WO1999056790A3 - 13c glucose breath test for the diagnosis of diabetes - Google Patents

13c glucose breath test for the diagnosis of diabetes Download PDF

Info

Publication number
WO1999056790A3
WO1999056790A3 PCT/IB1999/000933 IB9900933W WO9956790A3 WO 1999056790 A3 WO1999056790 A3 WO 1999056790A3 IB 9900933 W IB9900933 W IB 9900933W WO 9956790 A3 WO9956790 A3 WO 9956790A3
Authority
WO
WIPO (PCT)
Prior art keywords
breath test
diagnosis
diabetes
glucose breath
glucose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1999/000933
Other languages
French (fr)
Other versions
WO1999056790A2 (en
Inventor
Randall W Yatscoff
Robert T Foster
Launa J Aspeslet
Richard Lewanczuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isotechnika Inc
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Priority to CA002331812A priority Critical patent/CA2331812C/en
Priority to DE1075286T priority patent/DE1075286T1/en
Priority to AU37251/99A priority patent/AU3725199A/en
Priority to US09/674,806 priority patent/US6468802B1/en
Priority to EP99919475A priority patent/EP1075286A2/en
Priority to JP2000546814A priority patent/JP2002513911A/en
Publication of WO1999056790A2 publication Critical patent/WO1999056790A2/en
Publication of WO1999056790A3 publication Critical patent/WO1999056790A3/en
Anticipated expiration legal-status Critical
Priority to US11/069,169 priority patent/US7118919B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104998—Glucose, ketone, nitrate standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Atmospheric Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired 13C-labeled CO¿2? following the ingestion of a ?13¿C-enriched glucose source.
PCT/IB1999/000933 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes Ceased WO1999056790A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002331812A CA2331812C (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
DE1075286T DE1075286T1 (en) 1998-05-06 1999-05-06 13C-glucose breath test to diagnose diabetes indications and monitor glycemic control
AU37251/99A AU3725199A (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetic indications andmonitoring glycemic control
US09/674,806 US6468802B1 (en) 1998-05-06 1999-05-06 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
EP99919475A EP1075286A2 (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes
JP2000546814A JP2002513911A (en) 1998-05-06 1999-05-06 13C glucose breath test for diagnosis of diabetes symptoms and monitoring of blood sugar control
US11/069,169 US7118919B2 (en) 1998-05-06 2005-02-28 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8448298P 1998-05-06 1998-05-06
US60/084,482 1998-05-06

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US09674806 A-371-Of-International 1999-05-06
US09/674,806 A-371-Of-International US6468802B1 (en) 1998-05-06 1999-05-06 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
US09/910,701 Continuation-In-Part US6461870B2 (en) 1998-05-06 2001-07-20 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
US10/228,276 Continuation US6602715B2 (en) 1998-05-06 2002-08-27 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control

Publications (2)

Publication Number Publication Date
WO1999056790A2 WO1999056790A2 (en) 1999-11-11
WO1999056790A3 true WO1999056790A3 (en) 1999-12-16

Family

ID=22185237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000933 Ceased WO1999056790A2 (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes

Country Status (8)

Country Link
US (3) US6468802B1 (en)
EP (1) EP1075286A2 (en)
JP (3) JP2002513911A (en)
AU (1) AU3725199A (en)
CA (1) CA2331812C (en)
DE (1) DE1075286T1 (en)
ES (1) ES2161669T1 (en)
WO (1) WO1999056790A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10393730B2 (en) 2014-07-09 2019-08-27 Otsuka Pharmaceutical Co., Ltd. Energy malnutrition evaluation for liver disease test subject

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
CA2250485C (en) 1997-10-21 2008-04-29 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
EP1075286A2 (en) * 1998-05-06 2001-02-14 Isotechnika, Inc. 13c glucose breath test for the diagnosis of diabetes
US6461870B2 (en) * 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
DE10028548C1 (en) * 2000-06-09 2001-08-30 Inst Chemo Biosensorik Method for the detection of alpha-oxoaldehydes in whole blood, blood plasma and / or serum of a patient
FR2815074B1 (en) * 2000-10-10 2002-12-06 Inst Francais Du Petrole METHOD OF CHEMICAL AND ISOTOPIC ANALYSIS AND MEASUREMENT ON COMPONENTS TRANSPORTED BY A DRILLING FLUID
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10057832C1 (en) 2000-11-21 2002-02-21 Hartmann Paul Ag Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample
WO2002100252A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Blood sampling apparatus and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
EP1404235A4 (en) 2001-06-12 2008-08-20 Pelikan Technologies Inc METHOD AND APPARATUS FOR INTEGRATED LANCET LAUNCH DEVICE ON BLOOD SAMPLING CARTRIDGE
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60234598D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES
AU2002320094A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Integrated blood sampling analysis system with multi-use sampling module
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
DE60239132D1 (en) 2001-06-12 2011-03-24 Pelikan Technologies Inc APPARATUS FOR INCREASING THE SUCCESS RATE IN RESPECT OF BLOOD EXPLOITATION OBTAINED BY A FINGERSTICK
AU2002315180A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Electric lancet actuator
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
EP1437966B1 (en) * 2001-10-24 2011-03-23 The Regents of The University of California Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water
WO2003068919A2 (en) * 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
CA2503681A1 (en) * 2002-04-05 2003-10-23 Marc K. Hellerstein Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US20060094057A1 (en) 2002-07-30 2006-05-04 Maro K. Hellerstein Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
CN100402093C (en) * 2002-08-26 2008-07-16 马永健 Drugs Used in Medical Breath Diagnosis
AU2003268416A1 (en) * 2002-09-04 2004-03-29 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
CA2498378C (en) * 2002-09-13 2013-12-17 The Regents Of The University Of California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
EP1545628A4 (en) * 2002-09-16 2010-07-28 Univ California BIOCHEMICAL METHODS FOR MEASURING THE METABOLIC ABILITY OF TISSUES OR WHOLE ORGANISMS
JP4611025B2 (en) * 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Deuterated glucose or fat tolerance test for high-throughput measurement of glucose or fatty acid metabolism in the body
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040137637A1 (en) * 2003-01-13 2004-07-15 Chuji Wang Breath gas analyzer for diagnosing diabetes and method of use thereof
WO2004107964A2 (en) 2003-06-06 2004-12-16 Pelikan Technologies, Inc. Blood harvesting device with electronic control
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (en) * 2004-03-11 2005-09-22 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
WO2005094327A2 (en) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
WO2007142644A1 (en) * 2006-06-08 2007-12-13 Braun Charles L Spectroscopic breath profile analysis device and uses thereof for facilitating diagnosis of medical conditions
US20080306353A1 (en) * 2006-11-03 2008-12-11 Douglas Joel S Calculation device for metabolic control of critically ill and/or diabetic patients
GB0716427D0 (en) 2007-08-23 2007-10-03 Smartsensor Telemed Ltd Glucose tolerance test device
CA2715036A1 (en) 2008-03-14 2009-09-17 Retrotope, Inc. Therapies for cancer using isotopically substituted lysine
WO2009114814A2 (en) 2008-03-14 2009-09-17 Retrotope, Inc. Therapeutic substances that modulate genome methylation
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100279418A1 (en) * 2009-05-04 2010-11-04 Loren Robert Larson Glucose meter adaptable for use with handheld devices, and associated communication network
CA2777827C (en) 2009-10-30 2020-08-18 Retrotope, Inc. Alleviating oxidative stress disorders with pufa derivatives
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2012249920B2 (en) 2011-04-26 2017-06-15 Biojiva Llc Disorders implicating PUFA oxidation
EP3689342A1 (en) 2011-04-26 2020-08-05 Retrotope, Inc. Oxidative retinal diseases
AU2012249917B2 (en) 2011-04-26 2017-06-15 Biojiva Llc Neurodegenerative disorders and muscle diseases implicating PUFAs
AU2012249918B2 (en) 2011-04-26 2017-06-15 Biojiva Llc Impaired energy processing disorders and mitochondrial deficiency
WO2013036885A1 (en) 2011-09-08 2013-03-14 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
US20140353486A1 (en) 2011-12-07 2014-12-04 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
CN104040347B (en) 2012-04-30 2016-06-15 科学与工业研究会 For the sensor combinations thing that the acetone in breathing detects
WO2014030650A1 (en) 2012-08-20 2014-02-27 大塚製薬株式会社 Method for measuring carbohydrate metabolism ability, and composition for use in said method
EP2975400B1 (en) 2013-03-15 2019-09-04 Otsuka Pharmaceutical Co., Ltd. Composition for use in a method for measuring sugar/fatty acid combustion ratio
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
AU2014261003B2 (en) 2013-05-02 2019-03-28 Atonarp Inc. Monitor and system for monitoring living organisms
CN109917125A (en) * 2013-12-03 2019-06-21 哈佛大学董事会 Methods and reagents for assessing gestational diabetes mellitus
US9753041B2 (en) * 2014-04-21 2017-09-05 Univeristy Of South Florida Salivary inflammatory biomarkers associated with glycemic control and oral health
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
EP3020437B1 (en) * 2014-11-13 2023-06-07 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Controlling a flow through a pneumatic system
CA3005983A1 (en) 2015-11-23 2017-06-01 Retrotope, Inc. Site-specific isotopic labeling of 1,4-diene systems
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
JP6721408B2 (en) * 2016-05-20 2020-07-15 株式会社Ｎｔｔドコモ Judgment device
JP6956977B2 (en) 2016-11-11 2021-11-02 大塚製薬株式会社 How to evaluate liver sugar uptake
EP3567356B1 (en) * 2018-05-07 2021-02-24 Inficon GmbH Sniffing leak detector with switching valve and buffer chamber
CA3172351A1 (en) 2020-02-21 2021-08-26 Retrotope, Inc. Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS
US20250090103A1 (en) * 2023-09-18 2025-03-20 Frank Healthcare Advisors, Llc Early recognition of change to pathophysiologic state of dysglycemia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826377A1 (en) * 1996-08-27 1998-03-04 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
EP0913161A2 (en) * 1997-10-21 1999-05-06 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
ES2120903B1 (en) * 1996-11-12 1999-05-16 Isomed S L METHOD AND KIT FOR THE DETECTION OF HELICOBACTER PYLORI.
US5962335A (en) * 1997-01-03 1999-10-05 Oridion Medical Ltd. Breath test for detection of drug metabolism
US6067989A (en) * 1997-02-26 2000-05-30 Oridion Medical, Ltd. Breath test for the diagnosis of Helicobacter pylori infection in the gastrointestinal tract
US6461870B2 (en) * 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
EP1075286A2 (en) * 1998-05-06 2001-02-14 Isotechnika, Inc. 13c glucose breath test for the diagnosis of diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826377A1 (en) * 1996-08-27 1998-03-04 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
EP0913161A2 (en) * 1997-10-21 1999-05-06 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; HIRAI, M. (1) ET AL: "The breath test using pure (1-13C) glucose: A new simple method for evaluating the glucose oxidation capacity.", XP002120264, retrieved from STN *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; TANIS, A. A. (1) ET AL: "Human liver glycogen metabolism assessed with a 13C-enriched diet and a 13CO2 breath test.", XP002120263, retrieved from STN *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HELGE, H. ET AL: "Carbon-13 dioxide breath tests in normal and diabetic children following ingestion of 13C-glucose", XP002120262, retrieved from STN Database accession no. 90:37276 *
DIABETOLOGIA, (1997) VOL. 40, NO. SUPPL. 1, PP. A278. MEETING INFO.: 16TH INTERNATIONAL DIABETES FEDERATION CONGRESS HELSINKI, FINLAND JULY 20-25, 1997 *
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, (JUNE, 1998) VOL. 28, NO. 6, PP. 466-474. *
STABLE ISOT., PROC. INT. SYMP. (1978), MEETING DATE 1977, 227-34. EDITOR(S): BAILLIE, T. A. PUBLISHER: MACMILLAN, LONDON, ENGL. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10393730B2 (en) 2014-07-09 2019-08-27 Otsuka Pharmaceutical Co., Ltd. Energy malnutrition evaluation for liver disease test subject

Also Published As

Publication number Publication date
US7118919B2 (en) 2006-10-10
US20050147560A1 (en) 2005-07-07
US6602715B2 (en) 2003-08-05
US20030044993A1 (en) 2003-03-06
JP2008292506A (en) 2008-12-04
CA2331812C (en) 2006-08-22
US6468802B1 (en) 2002-10-22
DE1075286T1 (en) 2002-05-23
JP2007192831A (en) 2007-08-02
WO1999056790A2 (en) 1999-11-11
AU3725199A (en) 1999-11-23
CA2331812A1 (en) 1999-11-11
EP1075286A2 (en) 2001-02-14
JP2002513911A (en) 2002-05-14
ES2161669T1 (en) 2001-12-16

Similar Documents

Publication Publication Date Title
WO1999056790A3 (en) 13c glucose breath test for the diagnosis of diabetes
CA2330629A1 (en) Method and device for predicting physiological values
CA2433630A1 (en) Meter strip dispenser assembly
DK0887421T3 (en) Diagnostic test strip with calibration on the strip
WO2000049941A8 (en) Glucose monitor calibration methods
DE69941366D1 (en)
WO2002075320A3 (en) Liver function test
WO2003071940A8 (en) Blood sampling device
WO2003008933A3 (en) Test strip for a lateral flow assay
JP2006015148A (en) Liquid handling equipment
AU1726797A (en) A method for monitoring the health of a patient by measuring and predicting the glucose level of the patient's blood sample
PL368047A1 (en) Integrated sample testing meter
CA2319731A1 (en) Point of care diagnostic systems
EP1950562A3 (en) Integrated sample testing meter
WO1999051142A3 (en) Non-invasive tissue glucose level monitoring
EP0922954A3 (en) Method for recognizing the presence of sample fluid on a test strip by evaluating first and second derivatives
CA2617939A1 (en) Meter having post-meal test-time alarm
AU6061394A (en) Methods for the in vivo measurement of the concentration of NMR-detectable xenobiotic compounds
AU132568S (en) Device for measuring the concentration of an analyte in a sample of blood
AU577106B2 (en) Test strip for recording daily blood glucose profiles
AU132685S (en) Device for measuring the concentration of an analyte in a sample of blood
AU132569S (en) Device for measuring the concentration of an analyte in a sample of blood
DE69839314D1 (en) Diagenetic diagnostic agent containing 13C-labeled composition
Cartier et al. Toxic levels of acetaminophen produce a major positive interference on Glucometer Elite and Accu-chek Advantage glucose meters
EP2071338A3 (en) Human diabetes-mediating proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2331812

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 1999919475

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09674806

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999919475

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642