WO1999056727A3 - Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems - Google Patents

Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems Download PDF

Info

Publication number
WO1999056727A3
WO1999056727A3 PCT/IE1999/000031 IE9900031W WO9956727A3 WO 1999056727 A3 WO1999056727 A3 WO 1999056727A3 IE 9900031 W IE9900031 W IE 9900031W WO 9956727 A3 WO9956727 A3 WO 9956727A3
Authority
WO
WIPO (PCT)
Prior art keywords
preconcentrate
solvent
emulsion
drug delivery
delivery systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE1999/000031
Other languages
French (fr)
Other versions
WO1999056727A2 (en
Inventor
Zebunnissa Ramtoola
Nuala Marie Clarke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Corp PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Priority to EP99921098A priority Critical patent/EP1075252A2/en
Priority to AU38439/99A priority patent/AU3843999A/en
Priority to JP2000546754A priority patent/JP2002513750A/en
Priority to CA002331640A priority patent/CA2331640A1/en
Publication of WO1999056727A2 publication Critical patent/WO1999056727A2/en
Publication of WO1999056727A3 publication Critical patent/WO1999056727A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Self-emulsifying microemulsion or emulsion preconcentrate pharmaceutical compositions capable of forming an oil-in-water microemulsion or emulsion upon dilution with an aqueous solution are disclosed. The preconcentrate contains a therapeutically effective amount of a poorly water soluble therapeutic agent; a pharmaceutically effective amount of a low HLB oil component; and a surfactant system consisting essentially of at least one surfactant having an HLB of from about 10 to 20 and is substantially free or contains only minor amounts of a hydrophilic solvent system. Microemulsions or emulsions formed by diluting the self-emulsifying preconcentrate with an aqueous solution are also provided.
PCT/IE1999/000031 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems Ceased WO1999056727A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99921098A EP1075252A2 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
AU38439/99A AU3843999A (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
JP2000546754A JP2002513750A (en) 1998-05-07 1999-05-07 Solvent / co-solvent free microemulsion and emulsion pre-concentrate drug delivery system
CA002331640A CA2331640A1 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8451898P 1998-05-07 1998-05-07
US60/084,518 1998-05-07

Publications (2)

Publication Number Publication Date
WO1999056727A2 WO1999056727A2 (en) 1999-11-11
WO1999056727A3 true WO1999056727A3 (en) 2000-03-02

Family

ID=22185451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE1999/000031 Ceased WO1999056727A2 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems

Country Status (5)

Country Link
EP (1) EP1075252A2 (en)
JP (1) JP2002513750A (en)
AU (1) AU3843999A (en)
CA (1) CA2331640A1 (en)
WO (1) WO1999056727A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7709669B2 (en) 2000-02-16 2010-05-04 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7741368B2 (en) 2001-12-18 2010-06-22 The Brigham And Women's Hospital, Inc. Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US9364454B2 (en) 2005-10-03 2016-06-14 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
AU7638200A (en) * 1999-10-20 2001-04-30 Vesifact Ag Microemulsion preconcentrates which contain cyclosporines and corresponding microemulsions
SE0000773D0 (en) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (en) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
MY120392A (en) * 2000-06-08 2005-10-31 Hovid Berhad A novel drug delivery system : formulation for fat-soluble drugs
US6596306B1 (en) * 2000-07-07 2003-07-22 David Ho Sue San Ho Drug delivery system:formulation for fat-soluble drugs
DE60137069D1 (en) * 2000-10-11 2009-01-29 Cephalon Inc PHARMACEUTICAL COMPOSITIONS CONTAINING MODAFINE COMPOUNDS
FR2818905A1 (en) * 2000-12-28 2002-07-05 Cll Pharma MICELLAR COLLOIDAL PHARMACEUTICAL COMPOSITIONS COMPRISING A LIPOPHILIC ACTIVE INGREDIENT
MXPA03007141A (en) * 2001-02-11 2003-11-18 Aquanova Ger Solubilisate Tech Method for producing an active ingredient concentrate, and an active ingredient concentrate.
AU2002231970B2 (en) * 2001-02-14 2007-08-16 CNX Therapeutics Limited Mucoadhesive pharmaceutical formulations
DE50101395D1 (en) * 2001-04-12 2004-03-04 Vesifact Ag Baar Pharmaceutical formulations containing anti-inflammatory agents and their use
SE0102993D0 (en) * 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
KR100441167B1 (en) * 2001-12-27 2004-07-21 씨제이 주식회사 Composition of microemulsion preconcentrate
AU2003254168A1 (en) 2002-07-30 2004-02-16 Wyeth Parenteral formulations containing a rapamycin hydroxyester
AU2003258194B2 (en) 2002-08-12 2009-11-12 The Brigham And Women's Hospital, Inc. Resolvins: biotemplates for therapeutic interventions
JP4886297B2 (en) * 2002-11-01 2012-02-29 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド Geodate delivery vehicle
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
US7879345B2 (en) 2003-04-11 2011-02-01 L'oreal Composition containing an amphiphilic polymer, uses thereof
FR2853527B1 (en) * 2003-04-11 2006-06-23 Oreal COMPOSITION IN THE FORM OF OIL-IN-WATER EMULSION CONTAINING AN AMPHIPHILIC POLYMER, AND ITS PARTICULARLY COSMETIC USES
CA2558393A1 (en) * 2004-03-10 2005-09-22 Schering Aktiengesellschaft Compositions comprising drospirenone molecularly dispersed
CA2562388A1 (en) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited Emulsion-stabilized preparation
US20050232974A1 (en) * 2004-04-19 2005-10-20 Gore Makarand P System and a method for pharmaceutical dosage preparation using jettable microemulsions
CA2573316A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
CN100361656C (en) 2004-08-27 2008-01-16 石药集团中奇制药技术（石家庄）有限公司 Butylbenzene phthalein self emulsifying releasing medicine system, preparation method and application
GT200500310A (en) 2004-11-19 2006-06-19 ORGANIC COMPOUNDS
CA2618974C (en) * 2005-08-09 2014-01-28 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
US20140287004A1 (en) * 2005-11-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs
US20070149617A1 (en) * 2005-11-14 2007-06-28 Deckelbaum Richard J Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
CN101547687A (en) * 2005-11-17 2009-09-30 生物药效率有限公司 biocompatible latent emulsifier
MY153288A (en) * 2006-06-28 2015-01-29 Hovid Berhad An effective pharmaceutical carrier for poorly bioavailable drugs
CA2664427C (en) * 2006-10-04 2012-06-05 M & P Patent Aktiengesellschaft Controlled release delivery system for nasal application of neurotransmitters
KR101493546B1 (en) * 2007-08-21 2015-02-16 바실리어 파마슈티카 아게 Antifungal composition
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
FR2925855B1 (en) 2007-12-26 2010-11-05 Virbac Sa FLORFENICOL SELF-CONTAINING LIQUID COMPOSITION FOR INCORPORATING BEVERAGE WATER IN ANIMAL BREEDING ANIMALS.
US9532963B2 (en) 2009-03-09 2017-01-03 Pronova Biopharma Norge As Compositions comprising a fatty acid oil mixture and a free fatty acid, and methods and uses thereof
JP2011006380A (en) * 2009-05-22 2011-01-13 Mochida Pharmaceut Co Ltd EMULSIFIED COMPOSITION OF ω3 FATTY ACID
CA3059911C (en) 2009-05-22 2022-01-11 Mochida Pharmaceutical Co., Ltd. Self-emulsifying composition of .omega.3 fatty acid
ES2661812T3 (en) 2009-10-16 2018-04-04 Mochida Pharmaceutical Co., Ltd. Compositions
KR101904388B1 (en) * 2009-10-23 2018-10-05 프로노바 바이오파마 너지 에이에스 Coated capsules and tablets of a fatty acid oil mixture
DK2366408T3 (en) 2010-03-01 2012-10-22 Salvat Lab Sa Aqueous clear solutions of fluocinolone acetonide to treat inflammation of the ear
JP5824511B2 (en) 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド Non-aqueous taxane proemulsion formulations and methods for preparing and using the same
AR082930A1 (en) * 2010-09-08 2013-01-16 Pronova Biopharma Norge As COMPOSITIONS THAT INCLUDE AN OILY MIXTURE OF FATTY ACIDS, A TENSIOACTIVE AND A STATIN
KR20130103521A (en) * 2010-09-08 2013-09-23 프로노바 바이오파마 너지 에이에스 Compositions comprising a fatty acid oil mixture, a free fatty acid, and a statin
KR20130139896A (en) * 2010-09-08 2013-12-23 프로노바 바이오파마 너지 에이에스 Compositions comprising a fatty acid oil mixture comprising epa and dha in free acid form, a surfactant, and a statin
JO3337B1 (en) * 2010-12-13 2019-03-13 Debiopharm Sa Pharmaceutical Compositions Comprising Alisporivir
JO3685B1 (en) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc Non-aqueous taxane nanodispersion formulations and methods of using the same
SG11201505076UA (en) 2012-12-31 2015-07-30 Jrx Biotechnology Inc Liquid topical pharmaceutical nano-emulsion formulations
CN105263321B (en) 2013-03-28 2018-07-27 哥伦比亚大学纽约管理委员会 Promote the protection to the donor organ for transplanting with omega-3 glyceride Reperfu- sions
US11400048B2 (en) 2014-06-25 2022-08-02 Synergia Bio Sciences Private Limited Pharmaceutical oil-in-water nano-emulsion
WO2015198350A1 (en) * 2014-06-25 2015-12-30 Synergia Bio Sciences Private Limited A pharmaceutical oil-in-water nano-emulsion
US11260018B2 (en) 2015-09-17 2022-03-01 Jrx Biotechnology, Inc. Approaches for improving skin hydration and moisturization
US12303504B2 (en) * 2018-09-13 2025-05-20 Oncosol Limited Non-aqueous chemotherapeutic suspensions for oral dosage
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
US20200215027A1 (en) * 2018-12-28 2020-07-09 Robert K. Prud'homme Dihydromyricetin nanoemulsion formulations and methods for forming them
US11465107B2 (en) * 2019-01-31 2022-10-11 Hong Ngoc Thi Dang Process for producing a nano omega-3 microemulsion system
JP6880352B1 (en) 2019-11-07 2021-06-02 中外製薬株式会社 Cyclic peptide compound with Kras inhibitory effect
CZ309587B6 (en) * 2021-01-22 2023-05-03 Oncora S.R.O. Microemulsion preconcentrate containing cladribine and preparing it

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372635A1 (en) * 1976-12-03 1978-06-30 Scherer Ltd R P Pharmaceutical compsn. contg. self-emulsifying oil e.g. silicone - for admin. as capsules, giving rapid gastrointestinal resorption
WO1994005298A1 (en) * 1992-08-28 1994-03-17 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
WO1995008983A1 (en) * 1993-09-30 1995-04-06 Gattefosse S.A. Oral delivery composition forming a microemulsion
EP0650721A1 (en) * 1993-07-01 1995-05-03 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin soft capsule
WO1995012384A1 (en) * 1993-11-02 1995-05-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Self-emulsible formulation forming an oil-in-water emulsion
WO1995025504A1 (en) * 1994-03-18 1995-09-28 Pharmavene, Inc. Emulsified drug delivery systems
WO1996013273A1 (en) * 1994-10-26 1996-05-09 Novartis Ag Pharmaceutical compositions
EP0760237A1 (en) * 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
WO1997036610A1 (en) * 1996-07-26 1997-10-09 Chong Kun Dang Corp. Cyclosporin-containing pharmaceutical composition
FR2753376A1 (en) * 1996-09-18 1998-03-20 Synthelabo PHARMACEUTICAL COMPOSITIONS COMPRISING AMISULPRIDE AND THERAPEUTIC APPLICATIONS THEREOF
WO1999029316A1 (en) * 1997-12-10 1999-06-17 Severson, Mary, L. Pharmaceutical compositions containing an omega-3 fatty acid oil
WO1999029300A1 (en) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Self-emulsifying fenofibrate formulations

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372635A1 (en) * 1976-12-03 1978-06-30 Scherer Ltd R P Pharmaceutical compsn. contg. self-emulsifying oil e.g. silicone - for admin. as capsules, giving rapid gastrointestinal resorption
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
WO1994005298A1 (en) * 1992-08-28 1994-03-17 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
EP0650721A1 (en) * 1993-07-01 1995-05-03 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin soft capsule
WO1995008983A1 (en) * 1993-09-30 1995-04-06 Gattefosse S.A. Oral delivery composition forming a microemulsion
WO1995012384A1 (en) * 1993-11-02 1995-05-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Self-emulsible formulation forming an oil-in-water emulsion
WO1995025504A1 (en) * 1994-03-18 1995-09-28 Pharmavene, Inc. Emulsified drug delivery systems
WO1996013273A1 (en) * 1994-10-26 1996-05-09 Novartis Ag Pharmaceutical compositions
EP0760237A1 (en) * 1995-08-30 1997-03-05 Cipla Limited Oil-in-water microemulsions
WO1997036610A1 (en) * 1996-07-26 1997-10-09 Chong Kun Dang Corp. Cyclosporin-containing pharmaceutical composition
FR2753376A1 (en) * 1996-09-18 1998-03-20 Synthelabo PHARMACEUTICAL COMPOSITIONS COMPRISING AMISULPRIDE AND THERAPEUTIC APPLICATIONS THEREOF
WO1999029316A1 (en) * 1997-12-10 1999-06-17 Severson, Mary, L. Pharmaceutical compositions containing an omega-3 fatty acid oil
WO1999029300A1 (en) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Self-emulsifying fenofibrate formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CRAIG D Q M ET AL: "A COMPARISON OF THE SELF-EMULSIFYING PROPERTIES OF POLYGLYCOLYSED GLYCERIDE OILS", PHARMACEUTICAL SCIENCES,GB,LONDON, vol. 1, no. 12, pages 559-561, XP002053051, ISSN: 1356-6881 *
SHAH N H ET AL: "SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) WITH POLYGLYCOLYZED GLYCERIDES FOR IMPROVING IN VITRO DISSOLUTION AND ORAL ABSORPTION OF LIPOPHILIC DRUGS", INTERNATIONAL JOURNAL OF PHARMACEUTICS,NL,AMSTERDAM, vol. 106, no. 1, pages 15-23, XP000561369, ISSN: 0378-5173 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7709669B2 (en) 2000-02-16 2010-05-04 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7741368B2 (en) 2001-12-18 2010-06-22 The Brigham And Women's Hospital, Inc. Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US7872152B2 (en) 2002-08-12 2011-01-18 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US9364454B2 (en) 2005-10-03 2016-06-14 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

Also Published As

Publication number Publication date
AU3843999A (en) 1999-11-23
WO1999056727A2 (en) 1999-11-11
CA2331640A1 (en) 1999-11-11
JP2002513750A (en) 2002-05-14
EP1075252A2 (en) 2001-02-14

Similar Documents

Publication Publication Date Title
CA2313024A1 (en) Pharmaceutical compositions containing an omega-3 fatty acid oil
WO1996040057A3 (en) Reverse fluorocarbon emulsion compositions for drug delivery
Kawakami et al. Microemulsion formulation for enhanced absorption of poorly soluble drugs: II. In vivo study
Nicolaos et al. Improvement of cefpodoxime proxetil oral absorption in rats by an oil-in-water submicron emulsion
AU2002356137B2 (en) Spontaneous emulsions containing cyclosporine
MacGregor et al. Influence of lipolysis on drug absorption from the gastro-intestinal tract
US4719239A (en) Pharmaceutical multicomponent systems and method of preparing same
Gao et al. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A
JP5764792B2 (en) Novel pharmaceutical composition comprising a macrolide immunosuppressant
Marti-Mestres et al. Emulsions in health care applications—an overview
EP0790822B1 (en) Controlled release composition forming a reversed micellar (l2) structure or a normal micellar (l1) structure
CA2142103A1 (en) Submicron emulsions as ocular drug delivery vehicles
US5389373A (en) Preparation of oil-in-water emulsions of drugs
KR870002835A (en) Pharmaceutical preparation method of ionizable hydrophobic drug
IL114212A0 (en) Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
MA23344A1 (en) NEW EMULSION COMPOSITIONS
WO2001089474A3 (en) O/w emulsion
HK1043936A1 (en) Novel formulations comprising lipid-regulating agents
ATE152613T1 (en) COMPOSITION WHICH FORMES A MICROEMULSION UPON PERORAL ADMINISTRATION
KR930001929A (en) Ophthalmic Composition
DE60132103T2 (en) PERORAL, SELF-EMULGATING PHARMACEUTICAL FORMS OF PYRANONE PROTEASE INHIBITORS
WO1998005300A2 (en) Delivery system for pharmaceutical agents encapsulated with oils
GB1567890A (en) Instillation composition
WO1997005882A1 (en) O/w emulsion composition for eye drops
US6770292B2 (en) Pharmaceutical compositions for oral administration

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999921098

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2331640

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 38439/99

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1999921098

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999921098

Country of ref document: EP