WO2000000617A3 - Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons - Google Patents

Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons Download PDF

Info

Publication number
WO2000000617A3
WO2000000617A3 PCT/US1999/014311 US9914311W WO0000617A3 WO 2000000617 A3 WO2000000617 A3 WO 2000000617A3 US 9914311 W US9914311 W US 9914311W WO 0000617 A3 WO0000617 A3 WO 0000617A3
Authority
WO
WIPO (PCT)
Prior art keywords
vee
proteins expressed
equine encephalitis
venezuelan equine
virion proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/014311
Other languages
French (fr)
Other versions
WO2000000617A9 (en
WO2000000617A2 (en
Inventor
Mary Katherine Hart
Julie A Wilson
Peter Pushko
Jonathan F Smith
Alan L Schmaljohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Army Medical Research Institute of Infectious Diseases
Original Assignee
US Army Medical Research Institute of Infectious Diseases
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Army Medical Research Institute of Infectious Diseases filed Critical US Army Medical Research Institute of Infectious Diseases
Priority to CA002332494A priority Critical patent/CA2332494A1/en
Priority to DE69942895T priority patent/DE69942895D1/en
Priority to AT99935350T priority patent/ATE486130T1/en
Priority to AU50844/99A priority patent/AU767147B2/en
Priority to AP2001002060A priority patent/AP2001002060A0/en
Priority to EP99935350A priority patent/EP1119627B1/en
Publication of WO2000000617A2 publication Critical patent/WO2000000617A2/en
Publication of WO2000000617A9 publication Critical patent/WO2000000617A9/en
Anticipated expiration legal-status Critical
Publication of WO2000000617A3 publication Critical patent/WO2000000617A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
    • C12N2760/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36161—Methods of inactivation or attenuation
    • C12N2770/36162—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Using the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
PCT/US1999/014311 1998-06-29 1999-06-22 Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons Ceased WO2000000617A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002332494A CA2332494A1 (en) 1998-06-29 1999-06-22 Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons
DE69942895T DE69942895D1 (en) 1998-06-29 1999-06-22 REPLICONS EXPRESSED EBOLA VIRION PROTEINS
AT99935350T ATE486130T1 (en) 1998-06-29 1999-06-22 EBOLA VIRION PROTEINS EXPRESSED BY VENEZUELIAN EQUINE ENCEPHALITIS VIRUS (VEEV) REPLICONS
AU50844/99A AU767147B2 (en) 1998-06-29 1999-06-22 Ebola virion proteins expressed from Venezuelan equine encephalitis (VEE) virus replicons
AP2001002060A AP2001002060A0 (en) 1998-06-29 1999-06-22 Ebola virion proteins expresses from venezuelan equine encephalitis (vee) virus replicons
EP99935350A EP1119627B1 (en) 1998-06-29 1999-06-22 Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9140398P 1998-06-29 1998-06-29
US60/091,403 1998-06-29

Publications (3)

Publication Number Publication Date
WO2000000617A2 WO2000000617A2 (en) 2000-01-06
WO2000000617A9 WO2000000617A9 (en) 2000-08-03
WO2000000617A3 true WO2000000617A3 (en) 2001-05-31

Family

ID=22227592

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1999/014174 Ceased WO2000000616A2 (en) 1998-06-29 1999-06-21 Marburg virus vaccines
PCT/US1999/014311 Ceased WO2000000617A2 (en) 1998-06-29 1999-06-22 Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1999/014174 Ceased WO2000000616A2 (en) 1998-06-29 1999-06-21 Marburg virus vaccines

Country Status (8)

Country Link
US (5) US6517842B1 (en)
EP (2) EP1092031A2 (en)
AP (2) AP2001002060A0 (en)
AT (1) ATE486130T1 (en)
AU (2) AU767551B2 (en)
CA (2) CA2336554A1 (en)
DE (1) DE69942895D1 (en)
WO (2) WO2000000616A2 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7267823B2 (en) * 1998-06-29 2007-09-11 United States Of America As Represented By The Secretary Of The Army Ebola peptides and immunogenic compositions containing same
US7736656B2 (en) 1998-06-29 2010-06-15 The United States Of America As Represented By The Secretary Of The Army Immunogenic compositions and vaccines for Ebola
WO2000000616A2 (en) 1998-06-29 2000-01-06 U.S. Medical Research Institute Of Infectious Diseases Marburg virus vaccines
DE69940157D1 (en) * 1998-07-10 2009-02-05 U S Medical Res Inst Of Infect Anthrax-impfstoff
US6630144B1 (en) 1999-08-30 2003-10-07 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies to Ebola glycoprotein
US6783939B2 (en) * 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
US7731975B2 (en) 2001-01-31 2010-06-08 The United States Of America As Represented By The Secretary Of The Army Chimeric filovirus glycoprotein
WO2003023026A1 (en) * 2001-09-06 2003-03-20 Alphavax, Inc. Alphavirus replicon vector systems
EP1461424B1 (en) * 2001-11-07 2013-01-16 U.S. Army Medical Research Institute of Infectious Diseases; Department of the Army Generation of virus-like particles and demonstration of lipid rafts as sites of filovirus entry and budding
US7682618B2 (en) * 2001-11-07 2010-03-23 The United States Of America As Represented By The Secretary Of The Army Generation of virus-like particles and use as panfilovirus vaccine
US6875433B2 (en) 2002-08-23 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
EP1551981A1 (en) * 2002-10-15 2005-07-13 Phytovation B.V. Expressional enhancers from viruses
US20040208848A1 (en) 2002-12-13 2004-10-21 Smith Jonathan F. Multi-antigenic alphavirus replicon particles and methods
CN1791678A (en) * 2003-03-20 2006-06-21 阿尔法瓦克斯公司 Improved alphavirus replicons and helper constructs
US8372409B2 (en) * 2003-04-09 2013-02-12 University Of Florida Research Foundation, Inc. Dendritic cell binding proteins and uses thereof
US7132398B2 (en) * 2003-05-06 2006-11-07 Dendreon Corporation Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor
DE602004021260D1 (en) * 2003-07-11 2009-07-09 Alphavax Inc CYTOMEGALOVIRUS VACCINES BASED ON ALPHAVIRUS
US7524829B2 (en) 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US7790182B2 (en) 2005-09-21 2010-09-07 The United States Of America As Represented By The Secretary Of The Army Protein vaccines against poxviruses
US7947286B2 (en) 2005-10-07 2011-05-24 Panthera Biopharma Llc Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain
WO2007127290A2 (en) * 2006-04-24 2007-11-08 Protelix, Inc. Method for producing viral vaccine and therapeutic peptide antigens
DK2947149T3 (en) 2007-06-21 2018-06-06 Alphavax Inc ALPHAVIRUS REPLICATION PARTICLES FOR USE IN VACCINATION
EP2217716A4 (en) 2007-11-09 2011-02-09 Salk Inst For Biological Studi USE OF TAM RECEPTOR INHIBITORS AS ANTIMICROBIALS
US8883170B2 (en) 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
US9097713B2 (en) 2009-09-02 2015-08-04 The United States Of America As Represented By The Secretary Of The Army On Behalf Of Usamrmc Monoclonal antibodies against glycoprotein of Ebola sudan boniface virus
EP2560680B1 (en) 2010-04-16 2018-11-28 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Chimpanzee adenoviral vector-based filovirus vaccines
RS63817B1 (en) 2010-07-06 2023-01-31 Glaxosmithkline Biologicals Sa Virion-like delivery particles for self-replicating rna molecules
PL2591114T3 (en) 2010-07-06 2017-08-31 Glaxosmithkline Biologicals Sa Immunisation of large mammals with low doses of rna
HUE026646T2 (en) 2010-07-06 2016-07-28 Glaxosmithkline Biologicals Sa Liposomes with lipids having an advantageous pka-value for rna delivery
HUE047796T2 (en) 2010-07-06 2020-05-28 Glaxosmithkline Biologicals Sa Introduction of RNA to activate multiple immune pathways
US8198429B2 (en) 2010-08-09 2012-06-12 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
PT3970742T (en) 2010-08-31 2022-06-27 Glaxosmithkline Biologicals Sa Pegylated liposomes for delivery of immunogen-encoding rna
JP2013544504A (en) 2010-10-11 2013-12-19 ノバルティス アーゲー Antigen delivery platform
WO2013006838A1 (en) 2011-07-06 2013-01-10 Novartis Ag Immunogenic combination compositions and uses thereof
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
US11414461B2 (en) 2014-06-03 2022-08-16 The Government Of The United States As Represented By The Secretary Of The Army Method and composition for determining specific antibody responses to species of filovirus
MX2017002890A (en) * 2014-09-03 2017-11-13 Bavarian Nordic As Methods and compositions for enhancing immune responses.
HUE065565T2 (en) 2014-09-03 2024-06-28 Bavarian Nordic As Methods and compositions for inducing protective immunity against filovirus infection
WO2016069853A2 (en) * 2014-10-30 2016-05-06 Cepheid Methods of detecting ebola
WO2017015457A1 (en) * 2015-07-21 2017-01-26 Modernatx, Inc. Ebola vaccine
EP3484507A1 (en) 2016-07-15 2019-05-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
US11173204B2 (en) 2017-04-06 2021-11-16 Janssen Vaccines & Prevention B.V. MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen
CN108484758B (en) * 2018-02-11 2020-05-29 浙江大学 anti-Ebola virus VP40 protein monoclonal antibody A2G7 and application thereof
RU2739505C1 (en) * 2020-01-09 2020-12-25 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Recombinant plasmid dna pet21-npve containing nucleoloprotein (np) gene of ebola virus and recombinant protein np-ve, obtained as result of expression of np gene of ebola virus using recombinant plasmid dna pet21-npve and possessing immunogenic and antigenic properties
CN111214663B (en) * 2020-03-06 2022-03-15 中国人民解放军军事科学院军事医学研究院 TMED2 as a therapeutic target for Ebola virus disease
KR20220164518A (en) * 2020-03-26 2022-12-13 시큐리티 매터스 엘티디. Apparatus and method for detection of viruses by XRF
EP4267593A2 (en) * 2020-12-23 2023-11-01 GlaxoSmithKline Biologicals SA Self-amplifying messenger rna

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037616A1 (en) * 1995-05-23 1996-11-28 The University Of North Carolina At Chapel Hill Alphavirus rna replicon systems
WO1999032147A1 (en) * 1997-12-23 1999-07-01 The Regents Of The University Of Michigan Immunization for ebola virus infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340463B1 (en) 1996-08-14 2002-01-22 Vanderbilt University Identification of antigenic peptide sequences
US6200959B1 (en) * 1996-12-04 2001-03-13 Powerject Vaccines Inc. Genetic induction of anti-viral immune response and genetic vaccine for filovirus
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow
WO2000000616A2 (en) 1998-06-29 2000-01-06 U.S. Medical Research Institute Of Infectious Diseases Marburg virus vaccines
US7267823B2 (en) 1998-06-29 2007-09-11 United States Of America As Represented By The Secretary Of The Army Ebola peptides and immunogenic compositions containing same
US6630144B1 (en) 1999-08-30 2003-10-07 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies to Ebola glycoprotein
US6875433B2 (en) 2002-08-23 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037616A1 (en) * 1995-05-23 1996-11-28 The University Of North Carolina At Chapel Hill Alphavirus rna replicon systems
WO1999032147A1 (en) * 1997-12-23 1999-07-01 The Regents Of The University Of Michigan Immunization for ebola virus infection

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A. SANCHEZ ET AL.: "Variation in the glycoprotein and VP35 genes of Marburg virus strains", VIROLOGY, vol. 240, no. 1, 5 January 1998 (1998-01-05), ACADEMIC PRESS, INC.,NEW YORK, US, pages 138 - 146, XP002128208 *
BROWN, F. [EDITOR];BURTON, D. [EDITOR]; DOHERTY, P. [EDITOR]; MEKALANOS, J. [EDITOR]. VACCINES (COLD SPRING HARBOR), (1997) VOL. 97, PP. 253-258. VACCINES (COLD SPRING HARBOR); MOLECULAR APPROACHES TO THE CONTROL OF INFECTIOUS DISEASES. PUBLISHER: CO *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; PUSHKO, PETER (1) ET AL: "Venezuelan equine encephalitis virus replicon vector: Immunogenicity studies with ebola NP and GP genes in guinea pigs.", XP002131517, retrieved from STN Database accession no. V199799764569 *
L. VANDERZANDEN ET AL.: "DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge", VIROLOGY, vol. 246, no. 1, 20 June 1998 (1998-06-20), ACADEMIC PRESS, INC.,NEW YORK, US, pages 134 - 144, XP002131516 *
L. XU ET AL.: "Immunization for Ebola virus infection", NATURE MEDICINE, vol. 4, no. 1, January 1998 (1998-01-01), NATURE PUBLISHING CO., NY, US, pages 37 - 42, XP002131515 *
P. PUSHKO ET AL.: "Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: Expression of heterologous genes in vitro and imunization against heterologous pathogens in vivo", VIROLOGY, vol. 239, 1997, ACADEMIC PRESS, INC.,NEW YORK, US, pages 389 - 401, XP002128209 *
SANCHEZ A ET AL: "SEQUENCE ANALYSIS OF THE EBOLA VIRUS GENOME: ORGANIZATION, GENETIC ELEMENTS, AND COMPARISON WITH THE GENOME OF MARBURG VIRUS", VIRUS RESEARCH,NL,AMSTERDAM, vol. 29, no. 3, pages 215-240, XP000198438, ISSN: 0168-1702 *

Also Published As

Publication number Publication date
WO2000000616A3 (en) 2000-07-06
AP2001002060A0 (en) 2001-03-31
US20060251681A1 (en) 2006-11-09
US6984504B2 (en) 2006-01-10
US20040146859A1 (en) 2004-07-29
WO2000000616A9 (en) 2001-04-12
US20020164582A1 (en) 2002-11-07
US20030152590A1 (en) 2003-08-14
US7455994B2 (en) 2008-11-25
AU5084499A (en) 2000-01-17
US6517842B1 (en) 2003-02-11
CA2332494A1 (en) 2000-01-06
AP1944A (en) 2009-02-02
US7090852B2 (en) 2006-08-15
ATE486130T1 (en) 2010-11-15
DE69942895D1 (en) 2010-12-09
EP1092031A2 (en) 2001-04-18
EP1119627A2 (en) 2001-08-01
CA2336554A1 (en) 2000-01-06
AU767551B2 (en) 2003-11-13
AU767147B2 (en) 2003-10-30
AU4709099A (en) 2000-01-17
WO2000000616A2 (en) 2000-01-06
WO2000000617A9 (en) 2000-08-03
WO2000000617A2 (en) 2000-01-06
EP1119627B1 (en) 2010-10-27

Similar Documents

Publication Publication Date Title
WO2000000617A3 (en) Ebola virion proteins expressed from venezuelan equine encephalitis (vee) virus replicons
WO2005023837A3 (en) Ebola peptides and immunogenic compositions containing same
WO2000002522A3 (en) Anthrax vaccine
AU6497694A (en) Method for selective inactivation of viral replication
ZA956797B (en) Method for preparing influenza virus, antigens obtained and the applications.
TW346398B (en) System and methods for removing viral agents from blood
WO2003028632A3 (en) Development of a preventive vaccine for filovirus infection in primates
AU6766298A (en) Apparatus, method, and system for concentrating adsorbable pollutants and abatement thereof
IL130198A0 (en) Methods for purifying viruses
MXPA03007891A (en) A method and apparatus for forming a laminated sheet material by spattering.
AU2001239279A1 (en) Device and method for performing syntheses, analyses or transport processes
AU2002314790A1 (en) Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
DK149589D0 (en) DNA SEQUENCE, DNA VECTOR, MUTERATED HIV VIRUS THROUGH, HIV VACCINE AND METHOD FOR PRODUCING SAME
CA2402060A1 (en) Slide heater
EG23434A (en) Improved high speed embossing and adhesive printing process.
SG87845A1 (en) Disk drive device, error recovery processing method therefor, and disk drive controller
AU2003232004A1 (en) Chimeric ebola virus envelopes and uses therefor
AU2001270685A1 (en) System and method for controlling air extraction speed, in particular in laboratory hoods
EP1126275A3 (en) Fused-silicia capillaries with photopolymer components
WO2004044182A3 (en) Highly permissive cell lines for hepatitis c virus replication
MXPA03005869A (en) Method and apparatus for reducing adhesive build-up on ultrasonic bonding surfaces.
EP0922771A3 (en) Method for the detection of large concentrations of a virus in blood plasma and/ or blood serum using the polymerase chain reaction
AU2204195A (en) Method for diagnosing chronic hepatitis b virus infection
AU3611900A (en) Stuffed potato, method, and apparatus
AU2002351787A1 (en) Method for concentrating and detecting hiv

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/6-6/6, DRAWINGS, REPLACED BY NEW PAGES 1/6-6/6; PAGES 1-11, SEQUENCE LISTING, REPLACED BY NEW PAGES 1-24; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

ENP Entry into the national phase

Ref document number: 2332494

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1999935350

Country of ref document: EP

Ref document number: 50844/99

Country of ref document: AU

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWP Wipo information: published in national office

Ref document number: 1999935350

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 50844/99

Country of ref document: AU