WO1999009955A3 - Lipid-containing compositions and uses thereof - Google Patents

Lipid-containing compositions and uses thereof Download PDF

Info

Publication number
WO1999009955A3
WO1999009955A3 PCT/GB1998/002546 GB9802546W WO9909955A3 WO 1999009955 A3 WO1999009955 A3 WO 1999009955A3 GB 9802546 W GB9802546 W GB 9802546W WO 9909955 A3 WO9909955 A3 WO 9909955A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
containing compositions
compositions
polymer
pmas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/002546
Other languages
French (fr)
Other versions
WO1999009955A2 (en
Inventor
Stephen Ronald Tonge
Brian John Tighe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aston University
Original Assignee
Aston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP98940374A priority Critical patent/EP1007002B1/en
Priority to AU88714/98A priority patent/AU752508B2/en
Priority to DE69819338T priority patent/DE69819338T2/en
Priority to CA002301711A priority patent/CA2301711C/en
Priority to JP2000507346A priority patent/JP2001513544A/en
Priority to NZ502839A priority patent/NZ502839A/en
Application filed by Aston University filed Critical Aston University
Priority to AT98940374T priority patent/ATE252888T1/en
Publication of WO1999009955A2 publication Critical patent/WO1999009955A2/en
Publication of WO1999009955A3 publication Critical patent/WO1999009955A3/en
Priority to US09/510,223 priority patent/US6436905B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Lipid-containing compositions are disclosed which provide surfactants and solubilising agents useful in medicine, biochemistry and other industries. The compositions comprise a membrane-forming polar lipid and a synthetic amphipathic polymer containing hydrophobic and anionic hydrophilic groups which preferably are evenly arranged along a linear backbone. In some embodiments the polymer is a copolymer, for example poly(maleic acid styrene) (PMAS), in which first and second monomer units are arranged in alternating relationship along its length.
PCT/GB1998/002546 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof Ceased WO1999009955A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU88714/98A AU752508B2 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
DE69819338T DE69819338T2 (en) 1997-08-22 1998-08-24 LIPID COMPOSITIONS AND THEIR USE
CA002301711A CA2301711C (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
JP2000507346A JP2001513544A (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
NZ502839A NZ502839A (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
EP98940374A EP1007002B1 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof
AT98940374T ATE252888T1 (en) 1997-08-22 1998-08-24 COMPOSITIONS CONTAINING LIPIDS AND THEIR USES
US09/510,223 US6436905B1 (en) 1997-08-22 2000-02-22 Lipid-containing compositions and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9717905.5A GB9717905D0 (en) 1997-08-22 1997-08-22 Lipid-containing compositions and uses thereof
GB9717905.5 1997-08-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/510,223 Continuation US6436905B1 (en) 1997-08-22 2000-02-22 Lipid-containing compositions and uses thereof

Publications (2)

Publication Number Publication Date
WO1999009955A2 WO1999009955A2 (en) 1999-03-04
WO1999009955A3 true WO1999009955A3 (en) 1999-07-08

Family

ID=10817944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002546 Ceased WO1999009955A2 (en) 1997-08-22 1998-08-24 Lipid-containing compositions and uses thereof

Country Status (11)

Country Link
US (1) US6436905B1 (en)
EP (1) EP1007002B1 (en)
JP (1) JP2001513544A (en)
AT (1) ATE252888T1 (en)
AU (1) AU752508B2 (en)
CA (1) CA2301711C (en)
DE (1) DE69819338T2 (en)
ES (1) ES2210802T3 (en)
GB (1) GB9717905D0 (en)
NZ (1) NZ502839A (en)
WO (1) WO1999009955A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180142B1 (en) * 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
RU2326699C2 (en) 2001-11-17 2008-06-20 Авентис Фарма Лимитед Adsorbents and their application
US7495116B2 (en) 2002-03-29 2009-02-24 Nof Corporation Phospholipid derivative
EP1550675B1 (en) * 2002-09-30 2008-01-02 Nof Corporation Phospholipid derivative
CN100339382C (en) 2003-01-06 2007-09-26 日本油脂株式会社 Phospholipid derivatives and process for the production there
US7871818B2 (en) * 2003-01-31 2011-01-18 Roche Madison Inc. Membrane active polymers
WO2004083219A1 (en) 2003-03-20 2004-09-30 Nof Corporation Phospholipid derivative
GB2426703B (en) * 2005-05-31 2007-09-19 Malvern Cosmeceutics Ltd Compositions
WO2007047498A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
GB0601251D0 (en) * 2006-01-21 2006-03-01 Babraham Bioscience Technologi Protein solubilisation composition
GB2442202A (en) * 2006-09-30 2008-04-02 Morvus Technology Ltd Vermin poison
GB0623838D0 (en) 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1932517A3 (en) * 2006-12-11 2008-07-16 Universiteit Utrecht Holding B.V. Liposomes containing a polyphenol derivative such as caffeic acid and a method of post-loading thereof
ES2355773T3 (en) * 2006-12-15 2011-03-30 BAUSCH & LOMB INCORPORATED SURFACE TREATMENT OF MEDICAL DEVICES.
WO2009143425A1 (en) * 2008-05-22 2009-11-26 The Regents Of The University Of California Membrane precursors and membranes formed therefrom
EP2303457B1 (en) 2008-07-21 2019-08-28 Becton, Dickinson and Company Density phase separation device
EP2452199A1 (en) * 2009-07-08 2012-05-16 The University of Birmingham Solubilisation of membrane proteins
EP2521650A4 (en) 2010-01-05 2013-05-15 Univ California DRYLET BILOLET FORMATION USING LIQUID VACUUM HANDLING TECHNIQUES
GB201107737D0 (en) 2011-05-09 2011-06-22 Univ Birmingham Extraction from cells
EP2578207A3 (en) 2011-10-05 2015-10-07 Jacob J. Schmidt Masking apertures enabling automation and solution exchange in sessile droplet lipid bilayers
GB201312343D0 (en) * 2013-07-10 2013-08-21 Univ Aston Lipid-Containing Nanoparticle
WO2019046573A1 (en) 2017-08-31 2019-03-07 Texas Tech University System Polymer-encased nanodiscs with improved buffer compatibility
GB201909680D0 (en) 2019-07-05 2019-08-21 Malvern Cosmeceutics Ltd Hypercoiling polymer derivatives
CN115364111B (en) * 2021-05-17 2024-04-02 中国医学科学院基础医学研究所 The use of glycerophospholipids in the treatment of tumors
GB2608837A (en) 2021-07-13 2023-01-18 Univ Stellenbosch Zwitterionic polymers for forming nanodiscs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6461424A (en) * 1987-09-01 1989-03-08 Yamanouchi Pharma Co Ltd Smancs preparation dispersible in administration
JPH05228358A (en) * 1992-02-21 1993-09-07 Noevir Co Ltd Temperature sensitive liposome
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374420A (en) * 1993-01-22 1994-12-20 Revlon Consumer Products Corporation Hair setting compositions
US5436010A (en) * 1993-07-30 1995-07-25 Sdg Technology, Inc. Hair penetrant and carrier

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6461424A (en) * 1987-09-01 1989-03-08 Yamanouchi Pharma Co Ltd Smancs preparation dispersible in administration
JPH05228358A (en) * 1992-02-21 1993-09-07 Noevir Co Ltd Temperature sensitive liposome
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8915, Derwent World Patents Index; Class 6, AN 89-117244, XP002099889 *
DATABASE WPI Week 9340, Derwent World Patents Index; AN 93-316735, XP002099890 *
K. SEKI ET AL.: "pH-dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes", MACROMOLECULES, vol. 17, 1984, Easton (US), pages 1692 - 1698, XP002099888 *

Also Published As

Publication number Publication date
CA2301711C (en) 2007-04-24
ATE252888T1 (en) 2003-11-15
EP1007002B1 (en) 2003-10-29
NZ502839A (en) 2003-01-31
WO1999009955A2 (en) 1999-03-04
ES2210802T3 (en) 2004-07-01
DE69819338T2 (en) 2004-07-15
CA2301711A1 (en) 1999-03-04
AU8871498A (en) 1999-03-16
DE69819338D1 (en) 2003-12-04
US6436905B1 (en) 2002-08-20
JP2001513544A (en) 2001-09-04
GB9717905D0 (en) 1997-10-29
EP1007002A1 (en) 2000-06-14
AU752508B2 (en) 2002-09-19

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