WO1999045155A3 - Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid - Google Patents

Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid Download PDF

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Publication number
WO1999045155A3
WO1999045155A3 PCT/EP1999/001392 EP9901392W WO9945155A3 WO 1999045155 A3 WO1999045155 A3 WO 1999045155A3 EP 9901392 W EP9901392 W EP 9901392W WO 9945155 A3 WO9945155 A3 WO 9945155A3
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WO
WIPO (PCT)
Prior art keywords
ebv
amplification
detection
oligonucleotides
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/001392
Other languages
French (fr)
Other versions
WO1999045155A9 (en
WO1999045155A2 (en
Inventor
Marcel Bartolina Hend Vervoort
Den Brule Adrianus Johanne Van
Jaap Michiel Middeldorp
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Akzo Nobel NV
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Akzo Nobel NV
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Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Priority to AU29321/99A priority Critical patent/AU757404B2/en
Priority to EP99910326A priority patent/EP1060271B1/en
Priority to JP2000534686A priority patent/JP4472171B2/en
Priority to AT99910326T priority patent/ATE429517T1/en
Priority to CA2321654A priority patent/CA2321654C/en
Priority to DE69940770T priority patent/DE69940770D1/en
Priority to US09/623,329 priority patent/US7026112B1/en
Publication of WO1999045155A2 publication Critical patent/WO1999045155A2/en
Publication of WO1999045155A9 publication Critical patent/WO1999045155A9/en
Publication of WO1999045155A3 publication Critical patent/WO1999045155A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention is concerned with oligonucleotides that can be used as in the amplification and detection of Epstein Barr Virus (EBV) nucleic acid, in particular RNA-specific sequences. Furthermore a method for the diagnosis of EBV associated malignant and non-malignant diseases is provided. The oligonucleotides according to the present invention are specifically suited for the detection of EBV gene expression in circulating peripheral blood cells, in human (tumor) tissue samples and thin sections thereof using 'in solution' amplification or 'in situ' amplification techniques and in other biological samples potentially containing EBV-infected cells.
PCT/EP1999/001392 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid Ceased WO1999045155A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU29321/99A AU757404B2 (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of epstein barr virus (EBV) nucleic acid
EP99910326A EP1060271B1 (en) 1998-03-04 1999-03-01 Amplification and detection of ebv-barf1 expression for diagnosis of nasopharyngeal carcinoma
JP2000534686A JP4472171B2 (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of Epstein-Barr virus (EBV) nucleic acids
AT99910326T ATE429517T1 (en) 1998-03-04 1999-03-01 DUPLICATION AND DETECTION OF EBV BARF1 FOR THE DIAGNOSIS OF NASOPHARYNGEAL CARCINOMA
CA2321654A CA2321654C (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid
DE69940770T DE69940770D1 (en) 1998-03-04 1999-03-01 REPRODUCTION AND DETECTION OF EBV BARF1 FOR THE DIAGNOSIS OF NASOPHARYNGEAL CARCINOMA
US09/623,329 US7026112B1 (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of Epstein Barr Virus (EBV) nucleic acid

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98200655.3 1998-03-04
EP98200655 1998-03-04
EP98204231 1998-12-14
EP98204231.9 1998-12-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/623,329 A-371-Of-International US7026112B1 (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of Epstein Barr Virus (EBV) nucleic acid
US10/744,635 Division US20040180331A1 (en) 1998-03-04 2003-12-23 Oligonucleotides for the amplification and detection of epstein barr virus (EBV) nucleic acid

Publications (3)

Publication Number Publication Date
WO1999045155A2 WO1999045155A2 (en) 1999-09-10
WO1999045155A9 WO1999045155A9 (en) 1999-11-25
WO1999045155A3 true WO1999045155A3 (en) 2000-05-04

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Family Applications (1)

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PCT/EP1999/001392 Ceased WO1999045155A2 (en) 1998-03-04 1999-03-01 Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid

Country Status (11)

Country Link
US (2) US7026112B1 (en)
EP (1) EP1060271B1 (en)
JP (1) JP4472171B2 (en)
KR (1) KR100718028B1 (en)
AT (1) ATE429517T1 (en)
AU (1) AU757404B2 (en)
CA (1) CA2321654C (en)
DE (1) DE69940770D1 (en)
ES (1) ES2323562T3 (en)
ID (1) ID27442A (en)
WO (1) WO1999045155A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691571B2 (en) 2001-01-31 2010-04-06 Mayo Foundation For Medical Education And Research Detection of bordetella
EP1364063B1 (en) 2001-01-31 2010-04-21 Mayo Foundation For Medical Education And Research Detection of herpes simplex virus
US7074598B2 (en) 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) * 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US7427475B2 (en) 2003-11-18 2008-09-23 Mayo Foundation For Medical Education And Research Detection of group B streptococcus
JP4182227B2 (en) * 2005-09-09 2008-11-19 国立大学法人 岡山大学 Test method and test kit for latent virus infection
WO2012072515A2 (en) * 2010-11-29 2012-06-07 Centre National De La Recherche Scientifique (Cnrs) Lmp1 a diagnostic and prognostic marker for epstein-barr virus (ebv)-associated lymphoma
US20190049453A1 (en) * 2016-02-09 2019-02-14 The General Hospital Corporation Classification and Treatment of Gastric Cancer
EP3830302B1 (en) 2018-08-01 2022-10-05 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
US20220373548A1 (en) * 2019-10-24 2022-11-24 Arizona Board Of Regents On Behalf Of Arizona State University Novel antibodies for detecting epstein barr virus-positive gastric cancer
CN112176110A (en) * 2020-11-04 2021-01-05 上海思路迪生物医学科技有限公司 EB virus detection technology based on capture sequencing
CN116590468A (en) * 2023-02-22 2023-08-15 卡秋(江苏)生物科技有限公司 In situ hybridization kit for EB virus detection and use method thereof
CN116536415A (en) * 2023-05-10 2023-08-04 首都医科大学附属北京儿童医院 Substances, kits and applications thereof for detecting differentially methylated genes of Epstein-Barr virus genomes of CAEBV and IM
CN117230258B (en) * 2023-11-10 2024-04-09 苏州驾玉生物医药有限公司 A method for detecting Epstein-Barr virus by combining culture amplification with PCR to improve sensitivity

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WO1993011267A1 (en) * 1991-12-05 1993-06-10 The Institute Of Cancer Research Antiviral agent comprising antisense oligonucleotides complementary to the bhrf1 gene of epstein-barr virus
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EP0574048A2 (en) * 1992-03-13 1993-12-15 Akzo Nobel N.V. Peptides and nucleic acid sequences related to Epstein Barr Virus
EP0628568A2 (en) * 1993-06-09 1994-12-14 Roche Diagnostics GmbH Method for the immobilisation of nucleic acids
WO1995003415A2 (en) * 1993-07-23 1995-02-02 Hans Joachim Wolf Epstein-barr virus dna sequences encoding a diagnostically relevant virus capsid antigen, expression clones derived through polymerase chain reaction and the use of this recombinant antigen in diagnostic tests
WO1997032036A1 (en) * 1996-02-28 1997-09-04 Akzo Nobel N.V. Primers and probes for the amplification, detection and typing of mycoplasma pneumoniae
WO1997037669A1 (en) * 1996-04-05 1997-10-16 University Of Massachusetts Oligonucleotides with anti-epstein-barr virus activity
DE19627932A1 (en) * 1996-07-11 1998-01-15 Boehringer Mannheim Gmbh Sensitive Epstein-Barr virus DNA detection
WO1998004746A1 (en) * 1996-07-31 1998-02-05 Mount Sinai School Of Medicine Of The City University Of New York Nucleic acid amplification method: ramification-extension amplification method (ram)

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JPH0628568A (en) * 1992-06-11 1994-02-04 Sanden Corp Merchandise housing device
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Publication number Priority date Publication date Assignee Title
EP0316170A2 (en) * 1987-11-11 1989-05-17 G Gene Galway Limited Method for the identification of antigens expressed in vivo, diagnostic assays therefor and vaccines containing them
WO1993007882A1 (en) * 1991-10-25 1993-04-29 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of epstein-barr virus-associated diseases
WO1993011267A1 (en) * 1991-12-05 1993-06-10 The Institute Of Cancer Research Antiviral agent comprising antisense oligonucleotides complementary to the bhrf1 gene of epstein-barr virus
EP0574048A2 (en) * 1992-03-13 1993-12-15 Akzo Nobel N.V. Peptides and nucleic acid sequences related to Epstein Barr Virus
WO1993023569A1 (en) * 1992-05-11 1993-11-25 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting viral replication
JPH05309000A (en) * 1992-05-13 1993-11-22 Iatron Lab Inc Method for detecting epstein-barr virus
EP0628568A2 (en) * 1993-06-09 1994-12-14 Roche Diagnostics GmbH Method for the immobilisation of nucleic acids
WO1995003415A2 (en) * 1993-07-23 1995-02-02 Hans Joachim Wolf Epstein-barr virus dna sequences encoding a diagnostically relevant virus capsid antigen, expression clones derived through polymerase chain reaction and the use of this recombinant antigen in diagnostic tests
WO1997032036A1 (en) * 1996-02-28 1997-09-04 Akzo Nobel N.V. Primers and probes for the amplification, detection and typing of mycoplasma pneumoniae
WO1997037669A1 (en) * 1996-04-05 1997-10-16 University Of Massachusetts Oligonucleotides with anti-epstein-barr virus activity
DE19627932A1 (en) * 1996-07-11 1998-01-15 Boehringer Mannheim Gmbh Sensitive Epstein-Barr virus DNA detection
WO1998004746A1 (en) * 1996-07-31 1998-02-05 Mount Sinai School Of Medicine Of The City University Of New York Nucleic acid amplification method: ramification-extension amplification method (ram)

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BRINK ET AL.: "NUCLEIC ACID SEQUENCE-BASED AMPLIFICATION, A NEW METHOD FOR ANALYSIS OF SPLICED AND UNSPLICED EPSTEIN-BARR VIRUS LATENT TRANSCRIPTS, AND ITS COMPARISON WITH REVERSE TRANSCRIPTASE", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 36, no. 11, November 1998 (1998-11-01), pages 3164 - 169, XP002118063 *
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WEI ET AL.: "EXPRESSION AND TUMORIGENICITY OF THE EPSTEIN-BARR VIRUS BARF1 GENE IN HUMAN LOUCKES B-LYMPHOCYTE CELL LINE", CANCER RESEARCH, vol. 54, 1994, pages 1843 - 1848, XP002131583 *
ZHANG ET AL.: "TRANSCRIPTIONAL EXPRESSION OF THE VIRAL GENOME IN THE EPSTEIN-BARR VIRUS-INDUCED TAMARIN LYMPHOMA AND THE CORRESPONDING LYMPHOBLASTOID TUMOUR LINES", VIRUS RESEARCH, vol. 26, 1992, pages 153 - 166, XP000877165 *

Also Published As

Publication number Publication date
KR20010041614A (en) 2001-05-25
WO1999045155A9 (en) 1999-11-25
EP1060271B1 (en) 2009-04-22
ES2323562T3 (en) 2009-07-20
CA2321654C (en) 2011-02-15
ID27442A (en) 2001-04-12
AU757404B2 (en) 2003-02-20
ATE429517T1 (en) 2009-05-15
WO1999045155A2 (en) 1999-09-10
JP2002505122A (en) 2002-02-19
US20040180331A1 (en) 2004-09-16
AU2932199A (en) 1999-09-20
KR100718028B1 (en) 2007-05-16
US7026112B1 (en) 2006-04-11
JP4472171B2 (en) 2010-06-02
EP1060271A2 (en) 2000-12-20
DE69940770D1 (en) 2009-06-04
CA2321654A1 (en) 1999-09-10

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