WO1999061607A3 - Antisense-oligonukleotide zur behandlung von proliferierenden zellen - Google Patents

Antisense-oligonukleotide zur behandlung von proliferierenden zellen Download PDF

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Publication number
WO1999061607A3
WO1999061607A3 PCT/EP1999/003451 EP9903451W WO9961607A3 WO 1999061607 A3 WO1999061607 A3 WO 1999061607A3 EP 9903451 W EP9903451 W EP 9903451W WO 9961607 A3 WO9961607 A3 WO 9961607A3
Authority
WO
WIPO (PCT)
Prior art keywords
antisense oligonucleotides
proliferating cells
treating proliferating
treating
oligodesoxyribonucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/003451
Other languages
English (en)
French (fr)
Other versions
WO1999061607A2 (de
Inventor
Hans-Dieter Flad
Johannes Gerdes
Andreas Boehle
Irina Deinert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Borstel Leibniz Lungenzentrum FZB
Original Assignee
Forschungszentrum Borstel Zentrum fuer Medizin und Biowissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Borstel Zentrum fuer Medizin und Biowissenschaften filed Critical Forschungszentrum Borstel Zentrum fuer Medizin und Biowissenschaften
Priority to AU43636/99A priority Critical patent/AU4363699A/en
Priority to AT99926337T priority patent/ATE272112T1/de
Priority to EP99926337A priority patent/EP1080192B1/de
Priority to DE59910072T priority patent/DE59910072D1/de
Publication of WO1999061607A2 publication Critical patent/WO1999061607A2/de
Publication of WO1999061607A3 publication Critical patent/WO1999061607A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft Oligoribo- und Oligodesoxyribonukleotide, die sich zur Behandlung von Krankheitszuständen eignen, die mit einer erhöhten Zellproliferation einhergehen. Die Oligoribo- und Oligodesoxyribonukleotide sind dadurch gekennzeichnet, daß sie in der Lage sind, mit der mRNA zu hybridisieren, die für das zellzyclusassoziierte Protein Ki-67 kodiert.
PCT/EP1999/003451 1998-05-22 1999-05-20 Antisense-oligonukleotide zur behandlung von proliferierenden zellen Ceased WO1999061607A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU43636/99A AU4363699A (en) 1998-05-22 1999-05-20 Antisense oligonucleotides for treating proliferating cells
AT99926337T ATE272112T1 (de) 1998-05-22 1999-05-20 Antisense-oligonukleotide zur behandlung von proliferierenden zellen
EP99926337A EP1080192B1 (de) 1998-05-22 1999-05-20 Antisense-oligonukleotide zur behandlung von proliferierenden zellen
DE59910072T DE59910072D1 (de) 1998-05-22 1999-05-20 Antisense-oligonukleotide zur behandlung von proliferierenden zellen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19822954.2 1998-05-22
DE19822954A DE19822954A1 (de) 1998-05-22 1998-05-22 Antisense-Oligonukleotide zur Behandlung von proliferierenden Zellen

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09700906 A-371-Of-International 2001-02-26
US10/739,946 Continuation US20040242519A1 (en) 1998-05-22 2003-12-19 Antisense oligonucleotides for treatment of proliferating cells

Publications (2)

Publication Number Publication Date
WO1999061607A2 WO1999061607A2 (de) 1999-12-02
WO1999061607A3 true WO1999061607A3 (de) 2000-03-23

Family

ID=7868624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003451 Ceased WO1999061607A2 (de) 1998-05-22 1999-05-20 Antisense-oligonukleotide zur behandlung von proliferierenden zellen

Country Status (8)

Country Link
EP (1) EP1080192B1 (de)
AT (1) ATE272112T1 (de)
AU (1) AU4363699A (de)
DE (2) DE19822954A1 (de)
DK (1) DK1080192T3 (de)
ES (1) ES2226393T3 (de)
PT (1) PT1080192E (de)
WO (1) WO1999061607A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19955576B4 (de) 1999-11-18 2008-02-28 Faustus Forschungs Cie. Translational Cancer Research Gmbh Transferverbindungen, ihre Herstellung und ihre Verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAESHIMA, YOHEI ET AL: "Antisense oligonucleotides to proliferating cell nuclear antigen and Ki-6 inhibit human mesangial cell proliferation", J. AM. SOC. NEPHROL. 7(10), 2219-2229, October 1996 (1996-10-01), XP000867392 *
SCHLUETER, C. ET AL: "The cell proliferation-associated antigen of antibody Ki-67: A very large ubiquitous nuclear protein with numerous repeated elements, representing new kind of cell cycle-maintaining proteins", J. CELL BIOL. (1993), 123(3), 513-22, XP000867381 *
UHLMANN E ET AL: "ANTISENSE OLIGONUCLEOTIDES: A NEW THERAPEUTIC PRINCIPLE", CHEMICAL REVIEWS, vol. 90, no. 4, 1990, pages 543-584, XP000141412, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
ES2226393T3 (es) 2005-03-16
DE19822954A1 (de) 1999-11-25
AU4363699A (en) 1999-12-13
EP1080192A2 (de) 2001-03-07
DK1080192T3 (da) 2004-11-29
EP1080192B1 (de) 2004-07-28
DE59910072D1 (de) 2004-09-02
WO1999061607A2 (de) 1999-12-02
ATE272112T1 (de) 2004-08-15
PT1080192E (pt) 2004-11-30

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