WO2000018226A3 - Apparatus and method for maintaining and/or restoring viability of organs - Google Patents

Apparatus and method for maintaining and/or restoring viability of organs Download PDF

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Publication number
WO2000018226A3
WO2000018226A3 PCT/US1999/022582 US9922582W WO0018226A3 WO 2000018226 A3 WO2000018226 A3 WO 2000018226A3 US 9922582 W US9922582 W US 9922582W WO 0018226 A3 WO0018226 A3 WO 0018226A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
perfusion
mode
medical fluid
viability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/022582
Other languages
French (fr)
Other versions
WO2000018226A2 (en
Inventor
Donald R Owen
David C Kravitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Science Holdings Inc
Original Assignee
Life Science Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Science Holdings Inc filed Critical Life Science Holdings Inc
Priority to DE69941362T priority Critical patent/DE69941362D1/en
Priority to AU62748/99A priority patent/AU6274899A/en
Priority to JP2000571754A priority patent/JP2002525290A/en
Priority to CA002342944A priority patent/CA2342944A1/en
Priority to EP99949991A priority patent/EP1117293B1/en
Publication of WO2000018226A2 publication Critical patent/WO2000018226A2/en
Publication of WO2000018226A3 publication Critical patent/WO2000018226A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/148—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving with provisions specially adapted for transporting
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

An organ perfusion apparatus and method for monitoring, sustaining and/or restoring the viability of the organ and for preserving the organ for storage and/or transport perfuse the organ at normothermic temperatures (normothermic perfusion mode), preferably prior to and followed by organ perfusion at hypothermic temperatures (hypothermic perfusion mode) for transport and/or storage of the organ. The restoring of organ viability is accomplished by restoring high energy nucleotide (e.g., ATP) levels in the organ, which were reduced by warm ischemia time, by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the normothermic perfusion mode, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir which may be used in combination with a stepping motor/cam valve which provides for perfusion pressure fine tuning, preventing overpressurization and providing emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution augmented with antioxidants, intermittently or at a slow continuous flow rate. The medical fluid may be fed into the organ by gravity from an intermediary tank which has alow pressure head so overpressurization of the organ is avoided. In either mode, preventing overpressurization prevents and/or reduces damage to the vascular endothelial lining and to the organ tissue in general. Also, viability of the organ may be automatically monitored in either mode, preferably by monitoring fluid characteristics of the medical fluid that has been perfused through the organ, such fluid characteristics being indicative of organ viability. The perfusion process can be automatically controlled using a control program.
PCT/US1999/022582 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs Ceased WO2000018226A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69941362T DE69941362D1 (en) 1998-09-29 1999-09-29 DEVICE AND METHOD FOR MAINTAINING AND / OR RESTORING THE VITABILITY OF ORGANS
AU62748/99A AU6274899A (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
JP2000571754A JP2002525290A (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and / or restoring organ viability
CA002342944A CA2342944A1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
EP99949991A EP1117293B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16212898A 1998-09-29 1998-09-29
US09/162,128 1998-09-29

Publications (2)

Publication Number Publication Date
WO2000018226A2 WO2000018226A2 (en) 2000-04-06
WO2000018226A3 true WO2000018226A3 (en) 2000-05-25

Family

ID=22584276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022582 Ceased WO2000018226A2 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs

Country Status (8)

Country Link
EP (4) EP1117293B1 (en)
JP (1) JP2002525290A (en)
CN (1) CN1320014A (en)
AU (1) AU6274899A (en)
CA (1) CA2342944A1 (en)
DE (1) DE69941362D1 (en)
TW (1) TW442306B (en)
WO (1) WO2000018226A2 (en)

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USD531320S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Cassette for organ transporter
USD531319S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Tube frame for organ transporter
US8962303B2 (en) 1998-09-29 2015-02-24 Lifeline Scientific, Inc. Apparatus and method for maintaining and/or restoring viability of organs
US12610943B2 (en) 2025-06-24 2026-04-28 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation

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US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
DE60314154T2 (en) 2002-08-23 2008-01-24 Organ Recovery Systems, Des Plaines CONNECTION ARRANGEMENTS, ESPECIALLY FOR TRANSPLANT ORGANS
US8741555B2 (en) 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
IL273422B (en) 2004-10-07 2022-07-01 Transmedics Inc Systems and methods for ex vivo organ care
NL1028848C2 (en) * 2005-04-22 2006-10-24 Doorzand Airdrive B V Device for transporting an organ.
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
US8173414B2 (en) * 2007-02-08 2012-05-08 Jerome E Brisson Sulfide perfusion apparatus
JP5704818B2 (en) * 2007-03-01 2015-04-22 ライフライン サイエンティフィック インコーポレイテッド Perfusion regulation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8771930B2 (en) 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
FR2919785B1 (en) * 2007-08-09 2017-10-20 Hemarina Sa USE OF AN EXTRACELLULAR GLOBIN, EXTRACELLULAR GLOBIN OR EXTRACELLOUS PROTOMER FOR THE PRESERVATION OF ORGANS, TISSUES, OR CELLS OF ORGANS OR TISSUES, OR THE CULTURE OF CELLS
US9814230B2 (en) 2008-01-31 2017-11-14 Transmedics, Inc. Systems and methods for ex vivo lung care
WO2011038251A1 (en) 2009-09-25 2011-03-31 Board Of Regents, The University Of Texas System Fluidics based pulsatile perfusion preservation device and method
US12082575B2 (en) 2010-09-01 2024-09-10 Organ Transport Pty Ltd Perfusion solution
AU2011295629B2 (en) 2010-09-01 2014-05-01 Organ Transport Pty Ltd Perfusion composition
EP2685814B1 (en) 2011-03-15 2016-08-17 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US12279610B2 (en) 2011-03-15 2025-04-22 Paragonix Technonogies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US12096765B1 (en) 2011-03-15 2024-09-24 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
WO2012142487A1 (en) 2011-04-14 2012-10-18 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US20140017666A1 (en) * 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
JP2017508984A (en) 2014-01-20 2017-03-30 ブルックス オートメーション インコーポレイテッド Portable low temperature workstation
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BR112016021971B1 (en) * 2014-03-26 2022-05-17 Tevosol, Inc. PORTABLE SYSTEM FOR PERFUSIONING EXCITED DONOR HEARTS
CA3185937A1 (en) 2014-06-02 2015-12-10 Transmedics, Inc. Ex vivo organ care system
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USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
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AU2015361996B2 (en) 2014-12-12 2019-09-26 Transmedics, Inc. Apparatus and method for organ perfusion
DK3824731T3 (en) 2015-09-09 2025-05-26 Transmedics Inc AORTIC CANNULATION FOR EX VIVO ORGAN CARE SYSTEM
EP3249039A1 (en) * 2016-05-25 2017-11-29 Université Catholique De Louvain Perfusion-bioreactor and method for processing vascularized composite tissue
EP4238417A3 (en) 2016-05-30 2023-12-06 Tevosol, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
CN106508890A (en) * 2016-10-28 2017-03-22 中山大学附属第医院 Multi-organ preservation device
US12329149B2 (en) 2017-04-04 2025-06-17 University Health Network Apparatus and methods for irradiating organ perfusates
EP3606564A4 (en) * 2017-04-04 2021-04-14 University Health Network APPARATUS AND METHODS FOR EXPOSING ORGAN PERFUSATES TO RADIATION
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
US20210400952A1 (en) 2017-06-07 2021-12-30 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CN113677201B (en) * 2019-04-12 2023-09-26 乌格勒克科学有限公司 Methods and devices for repairing kidneys
US20220183272A1 (en) * 2019-04-12 2022-06-16 Uglx Research Ab Method and apparatus for reconditioning organs
EP3982725A4 (en) 2019-06-11 2023-07-19 Paragonix Technologies Inc. ORGAN TRANSPORT VESSEL WITH ANTIVIRAL THERAPY
JP2021011451A (en) * 2019-07-08 2021-02-04 株式会社Ｓｃｒｅｅｎホールディングス Perfusion device
AU2020330309A1 (en) * 2019-08-15 2022-03-24 Iishield Pty Ltd An insulating medical device for protecting a graft for transplant
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
EP4106521A1 (en) * 2020-02-20 2022-12-28 DEKA Products Limited Partnership System and method for organ maintenance and transport
US11974568B2 (en) * 2020-03-20 2024-05-07 The Cleveland Clinic Foundation Portable, ex vivo, normothermic limb perfusion machine
CN111937861B (en) * 2020-08-17 2021-10-26 南昌大学第二附属医院 Sevoflurane ischemia reperfusion device and using method
JP2022144379A (en) * 2021-03-19 2022-10-03 株式会社Ｓｃｒｅｅｎホールディングス Organ preservation container
CN113396898B (en) 2021-08-02 2021-11-09 中山大学附属第一医院 Organ perfusion device and method without interrupting blood flow
CN114600872A (en) 2022-04-13 2022-06-10 西安北光医学生物技术有限公司 Method and system for anti-damage preservation of cells, tissues or organs
USD1031028S1 (en) 2022-09-08 2024-06-11 Paragonix Technologies, Inc. Tissue suspension adaptor
US12485064B2 (en) 2023-08-25 2025-12-02 Paragonix Technologies, Inc. Systems and methods for measuring oxygen concentration for lung preservation
US20250248390A1 (en) 2024-02-02 2025-08-07 Paragonix Technologies, Inc. System for perfusion of an organ
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962303B2 (en) 1998-09-29 2015-02-24 Lifeline Scientific, Inc. Apparatus and method for maintaining and/or restoring viability of organs
USD531320S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Cassette for organ transporter
USD531319S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Tube frame for organ transporter
US12610943B2 (en) 2025-06-24 2026-04-28 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation

Also Published As

Publication number Publication date
EP1929863A1 (en) 2008-06-11
EP2308295A3 (en) 2011-05-25
EP2308296A2 (en) 2011-04-13
WO2000018226A2 (en) 2000-04-06
EP2308296A3 (en) 2011-08-24
EP1117293B1 (en) 2009-09-02
EP2308295A2 (en) 2011-04-13
EP1929863B1 (en) 2016-11-09
DE69941362D1 (en) 2009-10-15
AU6274899A (en) 2000-04-17
TW442306B (en) 2001-06-23
CA2342944A1 (en) 2000-04-06
CN1320014A (en) 2001-10-31
EP1117293A2 (en) 2001-07-25
JP2002525290A (en) 2002-08-13

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