WO1999020769A3 - Multiply-substituted protease variants - Google Patents

Multiply-substituted protease variants

Info

Publication number
WO1999020769A3
WO1999020769A3 PCT/US1998/022500 US9822500W WO9920769A3 WO 1999020769 A3 WO1999020769 A3 WO 1999020769A3 US 9822500 W US9822500 W US 9822500W WO 9920769 A3 WO9920769 A3 WO 9920769A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
amino acid
precursor
naturally
occurring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/022500
Other languages
French (fr)
Other versions
WO1999020769A2 (en
Inventor
Volker Schellenberger
James T Kellis Jr
Christian Paech
Joanne Nadherny
Donald P Naki
Ayrookaran J Poulose
Katherine D Collier
Robert M Caldwell
Andre C Baeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Danisco US Inc
Original Assignee
Procter and Gamble Co
Genencor International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27420734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999020769(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to BR9814097-3A priority Critical patent/BR9814097A/en
Priority to CA2307640A priority patent/CA2307640C/en
Priority to DE69839057T priority patent/DE69839057T2/en
Priority to KR1020007004385A priority patent/KR100616143B1/en
Priority to EP98953936A priority patent/EP1025239B1/en
Priority to AU11181/99A priority patent/AU758371B2/en
Priority to HK02100781.1A priority patent/HK1039159B/en
Priority to JP2000517089A priority patent/JP4346237B2/en
Application filed by Procter and Gamble Co, Genencor International Inc filed Critical Procter and Gamble Co
Priority to DK98953936T priority patent/DK1025239T3/en
Publication of WO1999020769A2 publication Critical patent/WO1999020769A2/en
Publication of WO1999020769A3 publication Critical patent/WO1999020769A3/en
Priority to NO20001900A priority patent/NO326992B1/en
Anticipated expiration legal-status Critical
Priority to AU87337/01A priority patent/AU8733701A/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38609—Protease or amylase in solid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Confectionery (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
  • Exhaust Gas After Treatment (AREA)

Abstract

Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 62, 212, 230, 232, 252 and 257 of Bacillus amyloliquefaciens subtilisin.
PCT/US1998/022500 1997-10-23 1998-10-23 Multiply-substituted protease variants Ceased WO1999020769A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DK98953936T DK1025239T3 (en) 1997-10-23 1998-10-23 Multisubstituted protease variants
AU11181/99A AU758371B2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
CA2307640A CA2307640C (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
DE69839057T DE69839057T2 (en) 1997-10-23 1998-10-23 Multiple substituted protease variants
KR1020007004385A KR100616143B1 (en) 1997-10-23 1998-10-23 Multisubstituted Protease Variants
EP98953936A EP1025239B1 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
HK02100781.1A HK1039159B (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
BR9814097-3A BR9814097A (en) 1997-10-23 1998-10-23 Protease variant, DNA, expression vector, host cell, cleaning composition, animal food, and composition to treat a tissue
JP2000517089A JP4346237B2 (en) 1997-10-23 1998-10-23 Multiple substitution protease mutant
NO20001900A NO326992B1 (en) 1997-10-23 2000-04-12 Protease variant, DNA, expression vector, host cell, detergent, animal feed and blend for textile processing.
AU87337/01A AU8733701A (en) 1997-10-23 2001-11-02 Multiply-substituted protease variant and amylase variant-containing cleaning compositions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95632397A 1997-10-23 1997-10-23
US95656497A 1997-10-23 1997-10-23
US95632497A 1997-10-23 1997-10-23
US08/956,564 1997-10-23
US08/956,324 1997-10-23
US08/956,323 1997-10-23

Publications (2)

Publication Number Publication Date
WO1999020769A2 WO1999020769A2 (en) 1999-04-29
WO1999020769A3 true WO1999020769A3 (en) 1999-08-26

Family

ID=27420734

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1998/022500 Ceased WO1999020769A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
PCT/US1998/022590 Ceased WO1999020771A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants with altered net charge for use in detergents
PCT/US1998/022572 Ceased WO1999020770A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
PCT/US1998/022482 Ceased WO1999020726A1 (en) 1997-10-23 1998-10-23 Bleaching compositions comprising multiply-substituted protease variants
PCT/US1998/022486 Ceased WO1999020723A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variant and amylase variant-containing cleaning compositions

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US1998/022590 Ceased WO1999020771A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants with altered net charge for use in detergents
PCT/US1998/022572 Ceased WO1999020770A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
PCT/US1998/022482 Ceased WO1999020726A1 (en) 1997-10-23 1998-10-23 Bleaching compositions comprising multiply-substituted protease variants
PCT/US1998/022486 Ceased WO1999020723A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variant and amylase variant-containing cleaning compositions

Country Status (26)

Country Link
US (5) US6312936B1 (en)
EP (10) EP1025239B1 (en)
JP (7) JP2001520307A (en)
KR (6) KR100564039B1 (en)
CN (9) CN1195857C (en)
AR (10) AR016969A1 (en)
AT (9) ATE314478T1 (en)
AU (7) AU758371B2 (en)
BR (6) BR9813260A (en)
CA (9) CA2308206C (en)
CZ (6) CZ20001479A3 (en)
DE (7) DE69841226D1 (en)
DK (9) DK1025240T3 (en)
EG (2) EG22075A (en)
ES (7) ES2319470T5 (en)
HK (1) HK1039159B (en)
HU (3) HUP0104539A3 (en)
ID (4) ID25637A (en)
MA (2) MA25044A1 (en)
NO (3) NO326992B1 (en)
NZ (3) NZ520771A (en)
PL (1) PL191529B1 (en)
PT (8) PT1027418E (en)
TR (8) TR200001113T2 (en)
TW (2) TW585912B (en)
WO (5) WO1999020769A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4353828A2 (en) 2017-02-24 2024-04-17 Danisco US Inc. Compositions and methods for increased protein production in bacillus licheniformis

Families Citing this family (626)

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MA23346A1 (en) * 1993-10-14 1995-04-01 Genencor Int VARIANTS OF THE SUB-USE
ATE385254T1 (en) * 1997-08-29 2008-02-15 Novozymes As PROTEASE VARIANTS AND COMPOSITIONS
AR016969A1 (en) * 1997-10-23 2001-08-01 Procter & Gamble PROTEASE VARIANTE, ADN, EXPRESSION VECTOR, GUEST MICROORGANISM, CLEANING COMPOSITION, ANIMAL FOOD AND COMPOSITION TO TREAT A TEXTILE
ES2368718T3 (en) 1997-10-23 2011-11-21 Danisco Us Inc. SUBTILISINE VARIATIONS WITH MULTIPLE SUBSTITUTIONS.
ATE407941T1 (en) 1998-07-02 2008-09-15 Univ Toronto PROTEINS CHEMICALLY MODIFIED WITH A CARBOHYDRATE GROUP
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JP4932990B2 (en) 1998-11-10 2012-05-16 ダニスコ・ユーエス・インコーポレイテッド Chemically modified mutant serine hydrolase exhibits improved catalytic activity and chiral selectivity
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DK1495128T3 (en) 2002-03-29 2014-08-11 Genencor Int Enhanced protein expression in Bacillus
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US7082689B2 (en) * 2002-10-11 2006-08-01 Black & Decker Inc. Keyless shoe lock for reciprocating saw
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