WO1999019276A3 - Molecular compounds having complementary surfaces to targets - Google Patents

Molecular compounds having complementary surfaces to targets Download PDF

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Publication number
WO1999019276A3
WO1999019276A3 PCT/US1998/021804 US9821804W WO9919276A3 WO 1999019276 A3 WO1999019276 A3 WO 1999019276A3 US 9821804 W US9821804 W US 9821804W WO 9919276 A3 WO9919276 A3 WO 9919276A3
Authority
WO
WIPO (PCT)
Prior art keywords
target
targets
spcs
spc
network
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/021804
Other languages
French (fr)
Other versions
WO1999019276A2 (en
Inventor
David S Soane
Stephen E Barry
Andrew Goodwin
David A Offord
Michael G Perrot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnis LLC
Original Assignee
Alnis LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnis LLC filed Critical Alnis LLC
Priority to EP98957326A priority Critical patent/EP1025066A2/en
Priority to AU13610/99A priority patent/AU1361099A/en
Publication of WO1999019276A2 publication Critical patent/WO1999019276A2/en
Publication of WO1999019276A3 publication Critical patent/WO1999019276A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/14—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar alpha-D-Glucans, i.e. having alpha 1,n (n=3,4,6) linkages between saccharide units, e.g. pullulan
    • G01N2400/22—Dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Polymers & Plastics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)

Abstract

Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the cross-linked network. The SPC is isolated and used in many applications.
PCT/US1998/021804 1997-10-14 1998-10-14 Molecular compounds having complementary surfaces to targets Ceased WO1999019276A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98957326A EP1025066A2 (en) 1997-10-14 1998-10-14 Molecular compounds having complementary surfaces to targets
AU13610/99A AU1361099A (en) 1997-10-14 1998-10-14 Molecular compounds having complementary surfaces to targets and methods for thesynthesis and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6180597P 1997-10-14 1997-10-14
US60/061,805 1997-10-14
US09/172,921 1998-10-09
US17292198A 1998-10-14 1998-10-14

Publications (2)

Publication Number Publication Date
WO1999019276A2 WO1999019276A2 (en) 1999-04-22
WO1999019276A3 true WO1999019276A3 (en) 1999-08-19

Family

ID=26741507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/021804 Ceased WO1999019276A2 (en) 1997-10-14 1998-10-14 Molecular compounds having complementary surfaces to targets

Country Status (3)

Country Link
EP (1) EP1025066A2 (en)
AU (1) AU1361099A (en)
WO (1) WO1999019276A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380336B1 (en) 1998-03-24 2002-04-30 Nano-Tex, Llc Copolymers and oil-and water-repellent compositions containing them
US6217901B1 (en) 1999-05-25 2001-04-17 Alnis, Llc Liposome-assisted synthesis of polymeric nanoparticles
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
JP2005514438A (en) * 2001-12-21 2005-05-19 ソーン， デイビッド エス． Use of oligomers and polymers for solubilization, stabilization and delivery of drugs
US7618778B2 (en) 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
EP2212020B1 (en) 2007-11-12 2018-07-04 Sellergren, Börje Imprinted polymers with affinity for phosphorylated peptides and proteins
EP2386061A4 (en) * 2009-01-12 2012-07-18 Univ California POLYMERIC NANOPARTICLES WITH MOLECULAR FOOTPRINTS
CN104897846B (en) * 2015-06-23 2016-08-17 江南大学 A kind of based on the alkaline phosphatase activities detection method being formed in situ non-photoactive nanoparticles material simulation enzyme
JP7296636B2 (en) * 2018-07-20 2023-06-23 藤本化学製品株式会社 Alkoxyphenyl derivative, protected nucleoside and protected nucleotide, method for producing oligonucleotide, and method for removing substituent
JP6770553B2 (en) 2018-07-20 2020-10-14 藤本化学製品株式会社 Alkoxyphenyl derivative, nucleoside protector and nucleotide protector, oligonucleotide production method, and substituent removal method
US11963684B2 (en) * 2020-03-18 2024-04-23 Bvw Holding Ag Microstructured hemostat
CN118184929B (en) * 2024-04-15 2025-04-04 四川大学 Aromatic amide molecular cage material and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4770906A (en) * 1985-04-19 1988-09-13 The Board Of Regents For The University Of Oklahoma Producing polymeric films from a surfactant template
US5310648A (en) * 1991-02-01 1994-05-10 California Institute Of Technology Composition of matter comprising an imprinted matrix exhibiting selective binding interactions through chelated metals
DE19823432A1 (en) * 1997-09-09 1999-03-11 Thomas Prof Dr Bayerl Molecular imprinting of solid-supported amphiphile layer capable of undergoing reversible phase transition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4770906A (en) * 1985-04-19 1988-09-13 The Board Of Regents For The University Of Oklahoma Producing polymeric films from a surfactant template
US5310648A (en) * 1991-02-01 1994-05-10 California Institute Of Technology Composition of matter comprising an imprinted matrix exhibiting selective binding interactions through chelated metals
DE19823432A1 (en) * 1997-09-09 1999-03-11 Thomas Prof Dr Bayerl Molecular imprinting of solid-supported amphiphile layer capable of undergoing reversible phase transition

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KEMPE M ET AL: "Molecular imprinting used for chiral separations", JOURNAL OF CHROMATOGRAPHY A, vol. 694, no. 1, 3 March 1995 (1995-03-03), pages 3-13, XP004023308 *
M MURATA, S HIJIYA, M MAEDA, M TAKAGI: "Template-Dependent Selectivity in Metal Adsorption on Phosphoric Diester-Carrying Resins Prepared by Surface Template Polymerization Technique", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 69, no. 3, 1996, pages 637 - 642, XP002105145 *
N KAMIYA, M GOTO: "Preparation of surfactant-coated lipases utilizing the molecular imprinting technique", JOURNAL OF FERMENTATION AND BIOENGINEERING, vol. 85, no. 2, 1998, pages 237 - 239, XP002105148 *
S A PILETSKY, H S ANDERSSON, I A NICHOLLS: "The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers", JOURNAL OF MOLECULAR RECOGNITION, vol. 11, no. 1-6, 1998, pages 94 - 97, XP002105146 *
WULFF G: "MOLECULAR IMPRINTING IN CROSS-LINKED MATERIALS WITH THE AID OF MOLECULAR TEMPLATES - A WAY TOWARDS ARTIFICIAL ANTIBODIES", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 34, no. 17, 15 September 1995 (1995-09-15), pages 1812 - 1832, XP000524863 *
X X ZHU, K BANANA, R YEN: "Pore-size control in cross-linked polymer resins by reverse micellar imprinting", MACROMOLECULES, vol. 30, no. 10, 1997, pages 3031 - 3035, XP002105147 *

Also Published As

Publication number Publication date
AU1361099A (en) 1999-05-03
WO1999019276A2 (en) 1999-04-22
EP1025066A2 (en) 2000-08-09

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