WO1999009955A3 - Lipid-containing compositions and uses thereof - Google Patents

Lipid-containing compositions and uses thereof Download PDF

Info

Publication number
WO1999009955A3
WO1999009955A3 PCT/GB1998/002546 GB9802546W WO9909955A3 WO 1999009955 A3 WO1999009955 A3 WO 1999009955A3 GB 9802546 W GB9802546 W GB 9802546W WO 9909955 A3 WO9909955 A3 WO 9909955A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
containing compositions
compositions
polymer
pmas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/002546
Other languages
French (fr)
Other versions
WO1999009955A2 (en
Inventor
Stephen Ronald Tonge
Brian John Tighe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aston University
Original Assignee
Aston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000507346A priority Critical patent/JP2001513544A/en
Priority to EP98940374A priority patent/EP1007002B1/en
Priority to CA002301711A priority patent/CA2301711C/en
Priority to AT98940374T priority patent/ATE252888T1/en
Priority to AU88714/98A priority patent/AU752508B2/en
Priority to NZ502839A priority patent/NZ502839A/en
Application filed by Aston University filed Critical Aston University
Priority to DE69819338T priority patent/DE69819338T2/en
Publication of WO1999009955A2 publication Critical patent/WO1999009955A2/en
Publication of WO1999009955A3 publication Critical patent/WO1999009955A3/en
Priority to US09/510,223 priority patent/US6436905B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Lipid-containing compositions are disclosed which provide surfactants and solubilising agents useful in medicine, biochemistry and other industries. The compositions comprise a membrane-forming polar lipid and a synthetic amphipathic polymer containing hydrophobic and anionic hydrophilic groups which preferably are evenly arranged along a linear backbone. In some embodiments the polymer is a copolymer, for example poly(maleic acid styrene) (PMAS), in which first and second monomer units are arranged in alternating relationship along its length.
PCT/GB1998/002546 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof Ceased WO1999009955A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP98940374A EP1007002B1 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
CA002301711A CA2301711C (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
AT98940374T ATE252888T1 (en) 1997-08-22 1998-08-24 COMPOSITIONS CONTAINING LIPIDS AND THEIR USES
AU88714/98A AU752508B2 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
NZ502839A NZ502839A (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
JP2000507346A JP2001513544A (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
DE69819338T DE69819338T2 (en) 1997-08-22 1998-08-24 LIPID COMPOSITIONS AND THEIR USE
US09/510,223 US6436905B1 (en) 1997-08-22 2000-02-22 Lipid-containing compositions and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9717905.5 1997-08-22
GBGB9717905.5A GB9717905D0 (en) 1997-08-22 1997-08-22 Lipid-containing compositions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/510,223 Continuation US6436905B1 (en) 1997-08-22 2000-02-22 Lipid-containing compositions and uses thereof

Publications (2)

Publication Number Publication Date
WO1999009955A2 WO1999009955A2 (en) 1999-03-04
WO1999009955A3 true WO1999009955A3 (en) 1999-07-08

Family

ID=10817944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002546 Ceased WO1999009955A2 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof

Country Status (11)

Country Link
US (1) US6436905B1 (en)
EP (1) EP1007002B1 (en)
JP (1) JP2001513544A (en)
AT (1) ATE252888T1 (en)
AU (1) AU752508B2 (en)
CA (1) CA2301711C (en)
DE (1) DE69819338T2 (en)
ES (1) ES2210802T3 (en)
GB (1) GB9717905D0 (en)
NZ (1) NZ502839A (en)
WO (1) WO1999009955A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180142B1 (en) 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
KR20050044503A (en) 2001-11-17 2005-05-12 아벤티스 파마 리미티드 Adsorbents and uses thereof
AU2003220917A1 (en) 2002-03-29 2003-10-13 Daiichi Pharmaceutical Co., Ltd. Phospholipid derivative
EP1550675B1 (en) * 2002-09-30 2008-01-02 Nof Corporation Phospholipid derivative
EP1591447B1 (en) 2003-01-06 2014-11-26 Nof Corporation Phospholipid derivatives and process for their production
US7871818B2 (en) * 2003-01-31 2011-01-18 Roche Madison Inc. Membrane active polymers
JP4526479B2 (en) 2003-03-20 2010-08-18 日油株式会社 Phospholipid derivative
GB2426703B (en) * 2005-05-31 2007-09-19 Malvern Cosmeceutics Ltd Compositions
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
WO2007047498A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
GB0601251D0 (en) * 2006-01-21 2006-03-01 Babraham Bioscience Technologi Protein solubilisation composition
GB2442202A (en) * 2006-09-30 2008-04-02 Morvus Technology Ltd Vermin poison
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1932517A3 (en) * 2006-12-11 2008-07-16 Universiteit Utrecht Holding B.V. Liposomes containing a polyphenol derivative such as caffeic acid and a method of post-loading thereof
ATE491479T1 (en) * 2006-12-15 2011-01-15 Bausch & Lomb SURFACE TREATMENT OF BIOMEDICAL DEVICES
EP2293921A4 (en) * 2008-05-22 2013-05-22 Univ California PRECURSORS OF MEMBRANES AND MEMBRANES FORMED THEREFROM
CN104588140B (en) 2008-07-21 2016-06-29 贝克顿·迪金森公司 Density phase separation device
WO2011004158A1 (en) * 2009-07-08 2011-01-13 The University Of Birmingham Solubilisation of membrane proteins
WO2011085047A1 (en) 2010-01-05 2011-07-14 The Regents Of The University Of California Droplet bilayer formation using throughput liquid handling techniques
GB201107737D0 (en) 2011-05-09 2011-06-22 Univ Birmingham Extraction from cells
EP2578207A3 (en) 2011-10-05 2015-10-07 Jacob J. Schmidt Masking apertures enabling automation and solution exchange in sessile droplet lipid bilayers
GB201312343D0 (en) * 2013-07-10 2013-08-21 Univ Aston Lipid-Containing Nanoparticle
WO2019046573A1 (en) 2017-08-31 2019-03-07 Texas Tech University System Polymer-encased nanodiscs with improved buffer compatibility
GB201909680D0 (en) 2019-07-05 2019-08-21 Malvern Cosmeceutics Ltd Hypercoiling polymer derivatives
CN115364111B (en) * 2021-05-17 2024-04-02 中国医学科学院基础医学研究所 The use of glycerophospholipids in the treatment of tumors
GB2608837A (en) 2021-07-13 2023-01-18 Univ Stellenbosch Zwitterionic polymers for forming nanodiscs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6461424A (en) * 1987-09-01 1989-03-08 Yamanouchi Pharma Co Ltd Smancs preparation dispersible in administration
JPH05228358A (en) * 1992-02-21 1993-09-07 Noevir Co Ltd Temperature sensitive liposome
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374420A (en) * 1993-01-22 1994-12-20 Revlon Consumer Products Corporation Hair setting compositions
US5436010A (en) * 1993-07-30 1995-07-25 Sdg Technology, Inc. Hair penetrant and carrier

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6461424A (en) * 1987-09-01 1989-03-08 Yamanouchi Pharma Co Ltd Smancs preparation dispersible in administration
JPH05228358A (en) * 1992-02-21 1993-09-07 Noevir Co Ltd Temperature sensitive liposome
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8915, Derwent World Patents Index; Class 6, AN 89-117244, XP002099889 *
DATABASE WPI Week 9340, Derwent World Patents Index; AN 93-316735, XP002099890 *
K. SEKI ET AL.: "pH-dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes", MACROMOLECULES, vol. 17, 1984, Easton (US), pages 1692 - 1698, XP002099888 *

Also Published As

Publication number Publication date
US6436905B1 (en) 2002-08-20
ATE252888T1 (en) 2003-11-15
NZ502839A (en) 2003-01-31
DE69819338T2 (en) 2004-07-15
ES2210802T3 (en) 2004-07-01
DE69819338D1 (en) 2003-12-04
CA2301711A1 (en) 1999-03-04
AU8871498A (en) 1999-03-16
AU752508B2 (en) 2002-09-19
EP1007002A1 (en) 2000-06-14
WO1999009955A2 (en) 1999-03-04
JP2001513544A (en) 2001-09-04
GB9717905D0 (en) 1997-10-29
CA2301711C (en) 2007-04-24
EP1007002B1 (en) 2003-10-29

Similar Documents

Publication Publication Date Title
WO1999009955A3 (en) Lipid-containing compositions and uses thereof
EP0346995A3 (en) Liquid detergents
ATE321133T1 (en) AGENTS CONTAINING POLYNUCLEOTIDES
GB0114197D0 (en) Reactive polymeric surfactants
CA2294146A1 (en) Nanocomposite material
AU1069597A (en) Anionic surfactants having multiple hydrophobic and hydrophilic groups
CA2255691A1 (en) Cosmetic or pharmaceutical preparations with a reduced feeling of stickiness
CA2152258A1 (en) Novel Macromonomers
ATE339945T1 (en) NANOEMULSIONS BASED ON AMPHIPHILIC FAT AND A NON-IONIC POLYMER AND THEIR USES IN COSMETICS
EP0761723A3 (en) Liquid organopolysiloxane resins, process for their preparation and low viscous polydiorganosiloxane compositions and their use
AU4652596A (en) Liquid polymer delivery system
DK0691992T3 (en) Randomized block copolymers
CA2156289A1 (en) Drug composition containing nucleic acid copolymer
ATE231900T1 (en) THICKENED AQUEOUS COMPOSITION AND USE THEREOF
DE69232787D1 (en) Crosslinked diolefin block polymers containing functional epoxy groups, processes for their preparation, adhesive compositions and starting block copolymer
AU4401897A (en) Supramolecular polymer
WO1995030523A3 (en) Repulpable plastic films
EP0611800A3 (en) Hydrophilic polymer composite and product containing same.
HK1050755A1 (en) Biodegradable plastic food service items
BR0214120A (en) Graft polymers, process for preparation and use thereof
CA2023950A1 (en) Fabric softening composition
WO2000002938A3 (en) Water-soluble or water-dispersible grafted copolymers
AU4918597A (en) Conditioning shampoo compositions containing emulsion polymerized polymer
WO1998015608A3 (en) Alkoxylated, quaternized polyamine detergent ingredients
AU7833091A (en) Process for coating active principles with a ph-sensitive polymer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 09/99 UNDER "PUBLISHED", REPLACE "WITH INTERNATIONAL SEARCH REPORT. BEFORE EXPIRATION OF THE TIME LIMIT FOR AMENDING THE CLAIMS AND TO BE REPUBLISHED IN THE EVENT OF THE RECEIPT OF AMENDMENTS." BY "WITHOUT INTERNATIONAL SEARCH REPORT." AND REPLACE "A1" BY "A2"

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 502839

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2301711

Country of ref document: CA

Ref country code: CA

Ref document number: 2301711

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 88714/98

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1998940374

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998940374

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 88714/98

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1998940374

Country of ref document: EP