WO1998040069A3 - Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations - Google Patents

Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations Download PDF

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Publication number
WO1998040069A3
WO1998040069A3 PCT/EP1998/001478 EP9801478W WO9840069A3 WO 1998040069 A3 WO1998040069 A3 WO 1998040069A3 EP 9801478 W EP9801478 W EP 9801478W WO 9840069 A3 WO9840069 A3 WO 9840069A3
Authority
WO
WIPO (PCT)
Prior art keywords
stabilization
amino acid
acid
cyclodextrin
cyclodextrin combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/001478
Other languages
French (fr)
Other versions
WO1998040069A2 (en
Inventor
Karin Klokkers
Marion Kutschera
Wilfried Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexal AG
Original Assignee
Hexal AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8226585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998040069(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP98919099.6A priority Critical patent/EP0991407B2/en
Priority claimed from EP98919099.6A external-priority patent/EP0991407B2/en
Priority to PCT/EP1998/001478 priority patent/WO1998040069A2/en
Priority to HU0002364A priority patent/HU225587B1/en
Priority to DE69802688T priority patent/DE69802688T3/en
Priority to PL335571A priority patent/PL191570B1/en
Priority to SK1209-99A priority patent/SK284811B6/en
Priority to BR9808581-6A priority patent/BR9808581A/en
Priority to NZ337592A priority patent/NZ337592A/en
Priority to IL13165198A priority patent/IL131651A0/en
Priority to CA002282513A priority patent/CA2282513C/en
Application filed by Hexal AG filed Critical Hexal AG
Priority to HK00103624.8A priority patent/HK1024182B/en
Priority to AT98919099T priority patent/ATE209491T1/en
Priority to US09/319,895 priority patent/US6248758B1/en
Priority to AU72070/98A priority patent/AU731186B2/en
Priority to KR1019997008327A priority patent/KR100563764B1/en
Priority to DK98919099T priority patent/DK0991407T4/en
Priority to SI9830069T priority patent/SI0991407T2/en
Priority to JP53923798A priority patent/JP4608031B2/en
Publication of WO1998040069A2 publication Critical patent/WO1998040069A2/en
Publication of WO1998040069A3 publication Critical patent/WO1998040069A3/en
Priority to NO19994409A priority patent/NO327212B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A pharmaceutical formulation comprising or consisting of: a benzimidazole derivative as active ingredient, and as excipients, at least one cyclodextrin and at least one amino acid.
PCT/EP1998/001478 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations Ceased WO1998040069A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
SI9830069T SI0991407T2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazols with amino/cyclodextrin combinations
HK00103624.8A HK1024182B (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazols with amino acid/cyclodextrin combinations
PCT/EP1998/001478 WO1998040069A2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
HU0002364A HU225587B1 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
DE69802688T DE69802688T3 (en) 1997-03-13 1998-03-13 STABILIZATION OF ACID SULFUR BENZIMIDAZOLES USING AMINO ACID / CYCLODEXTRIN COMBINATIONS
PL335571A PL191570B1 (en) 1997-03-13 1998-03-13 Stabilisation of acid-sensitive benzimidazoles by combining them with amino acids and cyclodextrins
SK1209-99A SK284811B6 (en) 1997-03-13 1998-03-13 Pharmaceutical formulation and method of its preparation
BR9808581-6A BR9808581A (en) 1997-03-13 1998-03-13 Stabilization of acid-sensitive benzimidazoles with amino acid / cyclodextrin combinations
NZ337592A NZ337592A (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino/cyclodextrin combinations
IL13165198A IL131651A0 (en) 1997-03-13 1998-03-13 A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same
CA002282513A CA2282513C (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
EP98919099.6A EP0991407B2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazols with amino/cyclodextrin combinations
US09/319,895 US6248758B1 (en) 1997-03-13 1998-03-13 Pharmaceutical antacid
JP53923798A JP4608031B2 (en) 1997-03-13 1998-03-13 Stabilization of acid-sensitive benzimidazoles by amino acid / cyclodextrin mixtures
AT98919099T ATE209491T1 (en) 1997-03-13 1998-03-13 STABILIZATION OF ACID SENSITIVITY BENZIMIDAZOLES USING AMINO ACID/CYCLODEXTRIN COMBINATIONS
AU72070/98A AU731186B2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazols with amino acid/cyclodextrin combinations
KR1019997008327A KR100563764B1 (en) 1997-03-13 1998-03-13 Method for stabilizing acid sensitive benzimidazoles by using amino acids and cyclodextrins in combination
DK98919099T DK0991407T4 (en) 1997-03-13 1998-03-13 Stabilization of acid-sensitive benzimidazoles by amino / cyclodextrin combinations
NO19994409A NO327212B1 (en) 1997-03-13 1999-09-10 Pharmaceutical formulation comprising benzimidazoles and amino acid / cyclodextrin combinations as well as processes for their preparation.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97104200 1997-03-13
EP97104200.7 1997-03-13
PCT/EP1998/001478 WO1998040069A2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
EP98919099.6A EP0991407B2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazols with amino/cyclodextrin combinations

Publications (2)

Publication Number Publication Date
WO1998040069A2 WO1998040069A2 (en) 1998-09-17
WO1998040069A3 true WO1998040069A3 (en) 1998-12-17

Family

ID=8226585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001478 Ceased WO1998040069A2 (en) 1997-03-13 1998-03-13 Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations

Country Status (23)

Country Link
US (1) US6248758B1 (en)
JP (1) JP4608031B2 (en)
KR (1) KR100563764B1 (en)
CN (1) CN1113649C (en)
AT (1) ATE209491T1 (en)
AU (1) AU731186B2 (en)
BR (1) BR9808581A (en)
CA (1) CA2282513C (en)
CZ (1) CZ291842B6 (en)
DE (1) DE69802688T3 (en)
DK (1) DK0991407T4 (en)
ES (1) ES2167891T5 (en)
HU (1) HU225587B1 (en)
IL (1) IL131651A0 (en)
NO (1) NO327212B1 (en)
NZ (1) NZ337592A (en)
PL (1) PL191570B1 (en)
PT (1) PT991407E (en)
SI (1) SI0991407T2 (en)
SK (1) SK284811B6 (en)
TR (1) TR199902233T2 (en)
WO (1) WO1998040069A2 (en)
ZA (1) ZA982155B (en)

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DE102005008412A1 (en) 2005-02-24 2006-09-07 Ratiopharm Gmbh New piperazine salt of omeprazol is proton pump inhibitor useful to prevent/treat e.g. peptic ulcer, gastritis, gastroesophageal reflux, acute stress ulcer or dyspepsia

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