WO1999016412A3 - Non-irritating cosmetic and pharmaceutical compositions - Google Patents

Non-irritating cosmetic and pharmaceutical compositions Download PDF

Info

Publication number
WO1999016412A3
WO1999016412A3 PCT/US1998/019803 US9819803W WO9916412A3 WO 1999016412 A3 WO1999016412 A3 WO 1999016412A3 US 9819803 W US9819803 W US 9819803W WO 9916412 A3 WO9916412 A3 WO 9916412A3
Authority
WO
WIPO (PCT)
Prior art keywords
irritating
cosmetic
pharmaceutical compositions
emulsifier
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/019803
Other languages
French (fr)
Other versions
WO1999016412A2 (en
Inventor
E Althea Knight
Daniel H Maes
Jules Zecchino
Carmen Castillo-Bucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EL Management LLC
Original Assignee
EL Management LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EL Management LLC filed Critical EL Management LLC
Priority to AT98949425T priority Critical patent/ATE283031T1/en
Priority to CA002273026A priority patent/CA2273026C/en
Priority to AU95751/98A priority patent/AU759607B2/en
Priority to DK98949425T priority patent/DK0989846T3/en
Priority to HK00103997.7A priority patent/HK1024633B/en
Priority to EP98949425A priority patent/EP0989846B1/en
Priority to DE69827792T priority patent/DE69827792T2/en
Priority to JP11520293A priority patent/JP2001503069A/en
Publication of WO1999016412A2 publication Critical patent/WO1999016412A2/en
Publication of WO1999016412A3 publication Critical patent/WO1999016412A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a cosmetic or pharmaceutical emulsion for topical application to the skin comprising an irritating agent and at least one non-disruptive emulsifier. In a preferred embodiment the irritating agent is a retinoid. The invention also provides a method for decreasing the irritation on the skin caused by an irritating active agent in a topical cosmetic or pharmaceutical emulsion which comprises employing as an emulsifier at least one of an alkyl polyoside, a grafted water soluble protein on a hydrophobic backbone, and lecithin.
PCT/US1998/019803 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions Ceased WO1999016412A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT98949425T ATE283031T1 (en) 1997-09-30 1998-09-22 NON-IRRITATIVE COSMETIC AND PHARMACEUTICAL COMPOSITIONS
CA002273026A CA2273026C (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions
AU95751/98A AU759607B2 (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions
DK98949425T DK0989846T3 (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical preparations
HK00103997.7A HK1024633B (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions
EP98949425A EP0989846B1 (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions
DE69827792T DE69827792T2 (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions
JP11520293A JP2001503069A (en) 1997-09-30 1998-09-22 Non-inflammatory cosmetic and pharmaceutical compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/940,783 1997-09-30
US08/940,783 US6017549A (en) 1997-09-30 1997-09-30 Non-irritating cosmetic and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
WO1999016412A2 WO1999016412A2 (en) 1999-04-08
WO1999016412A3 true WO1999016412A3 (en) 1999-08-19

Family

ID=25475413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/019803 Ceased WO1999016412A2 (en) 1997-09-30 1998-09-22 Non-irritating cosmetic and pharmaceutical compositions

Country Status (12)

Country Link
US (1) US6017549A (en)
EP (1) EP0989846B1 (en)
JP (1) JP2001503069A (en)
KR (1) KR100402850B1 (en)
AT (1) ATE283031T1 (en)
AU (1) AU759607B2 (en)
CA (1) CA2273026C (en)
DE (1) DE69827792T2 (en)
DK (1) DK0989846T3 (en)
ES (1) ES2229537T3 (en)
PT (1) PT989846E (en)
WO (1) WO1999016412A2 (en)

Families Citing this family (45)

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Publication number Priority date Publication date Assignee Title
US8039026B1 (en) 1997-07-28 2011-10-18 Johnson & Johnson Consumer Companies, Inc Methods for treating skin pigmentation
US6017549A (en) * 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
US20030215473A1 (en) * 1998-03-06 2003-11-20 Anders Carlsson Topical formulation of oil-in-water type as a carrier for providing a reduced irritant effect
US6228894B1 (en) 1998-04-17 2001-05-08 Enhanced Derm Technologies, Inc. Softgel-compatible composition containing retinol
US8093293B2 (en) * 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) * 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US20020197244A1 (en) * 1998-12-07 2002-12-26 Miri Seiberg Compositions and methods for regulating phagocytosis and ICAM-1 expression
US7985404B1 (en) 1999-07-27 2011-07-26 Johnson & Johnson Consumer Companies, Inc. Reducing hair growth, hair follicle and hair shaft size and hair pigmentation
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
JP4711520B2 (en) * 2000-03-21 2011-06-29 日本ケミカルリサーチ株式会社 Bioactive peptide-containing powder
KR100402576B1 (en) * 2000-07-05 2003-10-22 동아제약 주식회사 Cosmetic composition containing retinol by multiple stabilization
US8431550B2 (en) * 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) * 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
US20040013698A1 (en) * 2001-07-09 2004-01-22 Aust Duncan T Method for preparing topical preparations containing skin protective agents with enhanced barrier properties
ITMI20012139A1 (en) * 2001-10-16 2003-04-16 B & T S R L NATURAL EMULSIFIER FOR COSMETICS
US20030224075A1 (en) * 2002-02-21 2003-12-04 Jue-Chen Liu Soy composition for balancing combination skin
US20050004561A1 (en) * 2003-07-01 2005-01-06 Lynn Halas Method for removing hair
US20050025817A1 (en) * 2003-07-03 2005-02-03 Bhatia Kuljit S. Delivery system for topical medications
US7776355B2 (en) * 2003-07-03 2010-08-17 Medics Pharmaceutical Corporation Delivery system for topical medications
AU2004290893A1 (en) * 2003-10-29 2005-06-02 Johnson & Johnson Consumer France S.A.S. Compositions comprising soy products and dioic acids
FR2863887B1 (en) * 2003-12-23 2008-05-16 Jean Noel Thorel PROCESS FOR INNOFORMING A BIOCOMPATIBLE GALENIC BASE
US7655682B2 (en) * 2004-07-02 2010-02-02 Medicis Pharmaceutical Corporation Triple anti-irritant composition
US7479289B2 (en) * 2004-07-02 2009-01-20 Medicis Pharmaceutical Corporation Stable cleanser compositions containing sulfur
AR054805A1 (en) * 2005-06-29 2007-07-18 Stiefel Laboratories TOPICAL COMPOSITIONS FOR SKIN TREATMENT
JP2009510087A (en) * 2005-09-30 2009-03-12 オーエムピー インコーポレーテッド Stable ascorbic acid composition
US20070269534A1 (en) * 2006-02-02 2007-11-22 Ramirez Jose E Methods of treating skin to enhance therapeutic treatment thereof
US20070178058A1 (en) * 2006-02-02 2007-08-02 Ramirez Jose E Methods of using stable ascorbic acid compositions
US9107844B2 (en) * 2006-02-03 2015-08-18 Stiefel Laboratories Inc. Topical skin treating compositions
WO2007115134A2 (en) 2006-03-29 2007-10-11 Wayne State University Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
BRPI0709674A2 (en) 2006-03-31 2011-12-06 Stiefel Research Australia Pty Ltd. sparkling suspension gel
US20080008818A1 (en) * 2006-06-23 2008-01-10 Miri Seiberg Partially denatured whole soybean extracts and methods of use thereof
US20080089960A1 (en) * 2006-10-16 2008-04-17 Miri Seiberg Use of Legume Products for the Treatment and Prevention of Radiotherapy-Induced Skin Damage
JP2011510059A (en) * 2008-01-25 2011-03-31 ビー アンド ティー エッセ．エッレ．エッレ． Use of transesterified olive oil in the cosmetics field
FR2929510B1 (en) * 2008-04-02 2011-01-21 Lvmh Rech USE OF AT LEAST ONE ALKYL GLYCOSIDE AS AGEN AGENT ANTI-AGING AND / OR CALMING SENSITIVE SKIN IN COSMETIC COMPOSITIONS, AND METHODS OF COSMETIC CARE USING THE SAME.
FR2991177B1 (en) 2012-06-01 2014-12-19 Galderma Res & Dev TOPICAL COMPOSITIONS, CONTAINING RETINOID, EMULSION TYPE EMULSION IN WATER WITHOUT EMULSIFIER
FR2991176B1 (en) 2012-06-01 2014-12-19 Galderma Res & Dev TOPICAL COMPOSITIONS CONTAINING SOLUBILIZED RETINOID OF HYDROGLYCOLIC GEL TYPE
WO2013178749A1 (en) 2012-06-01 2013-12-05 Galderma Research & Development Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing same, method of producing same and use thereof in dermatology
US9084778B2 (en) 2012-06-01 2015-07-21 Galderma Research & Development Topical compositions containing a retinoid of the oil-in-water emulsion type
KR102939277B1 (en) 2013-08-15 2026-03-13 마리 케이 인코포레이티드 Topical skin compositions for treating wrinkles
MX2016006896A (en) * 2013-12-04 2016-08-17 Galderma Res & Dev Lipid microcapsules preferably comprising a lipophilic active substance and composition containing same, method for the production thereof, and use of same in dermatology and in cosmetics.
US11197831B2 (en) 2015-05-29 2021-12-14 Galderma Research And Development Compositions comprising at least one dispersed active principle and lipid microcapsules
FR3131837B1 (en) * 2022-01-19 2024-10-04 Oreal STABLE COMPOSITION COMPRISING A RETINOID AND AN ASCORBIC ACID COMPOUND
WO2023120390A1 (en) * 2021-12-20 2023-06-29 L'oreal Stable composition comprising retinoid and ascorbic acid compound
JP2023091313A (en) * 2021-12-20 2023-06-30 ロレアル A stable composition comprising a retinoid and an ascorbic acid compound
CN114767630A (en) * 2022-06-06 2022-07-22 黑龙江中医药大学 Medicine composition for treating allergic rhinitis and application thereof

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GB906000A (en) * 1959-11-23 1962-09-19 Hoffmann La Roche Cosmetic compositions comprising vitamin-a derivatives
FR2403800A1 (en) * 1977-09-22 1979-04-20 Francis Genieyz SKIN TREATMENT COMPOSITION WITH ANTIVIRAL ACTIVITY
EP0330496A2 (en) * 1988-02-25 1989-08-30 Beecham Group Plc Skin treatment composition
EP0439042A1 (en) * 1990-01-24 1991-07-31 F. Hoffmann-La Roche AG Use of pharmaceutical and cosmetic preparations with mixed micellen
EP0611565A1 (en) * 1992-07-13 1994-08-24 Shiseido Company Limited Composition for dermatologic preparation
WO1996007396A2 (en) * 1994-09-07 1996-03-14 Johnson & Johnson Consumer Products, Inc. Retinoid compositions
DE4444237A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Against bad skin, mild forms of acne and gram-positive bacteria effective drug combinations
FR2732595A1 (en) * 1995-04-07 1996-10-11 Oreal USE OF POLYMERS TO REDUCE THE IRRITATING EFFECT OF ACTIVE INGREDIENTS IN A COSMETIC AND / OR DERMATOLOGICAL COMPOSITION
WO1997031620A2 (en) * 1996-03-01 1997-09-04 Johnson & Johnson Consumer Products, Inc. Topical compositions comprising an oil-in-water emulsion and a retinoid
WO1997046221A1 (en) * 1996-06-07 1997-12-11 Roc Cosmetic method for treating and preventing the signs of skin ageing
FR2754713A1 (en) * 1996-10-22 1998-04-24 Roc Sa USE OF COMPLEXES FOR THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF SENSITIVE SKIN, PREPARATION METHOD AND HYPOALLERGENIC COMPOSITIONS

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Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB906000A (en) * 1959-11-23 1962-09-19 Hoffmann La Roche Cosmetic compositions comprising vitamin-a derivatives
FR2403800A1 (en) * 1977-09-22 1979-04-20 Francis Genieyz SKIN TREATMENT COMPOSITION WITH ANTIVIRAL ACTIVITY
EP0330496A2 (en) * 1988-02-25 1989-08-30 Beecham Group Plc Skin treatment composition
EP0439042A1 (en) * 1990-01-24 1991-07-31 F. Hoffmann-La Roche AG Use of pharmaceutical and cosmetic preparations with mixed micellen
EP0611565A1 (en) * 1992-07-13 1994-08-24 Shiseido Company Limited Composition for dermatologic preparation
WO1996007396A2 (en) * 1994-09-07 1996-03-14 Johnson & Johnson Consumer Products, Inc. Retinoid compositions
DE4444237A1 (en) * 1994-12-13 1996-06-20 Beiersdorf Ag Against bad skin, mild forms of acne and gram-positive bacteria effective drug combinations
FR2732595A1 (en) * 1995-04-07 1996-10-11 Oreal USE OF POLYMERS TO REDUCE THE IRRITATING EFFECT OF ACTIVE INGREDIENTS IN A COSMETIC AND / OR DERMATOLOGICAL COMPOSITION
WO1997031620A2 (en) * 1996-03-01 1997-09-04 Johnson & Johnson Consumer Products, Inc. Topical compositions comprising an oil-in-water emulsion and a retinoid
WO1997046221A1 (en) * 1996-06-07 1997-12-11 Roc Cosmetic method for treating and preventing the signs of skin ageing
FR2754713A1 (en) * 1996-10-22 1998-04-24 Roc Sa USE OF COMPLEXES FOR THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF SENSITIVE SKIN, PREPARATION METHOD AND HYPOALLERGENIC COMPOSITIONS

Also Published As

Publication number Publication date
KR20000069187A (en) 2000-11-25
PT989846E (en) 2005-01-31
EP0989846A2 (en) 2000-04-05
DE69827792T2 (en) 2005-11-03
AU9575198A (en) 1999-04-23
ATE283031T1 (en) 2004-12-15
DK0989846T3 (en) 2005-02-14
CA2273026A1 (en) 1999-04-08
CA2273026C (en) 2002-11-19
US6017549A (en) 2000-01-25
ES2229537T3 (en) 2005-04-16
DE69827792D1 (en) 2004-12-30
KR100402850B1 (en) 2003-10-24
AU759607B2 (en) 2003-04-17
JP2001503069A (en) 2001-03-06
HK1024633A1 (en) 2000-10-20
WO1999016412A2 (en) 1999-04-08
EP0989846B1 (en) 2004-11-24

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