WO1999007839A3 - Immunoprotective influenza antigen and its use in vaccination - Google Patents

Immunoprotective influenza antigen and its use in vaccination Download PDF

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Publication number
WO1999007839A3
WO1999007839A3 PCT/EP1998/005106 EP9805106W WO9907839A3 WO 1999007839 A3 WO1999007839 A3 WO 1999007839A3 EP 9805106 W EP9805106 W EP 9805106W WO 9907839 A3 WO9907839 A3 WO 9907839A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
influenza
immunoprotective
vaccination
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/005106
Other languages
French (fr)
Other versions
WO1999007839A2 (en
Inventor
Sabine Neirynck
Jou Willy Min
Walter Fiers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228624&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999007839(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AT98946321T priority Critical patent/ATE312172T1/en
Priority to CA2297786A priority patent/CA2297786C/en
Priority to AU93416/98A priority patent/AU745951B2/en
Priority to JP2000506324A priority patent/JP5132851B2/en
Priority to DE69832706T priority patent/DE69832706T2/en
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Priority to EP98946321A priority patent/EP0996717B1/en
Publication of WO1999007839A2 publication Critical patent/WO1999007839A2/en
Publication of WO1999007839A3 publication Critical patent/WO1999007839A3/en
Anticipated expiration legal-status Critical
Priority to US11/374,922 priority patent/US7732130B2/en
Priority to US12/795,506 priority patent/US7993652B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
PCT/EP1998/005106 1997-08-05 1998-08-05 Immunoprotective influenza antigen and its use in vaccination Ceased WO1999007839A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP98946321A EP0996717B1 (en) 1997-08-05 1998-08-05 Immunoprotective influenza antigen and its use in vaccination
CA2297786A CA2297786C (en) 1997-08-05 1998-08-05 New immunoprotective influenza antigen and its use in vaccination
AU93416/98A AU745951B2 (en) 1997-08-05 1998-08-05 New immunoprotective influenza antigen and its use in vaccination
JP2000506324A JP5132851B2 (en) 1997-08-05 1998-08-05 New immunoprotective influenza antigens and their use in vaccination
DE69832706T DE69832706T2 (en) 1997-08-05 1998-08-05 IMMUNO-PROTECTING INFLUENZAANTIGEN AND ITS USE FOR VACCINATION
AT98946321T ATE312172T1 (en) 1997-08-05 1998-08-05 IMMUNOPROTECTIVE INFLUENCY ANTIGEN AND ITS USE FOR VACCINATION
US11/374,922 US7732130B2 (en) 1997-08-05 2006-03-14 Immunoprotective influenza antigen and its use in vaccination
US12/795,506 US7993652B2 (en) 1997-08-05 2010-06-07 Immunoprotective influenza antigen and its use in vaccination

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202434 1997-08-05
EP97202434.3 1997-08-05

Publications (2)

Publication Number Publication Date
WO1999007839A2 WO1999007839A2 (en) 1999-02-18
WO1999007839A3 true WO1999007839A3 (en) 1999-05-14

Family

ID=8228624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005106 Ceased WO1999007839A2 (en) 1997-08-05 1998-08-05 Immunoprotective influenza antigen and its use in vaccination

Country Status (10)

Country Link
US (1) US7732130B2 (en)
EP (1) EP0996717B1 (en)
JP (2) JP5132851B2 (en)
AT (1) ATE312172T1 (en)
AU (1) AU745951B2 (en)
CA (1) CA2297786C (en)
DE (1) DE69832706T2 (en)
DK (1) DK0996717T3 (en)
ES (1) ES2255181T3 (en)
WO (1) WO1999007839A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6932971B2 (en) 2002-07-18 2005-08-23 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
US7138252B2 (en) 2002-07-17 2006-11-21 Cytos Biotechnology Ag Molecular antigen arrays
US7279165B2 (en) 2002-07-19 2007-10-09 Cytos Biotechnology Ag Amyloid β1-6 antigen arrays
US8945579B2 (en) 2006-03-07 2015-02-03 Vaxinnate Corporation Methods of treatment with compositions that include hemagglutinin

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US7731972B1 (en) 2000-02-04 2010-06-08 Vlaams Interuniversitair Instituut Voor Biotechnologie Immunoprotective influenza antigen and its use in vaccination
WO1999007839A2 (en) 1997-08-05 1999-02-18 Vlaams Interuniversitair Instituut Voor Biotechnologie Immunoprotective influenza antigen and its use in vaccination
PL192016B1 (en) 1998-11-30 2006-08-31 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use
GB0008582D0 (en) * 2000-04-08 2000-05-31 Adprotech Plc DNA immunization vectors
US6872395B2 (en) * 2000-04-14 2005-03-29 Wisconsin Alumni Research Foundation Viruses comprising mutant ion channel protein
WO2001083528A2 (en) * 2000-05-01 2001-11-08 Powderject Vaccines, Inc. Nucleic acid immunization
WO2001085208A2 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
GB0025229D0 (en) * 2000-10-14 2000-11-29 Adprotech Ltd Veterinary immunisation vectors
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
EP1450856B1 (en) 2001-09-14 2009-11-11 Cytos Biotechnology AG Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
US7351413B2 (en) 2002-02-21 2008-04-01 Lorantis, Limited Stabilized HBc chimer particles as immunogens for chronic hepatitis
GB0204154D0 (en) * 2002-02-22 2002-04-10 Adprotech Ltd Cat immunisation vectors
WO2003078600A2 (en) * 2002-03-13 2003-09-25 Kirin Beer Kabushiki Kaisha Human monoclonal antibodies to influenza m2 protein and methods of making and using same
NZ542935A (en) * 2003-04-23 2008-08-29 Wisconsin Alumni Res Found Recombinant influenza viruses holding a mutation in a transmembrane protein gene
MXPA05014016A (en) * 2003-06-23 2006-03-17 Baxter Int Carrier proteins for vaccines.
EP1814990A2 (en) 2004-11-19 2007-08-08 Wisconsin Alumni Research Foundation Recombinant influenza vectors with tandem transcription units
EP1819732A2 (en) 2004-12-06 2007-08-22 Kirin Beer Kabushiki Kaisha Human monoclonal antibodies to influenza m2 protein and methods of making and using same
US20090162400A1 (en) * 2004-12-21 2009-06-25 Powell Thomas J Compositions of influenza viral proteins and methods of use thereof
AU2006311752A1 (en) * 2005-11-07 2007-05-18 Sidney Kimmel Cancer Center CD40 ligand fusion protein vaccine
ES2385842T3 (en) 2005-12-06 2012-08-01 Yeda Research And Development Co., Ltd. Improved flu vaccine
CN101472941B (en) 2006-03-31 2017-08-08 沃弗-威斯康星校友研究基金会 High titer recombinant influenza viruses for vaccine
RU2009105099A (en) 2006-07-14 2010-08-27 Санофи Пастер Байолоджикс Ко. (Us) CONSTRUCTION OF RECOMBINANT VIRAL VACCINES BY DIRECT TRANSPOSION-MEDIATED INSERATION OF ALIEN IMMUNOLOGICAL DETERMINANTS IN VECTOR VIRUS PROTEINS
KR20090096414A (en) 2006-09-29 2009-09-10 사노피 파스테르 바이오로직스 씨오 Recombinant rhino virus vectors
DK2069503T3 (en) * 2006-11-15 2016-02-15 Folia Biotech Inc PAPAYAMOSAIKVIRUS-BASED VACCINES AGAINST INFLUENZA
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
PL2173376T3 (en) 2007-08-02 2015-08-31 Biondvax Pharmaceuticals Ltd Multimeric multiepitope influenza vaccines
KR101255419B1 (en) * 2007-11-12 2013-04-17 이노비오 파마수티컬즈, 인크. Novel vaccines against multiple subtypes of influenza virus
AU2009236585B2 (en) 2008-04-18 2013-03-07 Vaxinnate Corporation Deletion mutants of flagellin and methods of use
WO2010012069A1 (en) * 2008-07-30 2010-02-04 Folio Biotech Inc. Multivalent vaccines based on papaya mosaic virus and uses thereof
EP2168987A1 (en) * 2008-09-22 2010-03-31 Mucosis B.V. Multifunctional linker protein containing an antibody against hemagglutinin, a conserved influenza antigen and an immunostimulating carrier binding domain
KR20120052369A (en) * 2009-07-31 2012-05-23 팍스박스, 인코포레이티드 Adenoviral-based vectors
EP2471915B1 (en) 2009-08-28 2018-05-23 The Chemo-Sero-Therapeutic Research Institute Modified peptide vaccine derived from influenza m2
WO2011046925A1 (en) * 2009-10-12 2011-04-21 Technovax, Inc. Respiratory syncytial virus (rsv) virus-like particles (vlps)
JP2013507990A (en) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション High-titer recombinant influenza virus with enhanced replication in Vero cells
WO2011054995A2 (en) 2009-11-06 2011-05-12 Chimera Pharma, S. L. U. PROPHYLACTIC FLU VACCINES FROM VIRAL CAPSIDS OF BIRNAVIRUS CONTAINING THE M2e ANTIGEN OF THE FLU VIRUS
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
CA2828068C (en) 2011-02-22 2019-03-19 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
ES2655051T3 (en) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Influenza virus with mutant PB2 gene segment as live attenuated vaccines
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
EP3103474A1 (en) * 2015-06-12 2016-12-14 Institut Pasteur Live recombinant measles-m2 virus and its use in eliciting immunity against influenza viruses
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CN109477074B (en) 2016-02-19 2023-01-24 威斯康星旧生研究基金会 Improved influenza b virus replication for vaccine development
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
JP7783047B2 (en) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant biologically contained filovirus vaccines
EP3840780A1 (en) 2018-08-20 2021-06-30 Wisconsin Alumni Research Foundation Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein
WO2020167432A2 (en) 2019-01-23 2020-08-20 Yoshihiro Kawaoka Mutations that confer genetic stability to additional genes in influenza viruses
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
CN114929269A (en) 2019-05-01 2022-08-19 威斯康星校友研究基金会(Warf) Improved influenza virus replication for vaccine development
JP7627911B2 (en) 2019-08-27 2025-02-07 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant influenza viruses with stabilized HA for replication in egg
EP4093415A1 (en) 2020-01-24 2022-11-30 Wisconsin Alumni Research Foundation (WARF) Recombinant influenza viruses with stabilized na
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138252B2 (en) 2002-07-17 2006-11-21 Cytos Biotechnology Ag Molecular antigen arrays
US7494656B2 (en) 2002-07-17 2009-02-24 Cytos Biotechnology Ag Molecular antigen arrays
US6932971B2 (en) 2002-07-18 2005-08-23 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
US7452541B2 (en) 2002-07-18 2008-11-18 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
US8187607B2 (en) 2002-07-18 2012-05-29 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
US7279165B2 (en) 2002-07-19 2007-10-09 Cytos Biotechnology Ag Amyloid β1-6 antigen arrays
US8945579B2 (en) 2006-03-07 2015-02-03 Vaxinnate Corporation Methods of treatment with compositions that include hemagglutinin
US9056901B2 (en) 2006-03-07 2015-06-16 Vaxinnate Corporation Methods of making hemagglutinin proteins
US9200042B2 (en) 2006-03-07 2015-12-01 Vaxinnate Corporation Flagellin fusion proteins

Also Published As

Publication number Publication date
JP2010059164A (en) 2010-03-18
ATE312172T1 (en) 2005-12-15
JP5132851B2 (en) 2013-01-30
EP0996717B1 (en) 2005-12-07
DE69832706D1 (en) 2006-01-12
DK0996717T3 (en) 2006-04-10
DE69832706T2 (en) 2006-08-10
ES2255181T3 (en) 2006-06-16
EP0996717A2 (en) 2000-05-03
CA2297786A1 (en) 1999-02-18
AU9341698A (en) 1999-03-01
US20060246092A1 (en) 2006-11-02
AU745951B2 (en) 2002-04-11
CA2297786C (en) 2011-06-14
WO1999007839A2 (en) 1999-02-18
JP2001512748A (en) 2001-08-28
US7732130B2 (en) 2010-06-08

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