WO1999026604A3 - Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood - Google Patents

Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood Download PDF

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Publication number
WO1999026604A3
WO1999026604A3 PCT/US1998/024632 US9824632W WO9926604A3 WO 1999026604 A3 WO1999026604 A3 WO 1999026604A3 US 9824632 W US9824632 W US 9824632W WO 9926604 A3 WO9926604 A3 WO 9926604A3
Authority
WO
WIPO (PCT)
Prior art keywords
artificial blood
liquid ventilation
perfluorinated hydrocarbons
mediums
perfluorinated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/024632
Other languages
French (fr)
Other versions
WO1999026604A2 (en
Inventor
Leland C Clark
Richard E Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tenax Therapeutics Inc
Original Assignee
Synthetic Blood International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthetic Blood International Inc filed Critical Synthetic Blood International Inc
Priority to EP19980958073 priority Critical patent/EP1037619A4/en
Priority to JP2000521806A priority patent/JP2003522094A/en
Priority to AU14184/99A priority patent/AU759557B2/en
Priority to CA002311122A priority patent/CA2311122C/en
Publication of WO1999026604A2 publication Critical patent/WO1999026604A2/en
Publication of WO1999026604A3 publication Critical patent/WO1999026604A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Perfluorinated alkylcyclohexane and alkyl cyclopentane derivatives of the empirical formula C10F20 boil at atmospheric pressure in the range of 144-146 °C and are utilized as mediums for gas transport in liquid ventilation and in artificial blood. Compounds of the C10F20 formula which can exist only as a single stereoisomer are preferred as mediums for gas transport.
PCT/US1998/024632 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood Ceased WO1999026604A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP19980958073 EP1037619A4 (en) 1997-11-21 1998-11-18 Selected c 10? perfluorinated hydrocarbons for liquid ventilation and artificial blood
JP2000521806A JP2003522094A (en) 1997-11-20 1998-11-18 Selected C10 perfluorohydrocarbons for liquid ventilation and artificial blood
AU14184/99A AU759557B2 (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood
CA002311122A CA2311122C (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/975,743 1997-11-20
US08/975,743 US6167887B1 (en) 1997-11-21 1997-11-21 Selected C-10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Publications (2)

Publication Number Publication Date
WO1999026604A2 WO1999026604A2 (en) 1999-06-03
WO1999026604A3 true WO1999026604A3 (en) 1999-10-14

Family

ID=25523336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/024632 Ceased WO1999026604A2 (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Country Status (6)

Country Link
US (1) US6167887B1 (en)
EP (1) EP1037619A4 (en)
JP (1) JP2003522094A (en)
AU (1) AU759557B2 (en)
CA (1) CA2311122C (en)
WO (1) WO1999026604A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2007081008A1 (en) * 2006-01-16 2009-06-11 旭硝子株式会社 Novel fluorosurfactant and novel fluorine-containing compound
CA2651957A1 (en) * 2006-05-15 2007-11-22 Virginia Commonwealth University Methods and compositions for controlled and sustained production and delivery of peroxides and/or oxygen for biological and industrial applications
JP5781727B2 (en) 2007-02-23 2015-09-24 株式会社ネクスト２１ Therapeutic or preventive agent for vasospasm
WO2009102487A2 (en) * 2008-02-13 2009-08-20 Oxygen Biotherapeutics, Inc. Gas based wound and tissue therapeutics
US8404752B2 (en) * 2008-07-18 2013-03-26 Oxygen Biotherapeutics, Inc. Method of treating traumatic brain injury
US8343515B2 (en) 2008-11-25 2013-01-01 Oxygen Biotherapeutics, Inc. Perfluorocarbon gel formulations
EP2367531A4 (en) * 2008-11-25 2013-11-27 Oxygen Biotherapeutics Inc Perfluorocarbon gel formulations
US20100144597A1 (en) * 2008-12-10 2010-06-10 Ward Kevin R Novel combinatorial approaches to enhancing oxygen transport to tissues
US20110086923A1 (en) * 2009-07-28 2011-04-14 Thompson Deborah P Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons
EP2459235B1 (en) * 2009-07-31 2014-04-23 Koninklijke Philips N.V. Perfluoro-t-butyl cyclohexane for use in imaging
WO2011116277A1 (en) * 2010-03-19 2011-09-22 Oxygen Biotherapeutics, Inc. Perfluorocarbon eye cream formulations
US8513309B2 (en) 2010-10-01 2013-08-20 Oxygen Biotherapeutics, Inc. Perfluorocarbons for use in treating pruritus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
EP0521492A2 (en) * 1991-07-02 1993-01-07 Air Products And Chemicals, Inc. Perfluoro (ethyldimethylcyclohexane)
WO1995031191A1 (en) * 1994-05-13 1995-11-23 Synthetic Blood International, Inc. Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders
WO1997019678A1 (en) * 1995-12-01 1997-06-05 Synthetic Blood International, Inc. Improved perfluorocarbons for biological gas exchange and method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
USRE33451E (en) 1982-04-12 1990-11-20 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4686024A (en) 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US5437272A (en) 1991-05-01 1995-08-01 Alliance Pharmaceutical Corp. Perfluorocarbon associated gas exchange
ATE173920T1 (en) 1991-05-03 1998-12-15 Alliance Pharma PARTIAL LIQUID VENTILATION USING HYDROFLUOROCARBONS
JP4289499B2 (en) * 2004-09-06 2009-07-01 城南鋼鉄工業株式会社 Door lock mechanism

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
EP0521492A2 (en) * 1991-07-02 1993-01-07 Air Products And Chemicals, Inc. Perfluoro (ethyldimethylcyclohexane)
WO1995031191A1 (en) * 1994-05-13 1995-11-23 Synthetic Blood International, Inc. Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders
WO1997019678A1 (en) * 1995-12-01 1997-06-05 Synthetic Blood International, Inc. Improved perfluorocarbons for biological gas exchange and method

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 3, 16 January 1984, Columbus, Ohio, US; abstract no. 17149, OKAMOTO H. ET AL: "Fate of perfluorochemical impurities contained in both perfluorodecaline (FDC) and perfluorotripropylamine (FTPA) in rats following intravenous injection of their emulsions" XP002097459 *
CHEMICAL ABSTRACTS, vol. 96, no. 9, 1 March 1982, Columbus, Ohio, US; abstract no. 68466, MAKAROV, K. N. ET AL: "Synthesis and physicochemical properties of perfluoroalkyl- and 1,4-dialkyl-substituted cyclohexanes" XP002110502 *
CLARK L. ET AL: "a NEW LOOK AT THE VAPOR PRESSURE PROBLEM IN RED CELL SUBSTITUTES", INT. CONGR. SER. - EXCERPTA MED. (1979), 486 (PROC. INT. SYMP. PERFLUOROCHEM. BLOOD SUBSTITUTES, 4TH, 1978 ), 1979, pages 55 - 67, XP002097458 *
LIN, WEN HUEY ET AL: "The synthesis of highly fluorinated alkylcyclohexanes for use as oxygen carriers and the fluorine-19 and carbon-13 NMR spectra of alkycyclohexane", J. FLUORINE CHEM. (1990), 50(3), 345-58, XP002110499 *
MOORE R E ET AL: "SYNTHESIS AND PHYSICAL PROPERTIES OF PERFLUOROCOMPOUNDS USEFUL AS SYNTHETIC BLOOD CANDIDATES", OXYGEN CARRYING COLLOIDAL BLOOD SUBSTITUTES. INTERNATIONAL SYMPOSIUM PERFLUOROCHEM. BLOOD SUBSTITUTES, 1982, pages 50 - 60, XP000646210 *
OKAMOTO H. ET AL, YAKURI TO CHIRYO, vol. 10, no. 7, 1983, pages 3801 - 3806 *
PERFTORIROVAN, UGLERODY V BIOL. I MED., PUSHCHINO (1980) 21-30 FROM: REF. ZH., KHIM. 1981, ABSTR. NO. 20B358 *
QUINTEL M ET AL: "[Liquid ventilation with perfluorocarbons (see comments)]. Flussigkeitsventilation mit Perfluorcarbonen.", ANASTHESIOLOGIE, INTENSIVMEDIZIN, NOTFALLMEDIZIN, SCHMERZTHERAPIE, (1996 OCT) 31 (8) 461-9. REF: 72, XP002110501 *
VARUSHCHENKO, RAISA M. ET AL: "Thermodynamics of vaporization of some cyclic perfluorocarbons", FLUID PHASE EQUILIB. (1996), 126(1), 93-104, XP002110500 *

Also Published As

Publication number Publication date
EP1037619A4 (en) 2001-08-13
CA2311122A1 (en) 1999-06-03
AU1418499A (en) 1999-06-15
CA2311122C (en) 2004-04-13
EP1037619A2 (en) 2000-09-27
WO1999026604A2 (en) 1999-06-03
US6167887B1 (en) 2001-01-02
JP2003522094A (en) 2003-07-22
AU759557B2 (en) 2003-04-17

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