WO1998019167A3 - Cell stress regulated human mhc class i gene - Google Patents

Cell stress regulated human mhc class i gene Download PDF

Info

Publication number
WO1998019167A3
WO1998019167A3 PCT/US1997/020170 US9720170W WO9819167A3 WO 1998019167 A3 WO1998019167 A3 WO 1998019167A3 US 9720170 W US9720170 W US 9720170W WO 9819167 A3 WO9819167 A3 WO 9819167A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
mhc class
human mhc
cell stress
regulated human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/020170
Other languages
French (fr)
Other versions
WO1998019167A2 (en
Inventor
Thomas Spies
Veronika Spies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fred Hutchinson Cancer Center
Original Assignee
Fred Hutchinson Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred Hutchinson Cancer Center filed Critical Fred Hutchinson Cancer Center
Priority to CA002275141A priority Critical patent/CA2275141A1/en
Priority to EP97946889A priority patent/EP0937258A2/en
Publication of WO1998019167A2 publication Critical patent/WO1998019167A2/en
Publication of WO1998019167A3 publication Critical patent/WO1998019167A3/en
Anticipated expiration legal-status Critical
Priority to US09/855,612 priority patent/US20030165835A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides various methods by which the use of certain MHC-related molecules can be exploited in understanding and regulating the immune response. More particularly, the present invention describes the use of molecules expressed by certain cell types as markers, reagents and targets in the diagnosis and treatment of certain disease states including GVHD, cancer and the like.
PCT/US1997/020170 1996-10-29 1997-10-29 Cell stress regulated human mhc class i gene Ceased WO1998019167A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002275141A CA2275141A1 (en) 1996-10-29 1997-10-29 Cell stress regulated human mhc class i gene
EP97946889A EP0937258A2 (en) 1996-10-29 1997-10-29 Cell stress regulated human mhc class i gene
US09/855,612 US20030165835A1 (en) 1996-10-29 2001-05-14 Cell stress regulated human MHC class I gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2904496P 1996-10-29 1996-10-29
US60/029,044 1996-10-29

Publications (2)

Publication Number Publication Date
WO1998019167A2 WO1998019167A2 (en) 1998-05-07
WO1998019167A3 true WO1998019167A3 (en) 1998-09-03

Family

ID=21846924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020170 Ceased WO1998019167A2 (en) 1996-10-29 1997-10-29 Cell stress regulated human mhc class i gene

Country Status (4)

Country Link
US (1) US20030165835A1 (en)
EP (1) EP0937258A2 (en)
CA (1) CA2275141A1 (en)
WO (1) WO1998019167A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007821A (en) * 1997-10-16 1999-12-28 Fordham University Method and compositions for the treatment of autoimmune disease using heat shock proteins
WO1999046365A1 (en) * 1998-03-12 1999-09-16 Emory University Methods and compositions for the selective expansion of gamma/delta t-cells
ATE421573T1 (en) 1998-11-04 2009-02-15 Therapure Biopharma Inc METHOD FOR PRODUCING GAMMA DELTA T CELLS
EP1287363A2 (en) * 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation of t-cell receptor interactions
US6821522B2 (en) * 2001-05-31 2004-11-23 The Regents Of The University Of California Tumor Therapy
CN100358917C (en) * 2002-03-04 2008-01-02 上海睿星基因技术有限公司 Tumor marker and use thereof
CA2483343A1 (en) 2002-04-22 2003-10-30 Fred Hutchinson Cancer Research Center Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions
AU2002335297A1 (en) * 2002-09-09 2004-03-29 Shanghai Genomics, Inc. Tumor tag and the use thereof
US7666417B2 (en) 2003-04-22 2010-02-23 Fred Hutchinson Cancer Research Center Methods and compositions for treating autoimmune diseases or conditions
EP2289534B1 (en) 2004-04-05 2017-08-30 The Regents of The University of California NKG2D antibodies for use in the treatment of rheumatoid arthritis or Crohn's disease
US7998481B2 (en) * 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection
WO2007055926A1 (en) * 2005-11-03 2007-05-18 Fred Hutchinson Cancer Research Center Negative immunomodulation of immune responses by nkg2d-positive cd4+ cells
EP2083857A4 (en) * 2006-09-22 2010-03-24 Dana Farber Cancer Res Inc METHODS FOR TREATING MICA RELATED DISORDERS
CA3011859A1 (en) 2007-04-23 2008-10-30 Fred Hutchinson Cancer Research Center Negative immunomodulation of immune responses by erp5
JP5924863B2 (en) 2007-05-06 2016-05-25 スローン ケタリング インスティテュート フォア キャンサー リサーチ Methods for treating and preventing GI syndrome and graft-versus-host disease
HUE034044T2 (en) 2011-09-30 2018-01-29 Dana Farber Cancer Inst Inc Therapeutic peptides
AU2013218017B2 (en) 2012-02-07 2017-12-07 Innate Pharma MICA binding agents
AU2013266069B2 (en) 2012-05-25 2018-03-15 Sloan Kettering Institute For Cancer Research Methods for treating GI syndrome and graft versus host disease
EP2970490A4 (en) 2013-03-15 2017-04-26 Novelogics Biotechnology, Inc. Antibodies to mica and micb proteins
SG11201506766PA (en) 2013-03-15 2015-09-29 Dana Farber Cancer Inst Inc Therapeutic peptides
WO2014190914A1 (en) * 2013-05-30 2014-12-04 The University Of Hong Kong Materials and methods for treatment of liver cancer background of the invention
EP3077504B1 (en) 2013-12-06 2019-08-14 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
CA2939006A1 (en) 2014-03-14 2015-09-17 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
US9819945B2 (en) 2014-06-25 2017-11-14 Qualcomm Incorporated Multi-layer video coding
CA3040421A1 (en) 2016-10-19 2018-04-26 Novelogics Biotechnology, Inc. Antibodies to mica and micb proteins
EP3768715A1 (en) 2018-03-23 2021-01-27 Bristol-Myers Squibb Company Antibodies against mica and/or micb and uses thereof
WO2020029171A1 (en) * 2018-08-09 2020-02-13 深圳华大生命科学研究院 Method for constructing antigen-presenting cell line without endogenous hla gene background, antigen-presenting cell line and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003378A1 (en) * 1991-07-29 1993-02-18 Radiation Oncology Center Research And Development Corporation Method for testing for the presence of metastatic tumor cells
EP0563627A2 (en) * 1992-03-05 1993-10-06 Bio Defence Institute Co., Ltd. Anti-tumor method and anti-tumor agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003378A1 (en) * 1991-07-29 1993-02-18 Radiation Oncology Center Research And Development Corporation Method for testing for the presence of metastatic tumor cells
EP0563627A2 (en) * 1992-03-05 1993-10-06 Bio Defence Institute Co., Ltd. Anti-tumor method and anti-tumor agent

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAHRAM S ET AL: "Nucleotide sequence of the human MHC class I MICA gene.", IMMUNOGENETICS, vol. 44, no. 1, 1996, pages 80 - 81, XP002057253 *
BAHRAM, S. ET AL.: "A second lineage of mammalian major histocompatibility complex class I genes", PROC. NATL. ACAD. SCI. USA, vol. 91, July 1994 (1994-07-01), pages 6259 - 6263, XP002057254 *
FODIL N ET AL: "Allelic repertoire of the human MHC class I MICA gene.", IMMUNOGENETICS, vol. 44, no. 5, 1996, pages 351 - 357, XP002057252 *
GROH V ET AL: "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.", PROC. NATL. ACAD. SCI. USA, vol. 93, October 1996 (1996-10-01), pages 12445 - 12450, XP002057255 *

Also Published As

Publication number Publication date
WO1998019167A2 (en) 1998-05-07
CA2275141A1 (en) 1998-05-07
US20030165835A1 (en) 2003-09-04
EP0937258A2 (en) 1999-08-25

Similar Documents

Publication Publication Date Title
WO1998019167A3 (en) Cell stress regulated human mhc class i gene
AU4882296A (en) DNA molecules, preparation and use in gene therapy
NO983718D0 (en) Sugar-midified oligonucleotides
WO2003057916A3 (en) Cancer profiles
MXPA02011656A (en) Nrg 2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods.
MXPA03002413A (en) B7-like molecules and uses thereof.
EP0955379A3 (en) Analysis of gene expression by display of 3'-end restriction fragments of cDNAs
WO2004096148A3 (en) Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
WO2000024365A8 (en) Treatment of skin with adenosine or adenosine analog
WO2002002624A3 (en) B7-like molecules and uses thereof
WO2004113571A3 (en) Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis
EP2322627A3 (en) Mutations in the BCR-abl tyrosine kinase associated with resistance to STI-571
WO2001070977A3 (en) Fibroblast growth factor receptor-like molecules and uses thereof
EP0957926A4 (en) OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR MODULATING B7 PROTEIN EXPRESSION
WO2002020762A3 (en) Tnf receptor-like molecules and uses thereof
AU9312198A (en) Genes amplified in tumours, antibodies against the proteins encoded thereby, andtheir use in diagnosis and treatment of cancer
CA2281895A1 (en) Ikb kinases
WO1999033998A3 (en) Regulatory dna sequences of the human catalytic telomerase sub-unit gene, diagnostic and therapeutic use thereof
WO1998059040A3 (en) Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
WO1999032634A3 (en) Compositions derived from mycobacterium vaccae and methods for their use
WO1997011667A3 (en) Therapeutic applications using horse serum
WO2001042474A3 (en) Interferon-like molecules and uses thereof
WO2006018632A3 (en) Cell therapy with exo 1
WO1999002704A3 (en) Dual specifically phosphatase and methods of use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09303161

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1997946889

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2275141

Country of ref document: CA

Ref country code: CA

Ref document number: 2275141

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1997946889

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1997946889

Country of ref document: EP