WO1999063081A3 - Ion channels - Google Patents

Ion channels Download PDF

Info

Publication number
WO1999063081A3
WO1999063081A3 PCT/GB1999/001743 GB9901743W WO9963081A3 WO 1999063081 A3 WO1999063081 A3 WO 1999063081A3 GB 9901743 W GB9901743 W GB 9901743W WO 9963081 A3 WO9963081 A3 WO 9963081A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
methods
proteins
agents
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/001743
Other languages
French (fr)
Other versions
WO1999063081A2 (en
Inventor
John Nicholas Wood
Steven England
Chih Cheng Chen
Armen Norakovitch Akopian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Priority to AU41567/99A priority Critical patent/AU4156799A/en
Priority to EP99925184A priority patent/EP1082425A2/en
Publication of WO1999063081A2 publication Critical patent/WO1999063081A2/en
Publication of WO1999063081A3 publication Critical patent/WO1999063081A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention provides acid sensitive cation channel proteins which are capable of reversibly mediating (i) a rapid, and (ii) a sustained cation current, particularly the SPASIC protein or variants (e.g. homologues or fragments) thereof. Also provided are nucleic acids encoding these, or which have utility in probing, amplifying or down-regulating these. Methods of providing the proteins and nucleic acids are disclosed, as are vectors, host cells, and organisms utilising them, and antibodies. Also disclosed are methods of influencing the electrophysiological and/or pharmacological properties of a cell (e.g. by way of therapy) based on manipulation of the proteins or nucleic acids, and methods for screening for substances having ion-channel modulating activity (which may be potential analgesics; neuromodulatory agents; anti-inflammatory agents; agents that regulate neurotransmitter release or neuronal excitability).
PCT/GB1999/001743 1998-06-03 1999-06-03 Ion channels Ceased WO1999063081A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU41567/99A AU4156799A (en) 1998-06-03 1999-06-03 Ion channels
EP99925184A EP1082425A2 (en) 1998-06-03 1999-06-03 Ion channels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9811965.4A GB9811965D0 (en) 1998-06-03 1998-06-03 Ion channels
GB9811965.4 1998-06-03

Publications (2)

Publication Number Publication Date
WO1999063081A2 WO1999063081A2 (en) 1999-12-09
WO1999063081A3 true WO1999063081A3 (en) 2000-01-27

Family

ID=10833161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001743 Ceased WO1999063081A2 (en) 1998-06-03 1999-06-03 Ion channels

Country Status (4)

Country Link
EP (1) EP1082425A2 (en)
AU (1) AU4156799A (en)
GB (1) GB9811965D0 (en)
WO (1) WO1999063081A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043514A2 (en) * 1999-01-22 2000-07-27 Millennium Pharmaceuticals, Inc. Human acid sensing ion channel and uses thereof
US6548270B1 (en) 2000-03-03 2003-04-15 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human acid-sensing ion channel BNaC4 (ASIC4)
CA2304494A1 (en) 2000-04-20 2001-10-20 Philippe Seguela A novel heteromultimeric ion channel receptor and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035034A1 (en) * 1997-02-11 1998-08-13 Centre National De La Recherche Scientifique (Cnrs) Mammal neuronal acid sensing cationic channel, cloning and applications thereof
EP0875570A2 (en) * 1997-05-01 1998-11-04 Smithkline Beecham Plc Neurodegenerative polypeptides HHPDZ65

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035034A1 (en) * 1997-02-11 1998-08-13 Centre National De La Recherche Scientifique (Cnrs) Mammal neuronal acid sensing cationic channel, cloning and applications thereof
EP0875570A2 (en) * 1997-05-01 1998-11-04 Smithkline Beecham Plc Neurodegenerative polypeptides HHPDZ65

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAINER WALDMANN ET AL.: "A proton-gated cation channel involved in acid-sensing", NATURE, vol. 386, no. 6621, 13 March 1997 (1997-03-13), LONDON GB, pages 173 - 177, XP002068589 *

Also Published As

Publication number Publication date
WO1999063081A2 (en) 1999-12-09
AU4156799A (en) 1999-12-20
EP1082425A2 (en) 2001-03-14
GB9811965D0 (en) 1998-07-29

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