WO1999040107A3 - Method of promoting keratinocyte proliferation - Google Patents

Method of promoting keratinocyte proliferation Download PDF

Info

Publication number
WO1999040107A3
WO1999040107A3 PCT/US1999/002725 US9902725W WO9940107A3 WO 1999040107 A3 WO1999040107 A3 WO 1999040107A3 US 9902725 W US9902725 W US 9902725W WO 9940107 A3 WO9940107 A3 WO 9940107A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
aii
keratinocyte proliferation
fragments
promoting keratinocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/002725
Other languages
French (fr)
Other versions
WO1999040107A2 (en
Inventor
Kathleen E Rodgers
Gere Dizerega
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Priority to CA002321168A priority Critical patent/CA2321168A1/en
Priority to EP99905876A priority patent/EP1053005A2/en
Priority to JP2000530535A priority patent/JP2002502858A/en
Priority to AU25935/99A priority patent/AU2593599A/en
Publication of WO1999040107A2 publication Critical patent/WO1999040107A2/en
Publication of WO1999040107A3 publication Critical patent/WO1999040107A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C12N5/063—Kereatinocyte stem cells; Keratinocyte progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides methods, improved cell culture medium and kits for promoting epithelial stem cell and keratinocyte proliferation and differentiation by growth in the presence of angiotensinogen, AI, AI analogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof, AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.
PCT/US1999/002725 1998-02-09 1999-02-08 Method of promoting keratinocyte proliferation Ceased WO1999040107A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002321168A CA2321168A1 (en) 1998-02-09 1999-02-08 Method of promoting keratinocyte proliferation
EP99905876A EP1053005A2 (en) 1998-02-09 1999-02-08 Method of promoting keratinocyte proliferation
JP2000530535A JP2002502858A (en) 1998-02-09 1999-02-08 Keratinocyte proliferation promotion method
AU25935/99A AU2593599A (en) 1998-02-09 1999-02-08 Method of promoting keratinocyte proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7410598P 1998-02-09 1998-02-09
US60/074,105 1998-02-09

Publications (2)

Publication Number Publication Date
WO1999040107A2 WO1999040107A2 (en) 1999-08-12
WO1999040107A3 true WO1999040107A3 (en) 1999-09-30

Family

ID=22117765

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002725 Ceased WO1999040107A2 (en) 1998-02-09 1999-02-08 Method of promoting keratinocyte proliferation

Country Status (5)

Country Link
EP (1) EP1053005A2 (en)
JP (1) JP2002502858A (en)
AU (1) AU2593599A (en)
CA (1) CA2321168A1 (en)
WO (1) WO1999040107A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU755943B2 (en) 1998-08-13 2003-01-02 University Of Southern California Methods to increase blood flow to ischemic tissue
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
US6747008B1 (en) 2000-06-19 2004-06-08 University Of Southern California Methods for treating and preventing alopecia
CN1529697B (en) 2001-05-31 2010-09-22 维科尔药物公司 Tricyclic compounds useful as angiotensin II agonists
AU2003202988A1 (en) 2002-01-14 2003-07-30 The Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
WO2008031767A1 (en) * 2006-09-12 2008-03-20 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Cell culture of keratinocytes under non-differentiating conditions
AT508569A1 (en) * 2009-07-23 2011-02-15 Affiris Ag PHARMACEUTICAL COMPOUND
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN102858360B (en) 2011-02-02 2017-07-25 南加利福尼亚大学 How to treat diabetic foot ulcers
WO2016107879A2 (en) * 2014-12-30 2016-07-07 Vicore Pharma Ab New use of angiotensin ii receptor agonists
EP4007592A1 (en) 2019-08-02 2022-06-08 LanthioPep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1997006750A1 (en) * 1995-08-11 1997-02-27 The Regents Of The University Of California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1997006750A1 (en) * 1995-08-11 1997-02-27 The Regents Of The University Of California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STECKELINGS U M ET AL: "Angiotensin II stimulates proliferation of primary human keratinocytes via a non-AT1, non- AT2 angiotensin receptor.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1996 DEC 4) 229 (1) 329-33., XP002110481 *

Also Published As

Publication number Publication date
WO1999040107A2 (en) 1999-08-12
JP2002502858A (en) 2002-01-29
AU2593599A (en) 1999-08-23
CA2321168A1 (en) 1999-08-12
EP1053005A2 (en) 2000-11-22

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