WO1998020322A1 - Test device for bodily fluids - Google Patents

Test device for bodily fluids Download PDF

Info

Publication number
WO1998020322A1
WO1998020322A1 PCT/EP1997/005984 EP9705984W WO9820322A1 WO 1998020322 A1 WO1998020322 A1 WO 1998020322A1 EP 9705984 W EP9705984 W EP 9705984W WO 9820322 A1 WO9820322 A1 WO 9820322A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
test device
carrier
detector
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/005984
Other languages
French (fr)
Inventor
Hermanus Johannus Maria Kreuwel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Priority to AT97948837T priority Critical patent/ATE216073T1/en
Priority to US09/297,596 priority patent/US6100966A/en
Priority to AU70029/98A priority patent/AU7002998A/en
Priority to DE69711909T priority patent/DE69711909D1/en
Priority to JP52102298A priority patent/JP2001508172A/en
Priority to BR9712728-0A priority patent/BR9712728A/en
Priority to EP97948837A priority patent/EP0935746B1/en
Publication of WO1998020322A1 publication Critical patent/WO1998020322A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors

Definitions

  • the invention relates to a test device for bodily fluids comprising a solid carrier with a bonded reagent, a light source for transmitting light to the carrier and a light detector for detecting light received from the carrier.
  • test devices are well known in the art.
  • 5,131,756 discloses a test carrier analysis device for determining the reflectivity of a test field surface.
  • An optical unit of the device contains several light transmitters and a measurement receiver, whereby the light transmitters are directed obliquely from above onto the measurement surface .
  • the light transmitters are arranged opposite to one another with off-set planes of incidence.
  • Other test devices known in the art employ light sources wherein the light impinges on the measurement surface uniformly from all directions in space. Commonly, the light sources that are used are light-emitting diodes, which are favoured in view of their low-energy use, low costs and high reliability.
  • Test devices to which the invention relates are particularly useful for pregnancy tests but are not confined hereto.
  • a prime consideration with these test devices is that they must be small, manageable and cheap to manufacture in view of the required suitability for self-diagnosis by a user.
  • the problem with known devices is the lack of accuracy, particularly in the area where the signals measured by the detector do not warrant an unambiguous positive or negative test result .
  • the test device according to the invention aims to provide a cheap, reliable and accurate test device suitable for both home- and professional use.
  • the test device according to the invention is therefore characterized in that in use the light source transmits light to the carrier in a direction suitable to cause the substance of the light to enter the carrier.
  • the test device according to the invention is not based on the reflection of light transmitted to a carrier-surface by the detector, but is based on a quite distinct principle ; i.e. the test device according to the invention realises a prolonged path for the light imparted in the carrier's interior for travelling to the detector.
  • the light is scattered and diffused allowing for an increased interaction through absorption of the light by such area of the carrier where a sample of bodily fluid has entertained a reaction with the reagent bonded in the carrier. Due to this measure the sensitivity and accuracy for measuring the occurrence and the extend of any such reaction is highly increased. This is particularly supported by assuring that in use the substance of the light received by the detector is received from the carrier.
  • a further increased sensitivity of the test device can be accomplished by covering the carrier at least partly by a reflective foil or coating.
  • the coating may be provided on one side or on all sides, but in all cases it is required that the carrier is at least partly covered by a reflective foil or coating and that this reflective foil or coating is locally absent near the light source and the detector, to allow light to travel to and from the carrier.
  • the reaction of the carrier bonded reagent with the sample of bodily fluid is particularly supported when the carrier is porous, providing therewith a large surface/volume ratio so that an effective reaction within a confined area is enabled, and the effective propagation of light through the carrier is promoted.
  • Very suitable materials for the carrier can be selected from the group comprising silica paper, polyethylene, nitrocellulose, glass beads, etc.
  • the distance between light source and detector can be kept at a moderate value in the range of 1-5 mm.
  • the sensitivity of the test device for the light transmitted by the light source is improved by the application of blocking means to prevent the light to travel directly from the light source to the detector.
  • the application of such blocking means improves the yield at 98/20322
  • the test device further comprises an arithmetic logic unit connected with the light source and the detector for controlling the emittance and duration of emittance of light by the light source and the processing of signals measured by the detector. This allows for automatic and controlled use of the test device with high immunity against false operation.
  • the arithmetic logic unit monitors and controls the beginning and ending of a test-run, and calculates a test -value in dependence of the signals measured by the detector in relation to a reference value.
  • the automatic determination of the test value as provided by the invention circumvents the subjective interpretation which follows from other conventional test methods known in the art such as those employing dipsticks . Dipsticks require a visual detection by the naked eye to see whether a detection reaction has occurred.
  • a further advantageous embodiment of the test device according to the invention is characterised in that the arithmetic logic unit includes a memory containing a typical signal-trajectory measured by the detector during a regular test-run, and that the arithmetic logic unit monitors the trajectory of the signals actually measured by the detector during a test run and compares same with the said signal- trajectory contained in the memory, and calculates and releases a test-value in dependence of the difference between the typical and the actual trajectory of the signal being less than a predetermined value. This further improves the accuracy and reliability of the test.
  • figure la shows a schematic drawing of a first embodiment of the test device according to the invention
  • figure lb shows a schematic drawing of a second embodiment of the test device according to the invention
  • figure lc shows a schematic drawing of a third embodiment of the test device according to the invention
  • figure 2 shows a typical signal-trajectory measured by the detector during a test run
  • figure 3 shows some results realised by the test device according to the invention when used in a pregnancy test .
  • FIG. la shows the basic detection principle of the invention in which a porous body 1 is used as a carrier of an immobilised specific binding reagent.
  • the porous body 1 may consist of silica paper, polyethylene, nitrocellulose, glass beads or another suitable material .
  • a sample of urine which may carry an analyte which is to be detected, is mixed with a conjugate that is labelled with a light -absorbing component such as a particle showing characteristics that are detectable due to its interference with the analyte as will be explained below.
  • a light source 2 for instance a light emitting diode, transmits light to the porous body l in a direction suitable to cause the substance of the light to enter the porous body 1.
  • the light travels then within the porous body 1 along a transmission path which is determined by scattering or reflection of the light within the carrier body until it arrives at the exit end, were the detector 3 is located. There is no direct visibility between the light emitting diode 2 and the detector 3 , nor is it desired to have light reach the detector 3 via reflection on the surface of the carrier body 1.
  • the substance of the light received by the detector 3 is departed therefore from the carrier 1. Due to the partly absorption of the light originating from the light emitting diode 2 by the part of the light absorbing component that is immobilized in the porous body 1, the light received by the detector 3 is a fraction thereof, the magnitude of which is measurable.
  • Figure 3 shows some experimental results using a hyperred light emitting diode 2 as a light source. Carbon particles were used as a label contained in the conjugate that was mixed with the bodily fluid to be measured by the test device according to the invention.
  • the carrier body 1 was made of silica paper, with thickness 0.7 mm, width 4 mm and length 10 mm. The volume of the coated area within this carrier was 1 mm 3 -
  • the test device was used to measure the hCG concentration in a sample of urine. The concentration of hCG is set forth on the X-axis in units per litre; the Y-axis shows the signal as detected by detector 3. The total test time for each sample was 2 minutes 30 seconds.
  • a reference line A shows the detection level corresponding to a clear urine sample being measured void of hCG and conjugate.
  • a first sample indicated by arrow B, corresponds with a hCG concentration of 0 units per litre, however, with the employment of conjugate.
  • Arrows C, D and E refer to further test results corresponding to hCG concentrations of 12.5, 25 and 50 units per litre respectively. From these measurements it is evident that the test device according to the invention is highly sensitive to any measured differences in concentration of the analyte to be detected, showing only moderate variations in the measured value detected by detector 3 with repeated measurements . The accuracy of the test device according to the invention assures therefore a high reliability of the test results.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A test device for bodily fluids comprising a solid carrier wtih a bonded reagent, a light source and a light detector. Light source and light detector are positioned is such a way that the majority of the light travels within the porous body along a transmission path, which is determined by scattering or reflection of the light within the porous body, until it arrives at the exit end where the transmitted light is measured.

Description

Test device for bodily fluids
The invention relates to a test device for bodily fluids comprising a solid carrier with a bonded reagent, a light source for transmitting light to the carrier and a light detector for detecting light received from the carrier. Such test devices are well known in the art. US-A-
5,131,756 discloses a test carrier analysis device for determining the reflectivity of a test field surface. An optical unit of the device contains several light transmitters and a measurement receiver, whereby the light transmitters are directed obliquely from above onto the measurement surface . The light transmitters are arranged opposite to one another with off-set planes of incidence. Other test devices known in the art employ light sources wherein the light impinges on the measurement surface uniformly from all directions in space. Commonly, the light sources that are used are light-emitting diodes, which are favoured in view of their low-energy use, low costs and high reliability.
Test devices to which the invention relates are particularly useful for pregnancy tests but are not confined hereto. A prime consideration with these test devices is that they must be small, manageable and cheap to manufacture in view of the required suitability for self-diagnosis by a user. The problem with known devices is the lack of accuracy, particularly in the area where the signals measured by the detector do not warrant an unambiguous positive or negative test result .
The test device according to the invention aims to provide a cheap, reliable and accurate test device suitable for both home- and professional use. The test device according to the invention is therefore characterized in that in use the light source transmits light to the carrier in a direction suitable to cause the substance of the light to enter the carrier. Contrary to any test device known in the art, the test device according to the invention is not based on the reflection of light transmitted to a carrier-surface by the detector, but is based on a quite distinct principle ; i.e. the test device according to the invention realises a prolonged path for the light imparted in the carrier's interior for travelling to the detector. Along that path in the interior of the carrier the light is scattered and diffused allowing for an increased interaction through absorption of the light by such area of the carrier where a sample of bodily fluid has entertained a reaction with the reagent bonded in the carrier. Due to this measure the sensitivity and accuracy for measuring the occurrence and the extend of any such reaction is highly increased. This is particularly supported by assuring that in use the substance of the light received by the detector is received from the carrier.
A further increased sensitivity of the test device can be accomplished by covering the carrier at least partly by a reflective foil or coating. The coating may be provided on one side or on all sides, but in all cases it is required that the carrier is at least partly covered by a reflective foil or coating and that this reflective foil or coating is locally absent near the light source and the detector, to allow light to travel to and from the carrier. The reaction of the carrier bonded reagent with the sample of bodily fluid, is particularly supported when the carrier is porous, providing therewith a large surface/volume ratio so that an effective reaction within a confined area is enabled, and the effective propagation of light through the carrier is promoted. Very suitable materials for the carrier can be selected from the group comprising silica paper, polyethylene, nitrocellulose, glass beads, etc.
Practice has shown that the distance between light source and detector can be kept at a moderate value in the range of 1-5 mm. The sensitivity of the test device for the light transmitted by the light source is improved by the application of blocking means to prevent the light to travel directly from the light source to the detector. In practice, the application of such blocking means improves the yield at 98/20322
the detector by a factor 2. A feasible solution is to vary the position of light source and detector such that the light transmitting and light receiving surfaces are not in the same plane. Preferably, and most simply, the blocking means are, however, formed as a light shield, such as a shield of material which is not translucent . It is advantageous that the test device further comprises an arithmetic logic unit connected with the light source and the detector for controlling the emittance and duration of emittance of light by the light source and the processing of signals measured by the detector. This allows for automatic and controlled use of the test device with high immunity against false operation.
It is desirable then that the arithmetic logic unit monitors and controls the beginning and ending of a test-run, and calculates a test -value in dependence of the signals measured by the detector in relation to a reference value. The automatic determination of the test value as provided by the invention circumvents the subjective interpretation which follows from other conventional test methods known in the art such as those employing dipsticks . Dipsticks require a visual detection by the naked eye to see whether a detection reaction has occurred.
A further advantageous embodiment of the test device according to the invention is characterised in that the arithmetic logic unit includes a memory containing a typical signal-trajectory measured by the detector during a regular test-run, and that the arithmetic logic unit monitors the trajectory of the signals actually measured by the detector during a test run and compares same with the said signal- trajectory contained in the memory, and calculates and releases a test-value in dependence of the difference between the typical and the actual trajectory of the signal being less than a predetermined value. This further improves the accuracy and reliability of the test. The invention shall now further be elucidated with reference to the enclosed drawings in which: figure la shows a schematic drawing of a first embodiment of the test device according to the invention; figure lb shows a schematic drawing of a second embodiment of the test device according to the invention; figure lc shows a schematic drawing of a third embodiment of the test device according to the invention; figure 2 shows a typical signal-trajectory measured by the detector during a test run; and figure 3 shows some results realised by the test device according to the invention when used in a pregnancy test .
Figure la shows the basic detection principle of the invention in which a porous body 1 is used as a carrier of an immobilised specific binding reagent. The porous body 1 may consist of silica paper, polyethylene, nitrocellulose, glass beads or another suitable material . When used for a pregnancy test, a sample of urine which may carry an analyte which is to be detected, is mixed with a conjugate that is labelled with a light -absorbing component such as a particle showing characteristics that are detectable due to its interference with the analyte as will be explained below. When the sample of urine containing the analyte flows through the porous body 1, at least a fraction of the label contained in the conjugate is immobilised within the porous body 1 due to a reaction with the reagent in the porous body 1. A light source 2, for instance a light emitting diode, transmits light to the porous body l in a direction suitable to cause the substance of the light to enter the porous body 1. The light travels then within the porous body 1 along a transmission path which is determined by scattering or reflection of the light within the carrier body until it arrives at the exit end, were the detector 3 is located. There is no direct visibility between the light emitting diode 2 and the detector 3 , nor is it desired to have light reach the detector 3 via reflection on the surface of the carrier body 1. The substance of the light received by the detector 3 is departed therefore from the carrier 1. Due to the partly absorption of the light originating from the light emitting diode 2 by the part of the light absorbing component that is immobilized in the porous body 1, the light received by the detector 3 is a fraction thereof, the magnitude of which is measurable.
Figure imgf000007_0001
in relation to the reference-value SI. Figure 3 shows some experimental results using a hyperred light emitting diode 2 as a light source. Carbon particles were used as a label contained in the conjugate that was mixed with the bodily fluid to be measured by the test device according to the invention. The carrier body 1 was made of silica paper, with thickness 0.7 mm, width 4 mm and length 10 mm. The volume of the coated area within this carrier was 1 mm3- The test device was used to measure the hCG concentration in a sample of urine. The concentration of hCG is set forth on the X-axis in units per litre; the Y-axis shows the signal as detected by detector 3. The total test time for each sample was 2 minutes 30 seconds. A reference line A shows the detection level corresponding to a clear urine sample being measured void of hCG and conjugate. A first sample, indicated by arrow B, corresponds with a hCG concentration of 0 units per litre, however, with the employment of conjugate. Arrows C, D and E refer to further test results corresponding to hCG concentrations of 12.5, 25 and 50 units per litre respectively. From these measurements it is evident that the test device according to the invention is highly sensitive to any measured differences in concentration of the analyte to be detected, showing only moderate variations in the measured value detected by detector 3 with repeated measurements . The accuracy of the test device according to the invention assures therefore a high reliability of the test results.

Claims

1. Test device for bodily fluids comprising a solid carrier with a bonded reagent, a light source for transmitting light to the carrier and a light detector for detecting light received from the carrier, characterized in that in use the light source transmits light to the carrier in a direction suitable to cause the substance of the light to enter the carrier.
2. Test device according to claim 1, wherein in use the substance of the light received by the detector is received from the carrier.
3. Test device according to claims 1 or 2 , wherein the carrier is at least partly covered by a reflective foil or coating.
4. Test device according to claim 3 , wherein the reflective foil or coating is locally absent near the light source and the detector to allow light to travel to and from the carrier.
5. Test device according to any one of claims 1-4, further comprising an arithmetic logic unit connected with the light source and the detector for controlling the emmittance and duration of emmittance of light by the light source and for processing of signals measured by the detector.
6. Test device according to claim 5, wherein the arithmetic logic unit monitors the beginning and ending of a test-run, and calculates a test-value in dependence of the signals measured by the detector in relation to a reference- value .
7. Test device according to claim 6, wherein the arithmetic logic unit includes a memory containing a typical signal-trajectory as measured by the detector during a regular test-run, and wherein the arithmetic logic unit monitors the trajectory of the signals actually measured by the detector during a test-run and compares same with the said signal -trajectory contained in the memory, and calculates and releases a test -value in dependence of the difference between the typical and the actual trajectory of the signal being less than a predetermined value.
8. Test device according to any one of claims 1-7, wherein the carrier is porous.
9. Test device according to any one of the previous claims wherein the carrier is selected from the group comprising silica paper, polyethylene, nitrocellulose, glass beads .
10. Test device according to any one of claims 1-9, wherein the distance between light source and detector is in the range 1-5 mm.
11. Test device according to any one of claims 1-10, wherein blocking means are provided to prevent the light to travel directly from the light source to the detector.
12. Test device according to claim 11, wherein the blocking means are formed as a light shield.
PCT/EP1997/005984 1996-11-04 1997-10-23 Test device for bodily fluids Ceased WO1998020322A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT97948837T ATE216073T1 (en) 1996-11-04 1997-10-23 TESTING DEVICE FOR BODY FLUID
US09/297,596 US6100966A (en) 1996-11-04 1997-10-23 Test device for bodily fluids
AU70029/98A AU7002998A (en) 1996-11-04 1997-10-23 Test device for bodily fluids dispositif pour effectuer un test sur des liquides du corps
DE69711909T DE69711909D1 (en) 1996-11-04 1997-10-23 BODY LIQUID TEST DEVICE
JP52102298A JP2001508172A (en) 1996-11-04 1997-10-23 Testing equipment for body fluids
BR9712728-0A BR9712728A (en) 1996-11-04 1997-10-23 Test device for body fluids.
EP97948837A EP0935746B1 (en) 1996-11-04 1997-10-23 Test device for bodily fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96203057.3 1996-11-04
EP96203057 1996-11-04

Publications (1)

Publication Number Publication Date
WO1998020322A1 true WO1998020322A1 (en) 1998-05-14

Family

ID=8224540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005984 Ceased WO1998020322A1 (en) 1996-11-04 1997-10-23 Test device for bodily fluids

Country Status (9)

Country Link
US (1) US6100966A (en)
EP (1) EP0935746B1 (en)
JP (1) JP2001508172A (en)
AT (1) ATE216073T1 (en)
AU (1) AU7002998A (en)
BR (1) BR9712728A (en)
DE (1) DE69711909D1 (en)
TR (1) TR199900967T2 (en)
WO (1) WO1998020322A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148056B2 (en) * 2000-03-24 2006-12-12 Mark B. Lyles Diagnostic devices containing porous material

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763454B2 (en) * 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3426335A1 (en) * 1984-07-17 1986-01-30 LRE Relais + Elektronik GmbH, 8000 München Measuring instrument
EP0394909A1 (en) * 1989-04-28 1990-10-31 Roche Diagnostics GmbH Method for diffuse illumination of a measuring area in a test carrier analysing system
DE9213278U1 (en) * 1992-10-02 1992-12-03 Endress + Hauser Conducta Gesellschaft für Meß- und Regeltechnik mbH & Co., 7016 Gerlingen Device for measuring turbidity in aqueous media
EP0654661A1 (en) * 1993-11-24 1995-05-24 Institut Français du Pétrole Intensity detector for light diffused by films in colloidal media

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3426335A1 (en) * 1984-07-17 1986-01-30 LRE Relais + Elektronik GmbH, 8000 München Measuring instrument
EP0394909A1 (en) * 1989-04-28 1990-10-31 Roche Diagnostics GmbH Method for diffuse illumination of a measuring area in a test carrier analysing system
US5131756A (en) * 1989-04-28 1992-07-21 Boehringer Mannheim Gmbh Test carrier analysis device
DE9213278U1 (en) * 1992-10-02 1992-12-03 Endress + Hauser Conducta Gesellschaft für Meß- und Regeltechnik mbH & Co., 7016 Gerlingen Device for measuring turbidity in aqueous media
EP0654661A1 (en) * 1993-11-24 1995-05-24 Institut Français du Pétrole Intensity detector for light diffused by films in colloidal media

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148056B2 (en) * 2000-03-24 2006-12-12 Mark B. Lyles Diagnostic devices containing porous material

Also Published As

Publication number Publication date
ATE216073T1 (en) 2002-04-15
BR9712728A (en) 1999-10-26
DE69711909D1 (en) 2002-05-16
TR199900967T2 (en) 2000-07-21
EP0935746A1 (en) 1999-08-18
EP0935746B1 (en) 2002-04-10
AU7002998A (en) 1998-05-29
JP2001508172A (en) 2001-06-19
US6100966A (en) 2000-08-08

Similar Documents

Publication Publication Date Title
KR100816799B1 (en) Test part analysis system and analysis method using the analysis system
US8367013B2 (en) Reading device, method, and system for conducting lateral flow assays
AU614010B2 (en) Scattered total internal reflectance immunoassay system
CA1136885A (en) Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream
EP0102189B1 (en) Reflectometer
US20010011480A1 (en) Pressure sensor
EP0064230A3 (en) Method and apparatus for measuring antigen-antibody reactions
JP2000503406A (en) Red blood cell outflow detection technology
DE3267501D1 (en) Assay method and device
CN101639451A (en) Early determination of assay results
ATE207542T1 (en) TEST DEVICE WITH A STABLE COUPLING DYE FOR DETERMINING ANALYTES
CA2521773C (en) Optical chemical sensing device with pyroelectric or piezoelectric transducer
FI813369L (en) HOMOGEN SPECIFIC BINDNINGSPROVANORDNING FOERFARANDE FOER DESS FRAMSTAELLNING OCH MED ANVAENDNING AV ANORDNINGEN UTFOERT ANALYTISKT FOERFARANDE
EP0223427A1 (en) Method and apparatus for the determination of the antibody content of blood
WO1982003460A1 (en) Application of optical fibre probes
JP2517102B2 (en) Method for detecting emitted light amount of immunoassay device
US6100966A (en) Test device for bodily fluids
MXPA99004117A (en) Test device for bodily fluids
US4658149A (en) Method and apparatus for measuring the depth of a flowing liquid
US4764023A (en) Heat transfer rate measurement using the optical properties of a dissolving coating
EP0840124A3 (en) Analytical element with dry reagent
NZ232361A (en) Detecting radiation absorption by temperature rise; transparent sensor
US5849591A (en) Method of determining the component of a gas in a gas sample
JPH0461030U (en)
CA2149537A1 (en) Method for preparing calibration curves

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BR CA CN JP KR MX TR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1997948837

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 1998 521022

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/004117

Country of ref document: MX

Ref document number: 1999/00967

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 09297596

Country of ref document: US

NENP Non-entry into the national phase

Ref document number: 1998521022

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 1997948837

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1997948837

Country of ref document: EP