WO1999020770A3 - Multiply-substituted protease variants - Google Patents

Multiply-substituted protease variants Download PDF

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Publication number
WO1999020770A3
WO1999020770A3 PCT/US1998/022572 US9822572W WO9920770A3 WO 1999020770 A3 WO1999020770 A3 WO 1999020770A3 US 9822572 W US9822572 W US 9822572W WO 9920770 A3 WO9920770 A3 WO 9920770A3
Authority
WO
WIPO (PCT)
Prior art keywords
residue
substitution
positions
protease
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/022572
Other languages
French (fr)
Other versions
WO1999020770A2 (en
Inventor
Volker Schellenberger
James T Kellis Jr
Christian Paech
Joanne Nadherny
Donald P Naki
Ayrookaran J Poulose
Katherine D Collier
Robert M Caldwell
Andre C Baeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Danisco US Inc
Original Assignee
Procter and Gamble Co
Genencor International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27420734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999020770(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to PL340600A priority Critical patent/PL191529B1/en
Priority to EP98956181A priority patent/EP1025241B2/en
Priority to DE69829577T priority patent/DE69829577T3/en
Priority to AT98956181T priority patent/ATE292179T1/en
Priority to JP2000517090A priority patent/JP4511025B2/en
Priority to AU12762/99A priority patent/AU1276299A/en
Priority to DK98956181.6T priority patent/DK1025241T4/en
Application filed by Procter and Gamble Co, Genencor International Inc filed Critical Procter and Gamble Co
Priority to CA2307638A priority patent/CA2307638C/en
Priority to KR1020007004382A priority patent/KR100612981B1/en
Priority to BRPI9813115-0A priority patent/BRPI9813115B1/en
Publication of WO1999020770A2 publication Critical patent/WO1999020770A2/en
Publication of WO1999020770A3 publication Critical patent/WO1999020770A3/en
Priority to NO20001899A priority patent/NO327607B1/en
Anticipated expiration legal-status Critical
Priority to AU2002320741A priority patent/AU2002320741B2/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38609—Protease or amylase in solid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Confectionery (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Slot Machines And Peripheral Devices (AREA)

Abstract

Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue corresponds to position 103 in combination with one or more of the following substitutions at residue positions corresponding to positions 1, 3, 4, 8, 10, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274, and 275 of Bacillus amyloliquefaciens subtilisin, wherein when a substitution at a position corresponding to residue position 103 is combined with a substitution at a position corresponding to residue position 76, there is also a substitution at one or more residue positions other than residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin.
PCT/US1998/022572 1997-10-23 1998-10-23 Multiply-substituted protease variants Ceased WO1999020770A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1020007004382A KR100612981B1 (en) 1997-10-23 1998-10-23 Multisubstituted Protease Variants
CA2307638A CA2307638C (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
DE69829577T DE69829577T3 (en) 1997-10-23 1998-10-23 MULTIPLE SUBSTITUTED PROTEASE VARIANTS
AT98956181T ATE292179T1 (en) 1997-10-23 1998-10-23 MULTIPLE SUBSTITUTED PROTEASE VARIANTS
JP2000517090A JP4511025B2 (en) 1997-10-23 1998-10-23 Multiple substitution protease mutant
AU12762/99A AU1276299A (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
DK98956181.6T DK1025241T4 (en) 1997-10-23 1998-10-23 Protease variants with multiple substitutions
PL340600A PL191529B1 (en) 1997-10-23 1998-10-23 Many times substituted varieties of protease
BRPI9813115-0A BRPI9813115B1 (en) 1997-10-23 1998-10-23 Protease variant, dna, expression vector, host cell, cleaning composition, animal food, and tissue treatment composition
EP98956181A EP1025241B2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
NO20001899A NO327607B1 (en) 1997-10-23 2000-04-12 Substituted protease variants, DNA, expression vector, host cell, detergent, animal feed and mixture for processing a textile.
AU2002320741A AU2002320741B2 (en) 1997-10-23 2002-12-20 Multiply-substituted protease variants

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95632397A 1997-10-23 1997-10-23
US95632497A 1997-10-23 1997-10-23
US95656497A 1997-10-23 1997-10-23
US08/956,564 1997-10-23
US08/956,323 1997-10-23
US08/956,324 1997-10-23

Publications (2)

Publication Number Publication Date
WO1999020770A2 WO1999020770A2 (en) 1999-04-29
WO1999020770A3 true WO1999020770A3 (en) 1999-09-02

Family

ID=27420734

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1998/022590 Ceased WO1999020771A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants with altered net charge for use in detergents
PCT/US1998/022500 Ceased WO1999020769A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
PCT/US1998/022572 Ceased WO1999020770A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants
PCT/US1998/022482 Ceased WO1999020726A1 (en) 1997-10-23 1998-10-23 Bleaching compositions comprising multiply-substituted protease variants
PCT/US1998/022486 Ceased WO1999020723A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variant and amylase variant-containing cleaning compositions

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US1998/022590 Ceased WO1999020771A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants with altered net charge for use in detergents
PCT/US1998/022500 Ceased WO1999020769A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US1998/022482 Ceased WO1999020726A1 (en) 1997-10-23 1998-10-23 Bleaching compositions comprising multiply-substituted protease variants
PCT/US1998/022486 Ceased WO1999020723A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variant and amylase variant-containing cleaning compositions

Country Status (26)

Country Link
US (5) US6312936B1 (en)
EP (10) EP1082404A2 (en)
JP (7) JP2001520307A (en)
KR (6) KR100616143B1 (en)
CN (9) CN1295313C (en)
AR (10) AR016969A1 (en)
AT (9) ATE314478T1 (en)
AU (7) AU1199699A (en)
BR (6) BR9813260A (en)
CA (9) CA2307640C (en)
CZ (6) CZ302287B6 (en)
DE (7) DE69839057T2 (en)
DK (9) DK1025241T4 (en)
EG (2) EG22075A (en)
ES (7) ES2319470T5 (en)
HK (1) HK1039159B (en)
HU (3) HUP0100859A2 (en)
ID (4) ID25637A (en)
MA (2) MA24811A1 (en)
NO (3) NO326992B1 (en)
NZ (3) NZ519204A (en)
PL (1) PL191529B1 (en)
PT (8) PT1027418E (en)
TR (8) TR200101861T2 (en)
TW (2) TW585912B (en)
WO (5) WO1999020771A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852912B2 (en) 2009-04-01 2014-10-07 Danisco Us Inc. Compositions and methods comprising alpha-amylase variants with altered properties
US8962283B2 (en) 2008-02-04 2015-02-24 Danisco Us Inc. TS-23 alpha-amylase variants with altered properties
EP4353828A2 (en) 2017-02-24 2024-04-17 Danisco US Inc. Compositions and methods for increased protein production in bacillus licheniformis

Families Citing this family (625)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA23346A1 (en) * 1993-10-14 1995-04-01 Genencor Int VARIANTS OF THE SUB-USE
WO1999011768A1 (en) * 1997-08-29 1999-03-11 Novo Nordisk A/S Protease variants and compositions
AR016969A1 (en) * 1997-10-23 2001-08-01 Procter & Gamble PROTEASE VARIANTE, ADN, EXPRESSION VECTOR, GUEST MICROORGANISM, CLEANING COMPOSITION, ANIMAL FOOD AND COMPOSITION TO TREAT A TEXTILE
ES2367505T3 (en) * 1997-10-23 2011-11-04 Danisco Us Inc. PROTEASE VARIANTS WITH MULTIPLE SUBSTITUTIONS WITH ALTERED NET LOAD FOR USE IN DETERGENTS.
EP1093459B1 (en) 1998-07-02 2008-09-10 The Governing Council Of The University Of Toronto Chemically modified proteins with a carbohydrate moiety
AR020951A1 (en) * 1998-10-23 2002-06-05 Procter & Gamble METHODS TO MASK PROTEASE VARIANTS FOR USE IN DETERGENT COMPOSITIONS
AU772427B2 (en) 1998-11-10 2004-04-29 Genencor International, Inc. Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity
KR20020057797A (en) * 1999-04-28 2002-07-12 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 Specifically targetted catalytic antagonists and uses thereof
US6627744B2 (en) 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
BR0012694A (en) * 1999-07-22 2002-04-09 Procter & Gamble Protease conjugate, cleaning composition and personal treatment composition
CA2376045A1 (en) * 1999-07-22 2001-02-01 The Procter & Gamble Company Subtilisin protease variants having amino acid substitutions in defined epitope regions
CA2382870A1 (en) * 1999-09-09 2001-03-15 Ryohei Ohtani A detergent composition containing a protease
US6899961B2 (en) * 1999-12-15 2005-05-31 Samsung Sdi Co., Ltd. Organic electroluminescence device
US7067049B1 (en) * 2000-02-04 2006-06-27 Exxonmobil Oil Corporation Formulated lubricant oils containing high-performance base oils derived from highly paraffinic hydrocarbons
DE10007608A1 (en) * 2000-02-18 2001-08-30 Henkel Kgaa Particulate laundry and other detergents contain genetically modified protease of subtilisin type and coated particulate alkali percarbonate
AU3724801A (en) * 2000-03-03 2001-09-12 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
US6777218B1 (en) * 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
US6902922B2 (en) * 2000-04-03 2005-06-07 Novozymes A/S Subtilisin variants
CA2406621A1 (en) * 2000-04-28 2001-11-08 Novozymes A/S Protein variants having modified immunogenicity
HUP0300967A2 (en) * 2000-06-30 2003-07-28 The Procter & Gamble Co. Detergent compositions comprising a cyclodextrin glucanotransferase enzyme
JP2004502832A (en) * 2000-06-30 2004-01-29 ザ、プロクター、エンド、ギャンブル、カンパニー Detergent composition containing maltogenic α-amylase enzyme
HUP0300840A2 (en) 2000-07-28 2003-07-28 Henkel Kommanditgesellschaft Auf Aktien Novel, amylolytic enzyme ectracted from bacillus sp. a 7-7 (dsm 12368) and washing and cleaning agents containing this novel amylolytic enzyme
US20020155574A1 (en) 2000-08-01 2002-10-24 Novozymes A/S Alpha-amylase mutants with altered properties
US6893855B2 (en) * 2000-10-13 2005-05-17 Novozymes A/S Subtilase variants
US6803222B2 (en) 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
US7303907B2 (en) * 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
EP1241112A3 (en) 2001-03-15 2003-02-26 The Procter & Gamble Company Flexible multiple compartment pouch
PL210859B1 (en) * 2001-03-23 2012-03-30 Genencor Int Proteins producing an altered immunogenic response and methods of making and using the same
US7498158B2 (en) 2001-05-15 2009-03-03 Novozymes A/S Alpha-amylase variant with altered properties
DK200101090A (en) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
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