WO1999044063A3 - Tumor tissue microarrays for rapid molecular profiling - Google Patents

Tumor tissue microarrays for rapid molecular profiling Download PDF

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Publication number
WO1999044063A3
WO1999044063A3 PCT/US1999/004001 US9904001W WO9944063A3 WO 1999044063 A3 WO1999044063 A3 WO 1999044063A3 US 9904001 W US9904001 W US 9904001W WO 9944063 A3 WO9944063 A3 WO 9944063A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumors
hundreds
molecular profiling
rapid molecular
rapid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/004001
Other languages
French (fr)
Other versions
WO1999044063B1 (en
WO1999044063A2 (en
Inventor
Stephen B Leighton
Juha Kononen
Olli Kallioniemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99909585A priority Critical patent/EP1068528B1/en
Priority to US09/622,686 priority patent/US6699710B1/en
Priority to DE69932607T priority patent/DE69932607T2/en
Priority to DK06016017T priority patent/DK1715340T3/en
Priority to AU28757/99A priority patent/AU754047B2/en
Priority to JP2000533760A priority patent/JP4374139B2/en
Priority to CA002318984A priority patent/CA2318984C/en
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of WO1999044063A2 publication Critical patent/WO1999044063A2/en
Publication of WO1999044063A3 publication Critical patent/WO1999044063A3/en
Publication of WO1999044063B1 publication Critical patent/WO1999044063B1/en
Anticipated expiration legal-status Critical
Priority to US11/374,178 priority patent/US20060166253A1/en
Priority to CY20061101587T priority patent/CY1105756T1/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

An array-based technology facilitates rapid correlated gene copy number and expression profiling of a very large numbers of human tumors. Hundreds of cylindrical tissue biopsies (diameter 0.6 mm) from morphologically representative regions of individual tumors can be arrayed in a single paraffin block. Consecutive sections from such arrays provide targets for parrallel in situ visualization and quantitation of DNA, RNA or protein targets. For example, amplifications of six loci (mybL2, erbB2, Cyclin-D1, myc, 17q23 and 20q13) were rapidly determined by fluorescence in situ hybridization from 372 ethanol-fixed breast cancers. Stratification of tumors by estrogen receptor and p53 expression data revealed dictinct patterns of gene amplification in the various subgroups of breast cancer that may have prognostic utility. The tissue array technology is useful in the rapid molecular profiling of hundreds of normal and pathological tissue specimens or cultured cells.
PCT/US1999/004001 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling Ceased WO1999044063A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002318984A CA2318984C (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling
DE69932607T DE69932607T2 (en) 1998-02-25 1999-02-24 METHOD AND DEVICE FOR CREATING AN ARRAY FOR FAST MOLECULAR PROFILE IDENTIFICATIONS
DK06016017T DK1715340T3 (en) 1998-02-25 1999-02-24 Method and apparatus for preparing tissue samples for parallel analysis
AU28757/99A AU754047B2 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling
JP2000533760A JP4374139B2 (en) 1998-02-25 1999-02-24 Tumor tissue microarray for rapid molecular profiling
EP99909585A EP1068528B1 (en) 1998-02-25 1999-02-24 Method and apparatus for making an array for rapid molecular profiling
US09/622,686 US6699710B1 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling
US11/374,178 US20060166253A1 (en) 1998-02-25 2006-03-14 Tumor tissue microarrays for rapid molecular profiling
CY20061101587T CY1105756T1 (en) 1998-02-25 2006-11-02 METHOD AND APPARATUS FOR FORMULATION OF RAPID MOLECULAR PROFILING COMPONENTS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25
US60/075,979 1998-02-25

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/622,686 A-371-Of-International US6699710B1 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling
US10/215,762 Division US20020192702A1 (en) 1998-02-25 2002-08-09 Tumor tissue microarrays for rapid molecular profiling
US10/305,800 Continuation US20030138827A1 (en) 1998-02-25 2002-11-26 Tumor tissue microarrays for rapid molecular profiling

Publications (3)

Publication Number Publication Date
WO1999044063A2 WO1999044063A2 (en) 1999-09-02
WO1999044063A3 true WO1999044063A3 (en) 1999-11-04
WO1999044063B1 WO1999044063B1 (en) 1999-12-02

Family

ID=22129137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/004001 Ceased WO1999044063A2 (en) 1998-02-25 1999-02-24 Tumor tissue microarrays for rapid molecular profiling

Country Status (11)

Country Link
EP (3) EP1980852A1 (en)
JP (2) JP4374139B2 (en)
AT (2) ATE335199T1 (en)
AU (1) AU754047B2 (en)
CA (2) CA2318984C (en)
CY (2) CY1105756T1 (en)
DE (2) DE69939503D1 (en)
DK (2) DK1715340T3 (en)
ES (2) ES2272057T3 (en)
PT (2) PT1068528E (en)
WO (1) WO1999044063A2 (en)

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US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
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US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
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US7008769B2 (en) * 2000-08-15 2006-03-07 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer
WO2002077231A2 (en) * 2000-11-13 2002-10-03 Incyte Genomics, Inc. Nucleic acid-associated proteins
US7171030B2 (en) 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
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US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
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Also Published As

Publication number Publication date
JP4374139B2 (en) 2009-12-02
ES2317380T3 (en) 2009-04-16
CY1105756T1 (en) 2010-12-22
DE69932607T2 (en) 2007-10-25
EP1715340A2 (en) 2006-10-25
JP2002505432A (en) 2002-02-19
DK1068528T3 (en) 2006-11-27
EP1068528B1 (en) 2006-08-02
EP1980852A1 (en) 2008-10-15
EP1715340B1 (en) 2008-09-03
ATE335199T1 (en) 2006-08-15
JP2009244269A (en) 2009-10-22
CA2318984A1 (en) 1999-09-02
CA2627799A1 (en) 1999-09-02
ATE407360T1 (en) 2008-09-15
EP1068528A2 (en) 2001-01-17
DK1715340T3 (en) 2009-01-26
CY1108634T1 (en) 2014-04-09
WO1999044063B1 (en) 1999-12-02
CA2318984C (en) 2009-04-28
PT1068528E (en) 2006-12-29
WO1999044063A2 (en) 1999-09-02
AU754047B2 (en) 2002-10-31
DE69939503D1 (en) 2008-10-16
PT1715340E (en) 2008-12-16
AU2875799A (en) 1999-09-15
DE69932607D1 (en) 2006-09-14
ES2272057T3 (en) 2007-04-16
EP1715340A3 (en) 2006-11-29

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