WO1999006557A3 - Mammalian cell membrane proteins; related reagents - Google Patents

Mammalian cell membrane proteins; related reagents Download PDF

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Publication number
WO1999006557A3
WO1999006557A3 PCT/US1998/015316 US9815316W WO9906557A3 WO 1999006557 A3 WO1999006557 A3 WO 1999006557A3 US 9815316 W US9815316 W US 9815316W WO 9906557 A3 WO9906557 A3 WO 9906557A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian cell
cell membrane
membrane proteins
related reagents
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/015316
Other languages
French (fr)
Other versions
WO1999006557A2 (en
Inventor
Alexander B H Bakker
Joseph H Phillips Jr
Lewis L Lanier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to EP98937993A priority Critical patent/EP1003861B1/en
Priority to JP2000505298A priority patent/JP2001512017A/en
Priority to AU86614/98A priority patent/AU8661498A/en
Priority to DE69836082T priority patent/DE69836082T2/en
Publication of WO1999006557A2 publication Critical patent/WO1999006557A2/en
Publication of WO1999006557A3 publication Critical patent/WO1999006557A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
PCT/US1998/015316 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents Ceased WO1999006557A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98937993A EP1003861B1 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
JP2000505298A JP2001512017A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
AU86614/98A AU8661498A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
DE69836082T DE69836082T2 (en) 1997-08-01 1998-07-31 MEMBRANE PROTEINS FROM MAMMALIAN CELLS; RELATED REAGENTS

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90490597A 1997-08-01 1997-08-01
US6371797P 1997-10-29 1997-10-29
US99082097A 1997-12-15 1997-12-15
US6969297P 1997-12-16 1997-12-16
US8916898P 1998-06-12 1998-06-12
US60/069,692 1998-06-12
US08/904,905 1998-06-12
US60/089,168 1998-06-12
US60/063,717 1998-06-12
US08/990,820 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999006557A2 WO1999006557A2 (en) 1999-02-11
WO1999006557A3 true WO1999006557A3 (en) 1999-05-20

Family

ID=27535631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/015316 Ceased WO1999006557A2 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents

Country Status (8)

Country Link
EP (3) EP1003861B1 (en)
JP (3) JP2001512017A (en)
AT (2) ATE341626T1 (en)
AU (1) AU8661498A (en)
DE (1) DE69836082T2 (en)
ES (1) ES2274574T3 (en)
PT (1) PT1003861E (en)
WO (1) WO1999006557A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
EP1557425A3 (en) * 1997-07-08 2005-08-17 Human Genome Sciences, Inc. 123 human secreted proteins
AU2002220591A1 (en) * 2000-09-20 2002-04-02 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M) Means for the identification of compounds capable of inhibiting karap-transduced signals
US7858094B2 (en) 2000-12-08 2010-12-28 Geneprint Corporation TREM-1 splice variant for use in modifying immune responses
CA2433474A1 (en) * 2001-02-23 2002-09-06 Human Genome Sciences, Inc. 70 human secreted proteins
JP2008518629A (en) * 2004-11-08 2008-06-05 シェーリング コーポレイション Association of MDL-1 with tumor and method thereof
AR059193A1 (en) * 2006-01-31 2008-03-12 Bayer Schering Pharma Ag MODULATION OF THE ACTIVITY OF MDL-1 FOR THE TREATMENT OF INFLAMMATORY DISEASES
CA2685015A1 (en) 2007-04-23 2008-11-06 Schering Corporation Anti-mdl-1 antibodies
WO2012112528A1 (en) * 2011-02-18 2012-08-23 Merck Sharp & Dohme Corp. Use of mdl-1 antagonists to treat spondylarthropathy
US20140227719A1 (en) 2011-09-23 2014-08-14 Merck Sharp & Dohme Corp Mdl-1 ligand
KR102038310B1 (en) 2011-11-16 2019-11-01 베링거 인겔하임 인터내셔날 게엠베하 Anti il-36r antibodies
AR090915A1 (en) 2012-05-04 2014-12-17 Intervet Int Bv PROTEIN OF FUSION OF PROTEIN LINFOPOYETINA ESTROMAL TIMICA CANINA WITH THE REGION FC OF IGG
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital NKG2D-SPECIFIC CHIMERIC RECEPTOR ADAPTED FOR USE IN CELL THERAPY AGAINST CANCER AND INFECTIOUS DISEASES
JP2016510342A (en) * 2013-02-15 2016-04-07 トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ Kit for tumor imaging
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
KR20250067191A (en) 2014-09-17 2025-05-14 노파르티스 아게 Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
KR102660336B1 (en) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 Truncated NKG2D chimeric receptor and its use in natural killer cell immunotherapy
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CA3093692A1 (en) 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Use of anti-il-36r antibodies for treatment of generalized pustular psoriasis
CN112055717B (en) 2018-04-02 2024-04-26 新加坡国立大学 Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
CN108728527B (en) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 HCST gene as target for diagnosing and treating preeclampsia
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD FOR SPECIFICALLY STIMULATING THE SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
BR112021016198A2 (en) 2019-03-08 2021-11-03 Boehringer Ingelheim Int Anti-il-36r antibody formulations
EP4182022A1 (en) 2020-07-17 2023-05-24 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for the treatment of neutrophilic dermatoses

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2031216A1 (en) 1969-06-19 1971-01-14 Citizen Watch Co Ltd , Tokio Day and date setting device for clocks with calendar
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
WO1999002546A1 (en) * 1997-07-08 1999-01-21 Human Genome Sciences, Inc. 123 human secreted proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
B L THOMAS: "Of ITAMs and ITIMs: Turning on and off the B cell antigene receptor", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 181, no. 6, 1 June 1995 (1995-06-01), pages 1953 - 1956, XP002084881 *
BLERY M ET AL: "RECONSTITUTED KILLER CELL INHIBITORY RECEPTORS FOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES CONTROL MAST CELL ACTIVATION INDUCED VIA IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 14, 4 April 1997 (1997-04-04), pages 8989 - 8996, XP002052877 *
K TAKASE ET AL: "A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes", JOURNAL OF IMMUNOLOGY, vol. 159, no. 2, 15 July 1997 (1997-07-15), pages 741 - 747, XP002084880 *
L HILLIER ET AL: "The WashU-Merck EST project 1997", EMBL NUCLEOTIDE SEQUENCE, 23 June 1997 (1997-06-23), XP002084878 *
L L LANIER ET AL: "Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells", NATURE, vol. 391, 12 February 1998 (1998-02-12), pages 703 - 707, XP002084882 *
M COLONNA: "Unmasking the killer's accomplice", NATURE, vol. 391, 12 February 1998 (1998-02-12), pages 642/643, XP002084914 *
M. MARRA ET AL.: "The WashU-HHMI Mouse EST Project", EMBL SEQUENCE DATABASE, 12 February 1997 (1997-02-12), Heidelberg, FRG, XP002095088 *
M. MARRA ET AL.: "The WashU-HHMI Mouse EST Project", EMBL SEQUENCE DATABASE, 30 April 1996 (1996-04-30), Heidleberg, FRG, XP002095087 *
M. MARRA ET AL.: "The WashU-HHMI Mouse EST Project", NCBI NATIONAL LIBRARY OF MEDICINE,, 25 October 1996 (1996-10-25), Bethesda, MD, US, XP002084879 *
OLCESE L ET AL: "HUMAN KILLER CELL ACTIVATORY RECEPTORS OF MHC CLASS I MOLECULES AREINCLUDED IN A MULTIMERIC COMPLEX EXPRESSED BY NATURAL KILLER CELLS", JOURNAL OF IMMUNOLOGY, vol. 158, no. 11, 1 June 1997 (1997-06-01), pages 5083 - 5086, XP002052878 *
R. STRAUSBERG: "nh52a05.r1 NCI_CGAP_Pr5 Homo sapiens cDNA clone IMAGE:955952.", EMBL SEQUENCE DATABASE, 15 July 1997 (1997-07-15), Heidelberg, FRG, XP002095086 *

Also Published As

Publication number Publication date
EP1798287A3 (en) 2007-11-14
EP1798286A3 (en) 2007-11-14
ES2274574T3 (en) 2007-05-16
EP1003861B1 (en) 2006-10-04
WO1999006557A2 (en) 1999-02-11
DE69836082D1 (en) 2006-11-16
ATE341626T1 (en) 2006-10-15
JP4855513B2 (en) 2012-01-18
JP2010099077A (en) 2010-05-06
DE69836082T2 (en) 2007-05-10
EP1798286A2 (en) 2007-06-20
JP2010099076A (en) 2010-05-06
EP1798287A2 (en) 2007-06-20
JP2001512017A (en) 2001-08-21
AU8661498A (en) 1999-02-22
PT1003861E (en) 2007-01-31
EP1003861A2 (en) 2000-05-31
ATE523593T1 (en) 2011-09-15
EP1798286B1 (en) 2011-09-07

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