WO2000035475A3 - Verfahren zur behandlung von cerebralen ischämien sowie verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien - Google Patents

Verfahren zur behandlung von cerebralen ischämien sowie verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien Download PDF

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Publication number
WO2000035475A3
WO2000035475A3 PCT/EP1999/009864 EP9909864W WO0035475A3 WO 2000035475 A3 WO2000035475 A3 WO 2000035475A3 EP 9909864 W EP9909864 W EP 9909864W WO 0035475 A3 WO0035475 A3 WO 0035475A3
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WO
WIPO (PCT)
Prior art keywords
erythropoietin
treatment
cerebral ischaemia
cerebral
ischaemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/009864
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English (en)
French (fr)
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WO2000035475A2 (de
Inventor
Hannelore Ehrenreich
Christoph Gleiter
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7891015&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000035475(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2000587794A priority Critical patent/JP4750947B2/ja
Priority to AU22831/00A priority patent/AU766216C/en
Priority to CA2353553A priority patent/CA2353553C/en
Priority to DE59907752T priority patent/DE59907752D1/de
Priority to HK02104485.2A priority patent/HK1042655B/zh
Priority to PL349335A priority patent/PL202483B1/pl
Priority to DK99966958T priority patent/DK1140139T4/da
Priority to US09/868,089 priority patent/US7514072B1/en
Priority to BR9916197-4A priority patent/BR9916197A/pt
Priority to HU0104709A priority patent/HUP0104709A3/hu
Priority to ROA200100684A priority patent/RO121409B1/ro
Priority to EP99966958A priority patent/EP1140139B2/de
Application filed by Individual filed Critical Individual
Priority to AT99966958T priority patent/ATE253932T1/de
Priority to MXPA01005971A priority patent/MXPA01005971A/es
Priority to IL14357999A priority patent/IL143579A0/xx
Publication of WO2000035475A2 publication Critical patent/WO2000035475A2/de
Publication of WO2000035475A3 publication Critical patent/WO2000035475A3/de
Priority to IL143579A priority patent/IL143579A/en
Priority to NO20012896A priority patent/NO330079B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf ein Verfahren zur Behandlung von cerebralen Ischämien sowie auf ein Mittel zur Behandlung cerebraler Ischämien insbesondere des Menschen, wie sie beispielsweise bei Schlaganfallpatienten auftreten. Überraschend wurde gefunden, daß die periphere Gabe von Erythropoietin auf das von der Ischämie betroffene cerebrale Gewebe einen ausgeprägt protektiven Effekt aufweist. Erythropoietin bewirkt dabei, daß der Bereich des dauerhaft geschädigten cerebralen Gewebes, insbesondere in der Penumbra, dramatisch verkleinert wird gegenüber herkömmlichen Maßnahmen bei cerebraler Ischämie ohne Erythropoietingabe.
PCT/EP1999/009864 1998-12-14 1999-12-13 Verfahren zur behandlung von cerebralen ischämien sowie verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien Ceased WO2000035475A2 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IL14357999A IL143579A0 (en) 1998-12-14 1999-12-13 Erythropoietin derivatives for the treatment of cerebral ischemia
ROA200100684A RO121409B1 (ro) 1998-12-14 1999-12-13 Utilizarea eritropoietinei sau a derivaţilor de eritropoietină, pentru tratamentul ischemiei cerebrale
CA2353553A CA2353553C (en) 1998-12-14 1999-12-13 Method for the treatment of cerebral ischaemia and use of erythropoietin or erythropoietin derivatives for the treatment of cerebral ischaemia
DE59907752T DE59907752D1 (de) 1998-12-14 1999-12-13 Verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien
HK02104485.2A HK1042655B (zh) 1998-12-14 1999-12-13 促紅細胞生成素用於生產腦局部缺血藥物的應用
PL349335A PL202483B1 (pl) 1998-12-14 1999-12-13 Zastosowanie erytropoetyny w leczeniu udaru
DK99966958T DK1140139T4 (da) 1998-12-14 1999-12-13 Anvendelse af erythropoietin eller erythropoietinderivater til behandling af cerebrale iskræmier
US09/868,089 US7514072B1 (en) 1998-12-14 1999-12-13 Method for the treatment of cerebral ischaemia and use of erythropoietin or erythropoietin derivatives for the treatment of cerebral ischaemia
BR9916197-4A BR9916197A (pt) 1998-12-14 1999-12-13 Método para o tratamento de isquemia cerebral e uso de eritropoietina ou derivados de eritropoietina para o tratamento de isquemia cerebral
JP2000587794A JP4750947B2 (ja) 1998-12-14 1999-12-13 脳虚血の処置法及び脳虚血の処置のためのエリスロポエチン又はエリスロポエチン誘導体類の使用
EP99966958A EP1140139B2 (de) 1998-12-14 1999-12-13 Verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien
AU22831/00A AU766216C (en) 1998-12-14 1999-12-13 Method for the treatment of cerebral ischaemia and use of erythropoietin or erythropoietin derivatives for the treatment of cerebral ischaemia
HU0104709A HUP0104709A3 (en) 1998-12-14 1999-12-13 Use of erythropoietin or erythropoietin derivatives for the manufacture of a medicament for treatment of cerebral ischaemia
AT99966958T ATE253932T1 (de) 1998-12-14 1999-12-13 Verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien
MXPA01005971A MXPA01005971A (es) 1998-12-14 1999-12-13 Metodo para el tratamiento de la isquemia cerebral y el uso de la eritropoyetina o derivados de la eritropoyetina para el tratamiento de la isquemia cerebral.
IL143579A IL143579A (en) 1998-12-14 2001-06-05 Erythropoietin history to treat local anemia of the brain
NO20012896A NO330079B1 (no) 1998-12-14 2001-06-12 Anvendelse av erytropoietin for fremstilling av et legemiddel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19857609A DE19857609A1 (de) 1998-12-14 1998-12-14 Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
DE19857609.9 1998-12-14

Publications (2)

Publication Number Publication Date
WO2000035475A2 WO2000035475A2 (de) 2000-06-22
WO2000035475A3 true WO2000035475A3 (de) 2000-10-19

Family

ID=7891015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/009864 Ceased WO2000035475A2 (de) 1998-12-14 1999-12-13 Verfahren zur behandlung von cerebralen ischämien sowie verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien

Country Status (26)

Country Link
US (1) US7514072B1 (de)
EP (1) EP1140139B2 (de)
JP (2) JP4750947B2 (de)
KR (1) KR100774827B1 (de)
CN (1) CN1187085C (de)
AT (1) ATE253932T1 (de)
AU (1) AU766216C (de)
BG (1) BG65417B1 (de)
BR (1) BR9916197A (de)
CA (1) CA2353553C (de)
DE (2) DE19857609A1 (de)
DK (1) DK1140139T4 (de)
ES (1) ES2211218T5 (de)
HK (1) HK1042655B (de)
HU (1) HUP0104709A3 (de)
ID (1) ID29107A (de)
IL (2) IL143579A0 (de)
MX (1) MXPA01005971A (de)
NO (1) NO330079B1 (de)
NZ (1) NZ541591A (de)
PL (1) PL202483B1 (de)
PT (1) PT1140139E (de)
RO (1) RO121409B1 (de)
RU (1) RU2242991C2 (de)
WO (1) WO2000035475A2 (de)
ZA (1) ZA200104626B (de)

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DE19857609A1 (de) 1998-12-14 2000-06-15 Hannelore Ehrenreich Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen
US7309687B1 (en) 1999-04-13 2007-12-18 The Kenneth S. Warren Institute, Inc. Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin
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US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
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DE10043457A1 (de) * 2000-09-04 2002-03-28 Hannelore Ehrenreich Verfahren zur Behandlung von Schizophrenie und verwandten Psychosen sowie Verwendung von Erythropoietin oder Erythropoietinderivaten zur Behandlung von Schizophrenien und verwandten Psychosen
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
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US6531121B2 (en) 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
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US9988427B2 (en) 2005-05-13 2018-06-05 Charite Universitaetsmedizen-Berlin Erythropoietin variants
EP1736481A1 (de) 2005-05-13 2006-12-27 Charite Universitätsmedizin-Berlin Erythropoietinvarianten
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BRPI0712063A2 (pt) * 2006-06-07 2011-12-20 Chugai Pharmaceutical Co Ltd tratamento de doenças isquêmicas usando eritropoietina
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Also Published As

Publication number Publication date
BG105575A (en) 2002-01-31
AU2283100A (en) 2000-07-03
HK1042655A1 (en) 2002-08-23
DK1140139T4 (da) 2009-06-08
WO2000035475A2 (de) 2000-06-22
KR20010082346A (ko) 2001-08-29
ES2211218T3 (es) 2004-07-01
NO20012896D0 (no) 2001-06-12
DE59907752D1 (de) 2003-12-18
PL349335A1 (en) 2002-07-15
PL202483B1 (pl) 2009-06-30
ES2211218T5 (es) 2009-06-03
JP4750947B2 (ja) 2011-08-17
EP1140139A2 (de) 2001-10-10
IL143579A0 (en) 2002-04-21
AU766216C (en) 2004-11-11
BR9916197A (pt) 2001-09-04
HUP0104709A2 (hu) 2002-04-29
NO330079B1 (no) 2011-02-14
HUP0104709A3 (en) 2002-05-28
KR100774827B1 (ko) 2007-11-07
CA2353553C (en) 2011-05-17
NZ541591A (en) 2007-08-31
EP1140139B1 (de) 2003-11-12
CN1187085C (zh) 2005-02-02
NO20012896L (no) 2001-08-14
HK1042655B (zh) 2005-09-23
JP2011079860A (ja) 2011-04-21
DE19857609A1 (de) 2000-06-15
MXPA01005971A (es) 2002-03-27
PT1140139E (pt) 2004-04-30
RU2242991C2 (ru) 2004-12-27
ZA200104626B (en) 2002-09-06
CN1335776A (zh) 2002-02-13
ATE253932T1 (de) 2003-11-15
US7514072B1 (en) 2009-04-07
RO121409B1 (ro) 2007-05-30
CA2353553A1 (en) 2000-06-22
AU766216B2 (en) 2003-10-09
JP2002532432A (ja) 2002-10-02
EP1140139B9 (de) 2004-03-31
BG65417B1 (bg) 2008-07-31
EP1140139B2 (de) 2009-03-18
IL143579A (en) 2007-10-31
ID29107A (id) 2001-07-26
DK1140139T3 (da) 2004-03-15

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