WO2000037491A3 - Dnas encoding proteins with signal sequences - Google Patents

Dnas encoding proteins with signal sequences Download PDF

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Publication number
WO2000037491A3
WO2000037491A3 PCT/IB1999/002058 IB9902058W WO0037491A3 WO 2000037491 A3 WO2000037491 A3 WO 2000037491A3 IB 9902058 W IB9902058 W IB 9902058W WO 0037491 A3 WO0037491 A3 WO 0037491A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdnas
signal sequences
encoding proteins
dnas encoding
secreted proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1999/002058
Other languages
French (fr)
Other versions
WO2000037491A2 (en
Inventor
Lydie Bougueleret
Jean-Baptiste Dumas
Aymeric Duclert
Catherine Clusel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset SA filed Critical Genset SA
Priority to CA002354369A priority Critical patent/CA2354369A1/en
Priority to AU16759/00A priority patent/AU1675900A/en
Priority to EP99959633A priority patent/EP1144444A3/en
Priority to JP2000589560A priority patent/JP2002539767A/en
Priority to PCT/IB2000/001011 priority patent/WO2001000803A2/en
Priority to AU58383/00A priority patent/AU5838300A/en
Publication of WO2000037491A2 publication Critical patent/WO2000037491A2/en
Priority to US09/751,877 priority patent/US20040204349A9/en
Priority to US09/750,580 priority patent/US6455280B1/en
Priority to US09/842,364 priority patent/US20030032783A1/en
Anticipated expiration legal-status Critical
Publication of WO2000037491A3 publication Critical patent/WO2000037491A3/en
Priority to US10/121,034 priority patent/US7122644B2/en
Priority to US11/412,373 priority patent/US20060189793A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.
PCT/IB1999/002058 1998-12-22 1999-12-20 Dnas encoding proteins with signal sequences Ceased WO2000037491A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002354369A CA2354369A1 (en) 1998-12-22 1999-12-20 Complementary dna's encoding proteins with signal peptides
AU16759/00A AU1675900A (en) 1998-12-22 1999-12-20 Complementary dna's encoding proteins with signal peptides
EP99959633A EP1144444A3 (en) 1998-12-22 1999-12-20 Dnas encoding proteins with signal sequences
JP2000589560A JP2002539767A (en) 1998-12-22 1999-12-20 Complementary DNA-encoding protein containing signal peptide
PCT/IB2000/001011 WO2001000803A2 (en) 1999-06-25 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
AU58383/00A AU5838300A (en) 1999-06-25 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
US09/750,580 US6455280B1 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cell growth
US09/751,877 US20040204349A9 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cells growth
US09/842,364 US20030032783A1 (en) 1998-12-22 2001-04-25 Apolipoprotein A-IV-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
US10/121,034 US7122644B2 (en) 1998-12-22 2002-04-10 Methods and compositions for inhibiting neoplastic cell growth
US11/412,373 US20060189793A1 (en) 1998-12-22 2006-04-27 Methods and compositions for inhibiting neoplastic cell growth

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11368698P 1998-12-22 1998-12-22
US14103299P 1999-06-25 1999-06-25
US60/141,032 1999-06-25
US60/113,686 1999-06-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US46909999A Continuation-In-Part 1998-12-22 1999-12-21

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US46909999A Continuation-In-Part 1998-12-22 1999-12-21
US59936200A Continuation-In-Part 1998-12-22 2000-06-21
PCT/IB2000/001011 Continuation-In-Part WO2001000803A2 (en) 1998-12-22 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof

Publications (2)

Publication Number Publication Date
WO2000037491A2 WO2000037491A2 (en) 2000-06-29
WO2000037491A3 true WO2000037491A3 (en) 2001-09-20

Family

ID=26811346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/002058 Ceased WO2000037491A2 (en) 1998-12-22 1999-12-20 Dnas encoding proteins with signal sequences

Country Status (5)

Country Link
EP (1) EP1144444A3 (en)
JP (1) JP2002539767A (en)
AU (1) AU1675900A (en)
CA (1) CA2354369A1 (en)
WO (1) WO2000037491A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223542B2 (en) 1999-10-28 2007-05-29 Agensys, Inc. 36P6D5: secreted tumor antigen

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787647B1 (en) 1998-12-22 2004-09-07 Genset S.A. Carnitine carrier related protein-1
CN1244584A (en) * 1999-05-14 2000-02-16 北京医科大学 Chemotarix factor with immunocyte chemotaxis and hemopoinesis stimulating activity
EP1200576A2 (en) * 1999-06-25 2002-05-02 Genset Dna's encoding proteins with signal peptides
CA2400981A1 (en) * 2000-02-21 2001-08-23 Kureha Chemical Industry Co., Ltd. Novel proteins and novel genes encoding the same
US7094566B2 (en) 2000-03-16 2006-08-22 Amgen Inc., IL-17 receptor like molecules and uses thereof
US20020142953A1 (en) * 2000-04-14 2002-10-03 Ballinger Dennis G. Materials and methods relating to lipid metabolism
EP1346042A2 (en) * 2000-11-17 2003-09-24 Xenon Genetics, Inc. Fat regulated genes, uses thereof, and compounds for modulating same
AU2002344741A1 (en) * 2001-06-15 2003-01-02 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Pate, a gene expressed in prostate cancer, prostate and testis, and uses thereof
WO2003002737A1 (en) * 2001-06-27 2003-01-09 Riken Novel human topoisomerase 2α inhibitory protein and utilization thereof
ES2275924T3 (en) * 2001-09-07 2007-06-16 Genfit COMPOSITIONS AND METHODS TO TEST AA4RP.
FR2843395A1 (en) * 2002-08-12 2004-02-13 Genfit S A New synthetic peptide from apolipoprotein AIV related protein, useful for raising antibodies, used for diagnosis and treatment of disorders of lipid metabolism
FR2829581A1 (en) * 2001-09-07 2003-03-14 Genfit S A New synthetic peptide from apolipoprotein AIV related protein, useful for raising antibodies, used for diagnosis and treatment of disorders of lipid metabolism
DE10344799A1 (en) * 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
US7892733B1 (en) 2004-04-22 2011-02-22 Amgen Inc. Response element regions
DE102005013846A1 (en) 2005-03-24 2006-10-05 Ganymed Pharmaceuticals Ag Identification of surface-associated antigens for tumor diagnosis and therapy
CA2626238C (en) 2005-10-17 2015-10-06 Memorial Sloan Kettering Cancer Center Wt1 hla class ii-binding peptides and compositions and methods comprising same
US9265816B2 (en) 2006-04-10 2016-02-23 Sloan Kettering Institute For Cancer Research Immunogenic WT-1 peptides and methods of use thereof
CA2861206C (en) 2012-01-13 2021-07-06 Richard J. O'reilly Immunogenic wt-1 peptides and methods of use thereof
CN110078813B (en) 2013-01-15 2023-03-28 纪念斯隆凯特林癌症中心 Immunogenic WT-1 peptides and methods of use thereof
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031818A2 (en) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
WO1998045437A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)
DE19816395A1 (en) * 1998-04-03 1999-10-07 Metagen Gesellschaft Fuer Genomforschung Mbh Human nucleic acid sequences from ovarian normal tissue

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976824A1 (en) * 1998-07-10 2000-02-02 Amsterdam Molecular Therapeutics Gene and protein involved in liver regeneration

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031818A2 (en) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
WO1998045437A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)
DE19816395A1 (en) * 1998-04-03 1999-10-07 Metagen Gesellschaft Fuer Genomforschung Mbh Human nucleic acid sequences from ovarian normal tissue

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JACOBS K A ET AL: "A GENETIC SELECTION FOR ISOLATING CDNAS ENCODING SECRETED PROTEINS", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 198, 1 October 1997 (1997-10-01), pages 289 - 296, XP002045919, ISSN: 0378-1119 *
JACOBS K ET AL: "A NOVEL METHOD FOR ISOLATING EUKARYOTIC CDNA CLONES ENCODING SECRETED PROTEINS", JOURNAL OF CELLULAR BIOCHEMISTRY - SUPPLEMENT, 10 March 1995 (1995-03-10), pages 19, XP002027246 *
SHIROZU M ET AL: "CHARACTERIZATION OF NOVEL SECRETED AND MEMBRANE PROTEINS ISOLATED BY THE SIGNAL SEQUENCE TRAP METHOD", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 273 - 280, XP002054773, ISSN: 0888-7543 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223542B2 (en) 1999-10-28 2007-05-29 Agensys, Inc. 36P6D5: secreted tumor antigen
US7507541B2 (en) 1999-10-28 2009-03-24 Agensys, Inc. 36P6D5: secreted tumor antigen

Also Published As

Publication number Publication date
CA2354369A1 (en) 2000-06-29
WO2000037491A2 (en) 2000-06-29
JP2002539767A (en) 2002-11-26
EP1144444A3 (en) 2002-01-02
EP1144444A2 (en) 2001-10-17
AU1675900A (en) 2000-07-12

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