WO2000008145A3 - Novel genes in control of hematopoiesis - Google Patents

Novel genes in control of hematopoiesis Download PDF

Info

Publication number
WO2000008145A3
WO2000008145A3 PCT/EP1999/005566 EP9905566W WO0008145A3 WO 2000008145 A3 WO2000008145 A3 WO 2000008145A3 EP 9905566 W EP9905566 W EP 9905566W WO 0008145 A3 WO0008145 A3 WO 0008145A3
Authority
WO
WIPO (PCT)
Prior art keywords
scm
hematopoiesis
control
novel genes
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/005566
Other languages
French (fr)
Other versions
WO2000008145A2 (en
Inventor
Michael Paul Cooke
Claire Louise Holness
Oksana Ivanivna Sirenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Priority to EP99944319A priority Critical patent/EP1100914A2/en
Priority to AU57300/99A priority patent/AU5730099A/en
Priority to JP2000563772A priority patent/JP2002524040A/en
Priority to CA002337904A priority patent/CA2337904A1/en
Publication of WO2000008145A2 publication Critical patent/WO2000008145A2/en
Publication of WO2000008145A3 publication Critical patent/WO2000008145A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides three novel HSC genes designated SCM 3, SCM 26 and SCM 113, the coding regions thereof, the gene products, applications of said genes, DNA constructs, vectors and transformed cells each comprising the gene or a fragment thereof. Methods of using the SCM 3, SCM 26 and SCM 113 polynucleotide and polypeptide sequences are also disclosed.
PCT/EP1999/005566 1998-08-03 1999-08-02 Novel genes in control of hematopoiesis Ceased WO2000008145A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99944319A EP1100914A2 (en) 1998-08-03 1999-08-02 Novel genes in control of hematopoiesis
AU57300/99A AU5730099A (en) 1998-08-03 1999-08-02 Novel genes in control of hematopoiesis
JP2000563772A JP2002524040A (en) 1998-08-03 1999-08-02 Novel genes in the control of hematopoiesis
CA002337904A CA2337904A1 (en) 1998-08-03 1999-08-02 Novel genes in control of hematopoiesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12831098A 1998-08-03 1998-08-03
US09/128,310 1998-08-03

Publications (2)

Publication Number Publication Date
WO2000008145A2 WO2000008145A2 (en) 2000-02-17
WO2000008145A3 true WO2000008145A3 (en) 2000-06-29

Family

ID=22434708

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005566 Ceased WO2000008145A2 (en) 1998-08-03 1999-08-02 Novel genes in control of hematopoiesis

Country Status (5)

Country Link
EP (1) EP1100914A2 (en)
JP (1) JP2002524040A (en)
AU (1) AU5730099A (en)
CA (1) CA2337904A1 (en)
WO (1) WO2000008145A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030068623A1 (en) 1997-06-16 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
US7264801B2 (en) 1998-08-11 2007-09-04 Genentech, Inc. EG-VEGF nucleic acids and polypeptides and method of use
US20030003507A1 (en) 1999-06-02 2003-01-02 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JP2004522402A (en) * 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド Secreted and transmembrane polypeptides and nucleic acids encoding the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012306A1 (en) * 1996-09-23 1998-03-26 Ontogeny, Inc. Hematopoietic stem cells and methods for generating such cells
WO1998039448A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
WO1998042741A2 (en) * 1997-03-25 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998045436A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012306A1 (en) * 1996-09-23 1998-03-26 Ontogeny, Inc. Hematopoietic stem cells and methods for generating such cells
WO1998039448A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
WO1998042741A2 (en) * 1997-03-25 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998045436A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST29 E.M.B.L. Databases; 15 December 1996 (1996-12-15), HILLIER L ET AL: "Homo sapiens cDNA clone 491654 5'", XP002130036 *

Also Published As

Publication number Publication date
JP2002524040A (en) 2002-08-06
EP1100914A2 (en) 2001-05-23
WO2000008145A2 (en) 2000-02-17
AU5730099A (en) 2000-02-28
CA2337904A1 (en) 2000-02-17

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