomique Inst Nat Rech MUTANTS OF LACTIC BACTERIA OVERPRODUCING EXOPOLYSACCHARIDES
JP2003530872A (en) * 2000-04-27 2003-10-21 メディミューン，インコーポレイテッド Immunogenic S. pneumoniae proteins and vaccine compositions thereof
EP1734050A3 (en) * 2000-06-12 2012-12-05 University Of Saskatchewan Immunization of dairy cattle with GapC protein against streptococcus infection
US6866855B2 (en) 2000-06-12 2005-03-15 University Of Saskatchewan Immunization of dairy cattle with GapC protein against Streptococcus infection
DK1294771T3 (en) 2000-06-12 2008-12-15 Univ Saskatchewan Streptococcus chimeric GapC protein and its use for vaccination and diagnosis
ES2273861T3 (en) * 2000-06-12 2007-05-16 University Of Saskatchewan IMMUNIZATION OF MILK VACCINE LIVESTOCK WITH GAPC PROTEIN AGAINST STREPTOCOCCUS INFECTIONS.
US6833134B2 (en) 2000-06-12 2004-12-21 University Of Saskacthewan Immunization of dairy cattle with GapC protein against Streptococcus infection
US7074415B2 (en) 2000-06-20 2006-07-11 Id Biomedical Corporation Streptococcus antigens
CA2413450C (en) 2000-06-20 2014-02-18 Shire Biochem Inc. Streptococcus antigens
WO2002006491A1 (en) * 2000-07-18 2002-01-24 Center For Advanced Science And Technology Incubation, Ltd. Isopentenyl pyrophosphate isomerase
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US6821746B2 (en) 2000-10-06 2004-11-23 Affinium Pharmaceuticals, Inc. Methods of screening for FabK antagonists and agonists
US7048926B2 (en) 2000-10-06 2006-05-23 Affinium Pharmaceuticals, Inc. Methods of agonizing and antagonizing FabK
US7033795B2 (en) 2000-10-06 2006-04-25 Affinium Pharmaceuticals, Inc. FabK variant
US7056697B2 (en) 2000-10-06 2006-06-06 Affinium Pharmaceuticals, Inc. FabK variant
CA2426738A1 (en) * 2000-10-26 2002-05-02 David William Holden Streptococcal genes
CA2881568C (en) 2000-10-27 2019-09-24 Novartis Vaccines And Diagnostics, Inc. Nucleic acids and proteins from streptococcus groups a & b
WO2002053761A2 (en) * 2000-12-28 2002-07-11 Wyeth Recombinant protective protein from $i(streptococcus pneumoniae)
EP1227152A1 (en) * 2001-01-30 2002-07-31 Société des Produits Nestlé S.A. Bacterial strain and genome of bifidobacterium
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
EP2277897A1 (en) * 2001-04-16 2011-01-26 Wyeth Holdings Corporation Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
EP1456231A2 (en) * 2001-12-20 2004-09-15 Shire Biochem Inc. Streptococcus antigens
US20030211470A1 (en) * 2002-03-15 2003-11-13 Olson William C. CD4-IgG2-based salvage therapy of HIV-1 infection
US20030199603A1 (en) * 2002-04-04 2003-10-23 3M Innovative Properties Company Cured compositions transparent to ultraviolet radiation
US20060057160A1 (en) 2002-08-02 2006-03-16 Ralph Biemans Vaccine composition
WO2004020609A2 (en) * 2002-08-30 2004-03-11 Tufts University Streptococcus pneumoniae antigens for diagnosis, treatment and prevention of active infection
EP1540559B1 (en) * 2002-09-13 2013-02-27 The Texas A & M University System Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
CA2503946C (en) 2002-11-01 2016-08-16 Glaxosmithkline Biologicals S.A. Drying process
FR2846668B1 (en) * 2002-11-05 2007-12-21 Univ Aix Marseille Ii MOLECULAR IDENTIFICATION OF BACTERIA OF THE GENUS STREPTOCOCCUS AND RELATED GENRES
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
AU2003286056A1 (en) * 2002-11-26 2004-06-18 Id Biomedical Corporation Streptococcus pneumoniae surface polypeptides
GB0302699D0 (en) * 2003-02-06 2003-03-12 Univ Bradford Immunoglobulin
EP2311988A1 (en) * 2003-04-15 2011-04-20 Intercell AG S. pneumoniae antigens
ES2505695T3 (en) 2003-07-31 2014-10-10 Novartis Vaccines And Diagnostics, Inc. Immunogenic compositions for Streptococcus pyogenes
US8945589B2 (en) 2003-09-15 2015-02-03 Novartis Vaccines And Diagnostics, Srl Immunogenic compositions for Streptococcus agalactiae
EP1667712B1 (en) 2003-10-02 2010-07-21 GlaxoSmithKline Biologicals S.A. B. pertussis antigens and use thereof in vaccination
JP2007512006A (en) 2003-11-10 2007-05-17 ザ ユーエービー リサーチ ファウンデーション Composition for reducing bacterial transport and CNS invasion and method of using the composition
EP1692277A4 (en) * 2003-11-26 2008-03-12 Binax Inc Methods and kits for predicting an infectious disease state
EP1607485A1 (en) * 2004-06-14 2005-12-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for quantifying VEGF121 isoform in a biological sample
WO2006002422A2 (en) 2004-06-24 2006-01-05 Novartis Vaccines And Diagnostics Inc. Compounds for immunopotentiation
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
JP2008508320A (en) 2004-07-29 2008-03-21 カイロン コーポレイション Immunogenic composition against gram positive bacteria such as STREPTOCOCCUSAGALACTIAE
US7838010B2 (en) 2004-10-08 2010-11-23 Novartis Vaccines And Diagnostics S.R.L. Immunogenic and therapeutic compositions for Streptococcus pyogenes
WO2006048753A2 (en) * 2004-11-05 2006-05-11 Pharmacia & Upjohn Company Llc Anti-bacterial vaccine compositions
JP2006223194A (en) * 2005-02-17 2006-08-31 Tosoh Corp Method for measuring stanniocalcin 1 (STC1) mRNA
CN103589650A (en) 2005-03-18 2014-02-19 米克罗比亚公司 Production of carotenoids in oleaginous yeast and fungi
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
US7476733B2 (en) 2005-03-25 2009-01-13 The United States Of America As Represented By The Department Of Health And Human Services Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
PE20110072A1 (en) 2005-06-27 2011-02-04 Glaxosmithkline Biolog Sa IMMUNOGENIC COMPOSITION
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
CA2626253A1 (en) 2005-10-18 2007-04-26 Novartis Vaccines And Diagnostics, Inc. Mucosal and systemic immunizations with alphavirus replicon particles
ES2514316T3 (en) 2005-11-22 2014-10-28 Novartis Vaccines And Diagnostics, Inc. Norovirus and Sapovirus virus-like particles (VLPs)
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
KR101515078B1 (en) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccines
MY150105A (en) 2006-01-17 2013-11-29 Forsgren Arne A novel surface exposed haemophilus influenzae protein (protein e; pe)
AU2007281934B2 (en) 2006-01-18 2012-11-15 University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
ES2536426T3 (en) 2006-03-23 2015-05-25 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
WO2008051285A2 (en) 2006-04-01 2008-05-02 Medical Service Consultation International, Llc Methods and compositions for detecting fungi and mycotoxins
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
WO2008022299A1 (en) * 2006-08-17 2008-02-21 The Uab Research Foundation Diagnosing pneumococcal pneumonia
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
EP1923069A1 (en) * 2006-11-20 2008-05-21 Intercell AG Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto
WO2008127094A2 (en) 2007-04-12 2008-10-23 Stichting Katholieke Universiteit, More Particularly The Radboud University Nijmegen Medical Center New virulence factors of streptococcus pnuemoniae
CN101688194B (en) 2007-05-23 2013-09-11 Uab研究基金会 Detoxified pneumococcal neuraminidase and uses thereof
CA2690708A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
KR101621837B1 (en) 2007-09-12 2016-05-17 노파르티스 아게 Gas57 mutant antigens and gas57 antibodies
EP2537857B1 (en) 2007-12-21 2017-01-18 GlaxoSmithKline Biologicals SA Mutant forms of streptolysin O
CN102356089B (en) 2008-02-21 2014-02-19 诺华股份有限公司 Meningococcal fHBP polypeptide
CN102015651B (en) 2008-03-03 2014-12-31 Irm责任有限公司 Compounds and compositions as TLR activity modulators
ES2553113T3 (en) 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vaccine
US20100068718A1 (en) 2008-08-22 2010-03-18 Hooper Dennis G Methods and Compositions for Identifying Yeast
EP2174664A1 (en) 2008-10-07 2010-04-14 Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre New virulence factors of Streptococcus pneumoniae
CN103897045A (en) 2009-01-12 2014-07-02 诺华股份有限公司 Cna_b domain antigens in vaccines against gram positive bacteria
CN102301008B (en) * 2009-01-19 2015-05-13 生物梅里埃公司 Method for determining susceptibility of patients to developing nosocomial infections and establishing prognosis for progression of septic syndrome
EP2411048B1 (en) 2009-03-24 2020-05-06 GlaxoSmithKline Biologicals SA Adjuvanting meningococcal factor h binding protein
EP3017826A1 (en) 2009-03-24 2016-05-11 Novartis AG Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
ITMI20090946A1 (en) 2009-05-28 2010-11-29 Novartis Ag EXPRESSION OF RECOMBINANT PROTEINS
JP5867952B2 (en) 2009-06-10 2016-02-24 ノバルティス アーゲー Benzonaphthyridine-containing vaccine
WO2011008400A2 (en) 2009-06-16 2011-01-20 Novartis Ag High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays
RU2580299C2 (en) 2009-06-29 2016-04-10 Дженосеа Биосайенсиз, Инк. Streptococcus pneumoniae vaccines and compositions
US8877356B2 (en) 2009-07-22 2014-11-04 Global Oled Technology Llc OLED device with stabilized yellow light-emitting layer
JO3257B1 (en) 2009-09-02 2018-09-16 Novartis Ag Vehicles and installations as TLR
WO2011027222A2 (en) 2009-09-02 2011-03-10 Novartis Ag Immunogenic compositions including tlr activity modulators
US20120237536A1 (en) 2009-09-10 2012-09-20 Novartis Combination vaccines against respiratory tract diseases
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
CN102648003B (en) * 2009-10-09 2016-01-13 儿童医疗中心有限公司 The whole-cell vaccines of selective splitting
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
US9241987B2 (en) 2009-11-20 2016-01-26 The University Of Chicago Methods and compositions related to immunogenic fibrils
BR112012014624A8 (en) 2009-12-15 2017-12-26 Novartis Ag homogeneous suspension of immunopotentiation compounds and uses of these
WO2011080595A2 (en) 2009-12-30 2011-07-07 Novartis Ag Polysaccharide immunogens conjugated to e. coli carrier proteins
WO2011100443A1 (en) * 2010-02-11 2011-08-18 Intelligent Medical Devices, Inc. Oligonucleotides relating to clostridium difficile genes encoding toxin b, toxin a, or binary toxin
ES2557431T3 (en) 2010-02-23 2016-01-26 Stichting Katholieke Universiteit Combination vaccine for Streptococcus
US10113206B2 (en) * 2010-02-24 2018-10-30 Grifols Therapeutics Inc. Methods, compositions, and kits for determining human immunodeficiency virus (HIV)
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
CA2792687A1 (en) 2010-03-10 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition
EA031379B1 (en) 2010-03-23 2018-12-28 Новартис Аг Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
WO2011137368A2 (en) 2010-04-30 2011-11-03 Life Technologies Corporation Systems and methods for analyzing nucleic acid sequences
KR20130121699A (en) 2010-05-28 2013-11-06 테트리스 온라인, 인코포레이티드 Interactive hybrid asynchronous computer game infrastructure
US9268903B2 (en) 2010-07-06 2016-02-23 Life Technologies Corporation Systems and methods for sequence data alignment quality assessment
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
US9127321B2 (en) * 2010-10-06 2015-09-08 The Translational Genomics Research Institute Method of detecting Coccidioides species
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
WO2012100233A1 (en) 2011-01-20 2012-07-26 Genocea Biosciences, Inc. Vaccines and compositions against streptococcus pneumoniae
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US8877909B2 (en) 2011-04-04 2014-11-04 Intelligent Medical Devices, Inc. Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantitation, monitoring, screening, and sequencing of group B Streptococcus
CN103648489A (en) 2011-05-11 2014-03-19 儿童医疗中心有限公司 Multiple antigen presenting immunogenic compositions and methods and uses thereof
CN103533953A (en) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 Vaccine against Streptococcus pneumoniae
JP2015510872A (en) 2012-03-07 2015-04-13 ノバルティス アーゲー Enhanced formulation of Streptococcus pneumoniae antigen
AU2013276083B2 (en) 2012-06-14 2018-04-05 Institut Pasteur Vaccines for serogroup X meningococcus
TR201808684T4 (en) 2012-10-02 2018-07-23 Glaxosmithkline Biologicals Sa Nonlinear saccharide conjugates.
BR112015018014A2 (en) 2013-02-01 2017-07-11 Glaxosmithkline Biologicals Sa intradermal release of immunological compositions comprising toll-like receptor agonists
US11576958B2 (en) 2013-02-07 2023-02-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
AU2014280190B2 (en) * 2013-06-14 2020-04-02 Deutsches Krebsforschungszentrum TTV mirRNA sequences as an early marker for the future development of cancer and as a target for cancer treatment and prevention
EP3077410B1 (en) 2013-12-03 2021-02-03 Virometix AG Proline-rich peptides protective against s. pneumoniae
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP3207055A1 (en) * 2014-10-15 2017-08-23 Xenothera Composition with reduced immunogenicity
JP6399589B2 (en) * 2014-10-28 2018-10-03 国立大学法人山口大学 Expression promoter in Streptococcus pneumoniae
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017023855A1 (en) * 2015-07-31 2017-02-09 The General Hospital Corporation Protein prostheses for mitochondrial diseases or conditions
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
EP3383426A1 (en) 2015-12-04 2018-10-10 Dana Farber Cancer Institute, Inc. Vaccination with mica/b alpha 3 domain for the treatment of cancer
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
AU2018243910B2 (en) 2017-03-28 2025-04-10 The Children's Medical Center Corporation A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
WO2018183666A1 (en) 2017-03-31 2018-10-04 Boston Medical Center Corporation Methods and compositions using highly converved pneumococcal surface proteins
MX2019015524A (en) 2017-06-23 2020-09-10 Univ Maryland Immunogenic compositions.
GB201711635D0 (en) 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
ES3058336T3 (en) 2017-12-06 2026-03-10 Merck Sharp & Dohme Llc Compositions comprising polysaccharide-protein conjugates of Streptococcus pneumoniae and methods of use thereof
JP7362667B2 (en) 2018-02-12 2023-10-17 イニミューン・コーポレーション Toll-like receptor ligand
EP3824019A1 (en) 2018-07-19 2021-05-26 GlaxoSmithKline Biologicals SA Processes for preparing dried polysaccharides
CN112969474A (en) 2018-09-12 2021-06-15 艾芬尼维克斯公司 Multivalent pneumococcal vaccine
SG11202101973YA (en) * 2018-09-12 2021-03-30 Childrens Medical Ct Corp Pneumococcal fusion protein vaccines
CR20210333A (en) 2018-12-19 2021-08-18 Merck Sharp & Dohme COMPOSITIONS INCLUDING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE CONJUGATES WITH PROTEIN AND THEIR USE METHODS
US12533418B2 (en) 2019-11-22 2026-01-27 Glaxosmithkline Biologicals Sa Dosage and administration of a bacterial saccharide glycoconjugate vaccine
JP2023547677A (en) 2020-11-04 2023-11-13 エリゴ・バイオサイエンス Cutibacterium acnes recombinant phage, its production method and use
US20250000962A1 (en) * 2021-07-29 2025-01-02 Université de Lausanne Pneumococcal polypeptide antigens
MX2024002779A (en) 2021-09-09 2024-06-11 Affinivax Inc Multivalent pneumococcal vaccines.

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010238A1 (en) * 1991-11-14 1993-05-27 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Pneumococcal fimbrial protein a vaccines
EP0622081A2 (en) * 1993-04-20 1994-11-02 The Uab Research Foundation Epitopic regions of phneumococcal surface protein A
WO1995006732A2 (en) * 1993-09-01 1995-03-09 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1995014712A1 (en) * 1993-11-24 1995-06-01 Research Corporation Technologies, Inc. Streptococcus pneumoniae hemin/hemoglobin-binding antigens
WO1995031548A1 (en) * 1994-05-16 1995-11-23 The Uab Research Foundation Streptococcus pneumoniae capsular polysaccharide genes and flanking regions
EP0687688A1 (en) * 1993-12-17 1995-12-20 Universidad De Oviedo Antibodies against pneumolysine and their applications
WO1996005859A1 (en) * 1994-08-24 1996-02-29 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
WO1996016082A1 (en) * 1994-11-24 1996-05-30 Astra Aktiebolag Novel polypeptides

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4433092A (en) 1981-03-09 1984-02-21 Champion Spark Plug Company Green ceramic of lead-free glass, conductive carbon, silicone resin and AlPO4, useful, after firing, as an electrical resistor
DE3586772T2 (en) 1984-07-24 1993-03-04 Coselco Mimotopes Pty Ltd METHOD FOR DETERMINING MIMOTOPES.
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
LU86128A1 (en) 1985-10-18 1987-06-02 Vander Poorten Henri PROCESS FOR PRINTING OR COATING CERAMIC SIMULTANEOUSLY TO ITS ELECTROFORMING AND CONDUCTING SINGLE-COOKING TO DECORATIVE OR TECHNICAL PRODUCTS
GB8904762D0 (en) * 1989-03-02 1989-04-12 Glaxo Group Ltd Biological process
EP0394827A1 (en) 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5534410A (en) * 1993-01-28 1996-07-09 The Regents Of The University Of California TATA-binding protein associated factors drug screens
US5480971A (en) 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
US5620190A (en) 1994-08-18 1997-04-15 Fisher-Price, Inc. In-line skate
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
JPH08116973A (en) 1994-10-25 1996-05-14 Yotsuba Nyugyo Kk Novel aminopeptidase and aminopeptidase gene encoding it
WO1996033276A1 (en) * 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
JP2000512487A (en) 1996-05-14 2000-09-26 スミスクライン・ビーチャム・コーポレイション New compound
JP4469026B2 (en) 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Streptococcus pneumoniae antigens and vaccines
US5958730A (en) 1996-12-13 1999-09-28 Eli Lilly And Company Streptococcus pneumoniae gene sequence FtsY
US6800744B1 (en) * 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US7115731B1 (en) * 1997-07-02 2006-10-03 sanofi pasteur limited/ sanofi pasteur limiteé Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
AU9510598A (en) * 1997-09-24 1999-04-12 American Cyanamid Company Human complement c3-degrading proteinase from (streptococcus pneumoniae)
US6251588B1 (en) * 1998-02-10 2001-06-26 Agilent Technologies, Inc. Method for evaluating oligonucleotide probe sequences
EP1115875A1 (en) * 1998-09-24 2001-07-18 Regents Of The University Of Minnesota Human complement c3-degrading polypeptide from streptococcus pneumoniae
EP1140157B1 (en) * 1998-12-21 2009-02-18 MedImmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010238A1 (en) * 1991-11-14 1993-05-27 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Pneumococcal fimbrial protein a vaccines
EP0622081A2 (en) * 1993-04-20 1994-11-02 The Uab Research Foundation Epitopic regions of phneumococcal surface protein A
WO1995006732A2 (en) * 1993-09-01 1995-03-09 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1995014712A1 (en) * 1993-11-24 1995-06-01 Research Corporation Technologies, Inc. Streptococcus pneumoniae hemin/hemoglobin-binding antigens
EP0687688A1 (en) * 1993-12-17 1995-12-20 Universidad De Oviedo Antibodies against pneumolysine and their applications
WO1995031548A1 (en) * 1994-05-16 1995-11-23 The Uab Research Foundation Streptococcus pneumoniae capsular polysaccharide genes and flanking regions
WO1996005859A1 (en) * 1994-08-24 1996-02-29 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
WO1996016082A1 (en) * 1994-11-24 1996-05-30 Astra Aktiebolag Novel polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B.J. PEARCE ET AL.: "Genetic identification of exported proteins in Streptococcus pneumoniae", MOLECULAR MICROBIOL., vol. 9, no. 5, 1993, BLACKWELL, OXFORD, GB, pages 1037 - 1050, XP002060149 *
C. MARTIN ET AL.: "Relateness of penicillin-binding protein 1a genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain", EMBO J., vol. 11, no. 11, November 1992 (1992-11-01), OXFORD UNIVERSITY PRESS,GB;, pages 3831 - 3836, XP002060148 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582731B2 (en) 1997-07-02 2009-09-01 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US7582449B2 (en) 1997-07-02 2009-09-01 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US7626000B2 (en) 1997-07-02 2009-12-01 sanofi pasteur limited/sanofi pasteur limitée Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
KR101170203B1 (en) * 1998-12-23 2012-07-31 아이디 바이오메디칼 코포레이션 Novel Streptococcus antigens

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