WO1999006557A3 - Mammalian cell membrane proteins; related reagents - Google Patents

Mammalian cell membrane proteins; related reagents Download PDF

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Publication number
WO1999006557A3
WO1999006557A3 PCT/US1998/015316 US9815316W WO9906557A3 WO 1999006557 A3 WO1999006557 A3 WO 1999006557A3 US 9815316 W US9815316 W US 9815316W WO 9906557 A3 WO9906557 A3 WO 9906557A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian cell
cell membrane
membrane proteins
related reagents
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/015316
Other languages
French (fr)
Other versions
WO1999006557A2 (en
Inventor
Alexander B H Bakker
Joseph H Phillips Jr
Lewis L Lanier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU86614/98A priority Critical patent/AU8661498A/en
Priority to JP2000505298A priority patent/JP2001512017A/en
Priority to EP98937993A priority patent/EP1003861B1/en
Priority to DE69836082T priority patent/DE69836082T2/en
Publication of WO1999006557A2 publication Critical patent/WO1999006557A2/en
Publication of WO1999006557A3 publication Critical patent/WO1999006557A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
PCT/US1998/015316 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents Ceased WO1999006557A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU86614/98A AU8661498A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
JP2000505298A JP2001512017A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
EP98937993A EP1003861B1 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
DE69836082T DE69836082T2 (en) 1997-08-01 1998-07-31 MEMBRANE PROTEINS FROM MAMMALIAN CELLS; RELATED REAGENTS

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90490597A 1997-08-01 1997-08-01
US6371797P 1997-10-29 1997-10-29
US99082097A 1997-12-15 1997-12-15
US6969297P 1997-12-16 1997-12-16
US8916898P 1998-06-12 1998-06-12
US60/069,692 1998-06-12
US60/089,168 1998-06-12
US08/990,820 1998-06-12
US60/063,717 1998-06-12
US08/904,905 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999006557A2 WO1999006557A2 (en) 1999-02-11
WO1999006557A3 true WO1999006557A3 (en) 1999-05-20

Family

ID=27535631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/015316 Ceased WO1999006557A2 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents

Country Status (8)

Country Link
EP (3) EP1003861B1 (en)
JP (3) JP2001512017A (en)
AT (2) ATE341626T1 (en)
AU (1) AU8661498A (en)
DE (1) DE69836082T2 (en)
ES (1) ES2274574T3 (en)
PT (1) PT1003861E (en)
WO (1) WO1999006557A2 (en)

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US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
EP1557425A3 (en) * 1997-07-08 2005-08-17 Human Genome Sciences, Inc. 123 human secreted proteins
AU2002220591A1 (en) * 2000-09-20 2002-04-02 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M) Means for the identification of compounds capable of inhibiting karap-transduced signals
EP1351702B1 (en) * 2000-12-08 2015-03-04 Bioprovar Corporation Trem-1 splice variant for use in modifying immune responses
EP1370651A4 (en) * 2001-02-23 2005-04-06 Human Genome Sciences Inc 70 human secreted proteins
CA2585719A1 (en) 2004-11-08 2006-05-18 Schering Corporation Tumor association of mdl-1 and methods
EP1991577A2 (en) * 2006-01-31 2008-11-19 Parkinson, John F. Modulation of mdl-1 activity for treatment of inflammatory disease
WO2008133857A1 (en) 2007-04-23 2008-11-06 Schering Corporation Anti-mdl-1 antibodies
WO2012112528A1 (en) * 2011-02-18 2012-08-23 Merck Sharp & Dohme Corp. Use of mdl-1 antagonists to treat spondylarthropathy
US20140227719A1 (en) 2011-09-23 2014-08-14 Merck Sharp & Dohme Corp Mdl-1 ligand
SI3536710T1 (en) 2011-11-16 2026-04-30 Boehringer Ingelheim International Gmbh Anti il-36r antibodies
AR090915A1 (en) 2012-05-04 2014-12-17 Intervet Int Bv PROTEIN OF FUSION OF PROTEIN LINFOPOYETINA ESTROMAL TIMICA CANINA WITH THE REGION FC OF IGG
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital NKG2D-SPECIFIC CHIMERIC RECEPTOR ADAPTED FOR USE IN CELL THERAPY AGAINST CANCER AND INFECTIOUS DISEASES
CA2901231C (en) * 2013-02-15 2020-06-23 Thomas Jefferson University Kit comprising lyophilized compositions for tumor imaging
DK3143134T3 (en) 2014-05-15 2021-01-04 Nat Univ Singapore Modified, natural killer cells and their uses
JP6839074B2 (en) 2014-09-17 2021-03-03 ノバルティス アーゲー Targeting cytotoxic cells at chimeric receptors for adoptive immunotherapy
BR112019019917A2 (en) 2017-03-27 2020-04-22 Nat Univ Singapore truncated nkg2d chimeric receptors and their uses in natural killer cell immunotherapy
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATION OF NKG2D CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNOTHERAPY WITH NATURAL KILLER CELLS
BR112020016738A2 (en) 2018-03-14 2020-12-15 Boehringer Ingelheim International Gmbh USE OF ANTI-IL-36R ANTIBODIES FOR THE TREATMENT OF GENERALIZED PUSTULAR PSORIASIS
JP7334985B2 (en) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール Neutralization of human cytokines by membrane-bound anti-cytokine non-signaling binders expressed in immune cells
CN108728527B (en) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 HCST gene as target for diagnosing and treating preeclampsia
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD FOR SPECIFICALLY STIMULATING THE SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY
IL286100B2 (en) 2019-03-08 2024-12-01 Boehringer Ingelheim Int Anti-IL-36R antibody formulations
BR112022026999A2 (en) 2020-07-17 2023-01-24 Boehringer Ingelheim Int ANTI-IL-36R ANTIBODIES FOR THE TREATMENT OF NEUTROPHILIC DERMATOSES

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

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B L THOMAS: "Of ITAMs and ITIMs: Turning on and off the B cell antigene receptor", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 181, no. 6, 1 June 1995 (1995-06-01), pages 1953 - 1956, XP002084881 *
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Also Published As

Publication number Publication date
ATE523593T1 (en) 2011-09-15
PT1003861E (en) 2007-01-31
EP1003861A2 (en) 2000-05-31
EP1798286B1 (en) 2011-09-07
EP1798286A3 (en) 2007-11-14
ES2274574T3 (en) 2007-05-16
WO1999006557A2 (en) 1999-02-11
EP1798287A2 (en) 2007-06-20
JP4855513B2 (en) 2012-01-18
EP1798287A3 (en) 2007-11-14
EP1003861B1 (en) 2006-10-04
DE69836082T2 (en) 2007-05-10
JP2010099077A (en) 2010-05-06
ATE341626T1 (en) 2006-10-15
DE69836082D1 (en) 2006-11-16
AU8661498A (en) 1999-02-22
EP1798286A2 (en) 2007-06-20
JP2001512017A (en) 2001-08-21
JP2010099076A (en) 2010-05-06

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