WO1999003684A3 - The production of microstructures for use in assays - Google Patents

The production of microstructures for use in assays Download PDF

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Publication number
WO1999003684A3
WO1999003684A3 PCT/GB1998/002161 GB9802161W WO9903684A3 WO 1999003684 A3 WO1999003684 A3 WO 1999003684A3 GB 9802161 W GB9802161 W GB 9802161W WO 9903684 A3 WO9903684 A3 WO 9903684A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
microstructures
assays
applying
onto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/002161
Other languages
French (fr)
Other versions
WO1999003684A2 (en
WO1999003684A8 (en
Inventor
Bernadette Yon-Hin
James Mccann
Saji Eapen
Christopher Robin Lowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Sensors Ltd
Original Assignee
Cambridge Sensors Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Sensors Ltd filed Critical Cambridge Sensors Ltd
Priority to US09/445,650 priority Critical patent/US6440645B1/en
Priority to DE69809913T priority patent/DE69809913T2/en
Priority to JP2000502944A priority patent/JP2001510276A/en
Priority to EP98935168A priority patent/EP0996547B1/en
Priority to CA002293597A priority patent/CA2293597A1/en
Priority to AT98935168T priority patent/ATE228939T1/en
Publication of WO1999003684A2 publication Critical patent/WO1999003684A2/en
Publication of WO1999003684A3 publication Critical patent/WO1999003684A3/en
Publication of WO1999003684A8 publication Critical patent/WO1999003684A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M1/00—Inking and printing with a printer's forme
    • B41M1/12—Stencil printing; Silk-screen printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M3/00—Printing processes to produce particular kinds of printed work, e.g. patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00909—Separation using filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0323—Grooves
    • B81B2203/0338—Channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/0183—Selective deposition
    • B81C2201/0184—Digital lithography, e.g. using an inkjet print-head

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Glass Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Micromachines (AREA)
  • Printing Methods (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

A process for the production of a device having a surface microstructure of wells or channels, comprises one or more steps of screen-printing the microstructure as a curable material onto a plastics substrate, and curing the material. Such a device may also be obtained by applying onto a substrate a material that is polymerisable or depolymerisable by irradiation, applying a negative or positive photoresist respectively, irradiating the structure and removing the unpolymerised or depolymerised material.
PCT/GB1998/002161 1997-07-18 1998-07-20 The production of microstructures for use in assays Ceased WO1999003684A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US09/445,650 US6440645B1 (en) 1997-07-18 1998-07-20 Production of microstructures for use in assays
DE69809913T DE69809913T2 (en) 1997-07-18 1998-07-20 THE PRODUCTION OF MICROSTRUCTURES FOR USE IN TESTS
JP2000502944A JP2001510276A (en) 1997-07-18 1998-07-20 Fabrication of microstructures for use in assays
EP98935168A EP0996547B1 (en) 1997-07-18 1998-07-20 The production of microstructures for use in assays
CA002293597A CA2293597A1 (en) 1997-07-18 1998-07-20 The production of microstructures for use in assays
AT98935168T ATE228939T1 (en) 1997-07-18 1998-07-20 THE PRODUCTION OF MICROSTRUCTURES FOR USE IN TESTS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9715101.3 1997-07-18
GB9715101A GB9715101D0 (en) 1997-07-18 1997-07-18 The production of microstructures for analysis of fluids

Publications (3)

Publication Number Publication Date
WO1999003684A2 WO1999003684A2 (en) 1999-01-28
WO1999003684A3 true WO1999003684A3 (en) 1999-05-14
WO1999003684A8 WO1999003684A8 (en) 1999-06-17

Family

ID=10816024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002161 Ceased WO1999003684A2 (en) 1997-07-18 1998-07-20 The production of microstructures for use in assays

Country Status (8)

Country Link
US (1) US6440645B1 (en)
EP (1) EP0996547B1 (en)
JP (1) JP2001510276A (en)
AT (1) ATE228939T1 (en)
CA (1) CA2293597A1 (en)
DE (1) DE69809913T2 (en)
GB (1) GB9715101D0 (en)
WO (1) WO1999003684A2 (en)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20030040105A1 (en) * 1999-09-30 2003-02-27 Sklar Larry A. Microfluidic micromixer
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
AU1476601A (en) 1999-11-09 2001-06-06 Sri International Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array
ATE323470T1 (en) 1999-12-10 2006-05-15 Massachusetts Inst Technology MICROCHIP DRUG DELIVERY SYSTEMS AND METHODS OF MANUFACTURING
ES2420279T3 (en) 2000-03-02 2013-08-23 Microchips, Inc. Microfabricated devices and methods for storage and selective exposure of chemicals
CA2408291C (en) * 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
SE0001790D0 (en) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
US6777245B2 (en) 2000-06-09 2004-08-17 Advalytix Ag Process for manipulation of small quantities of matter
AU2002216614A1 (en) * 2000-10-03 2002-04-15 Minerva Biotechnologies Corporation Electronic detection of interaction based on the interruption of flow
US7105304B1 (en) * 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US20050221385A1 (en) * 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
US6864065B2 (en) * 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US20020079220A1 (en) * 2000-11-09 2002-06-27 Pawliszyn Janusz B. Micromachining using printing technology
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002094440A2 (en) * 2001-05-22 2002-11-28 Northeastern University Microchip integrated multichannel electroosmotic pumping system
GR1004058B (en) * 2001-05-31 2002-11-15 Photoresists processable under biocompatible conditions for multi-biomolecule patterning
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
DE60239132D1 (en) 2001-06-12 2011-03-24 Pelikan Technologies Inc APPARATUS FOR INCREASING THE SUCCESS RATE IN RESPECT OF BLOOD EXPLOITATION OBTAINED BY A FINGERSTICK
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ATE494837T1 (en) 2001-06-12 2011-01-15 Pelikan Technologies Inc INTEGRATED SYSTEM FOR BLOOD SAMPLE ANALYSIS WITH MULTIPLE-USE SAMPLING MODULE
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
JP4209767B2 (en) 2001-06-12 2009-01-14 ペリカン テクノロジーズ インコーポレイテッド Self-optimized cutting instrument with adaptive means for temporary changes in skin properties
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
WO2003032957A2 (en) 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
WO2003012726A1 (en) * 2001-07-27 2003-02-13 Surface Logix, Inc. Method and device for monitoring cell motility in real-time
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
IE20020619A1 (en) * 2001-12-31 2003-07-23 Provost Fellows And Scholors O An assay assembly
US20030186405A1 (en) * 2002-04-01 2003-10-02 The Ohio State University Research Foundation Micro/nano-embossing process and useful applications thereof
EP2484751B1 (en) * 2002-04-16 2018-11-28 Princeton University Method of analysing polynucleotides
KR100453047B1 (en) * 2002-04-17 2004-10-15 삼성전자주식회사 Ink jet print head and manufacturing method thereof
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2003088824A2 (en) 2002-04-19 2003-10-30 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7534601B2 (en) * 2002-08-27 2009-05-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
WO2004020341A2 (en) * 2002-08-27 2004-03-11 Vanderbilt University Bioreactors with substance injection capacity
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
GB2393246A (en) 2002-09-21 2004-03-24 Sonoptix Ltd Transducer sensor
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE10312628A1 (en) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Method and device for wetting a substrate with a liquid
EP2238892A3 (en) 2003-05-30 2011-02-09 Pelikan Technologies Inc. Apparatus for body fluid sampling
ES2490740T3 (en) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Apparatus for blood fluid sampling and analyte detection
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
JP2005027659A (en) * 2003-06-20 2005-02-03 Nitto Denko Corp Cell microchip
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR AN IMPROVED SAMPLING INTERFERENCE DEVICE
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
FR2861609B1 (en) 2003-10-31 2006-02-03 Commissariat Energie Atomique METHOD FOR DISTRIBUTING DROPS OF A LIQUID OF INTEREST ON A SURFACE
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
DE102004005337A1 (en) * 2004-02-04 2005-08-25 Studiengesellschaft Kohle Mbh Microfluidic chips with intrinsic hydrophilic surfaces
JP2005234389A (en) * 2004-02-20 2005-09-02 Fuji Photo Film Co Ltd Evaluation apparatus for scientific phenomenon and teaching material for science experiment, and method for manufacturing same
DE102004013161B4 (en) * 2004-03-17 2008-04-10 microTec Gesellschaft für Mikrotechnologie mbH Microfluidic chip
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
JP2006071433A (en) * 2004-09-01 2006-03-16 Shimadzu Corp Electrophoresis method, electrophoresis medium and coating material
ATE424928T1 (en) 2004-09-01 2009-03-15 Microchips Inc CONTAINER DEVICES WITH MULTIPLE CLOSURES FOR CONTROLLED DISPENSING OR EXPOSURE OF CONTAINERS CONTENTS
US7638036B2 (en) * 2004-09-30 2009-12-29 E. I. Du Pont De Nemours And Company Redox potential mediated carbon nanotubes biosensing in homogeneous format
WO2006101530A1 (en) * 2004-10-21 2006-09-28 Capecod Biosystems, Inc Thin-film polarization sample cell for biological and chemical agents and a method of sampling
US20080204745A1 (en) * 2004-10-21 2008-08-28 Capecod Biosystems Inc Thin-Film Polarization Sample Cell For Biological And Chemical Agents And A Method Of Sampling
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US7785862B2 (en) * 2005-04-07 2010-08-31 454 Life Sciences Corporation Thin film coated microwell arrays
US7682816B2 (en) 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
CN101578520B (en) 2006-10-18 2015-09-16 哈佛学院院长等 Based on formed pattern porous medium cross flow and through biometric apparatus, and preparation method thereof and using method
US8649840B2 (en) 2007-06-07 2014-02-11 Microchips, Inc. Electrochemical biosensors and arrays
US8628729B2 (en) 2008-03-27 2014-01-14 President And Fellows Of Harvard College Three-dimensional microfluidic devices
CN103203210A (en) * 2008-03-27 2013-07-17 哈佛学院院长等 Paper-based Cellular Arrays
KR20100128340A (en) 2008-03-27 2010-12-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Paper-Based Microfluidic Systems
KR101510785B1 (en) * 2008-03-27 2015-04-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cotton thread as a low-cost multi-assay diagnostic platform
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
DE102008026696A1 (en) * 2008-06-04 2010-06-02 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Active ingredient depot for releasing active substance, comprises substrate with opening, and multiple individual reservoirs for active substance
CA2640787C (en) * 2008-10-08 2015-12-15 Sqi Diagnostics Systems Inc. Array fluorescence equalization method
TW201104253A (en) * 2008-12-31 2011-02-01 Nat Health Research Institutes Microarray chip and method of fabricating for the same
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
ES2612507T3 (en) 2009-03-06 2017-05-17 President And Fellows Of Harvard College Microfluidic and electrochemical devices
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
AU2010229490B2 (en) 2009-03-24 2015-02-12 University Of Chicago Slip chip device and methods
WO2011036509A1 (en) * 2009-09-28 2011-03-31 Universitat Rovira I Virgili Screen printed functional microsystems
JP2010008433A (en) * 2009-10-15 2010-01-14 Enplas Corp Electrophoretic apparatus
CN102821861B (en) 2010-02-03 2015-03-25 哈佛大学校长及研究员协会 Devices and methods for multiplexed assays
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2013101672A2 (en) * 2011-12-28 2013-07-04 Agilent Technologies, Inc. Two dimensional nanofluidic ccd arrays for manipulation of charged molecules in solution
EP3269445A4 (en) * 2015-03-09 2018-04-11 Panasonic Intellectual Property Management Co., Ltd. Microfluid device
US20170357656A1 (en) * 2016-06-08 2017-12-14 Hewlett Packard Enterprise Development Lp Reducing file system journaling writes
WO2019193126A1 (en) 2018-04-06 2019-10-10 Fundació Institut De Bioenginyeria De Catalunya (Ibec) Microfluidic structure for carrying out biological assays and chip provided with such structure

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0295258A (en) * 1988-09-30 1990-04-06 Toppan Printing Co Ltd Production of microplate
WO1991003375A1 (en) * 1989-08-31 1991-03-21 David Sarnoff Research Center, Inc. Manufacture of printed circuit boards
US5035939A (en) * 1989-08-31 1991-07-30 David Sarnoff Research Center, Inc. Manufacture of printed circuit boards
EP0471628A1 (en) * 1990-08-09 1992-02-19 Gtc Corporation Thin film transistor circuit and its manufacturing
WO1996015450A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. A partitioned microelectronic device array
DE19545130A1 (en) * 1995-12-04 1997-06-05 Karl Prof Dr Cammann Methods and devices for a modular microsystem for high-precision chemical rapid analyzes and methods of manufacture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306013A (en) * 1980-03-10 1981-12-15 Rca Corporation Asymmetrical radiation exposure of spin coated photoresist to obtain uniform thickness coating used to replicate spiral grooves in plastic substrate
JPS58220756A (en) * 1982-06-18 1983-12-22 Canon Inc Manufacture of ink jet recording head
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JP2974279B2 (en) * 1995-07-06 1999-11-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Ink jet head having photoresist layer containing polyamic acid
US5783452A (en) 1996-02-02 1998-07-21 University Of Washington Covered microchannels and the microfabrication thereof
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0295258A (en) * 1988-09-30 1990-04-06 Toppan Printing Co Ltd Production of microplate
WO1991003375A1 (en) * 1989-08-31 1991-03-21 David Sarnoff Research Center, Inc. Manufacture of printed circuit boards
US5035939A (en) * 1989-08-31 1991-07-30 David Sarnoff Research Center, Inc. Manufacture of printed circuit boards
EP0471628A1 (en) * 1990-08-09 1992-02-19 Gtc Corporation Thin film transistor circuit and its manufacturing
WO1996015450A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. A partitioned microelectronic device array
DE19545130A1 (en) * 1995-12-04 1997-06-05 Karl Prof Dr Cammann Methods and devices for a modular microsystem for high-precision chemical rapid analyzes and methods of manufacture

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9020, Derwent World Patents Index; Class B04, AN 90-151393, XP002900245 *

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JP2001510276A (en) 2001-07-31
WO1999003684A2 (en) 1999-01-28
EP0996547A2 (en) 2000-05-03
ATE228939T1 (en) 2002-12-15
EP0996547B1 (en) 2002-12-04
CA2293597A1 (en) 1999-01-28
GB9715101D0 (en) 1997-09-24
DE69809913D1 (en) 2003-01-16
WO1999003684A8 (en) 1999-06-17
US6440645B1 (en) 2002-08-27

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