WO1999057241A3 - Myelin basic protein peptides and uses thereof - Google Patents

Myelin basic protein peptides and uses thereof Download PDF

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Publication number
WO1999057241A3
WO1999057241A3 PCT/US1999/009930 US9909930W WO9957241A3 WO 1999057241 A3 WO1999057241 A3 WO 1999057241A3 US 9909930 W US9909930 W US 9909930W WO 9957241 A3 WO9957241 A3 WO 9957241A3
Authority
WO
WIPO (PCT)
Prior art keywords
basic protein
myelin basic
protein peptides
invention pertains
autoimmune diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/009930
Other languages
French (fr)
Other versions
WO1999057241A2 (en
WO1999057241A9 (en
Inventor
Subhashini Arimilli
Shrikant Deshpande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ507901A priority Critical patent/NZ507901A/en
Priority to HK02101092.3A priority patent/HK1039636A1/en
Priority to AU37890/99A priority patent/AU3789099A/en
Priority to CA002330826A priority patent/CA2330826A1/en
Priority to EP99920379A priority patent/EP1080185A4/en
Priority to JP2000547197A priority patent/JP2002513558A/en
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of WO1999057241A2 publication Critical patent/WO1999057241A2/en
Publication of WO1999057241A3 publication Critical patent/WO1999057241A3/en
Publication of WO1999057241A9 publication Critical patent/WO1999057241A9/en
Priority to NO20005547A priority patent/NO20005547L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rehabilitation Therapy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention pertains generally to the treatment of autoimmune diseases of the central nervous system characterized by demyelination. In particular, this invention pertains to novel peptides derived from human myelin basic protein (MBP). When complexed with the appropriate major histocompatibility complex (MHC) molecule, these peptides can be used to treat multiple sclerosis and other demyelinating autoimmune diseases.
PCT/US1999/009930 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof Ceased WO1999057241A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HK02101092.3A HK1039636A1 (en) 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof
AU37890/99A AU3789099A (en) 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof
CA002330826A CA2330826A1 (en) 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof
EP99920379A EP1080185A4 (en) 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof
JP2000547197A JP2002513558A (en) 1998-05-05 1999-05-05 Myelin basic protein peptide and use thereof
NZ507901A NZ507901A (en) 1998-05-05 1999-05-05 Isolated myelin basic protein (MBP) for treating mutliple sclerosis
NO20005547A NO20005547L (en) 1998-05-05 2000-11-03 Myelin base protein peptides and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7310998A 1998-05-05 1998-05-05
US09/073,109 1998-05-05

Publications (3)

Publication Number Publication Date
WO1999057241A2 WO1999057241A2 (en) 1999-11-11
WO1999057241A3 true WO1999057241A3 (en) 2000-01-13
WO1999057241A9 WO1999057241A9 (en) 2000-02-17

Family

ID=22111789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009930 Ceased WO1999057241A2 (en) 1998-05-05 1999-05-05 Myelin basic protein peptides and uses thereof

Country Status (10)

Country Link
EP (1) EP1080185A4 (en)
JP (1) JP2002513558A (en)
CN (1) CN1308671A (en)
AU (1) AU3789099A (en)
CA (1) CA2330826A1 (en)
HK (1) HK1039636A1 (en)
NO (1) NO20005547L (en)
NZ (1) NZ507901A (en)
WO (1) WO1999057241A2 (en)
ZA (1) ZA200006268B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002254753C1 (en) * 2001-05-01 2008-09-18 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US7265208B2 (en) 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
ITFI20010114A1 (en) * 2001-06-22 2002-12-22 Univ Firenze GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE IN THE DIAGNOSIS OR THERAPEUTIC TREATMENT OF MULTIPLE SCLEROSIS
WO2009066175A1 (en) * 2007-11-20 2009-05-28 Eldrug S.A. Peptide analogues and conjugates thereof
US20180064792A1 (en) * 2015-03-30 2018-03-08 Osaka University Immunizing peptide, method for producing immunizing peptide, pharmaceutical composition for immune disease containing same, and method for treating immune disease
JP7818405B2 (en) * 2019-06-18 2026-02-20 ザ スクリプス リサーチ インスティテュート Methods and compositions for treating inflammatory conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040944A2 (en) * 1995-06-07 1996-12-19 Zymogenetics, Inc. Fused soluble mhc heterodimer:peptide complexes and their uses
US5734023A (en) * 1991-11-19 1998-03-31 Anergen Inc. MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ122697A3 (en) * 1994-10-25 1997-09-17 Immulogic Pharma Corp Preparations and methods of treating disseminated sclerosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5734023A (en) * 1991-11-19 1998-03-31 Anergen Inc. MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses
WO1996040944A2 (en) * 1995-06-07 1996-12-19 Zymogenetics, Inc. Fused soluble mhc heterodimer:peptide complexes and their uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAG B., ET AL.: "FUNCTIONALLY ACTIVE RECOMBINANT ALPHA AND BETA CHAIN-PEPTIDE COMPLEXES OF HUMAN MAJOR HISTOCOMPATIBILITY CLASS II MOLECULES.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 271., no. 17., 26 April 1996 (1996-04-26), US, pages 10413 - 10418., XP002922540, ISSN: 0021-9258, DOI: 10.1074/jbc.271.17.10413 *
See also references of EP1080185A4 *

Also Published As

Publication number Publication date
WO1999057241A2 (en) 1999-11-11
HK1039636A1 (en) 2002-05-03
JP2002513558A (en) 2002-05-14
ZA200006268B (en) 2001-08-22
AU3789099A (en) 1999-11-23
NZ507901A (en) 2003-06-30
WO1999057241A9 (en) 2000-02-17
EP1080185A2 (en) 2001-03-07
CN1308671A (en) 2001-08-15
NO20005547L (en) 2001-01-02
CA2330826A1 (en) 1999-11-11
NO20005547D0 (en) 2000-11-03
EP1080185A4 (en) 2005-01-26

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