WO1998033933A3 - Method for identifying inducers and inhibitors of programmed cell death - Google Patents

Method for identifying inducers and inhibitors of programmed cell death Download PDF

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Publication number
WO1998033933A3
WO1998033933A3 PCT/US1998/001808 US9801808W WO9833933A3 WO 1998033933 A3 WO1998033933 A3 WO 1998033933A3 US 9801808 W US9801808 W US 9801808W WO 9833933 A3 WO9833933 A3 WO 9833933A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell death
programmed cell
inhibitors
inducers
identifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/001808
Other languages
French (fr)
Other versions
WO1998033933A2 (en
Inventor
Bernard Roizman
He Bin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arch Development Corp
Original Assignee
Arch Development Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/795,470 external-priority patent/US5795713A/en
Application filed by Arch Development Corp filed Critical Arch Development Corp
Priority to CA002279486A priority Critical patent/CA2279486C/en
Priority to EP98903847A priority patent/EP1019524B1/en
Priority to JP53310198A priority patent/JP2001510340A/en
Priority to DE69826698T priority patent/DE69826698T2/en
Priority to AT98903847T priority patent/ATE278033T1/en
Priority to AU60507/98A priority patent/AU6050798A/en
Publication of WO1998033933A2 publication Critical patent/WO1998033933A2/en
Publication of WO1998033933A3 publication Critical patent/WO1998033933A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2α and that the dephosphorylation of eIF-2α prevents the shutdown of protein synthesis.
PCT/US1998/001808 1997-01-31 1998-01-30 Method for identifying inducers and inhibitors of programmed cell death Ceased WO1998033933A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002279486A CA2279486C (en) 1997-01-31 1998-01-30 Method for identifying inducers and inhibitors of programmed cell death
EP98903847A EP1019524B1 (en) 1997-01-31 1998-01-30 Method for identifying inducers and inhibitors of programmed cell death
JP53310198A JP2001510340A (en) 1997-01-31 1998-01-30 Methods of identifying inducers and inhibitors of programmed cell death
DE69826698T DE69826698T2 (en) 1997-01-31 1998-01-30 METHOD FOR IDENTIFYING INDUCTORS AND PROGRAMMED CELL TODE INHIBITORS
AT98903847T ATE278033T1 (en) 1997-01-31 1998-01-30 METHOD FOR IDENTIFYING INDUCTORS AND INHIBITORS OF PROGRAMMED CELL DEATH
AU60507/98A AU6050798A (en) 1997-01-31 1998-01-30 Method for identifying inducers and inhibitors of programmed cell death

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3699797P 1997-01-31 1997-01-31
US60/036,997 1997-01-31
US08/795,470 1997-02-04
US08/795,470 US5795713A (en) 1997-02-04 1997-02-04 Methods for identifying inducers and inhibitors of programmed cell death

Publications (2)

Publication Number Publication Date
WO1998033933A2 WO1998033933A2 (en) 1998-08-06
WO1998033933A3 true WO1998033933A3 (en) 1998-11-05

Family

ID=26713706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/001808 Ceased WO1998033933A2 (en) 1997-01-31 1998-01-30 Method for identifying inducers and inhibitors of programmed cell death

Country Status (10)

Country Link
EP (1) EP1019524B1 (en)
JP (1) JP2001510340A (en)
AT (1) ATE278033T1 (en)
AU (1) AU6050798A (en)
CA (1) CA2279486C (en)
DE (1) DE69826698T2 (en)
DK (1) DK1019524T3 (en)
ES (1) ES2227802T3 (en)
PT (1) PT1019524E (en)
WO (1) WO1998033933A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019591A1 (en) * 1992-03-31 1993-10-14 Arch Development Corporation Methods and compositions for gene, tumor, and viral infection therapy, and prevention of programmed cell death (apoptosis)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019591A1 (en) * 1992-03-31 1993-10-14 Arch Development Corporation Methods and compositions for gene, tumor, and viral infection therapy, and prevention of programmed cell death (apoptosis)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XP002900195 *

Also Published As

Publication number Publication date
JP2001510340A (en) 2001-07-31
DE69826698T2 (en) 2005-11-10
ATE278033T1 (en) 2004-10-15
EP1019524A2 (en) 2000-07-19
DE69826698D1 (en) 2004-11-04
CA2279486A1 (en) 1998-08-06
CA2279486C (en) 2003-12-23
PT1019524E (en) 2004-12-31
EP1019524B1 (en) 2004-09-29
ES2227802T3 (en) 2005-04-01
DK1019524T3 (en) 2005-01-10
WO1998033933A2 (en) 1998-08-06
AU6050798A (en) 1998-08-25

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