WO2000037646A3 - Group b streptococcus proteins, and their use - Google Patents

Group b streptococcus proteins, and their use

Info

Publication number
WO2000037646A3
WO2000037646A3 PCT/GB1999/004377 GB9904377W WO0037646A3 WO 2000037646 A3 WO2000037646 A3 WO 2000037646A3 GB 9904377 W GB9904377 W GB 9904377W WO 0037646 A3 WO0037646 A3 WO 0037646A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
streptococcus
streptococcus proteins
genes
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/004377
Other languages
French (fr)
Other versions
WO2000037646A2 (en
Inventor
Martin John Glenton Hughes
Joseph David Santangelo
Jonathan Douglas Lane
Paul Everest
Robert Feldman
Joanne Christine Moore
Rebecca Kerry Wilson
Richard James Dobson
Gordon Dougan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergent Product Development UK Ltd
Original Assignee
Microscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828345.0A external-priority patent/GB9828345D0/en
Priority claimed from GBGB9828354.2A external-priority patent/GB9828354D0/en
Priority claimed from GBGB9828359.1A external-priority patent/GB9828359D0/en
Priority claimed from GBGB9828356.7A external-priority patent/GB9828356D0/en
Priority claimed from GBGB9828357.5A external-priority patent/GB9828357D0/en
Priority claimed from GBGB9828349.2A external-priority patent/GB9828349D0/en
Priority claimed from GBGB9828353.4A external-priority patent/GB9828353D0/en
Priority claimed from GBGB9828355.9A external-priority patent/GB9828355D0/en
Priority claimed from GBGB9828350.0A external-priority patent/GB9828350D0/en
Priority claimed from GBGB9828352.6A external-priority patent/GB9828352D0/en
Priority claimed from GBGB9900086.1A external-priority patent/GB9900086D0/en
Priority claimed from GBGB9900083.8A external-priority patent/GB9900083D0/en
Priority claimed from GBGB9900085.3A external-priority patent/GB9900085D0/en
Priority claimed from GBGB9900082.0A external-priority patent/GB9900082D0/en
Priority claimed from GBGB9900084.6A external-priority patent/GB9900084D0/en
Priority claimed from GBGB9901922.6A external-priority patent/GB9901922D0/en
Priority claimed from GBGB9901916.8A external-priority patent/GB9901916D0/en
Priority to JP2000589700A priority Critical patent/JP2002533083A/en
Priority to EA200100700A priority patent/EA004444B1/en
Priority to EP99962422A priority patent/EP1141308B1/en
Priority to AP2005003413A priority patent/AP2005003413A0/en
Priority to HU0104825A priority patent/HUP0104825A3/en
Priority to APAP/P/2001/002189A priority patent/AP1502A/en
Priority to DE69935080T priority patent/DE69935080T2/en
Priority to DK99962422T priority patent/DK1141308T3/en
Priority to AU18780/00A priority patent/AU776735B2/en
Priority to HK01108928.9A priority patent/HK1039353B/en
Priority to NZ512297A priority patent/NZ512297A/en
Priority to US09/868,352 priority patent/US6812021B1/en
Priority to BR9916474-4A priority patent/BR9916474A/en
Priority to SI9930959T priority patent/SI1141308T1/en
Priority to ES99962422T priority patent/ES2281977T3/en
Application filed by Microscience Ltd filed Critical Microscience Ltd
Priority to CA002354135A priority patent/CA2354135A1/en
Priority to CNA2007101018407A priority patent/CN101066447A/en
Publication of WO2000037646A2 publication Critical patent/WO2000037646A2/en
Publication of WO2000037646A3 publication Critical patent/WO2000037646A3/en
Priority to NO20013102A priority patent/NO20013102L/en
Anticipated expiration legal-status Critical
Priority to US10/096,162 priority patent/US6890539B2/en
Priority to US10/799,072 priority patent/US7419672B2/en
Priority to US10/944,521 priority patent/US7592011B2/en
Priority to CY20071100589T priority patent/CY1106559T1/en
Priority to US11/892,024 priority patent/US20090274717A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56944—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunise a patient against microbial infection.
PCT/GB1999/004377 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use Ceased WO2000037646A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
EP99962422A EP1141308B1 (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use
AP2005003413A AP2005003413A0 (en) 1998-12-22 1999-12-22 Genes and proteins, and their use.
HU0104825A HUP0104825A3 (en) 1998-12-22 1999-12-22 Genes and proteins, and their use
APAP/P/2001/002189A AP1502A (en) 1998-12-22 1999-12-22 Genes and proteins, and their uses.
DE69935080T DE69935080T2 (en) 1998-12-22 1999-12-22 GROUP B STREPTOCOCCUS PROTEINS AND THEIR USE
DK99962422T DK1141308T3 (en) 1998-12-22 1999-12-22 Group B streptococcus proteins and their use
EA200100700A EA004444B1 (en) 1998-12-22 1999-12-22 Genes and proteins and their use
AU18780/00A AU776735B2 (en) 1998-12-22 1999-12-22 Genes and proteins, and their use
CNA2007101018407A CN101066447A (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use
CA002354135A CA2354135A1 (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use
JP2000589700A JP2002533083A (en) 1998-12-22 1999-12-22 Genes and proteins and their uses
ES99962422T ES2281977T3 (en) 1998-12-22 1999-12-22 STREPTOCOCO PROTEINS OF GROUP B AND ITS USE.
SI9930959T SI1141308T1 (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use
BR9916474-4A BR9916474A (en) 1998-12-22 1999-12-22 Outer surface proteins, their genes and their use
US09/868,352 US6812021B1 (en) 1998-12-22 1999-12-22 Genes and proteins and their use
NZ512297A NZ512297A (en) 1998-12-22 1999-12-22 Genes and proteins of group a strep, and their use
HK01108928.9A HK1039353B (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use
NO20013102A NO20013102L (en) 1998-12-22 2001-06-21 Genes, proteins and their use
US10/096,162 US6890539B2 (en) 1998-12-22 2002-03-11 Genes and proteins, and their use
US10/799,072 US7419672B2 (en) 1998-12-22 2004-03-12 Genes and proteins, and their use
US10/944,521 US7592011B2 (en) 1998-12-22 2004-09-17 Genes and proteins, and their use
CY20071100589T CY1106559T1 (en) 1998-12-22 2007-05-04 GROUP B STREPTOCOCCAL PROTEINS, AND THEIR USE
US11/892,024 US20090274717A1 (en) 1998-12-22 2007-08-17 Genes and proteins, and their use

Applications Claiming Priority (34)

Application Number Priority Date Filing Date Title
GBGB9828353.4A GB9828353D0 (en) 1998-12-22 1998-12-22 Protein and compositions containig it
GB9828352.6 1998-12-22
GBGB9828359.1A GB9828359D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GB9828357.5 1998-12-22
GB9828355.9 1998-12-22
GBGB9828356.7A GB9828356D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GBGB9828357.5A GB9828357D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GB9828349.2 1998-12-22
GB9828350.0 1998-12-22
GBGB9828354.2A GB9828354D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GB9828354.2 1998-12-22
GBGB9828345.0A GB9828345D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GBGB9828355.9A GB9828355D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GBGB9828349.2A GB9828349D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GBGB9828352.6A GB9828352D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GB9828356.7 1998-12-22
GB9828345.0 1998-12-22
GB9828359.1 1998-12-22
GBGB9828350.0A GB9828350D0 (en) 1998-12-22 1998-12-22 Protein and compositions containing it
GB9828353.4 1998-12-22
GB9900085.3 1999-01-04
GBGB9900086.1A GB9900086D0 (en) 1999-01-04 1999-01-04 Protein and compositions containing it
GBGB9900083.8A GB9900083D0 (en) 1999-01-04 1999-01-04 Protein and compositions containing it
GBGB9900085.3A GB9900085D0 (en) 1999-01-04 1999-01-04 Protein and compositions containing it
GB9900084.6 1999-01-04
GB9900082.0 1999-01-04
GB9900083.8 1999-01-04
GBGB9900082.0A GB9900082D0 (en) 1999-01-04 1999-01-04 Protein and compositions containing it
GB9900086.1 1999-01-04
GBGB9900084.6A GB9900084D0 (en) 1999-01-04 1999-01-04 Protein and compositions containing it
GBGB9901916.8A GB9901916D0 (en) 1999-01-28 1999-01-28 Protein and compositions containing it
GB9901916.8 1999-01-28
GB9901922.6 1999-01-28
GBGB9901922.6A GB9901922D0 (en) 1999-01-28 1999-01-28 Protein and compositions containing it

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09868352 A-371-Of-International 1999-12-22
US10/096,162 Continuation-In-Part US6890539B2 (en) 1998-12-22 2002-03-11 Genes and proteins, and their use
US10/799,072 Continuation US7419672B2 (en) 1998-12-22 2004-03-12 Genes and proteins, and their use

Publications (2)

Publication Number Publication Date
WO2000037646A2 WO2000037646A2 (en) 2000-06-29
WO2000037646A3 true WO2000037646A3 (en) 2000-10-26

Family

ID=27585888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004377 Ceased WO2000037646A2 (en) 1998-12-22 1999-12-22 Group b streptococcus proteins, and their use

Country Status (22)

Country Link
US (3) US6812021B1 (en)
EP (3) EP1141308B1 (en)
JP (1) JP2002533083A (en)
KR (3) KR100790653B1 (en)
CN (1) CN101066447A (en)
AP (1) AP1502A (en)
AT (1) ATE353367T1 (en)
AU (1) AU776735B2 (en)
CA (1) CA2354135A1 (en)
CY (1) CY1106559T1 (en)
CZ (1) CZ20012172A3 (en)
DK (1) DK1141308T3 (en)
EA (1) EA004444B1 (en)
ES (1) ES2281977T3 (en)
HU (1) HUP0104825A3 (en)
NO (1) NO20013102L (en)
NZ (3) NZ526879A (en)
OA (1) OA11734A (en)
PL (1) PL201887B1 (en)
PT (1) PT1141308E (en)
SI (1) SI1141308T1 (en)
WO (1) WO2000037646A2 (en)

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GB0105922D0 (en) * 2001-03-09 2001-04-25 Microscience Ltd Genes and proteins, and their use
US6890539B2 (en) 1998-12-22 2005-05-10 Microscience, Ltd. Genes and proteins, and their use
PT1141308E (en) 1998-12-22 2007-05-31 Microscience Ltd Group b streptococcus proteins, and their use
PT1140994E (en) * 1998-12-22 2005-11-30 Microscience Ltd PROTEINS OF THE EXTERNAL SURFACE, THEIR GENES AND THEIR USE
US6849407B2 (en) 2000-08-31 2005-02-01 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
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US7074598B2 (en) 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
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US7427475B2 (en) 2003-11-18 2008-09-23 Mayo Foundation For Medical Education And Research Detection of group B streptococcus
WO2008152448A2 (en) * 2006-12-21 2008-12-18 Emergent Product Development Uk Limited Streptococcus proteins, and their use in vaccination
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