WO2000006726A3 - Delta-related polypeptides - Google Patents

Delta-related polypeptides Download PDF

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Publication number
WO2000006726A3
WO2000006726A3 PCT/US1999/015710 US9915710W WO0006726A3 WO 2000006726 A3 WO2000006726 A3 WO 2000006726A3 US 9915710 W US9915710 W US 9915710W WO 0006726 A3 WO0006726 A3 WO 0006726A3
Authority
WO
WIPO (PCT)
Prior art keywords
delta
related polypeptides
sequences
polypeptides
abundance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/015710
Other languages
French (fr)
Other versions
WO2000006726A2 (en
Inventor
John R Shutter
Kevin L Stark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to EP99932391A priority Critical patent/EP1100899A2/en
Priority to AU48705/99A priority patent/AU4870599A/en
Priority to JP2000562508A priority patent/JP2002523018A/en
Priority to CA002337492A priority patent/CA2337492A1/en
Publication of WO2000006726A2 publication Critical patent/WO2000006726A2/en
Publication of WO2000006726A3 publication Critical patent/WO2000006726A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Nucleic acid sequences are disclosed which encode polypeptide members of the Delta family of mammalian membrane surface-bound ligands; such sequences can be used, among other things, for chromosome mapping and analysis and to produce the polypeptides in abundance by recombinant expression of the corresponding DNA molecules.
PCT/US1999/015710 1998-07-27 1999-07-12 Delta-related polypeptides Ceased WO2000006726A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99932391A EP1100899A2 (en) 1998-07-27 1999-07-12 Delta-related polypeptides
AU48705/99A AU4870599A (en) 1998-07-27 1999-07-12 Delta-related polypeptides
JP2000562508A JP2002523018A (en) 1998-07-27 1999-07-12 Delta-related polypeptide
CA002337492A CA2337492A1 (en) 1998-07-27 1999-07-12 Delta-related polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12316898A 1998-07-27 1998-07-27
US09/123,168 1998-07-27

Publications (2)

Publication Number Publication Date
WO2000006726A2 WO2000006726A2 (en) 2000-02-10
WO2000006726A3 true WO2000006726A3 (en) 2000-06-15

Family

ID=22407099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015710 Ceased WO2000006726A2 (en) 1998-07-27 1999-07-12 Delta-related polypeptides

Country Status (5)

Country Link
EP (1) EP1100899A2 (en)
JP (1) JP2002523018A (en)
AU (1) AU4870599A (en)
CA (1) CA2337492A1 (en)
WO (1) WO2000006726A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
EP1683865A3 (en) 2001-02-02 2006-10-25 Eli Lilly & Company Mammalian proteins and in particular CD200
JP2005503792A (en) * 2001-08-22 2005-02-10 ガラパゴス・ジェノミックス・ナムローゼ・フェンノートシャップ Bone homeostasis modulator identified in high-throughput screening
US8029984B2 (en) 2003-08-08 2011-10-04 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis and therapy
US7780913B2 (en) 2005-08-26 2010-08-24 Lawrence Livermore National Security, Llc Paint for detection of corrosion and warning of chemical and radiological attack
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
DK2500360T3 (en) 2005-10-31 2015-10-26 Oncomed Pharm Inc Compositions and methods for the diagnosis and treatment of cancer
KR20090027227A (en) 2006-06-06 2009-03-16 제넨테크, 인크. Anti-DL4 Antibody and Method of Use thereof
EA018260B1 (en) 2006-09-29 2013-06-28 Онкомед Фармасьютикалз, Инк. Antibodies to human delta-like ligand 4 (dll4) and use thereof
NO347649B1 (en) 2006-12-14 2024-02-12 Regeneron Pharma Human antibody or antibody fragment that specifically binds human delta-like ligand 4 (hDII4), nucleic acid molecule that codes for such and vector and host-vector systems, as well as method for production, composition and use.
CN103002911B (en) 2008-09-26 2015-08-26 昂考梅德药品有限公司 Frizzled-binding agents and applications thereof
DK2356270T3 (en) 2008-11-07 2016-12-12 Fabrus Llc Combinatorial antibody libraries and uses thereof
ES2700450T3 (en) 2009-10-16 2019-02-15 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
LT3485903T (en) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/dll4 binding agents and uses thereof
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
JP2016510411A (en) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Methods and monitoring of treatment with WNT pathway inhibitors
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2016070051A2 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
CN111234003B (en) * 2020-02-07 2022-02-01 中国人民解放军第四军医大学 Short peptide for cancer targeted therapy, ultrasound response nano drug-loaded microbubble based on short peptide and application of short peptide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001571A1 (en) * 1995-06-28 1997-01-16 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
WO1998045434A1 (en) * 1997-04-04 1998-10-15 Millennium Biotherapeutics, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
WO1998051799A1 (en) * 1997-05-14 1998-11-19 Asahi Kasei Kogyo Kabushiki Kaisha Novel differentiation inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001571A1 (en) * 1995-06-28 1997-01-16 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
WO1998045434A1 (en) * 1997-04-04 1998-10-15 Millennium Biotherapeutics, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
WO1998051799A1 (en) * 1997-05-14 1998-11-19 Asahi Kasei Kogyo Kabushiki Kaisha Novel differentiation inhibitor
AU7236598A (en) * 1997-05-14 1998-12-08 Asahi Kasei Kabushiki Kaisha Novel differentiation-inhibitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002126915, Database accession no. AA427071 *
SALLY L. DUNWOODIE ET AL.: "Mouse DII3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse", DEVELOPMENT, vol. 124, no. 16, 1997, pages 3065 - 3076, XP002126914 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Also Published As

Publication number Publication date
AU4870599A (en) 2000-02-21
JP2002523018A (en) 2002-07-30
CA2337492A1 (en) 2000-02-10
EP1100899A2 (en) 2001-05-23
WO2000006726A2 (en) 2000-02-10

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