WO2000006050A1 - Composition for freshening nostrils and sinus cavities - Google Patents

Composition for freshening nostrils and sinus cavities Download PDF

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Publication number
WO2000006050A1
WO2000006050A1 PCT/US1999/017069 US9917069W WO0006050A1 WO 2000006050 A1 WO2000006050 A1 WO 2000006050A1 US 9917069 W US9917069 W US 9917069W WO 0006050 A1 WO0006050 A1 WO 0006050A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
nostrils
sinus cavities
freshening
further including
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/017069
Other languages
French (fr)
Inventor
Charles A. Fust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU53231/99A priority Critical patent/AU755333B2/en
Priority to KR1020017001176A priority patent/KR20010071043A/en
Priority to BR9912578-1A priority patent/BR9912578A/en
Priority to CA002338806A priority patent/CA2338806A1/en
Priority to EP99938833A priority patent/EP1100407A4/en
Priority to NZ510185A priority patent/NZ510185A/en
Priority to IL14113499A priority patent/IL141134A/en
Priority to JP2000561908A priority patent/JP2002521407A/en
Priority to EA200100185A priority patent/EA200100185A1/en
Publication of WO2000006050A1 publication Critical patent/WO2000006050A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • This invention relates to a composition that is applied to a person's nostrils and sinus cavities, using an inhaler or other suitable means, for freshening and deodorizing the named areas for controlling halitosis.
  • digestive organs can be responsible for objectionable odors that are produced from consuming certain foods or liquids.
  • Mouthwash rinses are used to flush the mouth with bacteria killing agents and, in most cases, with additives of various types designed to freshen the mouth and mask odors.
  • Bacterial elimination is normally accomplished by the use of alcohol and/or various dilutions of saline solution. The use of alcohol in these products often causes
  • Another object of the present invention is to provide a composition which may
  • an inhaler or atomizer - type container which causes no discomfort to the user.
  • a further object of the present invention is to provide an effective means of breath odor control as a substitute or supplement to conventional therapies and which has bom immediate and residual effect.
  • a carrier means such as water or a dilute saline solution
  • an odor masking agent can be an essential oil or flavoring means such as those used in conventional mouthwashes.
  • Other additives may include a small quantity of alcohol for acting on bacteria and an adherent means such as glycerine for mamtaining the composition in place in the nostrils and sinus cavities for a sufficient length of time to produce the desired effect.
  • Other means such as preserving agents may also be employed.
  • the present invention is a liquid composition that is inhaled through the nostrils and into the sinus cavities. It is of particular utility for use by persons who
  • the composition includes a carrier means, which can be water or a mild or dilute saline solution.
  • a carrier means can be water or a mild or dilute saline solution.
  • the saline solution is preferred and provides a mild antibacterial effect. Saline solutions are also commonly used as moisturizers at
  • Control and/or elimination of objectionable odors is accomplished using masking agents such as oil of peppermint, spearmint, etc., or agents having a fruity or citrus essence.
  • masking agents such as oil of peppermint, spearmint, etc., or agents having a fruity or citrus essence.
  • Other agents include, but are not limited to eucalyptol, methyl salicylate, and various other flavoring means.
  • a small quantity of alcohol may be used to provide an antibacterial effect.
  • a further component which may be added is a preserving agent such as benzalkonium
  • chloride which is used to extend shelf life.
  • the use of the preserving agent or agents depends on whether or not some or any of the other components are stable in storage.
  • the delivery method used for the present composition can vary, with spray bottles, droppers, and/or atomizers - type squeeze or pump bottles, all being suitable, among other delivery means.
  • spray bottles, droppers, and/or atomizers - type squeeze or pump bottles all being suitable, among other delivery means.
  • atomizers - type squeeze or pump bottles all being suitable, among other delivery means.
  • atomizer spray bottle proved to be an effective delivery means.
  • Containers of this type are currently used by several pharmaceutical companies for introducing sinus medication into the nostrils and sinus cavities.
  • the atomizer - type bottles reduce the contents of the bottle to a very fine mist, thus making the delivery of the composition minimally intrusive. No discomfort for the user was experienced in testing of the product.
  • no harmful effects on the nostrils or sinus cavities were caused by any of the components of the present composition.
  • the composition effectively eliminated or masked odors associated with smoking and with eating various foods such as onion,
  • Eucalyptol Flavoring Agent also containing antiseptic effect Methyl Salicylate Counterirritant, (Local Analgesic containing flavor similar to Wintergreen) Menthol Counterirritant Alcohol Aids in solubility effect of other ingredients also containing antibacterial effect.
  • the above listed formula has undergone testing and has proved effective for its stated purpose.
  • the composition was dispensed from a one-half (1/2 oz.) pump atomizer bottle and was successful in eliminating and/or masking odors which could be considered offensive in certain circumstances or by certain people, i.e. odors from smoking, consuming onions etc.
  • compositions of my invention are not limited to the ingredients stated in original application or the CIP formulation. Substitution ingredients are widely available for each of the essential components, as described in
  • the first intrinsic ingredients of my invention are the Antiseptic and Anti- Infective agents.
  • the elimination of certain types of bacteria, which are known to cause offensive odors, will aid in the freshening of the breath and are selected and formulated to produce the results as described.
  • the second intrinsic ingredient of my invention is the Aromatic Components which aid in the freshening and deodorizing of the nasal and sinus cavities. These ingredients are selected and formulated to produce the results as described in Claim 6.
  • the third intrinsic ingredient of my invention is the isotonic, aqueous solution acting as an Osmotic Agent. This ingredient is selected and formulated for the

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A composition for freshening nostrils and sinus cavities is disclosed for masking or eliminating objectionable odors in the breath. The composition is typically administered from a squeeze or pump-type bottle or the like and includes a carrier such as saline solution and a masking agent such as oil of peppermint or other flavoring.

Description

COMPOSITION FOR FRESHENING NOSTRILS AND SINUS CAVITIES
FIELD OF INVENTION
This invention relates to a composition that is applied to a person's nostrils and sinus cavities, using an inhaler or other suitable means, for freshening and deodorizing the named areas for controlling halitosis.
BACKGROUND OF THE INVENTION
Conventional control of halitosis or "bad breath", as it is often termed, is presently accomplished through the use of mouthwashes, breath mints, candy, chewing gum. brushing and flossing teeth, and other such means that are taken by mouth. Recent developments in this field have focused on the theory that the
digestive organs can be responsible for objectionable odors that are produced from consuming certain foods or liquids.
Mouthwash rinses are used to flush the mouth with bacteria killing agents and, in most cases, with additives of various types designed to freshen the mouth and mask odors. Bacterial elimination is normally accomplished by the use of alcohol and/or various dilutions of saline solution. The use of alcohol in these products often causes
the intrusive effect experienced by many persons as a burning sensation. Saline solutions are very effective bacteria killing agents and do not cause the burning sensation; however, the taste is not well received by most consumers. While effective in many cases, mouthwashes and other oral means of controlling breath odors can be
supplemented with the composition that is the subject matter of the present invention. SUMMARY OF THE INVENTION
It is, therefore, one of the principal objects of the present invention to freshen breath and eliminate or mask objectionable breath odors by introducing the present invention into the nostrils and therethrough, into the sinus cavities. Another object of the present invention is to provide a composition which may
be conveniently introduced through the nose with, for example, an inhaler or atomizer - type container and which causes no discomfort to the user.
A further object of the present invention is to provide an effective means of breath odor control as a substitute or supplement to conventional therapies and which has bom immediate and residual effect.
These and additional objects are attained by the present invention which, in the broadest sense, comprises a carrier means, such as water or a dilute saline solution, and an odor masking agent. The odor masking agent can be an essential oil or flavoring means such as those used in conventional mouthwashes. Other additives may include a small quantity of alcohol for acting on bacteria and an adherent means such as glycerine for mamtaining the composition in place in the nostrils and sinus cavities for a sufficient length of time to produce the desired effect. Other means such as preserving agents may also be employed.
Various additional objects and advantages of the present invention will become apparent from the following detailed description. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
The present invention is a liquid composition that is inhaled through the nostrils and into the sinus cavities. It is of particular utility for use by persons who
smoke cigarettes, cigars, and the like as the smoke necessarily invades the nostrils and sinus cavities when it is inhaled.
The composition includes a carrier means, which can be water or a mild or dilute saline solution. The saline solution is preferred and provides a mild antibacterial effect. Saline solutions are also commonly used as moisturizers at
present and are safely used in the nasal passages and sinuses. While the concentration may vary between 50% and 75%. a solution of 65% saline has been found to be effective and non-objectionable for the user.
Control and/or elimination of objectionable odors is accomplished using masking agents such as oil of peppermint, spearmint, etc., or agents having a fruity or citrus essence. Other agents include, but are not limited to eucalyptol, methyl salicylate, and various other flavoring means.
A small quantity of alcohol may be used to provide an antibacterial effect.
The alcohol is not necessary but may facilitate mixing of the other components. A further component which may be added is a preserving agent such as benzalkonium
chloride which is used to extend shelf life. The use of the preserving agent or agents depends on whether or not some or any of the other components are stable in storage.
The delivery method used for the present composition can vary, with spray bottles, droppers, and/or atomizers - type squeeze or pump bottles, all being suitable, among other delivery means. Experimentation with a one-half (1/2 oz.) pump
atomizer spray bottle proved to be an effective delivery means. Containers of this type are currently used by several pharmaceutical companies for introducing sinus medication into the nostrils and sinus cavities. The atomizer - type bottles reduce the contents of the bottle to a very fine mist, thus making the delivery of the composition minimally intrusive. No discomfort for the user was experienced in testing of the product. In addition, no harmful effects on the nostrils or sinus cavities were caused by any of the components of the present composition. The composition effectively eliminated or masked odors associated with smoking and with eating various foods such as onion,
garlic and other spices, and certain liquids, particularly alcoholic beverages, coffee, tea, etc.
Example 1
The following formula provides a representative example of a composition prepared according to the present invention.
Sodium Chloride 0.65% Benzalkonium Chloride 0.002%
Thimerosal 0.001%
Eucalyptol 0.03%
Methyl Salicylate 0.02%
Menthol 0.015% Alcohol 0.07%
PEG or Glycerin Trace (Optional)
Sodium Chloride Base ingredient also acting as a moisturizer
Benzalkonium Chloride Preservative
Thimerosal Preservative
Eucalyptol Flavoring Agent, also containing antiseptic effect Methyl Salicylate Counterirritant, (Local Analgesic containing flavor similar to Wintergreen) Menthol Counterirritant Alcohol Aids in solubility effect of other ingredients also containing antibacterial effect.
The above listed formula has undergone testing and has proved effective for its stated purpose. The composition was dispensed from a one-half (1/2 oz.) pump atomizer bottle and was successful in eliminating and/or masking odors which could be considered offensive in certain circumstances or by certain people, i.e. odors from smoking, consuming onions etc.
Based on experiments that have been conducted, the eucalypton, methyl salicylate and menthol can be replaced by other similar acting ingredients to completely change the flavor. The base ingredient, preservative(s) and alcohol percentages will remain relatively constant. The solution of the invention is prepared according to known techniques and excipients, as described in "Remington's
Pharmaceutical Sciences handbook," Hack Publ. Co., N.Y., U.S.A. It should be stated, the compositions of my invention are not limited to the ingredients stated in original application or the CIP formulation. Substitution ingredients are widely available for each of the essential components, as described in
Remington's Pharmaceutical Sciences.
The first intrinsic ingredients of my invention are the Antiseptic and Anti- Infective agents. The elimination of certain types of bacteria, which are known to cause offensive odors, will aid in the freshening of the breath and are selected and formulated to produce the results as described.
The second intrinsic ingredient of my invention is the Aromatic Components which aid in the freshening and deodorizing of the nasal and sinus cavities. These ingredients are selected and formulated to produce the results as described in Claim 6. The third intrinsic ingredient of my invention is the isotonic, aqueous solution acting as an Osmotic Agent. This ingredient is selected and formulated for the
isotonic value and fully disclosed in Remington's Pharmaceutical Sciences, 17th edition. This ingredient is selected and formulated to produce the results further described herein.
Example 2
The following formula provides a second representative example of An Isotonic, Sterile, Aqueous Solution prepared according to the present invention. In this formula, the function of the ingredients is given under "Application".
RANGE INGREDIENT APPLICATION PERCENTAGE
0.1. to 2% Sodium Chloride Osmotic Agent 0.650
0.1 to 5% Sodium Borate Buffering Agent 0.100
0.1 to 9% Alcohol SD Solubilizing Agent 0.090
0.001 to 2% Edetate Disodium Preservative 0.050
0.1 to 3% Glycerin Solubilizing Agent 0.001
0.001 to 5% Polysorbate 80 Surfactant 0.045
0.001 to 5% Poloxamer 407 Antiseptic 0.030
0.001 to 5% Domiphen Bromide Antiseptic 0.030
0.001 to 5% Cetylpyridinium Chloride Anti-Infective 0.040
0.1 to 2% Sorbitol Sweetener 0.002
0.1 to 2% Sodium Saccharin Sweetener 0.002
0.1 to 5% Aromatic Component Masking Agent 0.005
Deionized Water Solvent (Vehicle) < 100%
(w7W%) The examples I have given, both in the parent application and the CIP filing are representative of preferred embodiments. However, the range of my invention should not be limited to these examples in terms of ingredients and administration.
Thus, while an embodiment and various modifications thereof of a composition for freshening nostrils and sinus cavities has been described in detail
herein, various additional changes and modifications may be made without departing from the scope of the present invention.

Claims

I Claim:
1. A composition for freshening sinus cavities comprising a carrier means and a masking agent for concealing or eliminating odors emanating from the sinus cavities.
2. A composition as defined in Claim 1 and further including a preservative.
3. A composition as defined in Claim 1 and further including a counterirritant.
4. A composition as defined in Claim 1 and further including a solubility enhancer.
5. A composition as defined in Claim 1 and further including an antiseptic means.
6. A composition for freshening nostrils and sinus cavities comprising a saline solution as a moisturizing base component, a flavoring agent for masking or eliminating odors from the sinuses or nostrils, a preservative means for enhancing the shelf life of the composition, a counterirritant for facilitating acceptance of the composition by the nostrils and sinuses, and an alcohol for facilitating solubility of the
components.
7. A composition as defined in Claim 1 and further including an anti- infective means.
PCT/US1999/017069 1998-07-28 1999-07-28 Composition for freshening nostrils and sinus cavities Ceased WO2000006050A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU53231/99A AU755333B2 (en) 1998-07-28 1999-07-28 Composition for freshening nostrils and sinus cavities
KR1020017001176A KR20010071043A (en) 1998-07-28 1999-07-28 Composition for Freshening Nostrils and Sinus Cavities
BR9912578-1A BR9912578A (en) 1998-07-28 1999-07-28 Composition to refresh the nostrils and sinuses.
CA002338806A CA2338806A1 (en) 1998-07-28 1999-07-28 Composition for freshening nostrils and sinus cavities
EP99938833A EP1100407A4 (en) 1998-07-28 1999-07-28 COMPOSITION FOR REFRESHING THE NARINES OR SINUSES
NZ510185A NZ510185A (en) 1998-07-28 1999-07-28 Deodourising composition for freshening nasal and sinus cavities by way of a nasal spray delivery device
IL14113499A IL141134A (en) 1998-07-28 1999-07-28 Composition for freshening nostrils and sinus cavities
JP2000561908A JP2002521407A (en) 1998-07-28 1999-07-28 Nose and sinus cooling composition
EA200100185A EA200100185A1 (en) 1998-07-28 1999-07-28 COMPOSITION FOR IMPROVING NONGNESSES AND INFLAMMATORY CAVITY

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12364698A 1998-07-28 1998-07-28
US09/123,646 1998-07-28
US09/152,151 US6083525A (en) 1996-05-10 1998-09-11 Compositions for freshening nostrils and sinus cavities
US09/152,151 1998-09-11

Publications (1)

Publication Number Publication Date
WO2000006050A1 true WO2000006050A1 (en) 2000-02-10

Family

ID=26821754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017069 Ceased WO2000006050A1 (en) 1998-07-28 1999-07-28 Composition for freshening nostrils and sinus cavities

Country Status (13)

Country Link
US (1) US6083525A (en)
EP (1) EP1100407A4 (en)
JP (1) JP2002521407A (en)
KR (1) KR20010071043A (en)
AU (1) AU755333B2 (en)
BR (1) BR9912578A (en)
CA (1) CA2338806A1 (en)
EA (1) EA200100185A1 (en)
IL (1) IL141134A (en)
NZ (1) NZ510185A (en)
TR (1) TR200100356T2 (en)
TW (1) TWI239242B (en)
WO (1) WO2000006050A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003335647A (en) * 2002-05-14 2003-11-25 Lotte Co Ltd Deodorizer, and drink, food and deodorizing composition containing the same
RU2295950C2 (en) * 2000-11-24 2007-03-27 Симрайз Гмбх Унд Ко.Ко Rhinologic agent
WO2020021483A1 (en) * 2018-07-27 2020-01-30 Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii Composition for the treatment of oral cavity inflammations

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* Cited by examiner, † Cited by third party
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US6344210B2 (en) * 1996-05-10 2002-02-05 Charles A. Fust Composition for freshening nostrils and sinus cavities
US20090232748A1 (en) * 2003-11-07 2009-09-17 Viratox, L.L.C. Virucidal activities of cetylpyridinium chloride
US20050100601A1 (en) * 2003-11-07 2005-05-12 Viratox, L.L.C. Virucidal activities of cetylpyridinium chloride
WO2008008494A2 (en) * 2006-07-13 2008-01-17 Accentia Biopharmaceuticals, Inc. Methods and compositions for treating mucosal inflammation
JP2008161188A (en) * 2006-12-07 2008-07-17 Getto Chaya:Kk Functional beverage
WO2008103416A1 (en) * 2007-02-21 2008-08-28 Capps Charles L Synergistic enhancement of calcium propionate
US8524290B2 (en) 2010-10-20 2013-09-03 John E. Kulesza Non-occluding nasal moisturizer and methods of use
US9034401B1 (en) 2014-01-23 2015-05-19 Matrixx Initiatives, Inc. Pharmaceutical compositions comprising plant extracts and methods for reducing duration of a common cold using same

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US5622992A (en) * 1993-04-30 1997-04-22 The Procter & Gamble Company Topical aromatic releasing compositions

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GB1087842A (en) * 1963-05-01 1967-10-18 Leo Ab Nasal decongestive compositions
GB8916625D0 (en) * 1989-07-20 1989-09-06 Bryce Smith Derek Respiratory tract spray preparations
US5478565A (en) * 1990-03-27 1995-12-26 Warner-Lambert Company Treatment of sinus headache
FR2679775B1 (en) * 1991-08-01 1994-11-18 Grimbert Georges MEDICAMENT BASED ON NEUTRALIZED SULFUR DERIVATIVES.
RU2078566C1 (en) * 1994-06-29 1997-05-10 Донецкий медицинский институт им.Горького Method of treatment of patients with chronic suppurative highmoritis
US5785988A (en) * 1996-05-10 1998-07-28 Fust; Charles A. Composition for freshening nostrils and sinus cavities

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US5622992A (en) * 1993-04-30 1997-04-22 The Procter & Gamble Company Topical aromatic releasing compositions

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2295950C2 (en) * 2000-11-24 2007-03-27 Симрайз Гмбх Унд Ко.Ко Rhinologic agent
US7414079B2 (en) 2000-11-24 2008-08-19 Symrise Gmbh & Co. Kg Utilization of rhinologically active substances
JP2003335647A (en) * 2002-05-14 2003-11-25 Lotte Co Ltd Deodorizer, and drink, food and deodorizing composition containing the same
WO2020021483A1 (en) * 2018-07-27 2020-01-30 Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii Composition for the treatment of oral cavity inflammations

Also Published As

Publication number Publication date
CA2338806A1 (en) 2000-02-10
IL141134A0 (en) 2002-02-10
US6083525A (en) 2000-07-04
NZ510185A (en) 2003-05-30
AU5323199A (en) 2000-02-21
EP1100407A1 (en) 2001-05-23
TR200100356T2 (en) 2001-05-21
EA200100185A1 (en) 2001-08-27
JP2002521407A (en) 2002-07-16
BR9912578A (en) 2001-05-02
EP1100407A4 (en) 2004-09-22
KR20010071043A (en) 2001-07-28
TWI239242B (en) 2005-09-11
AU755333B2 (en) 2002-12-12
IL141134A (en) 2004-07-25

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