WO1999006552A3 - 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN - Google Patents

5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN Download PDF

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Publication number
WO1999006552A3
WO1999006552A3 PCT/IB1998/001236 IB9801236W WO9906552A3 WO 1999006552 A3 WO1999006552 A3 WO 1999006552A3 IB 9801236 W IB9801236 W IB 9801236W WO 9906552 A3 WO9906552 A3 WO 9906552A3
Authority
WO
WIPO (PCT)
Prior art keywords
ests
secreted proteins
brain
proteins expressed
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1998/001236
Other languages
French (fr)
Other versions
WO1999006552A2 (en
WO1999006552B1 (en
Inventor
Milne Edwards Jean-Bapti Dumas
Aymeric Duclert
Bruno Lacroix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset SA filed Critical Genset SA
Priority to DE69834190T priority Critical patent/DE69834190T2/en
Priority to CA002296667A priority patent/CA2296667A1/en
Priority to EP98936594A priority patent/EP1000150B1/en
Priority to AU85555/98A priority patent/AU8555598A/en
Priority to JP2000505293A priority patent/JP2001512015A/en
Publication of WO1999006552A2 publication Critical patent/WO1999006552A2/en
Publication of WO1999006552A3 publication Critical patent/WO1999006552A3/en
Publication of WO1999006552B1 publication Critical patent/WO1999006552B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The sequences of 5' ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5' ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5' ESTs. The 5' ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5' ESTs. The 5' ESTs may also be used to design expression vectors and secretion vectors.
PCT/IB1998/001236 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN Ceased WO1999006552A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69834190T DE69834190T2 (en) 1997-08-01 1998-07-31 5 'ESTS FOR SECRETED PROTEINS EXPRESSED IN THE BRAIN
CA002296667A CA2296667A1 (en) 1997-08-01 1998-07-31 5' ests for secreted proteins expressed in brain
EP98936594A EP1000150B1 (en) 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN
AU85555/98A AU8555598A (en) 1997-08-01 1998-07-31 5' ests for secreted proteins expressed in brain
JP2000505293A JP2001512015A (en) 1997-08-01 1998-07-31 5 'EST of secreted proteins in the brain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/905,223 US6222029B1 (en) 1997-08-01 1997-08-01 5′ ESTs for secreted proteins expressed in brain
US08/905,223 1997-08-01

Publications (3)

Publication Number Publication Date
WO1999006552A2 WO1999006552A2 (en) 1999-02-11
WO1999006552A3 true WO1999006552A3 (en) 1999-04-22
WO1999006552B1 WO1999006552B1 (en) 1999-06-03

Family

ID=25420448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001236 Ceased WO1999006552A2 (en) 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN BRAIN

Country Status (8)

Country Link
US (1) US6222029B1 (en)
EP (1) EP1000150B1 (en)
JP (1) JP2001512015A (en)
AT (1) ATE323161T1 (en)
AU (1) AU8555598A (en)
CA (1) CA2296667A1 (en)
DE (1) DE69834190T2 (en)
WO (1) WO1999006552A2 (en)

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* Cited by examiner, † Cited by third party
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EP1005546A2 (en) 1997-02-25 2000-06-07 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
US6465611B1 (en) 1997-02-25 2002-10-15 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
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US7517952B1 (en) 1997-02-25 2009-04-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6818751B1 (en) 1997-08-01 2004-11-16 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20030185830A1 (en) 1997-02-25 2003-10-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US7202342B1 (en) 1999-11-12 2007-04-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6894146B1 (en) 1997-02-25 2005-05-17 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6800746B2 (en) 1997-02-25 2004-10-05 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US7033827B2 (en) 1997-02-25 2006-04-25 Corixa Corporation Prostate-specific polynucleotide compositions
US6613872B1 (en) 1997-02-25 2003-09-02 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
US6261562B1 (en) 1997-02-25 2001-07-17 Corixa Corporation Compounds for immunotherapy of prostate cancer and methods for their use
US6759515B1 (en) 1997-02-25 2004-07-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6329505B1 (en) 1997-02-25 2001-12-11 Corixa Corporation Compositions and methods for therapy and diagnosis of prostate cancer
US6620922B1 (en) 1997-02-25 2003-09-16 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6630305B1 (en) 1999-11-12 2003-10-07 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6943236B2 (en) 1997-02-25 2005-09-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US20020132252A1 (en) * 1997-06-16 2002-09-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2248971A1 (en) * 1997-10-31 1999-04-30 Kyowa Hakko Kogyo Co., Ltd. .beta.1, 3-n-acetylglucosaminyltransferase, dna encoding it and its use
US6548633B1 (en) 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides
US7045612B2 (en) * 1998-01-16 2006-05-16 Mcgill University Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
AU3648499A (en) * 1998-04-17 1999-11-08 Emory University Protein phosphatase methylesterase dna
AU2006202355B2 (en) * 1998-05-01 2009-08-20 Glaxosmithkline Biologicals Sa Neisseria meningitidis antigens and compositions
US6096526A (en) 1998-05-20 2000-08-01 Incyte Pharmaceuticals, Inc. Human nucleic acid methylases
US6825328B1 (en) * 1998-07-20 2004-11-30 Stephen W. Scherer Lafora's disease gene
JP2002522016A (en) * 1998-07-22 2002-07-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Protein similar to neuroendocrine-specific protein and cDNA encoding the same
IL141330A0 (en) * 1998-08-20 2002-03-10 Regeneron Pharma Dcr5, a bmp-binding protein and aplications thereof
US20030009013A1 (en) * 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000061754A2 (en) * 1999-04-09 2000-10-19 Curagen Corporation Human proteins and polynucleotides encoding them
EP1191096B1 (en) * 1999-06-28 2011-10-12 Yusuke Nakamura Ovel protein and dna thereof
JP2001269184A (en) * 1999-06-28 2001-10-02 Takeda Chem Ind Ltd Novel protein and its DNA
CA2387655A1 (en) * 1999-07-31 2001-02-08 Board Of Regents, The University Of Texas System Sentrin-specific human proteases senp1-3
ES2189560B1 (en) 1999-10-01 2005-01-01 Consejo Superior De Investigaciones Cientificas DNA POLYMERASE K, NEW TUMOR MARKER.
IL149569A0 (en) * 1999-11-17 2002-11-10 Arena Pharm Inc Endogenous and non-endogenous versions of human g protein-coupled receptors
WO2001088119A1 (en) * 2000-04-28 2001-11-22 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
US6828097B1 (en) * 2000-05-16 2004-12-07 The Childrens Mercy Hospital Single copy genomic hybridization probes and method of generating same
AU6461001A (en) * 2000-05-16 2001-11-26 Childrens Mercy Hospital Single copy genomic hybridization probes and method of generating same
JP5048201B2 (en) 2000-08-04 2012-10-17 ディーエムアイ バイオサイエンシズ インコーポレイテッド Method for using diketopiperazines and compositions containing diketopiperazines
US7048931B1 (en) 2000-11-09 2006-05-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
EP1573024A4 (en) 2001-04-10 2007-08-29 Agensys Inc NUCLEIC ACIDS AND CORRESPONDING PROTEINS USEFUL FOR THE DETECTION AND TREATMENT OF VARIOUS CANCERS
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
US20030023042A1 (en) * 2001-12-06 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
DK1571970T3 (en) * 2002-10-02 2011-11-28 Dmi Biosciences Inc Diagnosis and monitoring of diseases
CN102210852B (en) 2003-05-15 2016-10-19 安皮奥制药股份有限公司 Treatment of T-cell mediated diseases
EP1636258A2 (en) * 2003-06-10 2006-03-22 Xantos Biomedicine AG Angiogenic factor and inhibitors thereof
RU2007104022A (en) * 2004-07-02 2008-08-10 Дженентек, Инк. (Us) COMPOSITIONS FOR THE TREATMENT OF NON-HODGKINIAN LYMPHOMA AND METHODS OF APPLICATION
US8354237B2 (en) * 2007-02-02 2013-01-15 University Of Vermont And State Agriculture College Anti-methylation-controlled j protein antibodies and uses thereof
JP5856843B2 (en) * 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド Pharmaceutical composition using diketopiperazine
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US10583169B2 (en) 2012-07-11 2020-03-10 University Of Vermont And State Agricultural College Methylation-controlled J protein (MCJ) for treatment of liver disease and altering mitochondrial metabolism
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
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CA2977050A1 (en) 2015-02-18 2016-08-25 University Of Vermont And State Agricultural College Mcj agonists and uses therefor
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A2 (en) * 1987-02-17 1988-08-24 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
EP0625572A1 (en) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCESS FOR SYNTHESIZING COMPLETE-LENGTH cDNA, PROCESS FOR PRODUCING INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING RECOMBINANT VECTOR CONTAINING COMPLETE-LENGTH cDNA
WO1996034981A2 (en) * 1995-05-02 1996-11-07 Genset Sa METHOD FOR THE SPECIFIC COUPLING OF THE CAP OF THE EXTREMITY 5' OF A FRAGMENT mRNA AND PREPARATION OF mRNA AND COMPLETE cDNA
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A2 (en) * 1987-02-17 1988-08-24 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
EP0625572A1 (en) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCESS FOR SYNTHESIZING COMPLETE-LENGTH cDNA, PROCESS FOR PRODUCING INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING RECOMBINANT VECTOR CONTAINING COMPLETE-LENGTH cDNA
WO1996034981A2 (en) * 1995-05-02 1996-11-07 Genset Sa METHOD FOR THE SPECIFIC COUPLING OF THE CAP OF THE EXTREMITY 5' OF A FRAGMENT mRNA AND PREPARATION OF mRNA AND COMPLETE cDNA
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ADAMS M D ET AL: "3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTS IN HUMAN BRAIN", NATURE GENETICS, vol. 4, no. 3, July 1993 (1993-07-01), pages 256 - 267, XP000645060 *
ADAMS M D ET AL: "RAPID CDNA SEQUENCING (EXPRESSED SEQUENCE TAGS) FROM A DIRECTIONALLY CLONED HUMAN INFANT BRAIN CDNA LIBRARY", NATURE GENETICS, vol. 4, no. 4, August 1993 (1993-08-01), pages 373 - 380, STANDARD, XP002064427 *
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729 *
DATABASE EMBL - R55U017 22 August 1996 (1996-08-22), LLOYD, D.: "Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 181C9", XP002083782 *
GREENWOOD M T ET AL: "Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5@?-flanking promoter region", GENE, vol. 159, no. 2, 4 July 1995 (1995-07-04), pages 291-292, XP004042228 *
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954 *
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364 *
LIN Y ET AL: "INHIBITION OF NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KB BY A SYNTHETIC PEPTIDE CONTAINING A CELL MEMBRANE-PERMEABLE MOTIF AND NUCLEAR LOCALIZATION SEQUENCE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 24, 16 June 1995 (1995-06-16), pages 14255 - 14258, XP002050723 *
LOCKHART D J ET AL: "EXPRESSION MONITORING BY HYBRIDIZATION TO HIGH-DENSITY OLIGONUCLEOTIDE ARRAYS", BIO/TECHNOLOGY, vol. 14, no. 13, December 1996 (1996-12-01), pages 1675 - 1680, XP002022521 *
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 *
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953 *

Also Published As

Publication number Publication date
AU8555598A (en) 1999-02-22
WO1999006552A2 (en) 1999-02-11
DE69834190D1 (en) 2006-05-24
WO1999006552B1 (en) 1999-06-03
US6222029B1 (en) 2001-04-24
CA2296667A1 (en) 1999-02-11
DE69834190T2 (en) 2007-01-11
ATE323161T1 (en) 2006-04-15
EP1000150A2 (en) 2000-05-17
EP1000150B1 (en) 2006-04-12
JP2001512015A (en) 2001-08-21

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