WO2000029583A3 - Immunoglobulin superfamily proteins - Google Patents

Immunoglobulin superfamily proteins Download PDF

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Publication number
WO2000029583A3
WO2000029583A3 PCT/US1999/027566 US9927566W WO0029583A3 WO 2000029583 A3 WO2000029583 A3 WO 2000029583A3 US 9927566 W US9927566 W US 9927566W WO 0029583 A3 WO0029583 A3 WO 0029583A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunoglobulin superfamily
igfam
superfamily proteins
provides
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/027566
Other languages
French (fr)
Other versions
WO2000029583A2 (en
Inventor
Henry Yue
Y Tom Tang
Neil C Corley
Karl J Guegler
Gina A Gorgone
Mariah R Baughn
Dyung Aina M Lu
Preeti Lal
Jennifer L Hillman
Junming Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Priority to JP2000582566A priority Critical patent/JP2002530080A/en
Priority to AU16310/00A priority patent/AU1631000A/en
Priority to CA002351313A priority patent/CA2351313A1/en
Priority to EP99959059A priority patent/EP1131428A2/en
Publication of WO2000029583A2 publication Critical patent/WO2000029583A2/en
Publication of WO2000029583A3 publication Critical patent/WO2000029583A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/02—Immunomodulators
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    • A61P37/08—Antiallergic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

The invention provides human immunoglobulin superfamily proteins (IGFAM) and polynucleotides which identify and encode IGFAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of IGFAM.
PCT/US1999/027566 1998-11-19 1999-11-19 Immunoglobulin superfamily proteins Ceased WO2000029583A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000582566A JP2002530080A (en) 1998-11-19 1999-11-19 Immunoglobulin / Superfamily / Protein
AU16310/00A AU1631000A (en) 1998-11-19 1999-11-19 Immunoglobulin superfamily proteins
CA002351313A CA2351313A1 (en) 1998-12-22 1999-11-19 Immunoglobulin superfamily proteins
EP99959059A EP1131428A2 (en) 1998-11-19 1999-11-19 Immunoglobulin superfamily proteins

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19585398A 1998-11-19 1998-11-19
US11363598P 1998-12-22 1998-12-22
US60/113,635 1998-12-22
US12819499P 1999-04-07 1999-04-07
US60/128,194 1999-04-07

Publications (2)

Publication Number Publication Date
WO2000029583A2 WO2000029583A2 (en) 2000-05-25
WO2000029583A3 true WO2000029583A3 (en) 2000-09-08

Family

ID=27381363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027566 Ceased WO2000029583A2 (en) 1998-11-19 1999-11-19 Immunoglobulin superfamily proteins

Country Status (4)

Country Link
EP (1) EP1131428A2 (en)
JP (1) JP2002530080A (en)
AU (1) AU1631000A (en)
WO (1) WO2000029583A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410708B1 (en) 1997-11-21 2002-06-25 Genentech, Inc. Nucleic acids encoding A-33 related antigen polypeptides
US7282565B2 (en) 1998-03-20 2007-10-16 Genentech, Inc. PRO362 polypeptides
US7192589B2 (en) 1998-09-16 2007-03-20 Genentech, Inc. Treatment of inflammatory disorders with STIgMA immunoadhesins
US7419663B2 (en) 1998-03-20 2008-09-02 Genentech, Inc. Treatment of complement-associated disorders
US8088386B2 (en) 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
US7198917B2 (en) 1997-11-21 2007-04-03 Genentech, Inc. Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
US8007798B2 (en) 1997-11-21 2011-08-30 Genentech, Inc. Treatment of complement-associated disorders
IL142794A0 (en) * 1998-12-16 2002-03-10 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2003533968A (en) * 1999-09-03 2003-11-18 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド Immunoglobulin superfamily polynucleotides, polypeptides, and antibodies
CA2402729A1 (en) * 2000-03-15 2001-09-20 Incyte Genomics, Inc. Human immune response proteins
NZ523477A (en) * 2000-06-23 2004-11-26 Biogen Idec Inc GP286 nucleic acids and polypeptides
WO2002006315A2 (en) * 2000-07-18 2002-01-24 Compugen Ltd. Novel nucleic acid and amino acid sequences
JP2004535759A (en) * 2000-11-16 2004-12-02 インサイト・ゲノミックス・インコーポレイテッド Immunoglobulin superfamily proteins
CA2440618A1 (en) * 2001-03-12 2002-09-19 Incyte Genomics, Inc. Immunoglobulin superfamily proteins
AU2002315404A1 (en) * 2001-07-16 2003-03-03 Eli Lilly And Company Extracellular junctional adhesion molecules
US7179606B2 (en) * 2001-11-23 2007-02-20 Syn X Pharma, Inc. IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
EP1631315B1 (en) 2003-09-24 2014-07-30 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
WO2006078766A2 (en) * 2005-01-19 2006-07-27 University Of Connecticut Methods and compositions for metastatic tumor screening
US20100168382A1 (en) * 2007-06-12 2010-07-01 Vladimir Berezin Neuroplastin derived peptides
HRP20161580T1 (en) 2008-05-06 2016-12-30 Genentech, Inc. AFFINITY MATURED CRIg VARIANTS

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0737747A2 (en) * 1995-04-11 1996-10-16 Behringwerke Ag Cytoplasmatic expression in E. coli of antibodies, antibody fragments and fusions thereof
WO1997008320A1 (en) * 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
WO1997023613A2 (en) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Cell activation process and reagents therefor
WO1997042329A1 (en) * 1996-05-04 1997-11-13 Zeneca Limited Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system
WO1997049809A1 (en) * 1996-06-24 1997-12-31 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Polypeptides capable of forming antigen binding structures with specificity for the rhesus d antigens, the dna encoding them and the process for their preparation and use
WO1998002462A1 (en) * 1996-07-16 1998-01-22 Morphosys Gesellschaft Für Proteinoptimierung Mbh Immunoglobulin superfamily domains and fragments with increased solubility
WO1998011241A1 (en) * 1996-09-16 1998-03-19 Merck Patent Gmbh Oligocistronic expression system for the production of heteromeric proteins

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0737747A2 (en) * 1995-04-11 1996-10-16 Behringwerke Ag Cytoplasmatic expression in E. coli of antibodies, antibody fragments and fusions thereof
WO1997008320A1 (en) * 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
WO1997023613A2 (en) * 1995-12-21 1997-07-03 Celltech Therapeutics Ltd. Cell activation process and reagents therefor
WO1997042329A1 (en) * 1996-05-04 1997-11-13 Zeneca Limited Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system
WO1997049809A1 (en) * 1996-06-24 1997-12-31 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Polypeptides capable of forming antigen binding structures with specificity for the rhesus d antigens, the dna encoding them and the process for their preparation and use
WO1998002462A1 (en) * 1996-07-16 1998-01-22 Morphosys Gesellschaft Für Proteinoptimierung Mbh Immunoglobulin superfamily domains and fragments with increased solubility
WO1998011241A1 (en) * 1996-09-16 1998-03-19 Merck Patent Gmbh Oligocistronic expression system for the production of heteromeric proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLONNA M ET AL: "CLONING OF IMMUNOGLOBULIN-SUPERFAMILY MEMBERS ASSOCIATED WITH HLA-CAND HLA-B RECOGNITION BY HUMAN NATURAL KILLER CELLS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 268, 21 April 1995 (1995-04-21), pages 405 - 408, XP002067321, ISSN: 0036-8075 *
DATABASE GENBANK 8 January 1998 (1998-01-08), PATERSON T.: ". sapiens mRNA for immunoglobulin kappa light chain", XP002132529 *
LI S ET AL: "A COMPUTER SCREENING APPROACH TO IMMUNOGLOBULIN SUPERFAMILY STRUCTURES AND INTERACTIONS: DISCOVERY OF SMALL NON-PEPTIDIC CD4 INHIBITORS AS NOVEL IMMUNOTHERAPEUTICS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 94, 1 January 1997 (1997-01-01), pages 73 - 78, XP000619663, ISSN: 0027-8424 *

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JP2002530080A (en) 2002-09-17
WO2000029583A2 (en) 2000-05-25
EP1131428A2 (en) 2001-09-12
AU1631000A (en) 2000-06-05

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