WO2000004388A3 - System for the quantification of platelet activation - Google Patents

System for the quantification of platelet activation Download PDF

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Publication number
WO2000004388A3
WO2000004388A3 PCT/US1999/014126 US9914126W WO0004388A3 WO 2000004388 A3 WO2000004388 A3 WO 2000004388A3 US 9914126 W US9914126 W US 9914126W WO 0004388 A3 WO0004388 A3 WO 0004388A3
Authority
WO
WIPO (PCT)
Prior art keywords
platelet activation
platelets
quantification
provides
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/014126
Other languages
French (fr)
Other versions
WO2000004388A2 (en
Inventor
David J Schneider
Burton E Sobel
Paula B Tracy
Paul G Held
Paul D Hale
Norman R Alpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lionheart Technologies Inc
Original Assignee
Lionheart Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lionheart Technologies Inc filed Critical Lionheart Technologies Inc
Priority to DE69937146T priority Critical patent/DE69937146T2/en
Priority to EP99933539A priority patent/EP1095280B1/en
Publication of WO2000004388A2 publication Critical patent/WO2000004388A2/en
Publication of WO2000004388A3 publication Critical patent/WO2000004388A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/7056—Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for quantifying platelet activation includes exposing platelets to a physiological concentration of an agonist that activates some of the platelets, resulting in the formation of at least one binding site on the surface of the activated platelets, and measuring the activated platelets. The present invention provides a method of assessing specific components of platelet activation.
PCT/US1999/014126 1998-07-15 1999-07-02 System for the quantification of platelet activation Ceased WO2000004388A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE69937146T DE69937146T2 (en) 1998-07-15 1999-07-02 METHOD FOR QUANTIFYING BLOOD PLATE ACTIVATION
EP99933539A EP1095280B1 (en) 1998-07-15 1999-07-02 System for the quantification of platelet activation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/115,992 1998-07-15
US09/115,992 US6391568B1 (en) 1998-07-15 1998-07-15 Method for determining platelet reactivity in a whole blood sample

Publications (2)

Publication Number Publication Date
WO2000004388A2 WO2000004388A2 (en) 2000-01-27
WO2000004388A3 true WO2000004388A3 (en) 2000-06-29

Family

ID=22364609

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/014126 Ceased WO2000004388A2 (en) 1998-07-15 1999-07-02 System for the quantification of platelet activation

Country Status (5)

Country Link
US (1) US6391568B1 (en)
EP (1) EP1095280B1 (en)
AT (1) ATE373828T1 (en)
DE (1) DE69937146T2 (en)
WO (1) WO2000004388A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221672B1 (en) * 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
GB9901504D0 (en) * 1999-01-22 1999-03-17 Gray Charles R W Accelrrated whole blood clotting time (A.W.B.C.T.)
DE60118362T2 (en) * 2000-05-19 2007-05-24 The Center for Blood Research, Inc., Boston METHOD FOR TREATING HEMOSTATIC INTERFERENCE BY SOLUBLE P-SELECTIN
US6913932B2 (en) * 2002-08-23 2005-07-05 Beckman Coulter, Inc. Formaldehyde-ammonium salt complexes for the stabilization of blood cells
JP2005538383A (en) * 2002-09-10 2005-12-15 プラコア・インコーポレーテッド Method and apparatus for monitoring platelet function
US7071001B2 (en) 2003-01-10 2006-07-04 Dnk Associates, Inc. System and method for in vitro bleeding time testing
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
EP1875232A2 (en) * 2005-04-25 2008-01-09 PlaCor, Inc. Methods and devices for monitoring platelet function
RU2432577C2 (en) * 2005-10-18 2011-10-27 Фудзимори Когио Ко., Лтд. Thrombosis monitor and method of thrombosis monitoring
AU2006305163B2 (en) 2005-10-18 2012-09-27 Fujimori Kogyo Co., Ltd. Apparatus for monitoring thrombus formation and method of monitoring thrombus formation
EP1890155A1 (en) * 2006-08-17 2008-02-20 F. Hoffmann-Roche AG Methods and means for determining platelet function and diagnosing platelet-related and cardiovascular disorders
US20100099130A1 (en) * 2006-10-25 2010-04-22 Placor Inc. Methods and devices for monitoring platelet function
EP2352025B1 (en) * 2008-08-11 2020-07-15 Fujimori Kogyo Co., Ltd. Blood-platelet test method
FR2945126B1 (en) * 2009-04-29 2019-11-01 Commissariat A L'energie Atomique METHOD AND APPARATUS FOR COUNTING THROMBOCYTES
WO2015054662A1 (en) 2013-10-10 2015-04-16 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors
EP3700419A4 (en) * 2017-10-26 2021-11-10 Essenlix Corporation Rapid measurement of platelets
JP2021501321A (en) 2017-10-26 2021-01-14 エッセンリックス コーポレーション Devices and methods for tissue and cell staining
US12235278B2 (en) 2018-08-24 2025-02-25 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for evaluation of antiplatelet drug sensitivity
WO2022136959A1 (en) * 2020-12-21 2022-06-30 Sedicidodici S.R.L. Method for evaluating blood parameters
CN115792222B (en) * 2022-12-29 2025-08-05 北京乐普诊断科技股份有限公司 An immunochromatographic detection kit for platelet P2Y12 receptor inhibition rate, preparation method, and detection method
CN115902203B (en) * 2023-01-03 2025-07-11 北京乐普诊断科技股份有限公司 Immunochromatographic detection kit for platelet GP IIb/IIIa receptor inhibition rate, preparation method and detection method
CN116840485B (en) * 2023-05-18 2025-03-14 河络新图生物科技(上海)有限公司 A detection system, a detection method and a detection kit for detecting platelet function subgroup PAC-1 marker, Annexin-V marker and CD62P marker

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273671A2 (en) * 1986-12-31 1988-07-06 AMERSHAM INTERNATIONAL plc Shutter assembly
WO1991006859A1 (en) * 1989-10-25 1991-05-16 Jaffe Russell M Enzyme assay and assay kit to measure cellular activation
WO1994013307A1 (en) * 1992-12-11 1994-06-23 Steritech, Inc. Platelet activation and function

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2144180A1 (en) * 1992-09-08 1994-03-17 George A. Heavner Peptide inhibitors of cellular adhesion
AU1128195A (en) 1993-10-26 1995-05-22 Mayo Foundation For Medical Education And Research Direct fluorescence-conjugated immunoassay for platelet activation
ATE202942T1 (en) * 1994-04-15 2001-07-15 Cobe Cardiovascular Inc BLOOD COMPATIBLE COATED ITEM

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273671A2 (en) * 1986-12-31 1988-07-06 AMERSHAM INTERNATIONAL plc Shutter assembly
WO1991006859A1 (en) * 1989-10-25 1991-05-16 Jaffe Russell M Enzyme assay and assay kit to measure cellular activation
WO1994013307A1 (en) * 1992-12-11 1994-06-23 Steritech, Inc. Platelet activation and function

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BESSOS H ET AL: "A whole blood assay for platelet HPA1 (PLA1) phenotyping applicable to large-scale screening", BRITISH JOURNAL OF HAEMATOLOGY, vol. 92, no. 1, January 1996 (1996-01-01), pages 221 - 225, XP002122619 *
WEN D ET AL: "A fluorescence-conjugated immunobinding assay for the detection of P-selectin on platelets", THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE, vol. 124, no. 3, September 1994 (1994-09-01), pages 447 - 454, XP002122618 *

Also Published As

Publication number Publication date
DE69937146T2 (en) 2008-08-28
DE69937146D1 (en) 2007-10-31
US6391568B1 (en) 2002-05-21
WO2000004388A2 (en) 2000-01-27
EP1095280A2 (en) 2001-05-02
ATE373828T1 (en) 2007-10-15
EP1095280B1 (en) 2007-09-19

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