WO1999057107A3 - Cannabinoids selective for the cb2 receptor - Google Patents

Cannabinoids selective for the cb2 receptor Download PDF

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Publication number
WO1999057107A3
WO1999057107A3 PCT/US1999/009806 US9909806W WO9957107A3 WO 1999057107 A3 WO1999057107 A3 WO 1999057107A3 US 9909806 W US9909806 W US 9909806W WO 9957107 A3 WO9957107 A3 WO 9957107A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
selective
cannabinoids
cannabinoid
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/009806
Other languages
French (fr)
Other versions
WO1999057107A2 (en
Inventor
Alexandros Makriyannis
Atmaram Khanolkar
Dai Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Priority to AT99921676T priority Critical patent/ATE277921T1/en
Priority to DE69920683T priority patent/DE69920683T2/en
Priority to CA002340444A priority patent/CA2340444A1/en
Priority to EP99921676A priority patent/EP1076653B1/en
Publication of WO1999057107A2 publication Critical patent/WO1999057107A2/en
Publication of WO1999057107A3 publication Critical patent/WO1999057107A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocyclic ring or a seven to ten membered bicyclic ring system fused to the monohydroxylated phenyl ring of the cannabinoid core. Also disclosed are methods of suppressing the immune system in a subject by administering to the subject a (e.g. immunosuppressive amount) effective amount of a novel cannabinoid described above.
PCT/US1999/009806 1998-05-04 1999-05-04 Cannabinoids selective for the cb2 receptor Ceased WO1999057107A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT99921676T ATE277921T1 (en) 1998-05-04 1999-05-04 CANNABINOIDS SELECTIVELY ACTING ON THE CB2 RECEPTOR
DE69920683T DE69920683T2 (en) 1998-05-04 1999-05-04 Selective on the CB2 receptor acting cannabinoids
CA002340444A CA2340444A1 (en) 1998-05-04 1999-05-04 Cannabinoids selective for the cb2 receptor
EP99921676A EP1076653B1 (en) 1998-05-04 1999-05-04 Novel cannabinoids selective for the cb2 receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8412998P 1998-05-04 1998-05-04
US60/084,129 1998-05-04

Publications (2)

Publication Number Publication Date
WO1999057107A2 WO1999057107A2 (en) 1999-11-11
WO1999057107A3 true WO1999057107A3 (en) 2000-02-03

Family

ID=22183058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009806 Ceased WO1999057107A2 (en) 1998-05-04 1999-05-04 Cannabinoids selective for the cb2 receptor

Country Status (7)

Country Link
US (1) US6166066A (en)
EP (1) EP1076653B1 (en)
AT (1) ATE277921T1 (en)
CA (1) CA2340444A1 (en)
DE (1) DE69920683T2 (en)
ES (1) ES2224658T3 (en)
WO (1) WO1999057107A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241799B2 (en) 1999-10-18 2007-07-10 University Of Connecticut Cannabimimetic indole derivatives
US7285683B2 (en) 2001-07-13 2007-10-23 University Of Connecticut Bicyclic and tricyclic cannabinoids
US7329651B2 (en) 2001-01-26 2008-02-12 University Of Connecticut Cannabimimetic ligands
US7335688B2 (en) 1999-10-18 2008-02-26 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7393842B2 (en) 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US7589220B2 (en) 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999057106A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
WO1999057107A2 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Cannabinoids selective for the cb2 receptor
US7897598B2 (en) 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US20070179135A1 (en) * 2006-01-05 2007-08-02 Travis Craig R Cannabinoid derivatives
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
DE60033834T2 (en) 1999-10-18 2007-11-15 The University Of Connecticut, Farmington FOR PERIPHERAL CANNABINOID RECEPTORS SELECTIVE LIGANDS
US7235584B2 (en) * 2000-06-22 2007-06-26 Pharmos Corporation Non-psychotropic cannabinoids
EP1299374B1 (en) 2000-06-22 2006-12-27 Pharmos Corporation Novel non-psychotropic cannabinoids
WO2002060447A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
CA2464333C (en) * 2001-10-26 2011-07-26 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
AU2002357114B2 (en) * 2001-12-07 2008-07-24 Virginia Commonwealth University Treatment of neoplasia
AU2003217961B2 (en) 2002-03-08 2008-02-28 Signal Pharmaceuticals, Llc Combination therapy for treating, preventing or managing proliferative disorders and cancers
WO2004103410A1 (en) 2002-06-06 2004-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods compositions and articles of manufacture for modulating bone growth
US7183313B2 (en) 2002-08-23 2007-02-27 University Of Connecticut Keto cannabinoids with therapeutic indications
IL160420A0 (en) * 2004-02-16 2004-07-25 Yissum Res Dev Co Treating or preventing diabetes with cannabidiol
WO2005123053A2 (en) * 2004-06-22 2005-12-29 Pharmos Limited Use of cb2 receptors agonists for the treatment of huntington’s disease
US7781650B2 (en) * 2007-04-30 2010-08-24 Monsanto Technology Llc Plants and seeds of corn variety CV202909
US9575319B2 (en) 2014-03-10 2017-02-21 Ion Virtual Technology Corporation Method and system for reducing motion blur when experiencing virtual or augmented reality environments
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
PT3509638T (en) 2017-06-20 2022-03-02 Univ Guelph Cannabidiolic acid esters compositions and uses thereof
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
KR20210151816A (en) 2019-03-12 2021-12-14 이피엠 (아이피), 인코포레이티드 Cannabinoid acid ester compositions and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276732A2 (en) * 1987-01-27 1988-08-03 F. Hoffmann-La Roche Ag Novel cannabinol derivatives and improved immunoassay
FR2735774A1 (en) * 1995-06-21 1996-12-27 Sanofi Sa USE OF HUMAN CB2 RECEPTOR AGONISTIC COMPOUNDS FOR THE PREPARATION OF IMMUNOMODULATORY DRUGS, NOVEL AGONIST COMPOUNDS OF CB2 RECEPTOR AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915996A (en) * 1972-10-16 1975-10-28 Abbott Lab Process for making benzopyrans
US3886184A (en) * 1973-08-03 1975-05-27 Lilly Co Eli Aminodibenzo(b,d)pyrans
US5440052A (en) * 1993-08-06 1995-08-08 University Of Connecticut Compositions useful as a cannabinoid receptor probe
US5688825A (en) * 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
WO1999057107A2 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Cannabinoids selective for the cb2 receptor
WO1999057106A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276732A2 (en) * 1987-01-27 1988-08-03 F. Hoffmann-La Roche Ag Novel cannabinol derivatives and improved immunoassay
FR2735774A1 (en) * 1995-06-21 1996-12-27 Sanofi Sa USE OF HUMAN CB2 RECEPTOR AGONISTIC COMPOUNDS FOR THE PREPARATION OF IMMUNOMODULATORY DRUGS, NOVEL AGONIST COMPOUNDS OF CB2 RECEPTOR AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C. G. PITT ET AL., JOURNAL OF LABELLED COMPOUNDS, vol. 11, no. 4, 1975, pages 551 - 75, XP002123229 *
J. W. HUFFMAN ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, no. 12, 1998, pages 2281 - 8, XP002123230 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589220B2 (en) 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7241799B2 (en) 1999-10-18 2007-07-10 University Of Connecticut Cannabimimetic indole derivatives
US7335688B2 (en) 1999-10-18 2008-02-26 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7329651B2 (en) 2001-01-26 2008-02-12 University Of Connecticut Cannabimimetic ligands
US7285683B2 (en) 2001-07-13 2007-10-23 University Of Connecticut Bicyclic and tricyclic cannabinoids
US7393842B2 (en) 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors

Also Published As

Publication number Publication date
EP1076653B1 (en) 2004-09-29
ATE277921T1 (en) 2004-10-15
DE69920683D1 (en) 2004-11-04
EP1076653A2 (en) 2001-02-21
US6166066A (en) 2000-12-26
WO1999057107A2 (en) 1999-11-11
ES2224658T3 (en) 2005-03-01
CA2340444A1 (en) 1999-11-11
DE69920683T2 (en) 2005-04-07

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