WO1998021580A3 - Vitamin d immunoassay systems - Google Patents

Vitamin d immunoassay systems Download PDF

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Publication number
WO1998021580A3
WO1998021580A3 PCT/GB1997/003097 GB9703097W WO9821580A3 WO 1998021580 A3 WO1998021580 A3 WO 1998021580A3 GB 9703097 W GB9703097 W GB 9703097W WO 9821580 A3 WO9821580 A3 WO 9821580A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituent
vitamin
compound
composition
analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1997/003097
Other languages
French (fr)
Other versions
WO1998021580A2 (en
Inventor
David Laurie
Alexander Kirkley Barnes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunodiagnostic Systems Ltd
Original Assignee
Immunodiagnostic Systems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunodiagnostic Systems Ltd filed Critical Immunodiagnostic Systems Ltd
Priority to DE69713138T priority Critical patent/DE69713138T2/en
Priority to JP52230998A priority patent/JP2001504114A/en
Priority to AT97912320T priority patent/ATE218542T1/en
Priority to EP97912320A priority patent/EP0944591B1/en
Publication of WO1998021580A2 publication Critical patent/WO1998021580A2/en
Publication of WO1998021580A3 publication Critical patent/WO1998021580A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compound comprising an analogue of 1,25-dihydroxy vitamin D, modified at the C20 position, which is adapted to bind to at least an existing or readily produced antibody, wherein the analogue comprises a substituent adapted for quantitative detection, preferably comprises a radioactive substituent, more preferably iodine 125, or comprises a chemiluminescent or fluorescent substituent adapted for luminescent or fluorescent intensity determination, process for the preparation thereof and of intermediates thereof novel intermediates prepared by the process, composition comprising the compound and its use in an immunoassay method, preferably comprising an immunoassay kit, the novel use of an inhibitor comprised in composition and the method for determining the concentration of 1,25-dihydroxy vitamin D.
PCT/GB1997/003097 1996-11-13 1997-11-12 Vitamin d immunoassay systems Ceased WO1998021580A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE69713138T DE69713138T2 (en) 1996-11-13 1997-11-12 IMMUNITY TEST SYSTEM FOR DETERMINING VITAMIN D
JP52230998A JP2001504114A (en) 1996-11-13 1997-11-12 Vitamin D immunoassay system
AT97912320T ATE218542T1 (en) 1996-11-13 1997-11-12 IMMUNE TEST SYSTEM FOR DETERMINING VITAMIN D
EP97912320A EP0944591B1 (en) 1996-11-13 1997-11-12 Vitamin d immunoassay systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9623569.2A GB9623569D0 (en) 1996-11-13 1996-11-13 Vitamin D immumoassay systems
GB9623569.2 1996-11-13

Publications (2)

Publication Number Publication Date
WO1998021580A2 WO1998021580A2 (en) 1998-05-22
WO1998021580A3 true WO1998021580A3 (en) 1998-07-30

Family

ID=10802841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/003097 Ceased WO1998021580A2 (en) 1996-11-13 1997-11-12 Vitamin d immunoassay systems

Country Status (6)

Country Link
EP (1) EP0944591B1 (en)
JP (1) JP2001504114A (en)
AT (1) ATE218542T1 (en)
DE (1) DE69713138T2 (en)
GB (1) GB9623569D0 (en)
WO (1) WO1998021580A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0029729D0 (en) * 2000-12-06 2001-01-17 Ids Ltd Method for detection of vitamin D metabolites
JP4436674B2 (en) * 2001-10-12 2010-03-24 ジョンズ ホプキンス ユニバーシティ Hypocalcemic oxime analog of 1α, 25-dihydroxyvitamin D3
DE102013215580A1 (en) 2013-08-07 2015-02-12 Orgentec Diagnostika Gmbh 25-OH Vitamin D derivatives for the determination of vitamin D metabolites
EP2881740B1 (en) * 2013-12-03 2019-02-13 Immunodiagnostic Systems Limited A method for quantifying an analyte, and an automatic analytical device configured to implement said method
CN107286067A (en) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 A kind of preparation method of Maxacalcitol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002562A1 (en) * 1979-05-21 1980-11-27 Wisconsin Alumni Res Found Isotopically labeled vitamin d derivatives and processes for preparing same
EP0092004A1 (en) * 1982-04-20 1983-10-26 Teijin Limited Novel vitamin D3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4585741A (en) * 1983-08-25 1986-04-29 Clevinger Brian L Method of assay for vitamin D metabolites
JPH0641058A (en) * 1992-07-21 1994-02-15 Asahi Chem Ind Co Ltd New vitamin d derivatives containing residue on hydroxyl group at 25-position, their production and their use
WO1994026707A1 (en) * 1993-05-07 1994-11-24 Holmes, Michael, John Vitamin d amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126861A (en) * 1981-11-02 1983-07-28 リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレ−テツド Novel compound and manufacture
FR2631025B1 (en) * 1988-05-04 1991-04-12 Ire Medgenix Sa NOVEL VITAMIN D3 DERIVATIVES AND APPLICATION TO DETERMINATIONS OF VITAMIN D3 METABOLITES
JPH02104570A (en) * 1988-10-11 1990-04-17 Toyo Jozo Co Ltd Novel 1alpha,25-dihydroxyvitamin d3 derivative and production thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002562A1 (en) * 1979-05-21 1980-11-27 Wisconsin Alumni Res Found Isotopically labeled vitamin d derivatives and processes for preparing same
EP0092004A1 (en) * 1982-04-20 1983-10-26 Teijin Limited Novel vitamin D3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4585741A (en) * 1983-08-25 1986-04-29 Clevinger Brian L Method of assay for vitamin D metabolites
JPH0641058A (en) * 1992-07-21 1994-02-15 Asahi Chem Ind Co Ltd New vitamin d derivatives containing residue on hydroxyl group at 25-position, their production and their use
WO1994026707A1 (en) * 1993-05-07 1994-11-24 Holmes, Michael, John Vitamin d amide derivatives

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
A. CALDAS ET AL: "The Simultaneous Measurement of Vitamin D Metabolites in Plasma: Studies in Healthy Adults and in Patients with Calcium Nephrolithiasis", JOURNAL OF LABORATORY AND CLINICAL MEDICINE, vol. 91, no. 5, 1978, pages 840 - 849, XP002065441 *
AMERICAN CHEMICAL SOCIETY: "CHEMICAL ABSTRACTS FORMULA INDEX, C25H52O-Z, VOLUME 121 (PART 3 OF 3 PARTS)", 1994, CHEMICAL ABSTRACTS, COLUMBUS OHIO US *
ANALYTICAL BIOCHEMISTRY., vol. 161, no. 1, 1987, ORLANDO US, pages 96 - 102 *
ANALYTICAL BIOCHEMISTRY., vol. 85, no. 1, 1978, pages 34 - 41 *
B. HALLORAN ET AL: "Isotopic Labeling Affects 1,25-Dihydroxyvitamin D Metabolism", BIOCHEMISTRY., vol. 28, no. 3, 7 February 1989 (1989-02-07), EASTON, PA US, pages 1278 - 1281, XP002065442 *
B. HOLLIS ET AL: "Determination of Vitamin D Status by Radioimmunoassay with an 125-Iodine Labelled Tracer", CLINICAL CHEMISTRY., vol. 39, no. 3, 1993, WINSTON US, pages 529 - 533, XP002054204 *
CHEMICAL ABSTRACTS, vol. 107, no. 25, 21 December 1987, Columbus, Ohio, US; abstract no. 236332, R. SICINSKI ET AL: "Synthesis of 25-Hydroxy-[26,27-3H]-vitamin D2, 1.alpha.,25-Dihydroxy-[26,27-3H]-vitamin D2 and their (24R)-epimers" page 751; column 2; XP002065445 *
CHEMICAL ABSTRACTS, vol. 121, no. 9, 29 August 1994, Columbus, Ohio, US; abstract no. 109401, M. TANABE ET AL: "Preparation of Vitamin D Derivatives Containing a Substituent at the 25-Hydroxy Group" page 1143; column 1; XP002054205 *
CHEMICAL ABSTRACTS, vol. 123, no. 15, 9 October 1995, Columbus, Ohio, US; abstract no. 199203, H. WATANABE ET AL: "Synthetic studies of Vitamin D Analogs. 20. Synthesis of Tritiated 1.alpha.,25-Dihydroxy-22-oxavitamin D2" page 1295; column 1; XP002065444 *
CHEMICAL ABSTRACTS, vol. 89, no. 5, 31 July 1978, Columbus, Ohio, US; abstract no. 38985, S. YAMADA ET AL: "Synthesis of 25-Hydroxy[23,24-3H]-vitamin D3" page 259; column 2; XP002065448 *
CHEMICAL ABSTRACTS, vol. 91, no. 25, 17 December 1979, Columbus, Ohio, US; abstract no. 211666, K. BANNAI ET AL: "Synthesis of (24S)- and (24R)-1.alpha.-Hydroxy-cholecalciferol" page 711; column 2; XP002065447 *
CHEMICAL ABSTRACTS, vol. 97, no. 9, 30 August 1982, Columbus, Ohio, US; abstract no. 66509, J. CHANDLER ET AL: "Biosynthesis, Purification and Receptor Binding Properties of High Specific Radioactivity 1.alpha.,24(R),25-Trihydroxy-[26,27-methyl-3H]-vitamin D3" page 76; column 2; XP002065446 *
DATABASE WPI Section Ch Week 9411, Derwent World Patents Index; Class B01, AN 94-089316, M. TANABE ET AL *
J. LABELLED COMPD. RADIOPHARM., vol. 36, no. 7, 1995, pages 645 - 654 *
J. NAPOLI ET AL: "Direct Chemical Synthesis of 1.alpha.,25-Dihydroxy[26,27-3H]vitamin D3 with High Specific Activity: Its Use in Receptor Studies", BIOCHEMISTRY., vol. 19, no. 11, 27 May 1980 (1980-05-27), EASTON, PA US, pages 2515 - 2521, XP002065443 *
JOURNAL OF STEROID BIOCHEMISTRY, vol. 10, no. 4, 1979, pages 411 - 418 *
JOURNAL OF STEROID BIOCHEMISTRY, vol. 16, no. 2, 1982, pages 303 - 310 *

Also Published As

Publication number Publication date
ATE218542T1 (en) 2002-06-15
EP0944591B1 (en) 2002-06-05
DE69713138T2 (en) 2003-01-16
JP2001504114A (en) 2001-03-27
GB9623569D0 (en) 1997-01-08
WO1998021580A2 (en) 1998-05-22
DE69713138D1 (en) 2002-07-11
EP0944591A2 (en) 1999-09-29

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