WO2000006771A3 - Nucleic acid labeling compounds - Google Patents

Nucleic acid labeling compounds Download PDF

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Publication number
WO2000006771A3
WO2000006771A3 PCT/US1999/012390 US9912390W WO0006771A3 WO 2000006771 A3 WO2000006771 A3 WO 2000006771A3 US 9912390 W US9912390 W US 9912390W WO 0006771 A3 WO0006771 A3 WO 0006771A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
labeling compounds
acid labeling
compounds
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/012390
Other languages
French (fr)
Other versions
WO2000006771A2 (en
WO2000006771A9 (en
Inventor
Glenn H Mcgall
Anthony D Barone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
Original Assignee
Affymetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc filed Critical Affymetrix Inc
Priority to EP99937150A priority Critical patent/EP1124838B1/en
Priority to AU52035/99A priority patent/AU5203599A/en
Priority to JP2000562553A priority patent/JP2002521495A/en
Priority to DE69925624T priority patent/DE69925624T2/en
Priority to AT99937150T priority patent/ATE296833T1/en
Priority to CA002339016A priority patent/CA2339016A1/en
Publication of WO2000006771A2 publication Critical patent/WO2000006771A2/en
Anticipated expiration legal-status Critical
Publication of WO2000006771A3 publication Critical patent/WO2000006771A3/en
Publication of WO2000006771A9 publication Critical patent/WO2000006771A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
PCT/US1999/012390 1998-07-31 1999-07-20 Nucleic acid labeling compounds Ceased WO2000006771A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP99937150A EP1124838B1 (en) 1998-07-31 1999-07-20 Nucleic acid labeling compounds
AU52035/99A AU5203599A (en) 1998-07-31 1999-07-20 Nucleic acid labeling compounds
JP2000562553A JP2002521495A (en) 1998-07-31 1999-07-20 Nucleic acid labeling compound
DE69925624T DE69925624T2 (en) 1998-07-31 1999-07-20 Nucleic Acid MARKING CONNECTIONS
AT99937150T ATE296833T1 (en) 1998-07-31 1999-07-20 NUCLEIC ACID MARKING COMPOUNDS
CA002339016A CA2339016A1 (en) 1998-07-31 1999-07-20 Nucleic acid labeling compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/126,645 1998-07-31
US09/126,645 US20010018514A1 (en) 1998-07-31 1998-07-31 Nucleic acid labeling compounds

Publications (3)

Publication Number Publication Date
WO2000006771A2 WO2000006771A2 (en) 2000-02-10
WO2000006771A3 true WO2000006771A3 (en) 2001-06-21
WO2000006771A9 WO2000006771A9 (en) 2002-08-22

Family

ID=22425958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012390 Ceased WO2000006771A2 (en) 1998-07-31 1999-07-20 Nucleic acid labeling compounds

Country Status (8)

Country Link
US (5) US20010018514A1 (en)
EP (2) EP1124838B1 (en)
JP (2) JP2002521495A (en)
AT (1) ATE296833T1 (en)
AU (1) AU5203599A (en)
CA (1) CA2339016A1 (en)
DE (1) DE69925624T2 (en)
WO (1) WO2000006771A2 (en)

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