WO2000008146A3 - Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika - Google Patents

Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika Download PDF

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Publication number
WO2000008146A3
WO2000008146A3 PCT/EP1999/005983 EP9905983W WO0008146A3 WO 2000008146 A3 WO2000008146 A3 WO 2000008146A3 EP 9905983 W EP9905983 W EP 9905983W WO 0008146 A3 WO0008146 A3 WO 0008146A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
potassium channel
development
novel
dependent potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/005983
Other languages
English (en)
French (fr)
Other versions
WO2000008146A2 (de
Inventor
Rainer Netzer
Olaf Pongs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FORSCHUNGSGESELLSCHAFT GENION MBH
FORSCHUNGSGESELLSCHAFT GENION
Original Assignee
FORSCHUNGSGESELLSCHAFT GENION MBH
FORSCHUNGSGESELLSCHAFT GENION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FORSCHUNGSGESELLSCHAFT GENION MBH, FORSCHUNGSGESELLSCHAFT GENION filed Critical FORSCHUNGSGESELLSCHAFT GENION MBH
Priority to EP99941625A priority Critical patent/EP1102847B1/de
Priority to DE59914878T priority patent/DE59914878D1/de
Priority to US09/762,278 priority patent/US6984501B1/en
Publication of WO2000008146A2 publication Critical patent/WO2000008146A2/de
Publication of WO2000008146A3 publication Critical patent/WO2000008146A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Thermistors And Varistors (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Gegenstand der Erfindung ist ein neues spannungsabhängiges Kaliumkanalprotein, Kv6.2 (SEQ ID NO: 1). Das Kv6.2 Gen wird präferentiell im Myocard und im Hippocampus exprimiert. In Verbindung mit der Untereinheit Kv2.1 werden neuartige funktionelle heteromultimere Kaliumkanäle ausgebildet, die eine hohe Affinität zu Propafenon besitzen. Erfindungsgemäß werden diese neuartigen Kaliumkanäle für Testsysteme verwendet, die geeignet sind, Stoffe zu identifizieren, die Kv2.1/Kv6.2 Kanäle modulieren, öffnen bzw. schließen können und die damit als Therapeutika eingesetzt werden können.
PCT/EP1999/005983 1998-08-06 1999-08-06 Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika Ceased WO2000008146A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99941625A EP1102847B1 (de) 1998-08-06 1999-08-06 Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika
DE59914878T DE59914878D1 (de) 1998-08-06 1999-08-06 Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika
US09/762,278 US6984501B1 (en) 1998-08-06 1999-08-06 Voltage-gated potassium channel and its use for development of therapeutics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19841413.7 1998-08-06
DE19841413A DE19841413C1 (de) 1998-08-06 1998-08-06 Neuer spannungsabhängiger Kaliumkanal und seine Verwendung zur Entwicklung von Therpeutika

Publications (2)

Publication Number Publication Date
WO2000008146A2 WO2000008146A2 (de) 2000-02-17
WO2000008146A3 true WO2000008146A3 (de) 2000-05-11

Family

ID=7880519

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005983 Ceased WO2000008146A2 (de) 1998-08-06 1999-08-06 Neuer spannungsabhängiger kaliumkanal und seine verwendung zur entwicklung von therapeutika

Country Status (5)

Country Link
US (1) US6984501B1 (de)
EP (2) EP1944370A1 (de)
AT (1) ATE409746T1 (de)
DE (2) DE19841413C1 (de)
WO (1) WO2000008146A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415816A (en) 1986-01-28 1995-05-16 Q2100, Inc. Method for the production of plastic lenses
JP2005502307A (ja) * 2000-12-20 2005-01-27 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトイオンチャンネルタンパクおよびそれをコードするポリヌクレオチド
WO2009120082A2 (en) * 2008-03-27 2009-10-01 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for influencing electrical activity of cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003415A1 (en) * 1994-07-28 1996-02-08 Human Genome Sciences, Inc. Human potassium channel 1 and 2 proteins
US5710019A (en) * 1995-06-05 1998-01-20 Human Genome Sciences, Inc. Human potassium channel 1 and 2 proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Shab-like voltage-gated potassium channel cKv6.2", TREMBL DATABASE ENTRY O73606, ACCESSION NUMBER O73606, 1 August 1998 (1998-08-01), XP002129598 *
PEALE F. V. ET AL: "Gallus gallus shab-like voltage-gated potassium channel cKv6.2 mRNA, complete cds", EMBL DATABASE ENTRY U62139, ACCESSION NUMBER U62139, 23 March 1998 (1998-03-23), XP002129599 *
ZHU X.-R.: "Structural and functional characterization of Kv6.2, a new gamma-subunit of voltage-gated potassium channel", RECEPTORS AND CHANNELS, vol. 6, 1999, Malaysia, pages 337- - 350, XP000874502 *

Also Published As

Publication number Publication date
ATE409746T1 (de) 2008-10-15
DE19841413C1 (de) 1999-09-23
WO2000008146A2 (de) 2000-02-17
EP1102847B1 (de) 2008-10-01
EP1102847A2 (de) 2001-05-30
US6984501B1 (en) 2006-01-10
DE59914878D1 (de) 2008-11-13
EP1944370A1 (de) 2008-07-16

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