WO1999006553A3 - 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN VARIOUS TISSUES - Google Patents

5' ESTs FOR SECRETED PROTEINS EXPRESSED IN VARIOUS TISSUES Download PDF

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Publication number
WO1999006553A3
WO1999006553A3 PCT/IB1998/001237 IB9801237W WO9906553A3 WO 1999006553 A3 WO1999006553 A3 WO 1999006553A3 IB 9801237 W IB9801237 W IB 9801237W WO 9906553 A3 WO9906553 A3 WO 9906553A3
Authority
WO
WIPO (PCT)
Prior art keywords
ests
secreted proteins
various tissues
proteins expressed
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1998/001237
Other languages
French (fr)
Other versions
WO1999006553A2 (en
WO1999006553B1 (en
Inventor
Milne Edwards Jean-Bapti Dumas
Aymeric Duclert
Bruno Lacroix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK03016497T priority Critical patent/DK1375514T3/en
Priority to JP2000505294A priority patent/JP2002525024A/en
Priority to AU85556/98A priority patent/AU8555698A/en
Priority to EP98936595A priority patent/EP1000151B1/en
Priority to DE69834727T priority patent/DE69834727T2/en
Priority to CA002296844A priority patent/CA2296844A1/en
Application filed by Genset SA filed Critical Genset SA
Publication of WO1999006553A2 publication Critical patent/WO1999006553A2/en
Publication of WO1999006553A3 publication Critical patent/WO1999006553A3/en
Publication of WO1999006553B1 publication Critical patent/WO1999006553B1/en
Anticipated expiration legal-status Critical
Priority to CY20061100841T priority patent/CY1105398T1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The sequences of 5' ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5' ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5' ESTs. The 5' ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5' ESTs. The 5' ESTs may also be used to design expression vectors and secretion vectors.
PCT/IB1998/001237 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN VARIOUS TISSUES Ceased WO1999006553A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000505294A JP2002525024A (en) 1997-08-01 1998-07-31 5'EST of secreted proteins expressed in various tissues
AU85556/98A AU8555698A (en) 1997-08-01 1998-07-31 5' ests for secreted proteins expressed in various tissues
EP98936595A EP1000151B1 (en) 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN VARIOUS TISSUES
DE69834727T DE69834727T2 (en) 1997-08-01 1998-07-31 5 'ESTS FOR SECRETED PROTEINS EXPOSED IN DIFFERENT TISSUE
CA002296844A CA2296844A1 (en) 1997-08-01 1998-07-31 5' ests for secreted proteins expressed in various tissues
DK03016497T DK1375514T3 (en) 1997-08-01 1998-07-31 5 'ESTs for secreted proteins expressed in different tissues
CY20061100841T CY1105398T1 (en) 1997-08-01 2006-06-21 5΄ ESTs FOR SECRETORY PROTEINS EXPRESSED IN DIFFERENT TISSUES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90505197A 1997-08-01 1997-08-01
US08/905,051 1997-08-01

Publications (3)

Publication Number Publication Date
WO1999006553A2 WO1999006553A2 (en) 1999-02-11
WO1999006553A3 true WO1999006553A3 (en) 1999-04-08
WO1999006553B1 WO1999006553B1 (en) 1999-05-27

Family

ID=25420220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/001237 Ceased WO1999006553A2 (en) 1997-08-01 1998-07-31 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN VARIOUS TISSUES

Country Status (11)

Country Link
EP (2) EP1000151B1 (en)
JP (1) JP2002525024A (en)
AT (2) ATE328078T1 (en)
AU (1) AU8555698A (en)
CA (1) CA2296844A1 (en)
CY (2) CY1105398T1 (en)
DE (2) DE69835777T2 (en)
DK (2) DK1000151T3 (en)
ES (2) ES2266693T3 (en)
PT (2) PT1375514E (en)
WO (1) WO1999006553A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372473B1 (en) 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
JP2001512012A (en) * 1997-08-01 2001-08-21 ジェンセット 5'EST of secreted protein expressed in testis and other tissues
US7704944B2 (en) 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
US7220717B2 (en) 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
WO1999027096A1 (en) * 1997-11-22 1999-06-03 Hyseq, Inc. A NOVEL EGF MOTIF PROTEIN OBTAINED FROM A cDNA LIBRARY OF FETAL LIVER-SPLEEN
CA2311640A1 (en) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides and nucleic acids encoding the same
DK1191101T3 (en) * 1997-12-11 2004-10-11 Genentech Inc PRO241 polypeptides and nucleic acid encoding them
AU5312699A (en) * 1998-06-25 2000-01-10 Millennium Pharmaceuticals, Inc. Novel mp-7 protein and nucleic acid molecules and uses therefor
AU2596700A (en) * 1999-03-08 2000-09-28 Genentech Inc. Promotion or inhibition of angiogenesis and cardiovascularization
FR2796652B1 (en) * 1999-07-20 2003-03-21 Inst Nat Sante Rech Med NUCLEIC ACIDS ENCODING PEPTIDES HAVING SORBIN BIOLOGICAL ACTIVITY
US6979551B2 (en) 2000-04-03 2005-12-27 Rigel Pharmaceuticals, Inc. Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
US6740495B1 (en) 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay
AU2001253907A1 (en) * 2000-04-25 2001-11-07 Millenium Pharmaceuticals, Inc. 27960, a novel ubiquitin conjugating enzyme family member and uses therefor
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
US7736654B2 (en) 2001-04-10 2010-06-15 Agensys, Inc. Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7109302B1 (en) 2002-04-01 2006-09-19 Human Genome Sciences, Inc. Antibodies that specifically bind to GMAD
WO2015060333A1 (en) * 2013-10-25 2015-04-30 国立大学法人神戸大学 Artificial peptide capable of degrading amyloids and utilization thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A2 (en) * 1987-02-17 1988-08-24 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
EP0625572A1 (en) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCESS FOR SYNTHESIZING COMPLETE-LENGTH cDNA, PROCESS FOR PRODUCING INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING RECOMBINANT VECTOR CONTAINING COMPLETE-LENGTH cDNA
WO1996034981A2 (en) * 1995-05-02 1996-11-07 Genset Sa METHOD FOR THE SPECIFIC COUPLING OF THE CAP OF THE EXTREMITY 5' OF A FRAGMENT mRNA AND PREPARATION OF mRNA AND COMPLETE cDNA
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001512012A (en) * 1997-08-01 2001-08-21 ジェンセット 5'EST of secreted protein expressed in testis and other tissues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A2 (en) * 1987-02-17 1988-08-24 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
EP0625572A1 (en) * 1992-09-25 1994-11-23 The Kanagawa Academy Of Science And Technology Foundation PROCESS FOR SYNTHESIZING COMPLETE-LENGTH cDNA, PROCESS FOR PRODUCING INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING RECOMBINANT VECTOR CONTAINING COMPLETE-LENGTH cDNA
WO1996034981A2 (en) * 1995-05-02 1996-11-07 Genset Sa METHOD FOR THE SPECIFIC COUPLING OF THE CAP OF THE EXTREMITY 5' OF A FRAGMENT mRNA AND PREPARATION OF mRNA AND COMPLETE cDNA
WO1997007198A2 (en) * 1995-08-11 1997-02-27 Genetics Institute, Inc. Dna sequences and secreted proteins encoded thereby

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ADAMS M D ET AL: "INITIAL ASSESSMENT OF HUMAN GENE DIVERSITY AND EXPRESSION PATTERNS BASED UPON 83 MILLION NUCLEOTIDES OF CDNA SEQUENCE", NATURE, vol. 377, no. SUPPL, 28 September 1995 (1995-09-28), pages 3 - 17, XP002069461 *
CARNINCI P. ET AL.: "High-efficiency full-length cDNA cloning by biotinylated CAP trapper", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 327 - 336, XP002081729 *
DATABASE EMBL - EMEST14 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST94680 ACtivated T-cell I Homo sapiens CDNA 5' end.", XP002083843 *
DATABASE EMBL - EMEST14 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST95896 Testis I Homo spaiens cDNA 5' end.", XP002083842 *
DATABASE EMBL - EMEST3 16 February 1998 (1998-02-16), STRAUSBERG, R.: "oc15a05.s1 NCI_CGAP_GCB1 Homo spaiens cDNA clone IMAGE:1340912.", XP002083844 *
GREENWOOD M T ET AL: "Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region", GENE, vol. 159, no. 2, 4 July 1995 (1995-07-04), pages 291-292, XP004042228 *
HEIJNE VON G.: "A new method for predicting signal sequence cleavage sites", NUCLEIC ACIDS RESEARCH, vol. 14, no. 11, 1986, pages 4683 - 4690, XP002053954 *
KATO S. ET AL.: "Construction of a human full-length cDNA bank", GENE, vol. 150, 1994, pages 243 - 250, XP002081364 *
LIN Y ET AL: "INHIBITION OF NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KB BY A SYNTHETIC PEPTIDE CONTAINING A CELL MEMBRANE-PERMEABLE MOTIF AND NUCLEAR LOCALIZATION SEQUENCE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 24, 16 June 1995 (1995-06-16), pages 14255 - 14258, XP002050723 *
LOCKHART D J ET AL: "EXPRESSION MONITORING BY HYBRIDIZATION TO HIGH-DENSITY OLIGONUCLEOTIDE ARRAYS", BIO/TECHNOLOGY, vol. 14, no. 13, December 1996 (1996-12-01), pages 1675 - 1680, XP002022521 *
TASHIRO K. ET AL.: "Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 *
YOKOYAMA-KOBAYASHI M. ET AL.: "A signal sequence detection system using secreted protease activity as an indicator", GENE, vol. 163, 1995, pages 193 - 196, XP002053953 *

Also Published As

Publication number Publication date
CA2296844A1 (en) 1999-02-11
EP1375514A3 (en) 2004-05-19
EP1375514B1 (en) 2006-08-30
PT1375514E (en) 2006-10-31
CY1105240T1 (en) 2010-03-03
EP1000151B1 (en) 2006-05-31
EP1000151A2 (en) 2000-05-17
ATE328078T1 (en) 2006-06-15
CY1105398T1 (en) 2010-04-28
ES2260841T3 (en) 2006-11-01
AU8555698A (en) 1999-02-22
JP2002525024A (en) 2002-08-13
WO1999006553A2 (en) 1999-02-11
PT1000151E (en) 2006-07-31
ATE338064T1 (en) 2006-09-15
DE69834727T2 (en) 2007-01-25
WO1999006553B1 (en) 1999-05-27
DK1000151T3 (en) 2006-10-02
DK1375514T3 (en) 2007-01-08
EP1375514A2 (en) 2004-01-02
DE69835777D1 (en) 2006-10-12
DE69835777T2 (en) 2007-09-06
ES2266693T3 (en) 2007-03-01
DE69834727D1 (en) 2006-07-06

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