WO2000045853A3 - Treatment of tumors with genetically engineered herpes virus - Google Patents

Treatment of tumors with genetically engineered herpes virus Download PDF

Info

Publication number
WO2000045853A3
WO2000045853A3 PCT/US2000/002814 US0002814W WO0045853A3 WO 2000045853 A3 WO2000045853 A3 WO 2000045853A3 US 0002814 W US0002814 W US 0002814W WO 0045853 A3 WO0045853 A3 WO 0045853A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumors
treatment
genetically engineered
herpes virus
engineered herpes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/002814
Other languages
French (fr)
Other versions
WO2000045853A2 (en
Inventor
Ralph Weichselbaum
Bernard Roizman
Richard Whitley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arch Development Corp
U A B RES FOUNDATION
Original Assignee
Arch Development Corp
U A B RES FOUNDATION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arch Development Corp, U A B RES FOUNDATION filed Critical Arch Development Corp
Priority to JP2000596972A priority Critical patent/JP4623832B2/en
Priority to AU29800/00A priority patent/AU772471B2/en
Priority to DE60027870T priority patent/DE60027870T2/en
Priority to EP00908465A priority patent/EP1150696B1/en
Priority to DK06009428T priority patent/DK1695714T3/en
Priority to CA2361892A priority patent/CA2361892C/en
Publication of WO2000045853A2 publication Critical patent/WO2000045853A2/en
Publication of WO2000045853A3 publication Critical patent/WO2000045853A3/en
Anticipated expiration legal-status Critical
Priority to AU2004203458A priority patent/AU2004203458B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
PCT/US2000/002814 1999-02-05 2000-02-04 Treatment of tumors with genetically engineered herpes virus Ceased WO2000045853A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000596972A JP4623832B2 (en) 1999-02-05 2000-02-04 Treatment of tumors with genetically engineered herpesviruses
AU29800/00A AU772471B2 (en) 1999-02-05 2000-02-04 Treatment of tumors with genetically engineered herpes virus
DE60027870T DE60027870T2 (en) 1999-02-05 2000-02-04 GENETIC MANIPULATED HERPESVIRUS FOR THE TREATMENT OF TUMORS
EP00908465A EP1150696B1 (en) 1999-02-05 2000-02-04 Genetically engineered herpes virus for the treatment of tumours
DK06009428T DK1695714T3 (en) 1999-02-05 2000-02-04 Genetically engineered herpes virus for the treatment of tumors
CA2361892A CA2361892C (en) 1999-02-05 2000-02-04 Treatment of tumors with genetically engineered herpes virus
AU2004203458A AU2004203458B2 (en) 1999-02-05 2004-07-29 Treatment of Tumors with Genetically Engineered Herpes Virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24474899A 1999-02-05 1999-02-05
US09/244,748 1999-02-05

Publications (2)

Publication Number Publication Date
WO2000045853A2 WO2000045853A2 (en) 2000-08-10
WO2000045853A3 true WO2000045853A3 (en) 2001-05-31

Family

ID=22923971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002814 Ceased WO2000045853A2 (en) 1999-02-05 2000-02-04 Treatment of tumors with genetically engineered herpes virus

Country Status (10)

Country Link
US (3) US20030207829A9 (en)
EP (2) EP1150696B1 (en)
JP (1) JP4623832B2 (en)
AT (2) ATE402713T1 (en)
AU (2) AU772471B2 (en)
CA (1) CA2361892C (en)
DE (2) DE60027870T2 (en)
DK (1) DK1695714T3 (en)
ES (2) ES2310382T3 (en)
WO (1) WO2000045853A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
IL145899A0 (en) 1999-04-15 2002-07-25 Pro Virus Inc Treatment of neoplasms with viruses
US8147822B1 (en) 1999-09-17 2012-04-03 Wellstat Biologics Corporation Oncolytic virus
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
EP2213300B1 (en) * 2001-05-09 2015-03-25 Takara Bio, Inc. Composition and method for treating cancer using herpes virus
CA2476724A1 (en) * 2002-03-01 2003-09-12 Sloan-Kettering Institute For Cancer Research Prevention of recurrence and metastasis of cancer
JP2004099584A (en) * 2002-05-02 2004-04-02 Keio Gijuku Anti-tumor agent using HSV
EP1549339B1 (en) 2002-10-07 2019-06-05 University Of Chicago Targeting of herpes simplex virus to specific receptors
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
WO2006002394A2 (en) 2004-06-24 2006-01-05 New York University Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
EP2144632B1 (en) * 2007-05-09 2016-11-16 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Synthetic herpes simplex viruses type-1 for treatment of cancers
WO2009148488A2 (en) * 2008-05-29 2009-12-10 The General Hospital Corporation Use of oncolytic herpes viruses for killing cancer stem cells
WO2016201450A2 (en) * 2015-06-11 2016-12-15 University Of Miami Cancer treatment and diagnosis
AU2016403583B2 (en) * 2016-04-22 2020-05-28 Immvira Co., Limited Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
TWI666321B (en) * 2017-10-23 2019-07-21 大陸商深圳市亦諾微醫藥科技有限公司 Construction of oncolytic herpes simplex viruses (ohsv) obligate vector and constructs for cancer therapy
KR101974169B1 (en) * 2018-08-10 2019-04-30 의료법인 성광의료재단 Recombinant herpes simplex virus and method for manufacturing the same
KR102834430B1 (en) * 2019-08-16 2025-07-15 임비라 컴퍼니 리미티드 Pharmaceutical composition comprising oncolytic herpes simplex virus for systemic administration
EP4075980B1 (en) 2019-12-18 2025-07-23 Stinginn LLC Substituted 1,2, 4-triazoles and methods of use
US11897888B1 (en) 2020-04-30 2024-02-13 Stinginn Llc Small molecular inhibitors of sting signaling compositions and methods of use
JP7235334B2 (en) * 2020-11-26 2023-03-08 イムヴィラ・カンパニー・リミテッド Construction of oncolytic herpes simplex virus (oHSV) obligate vectors and their constructs for cancer therapy
US20240024392A1 (en) * 2020-12-04 2024-01-25 Immvira Co., Limited Oncolytic herpes simplex type 1 viruses for treatment of brain tumors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859587A (en) * 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
WO1996000007A1 (en) * 1994-06-23 1996-01-04 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
WO1997026904A1 (en) * 1996-01-25 1997-07-31 Medical Research Council Treatment of non-neuronal cancer using hsv mutant

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769331A (en) * 1981-09-16 1988-09-06 University Patents, Inc. Recombinant methods and materials
US5288641A (en) * 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
US5068192A (en) * 1986-01-27 1991-11-26 Prutech Research And Development Partnership Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence
US4999296A (en) * 1986-04-29 1991-03-12 Novagene, Inc. Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same
CA2039921A1 (en) 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5328688A (en) * 1990-09-10 1994-07-12 Arch Development Corporation Recombinant herpes simplex viruses vaccines and methods
US5360893A (en) * 1992-07-20 1994-11-01 University Of Colorado Foundation, Inc. DNA sequences encoding proteins used to elicit and detect programmed cell death
US5593879A (en) * 1993-01-15 1997-01-14 Massachusetts Institute Of Technology Cell death genes of Drosophila melanogaster and vertebrate analogs
CA2200633A1 (en) * 1997-03-21 1998-09-21 Yuman Fong Rapid production of autologous tumor vaccines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859587A (en) * 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
WO1996000007A1 (en) * 1994-06-23 1996-01-04 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
WO1997026904A1 (en) * 1996-01-25 1997-07-31 Medical Research Council Treatment of non-neuronal cancer using hsv mutant

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ADVANI S J ET AL: "Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: A new paradigm for destruction of therapeutically intractable tumors.", GENE THERAPY, vol. 5, no. 2, February 1998 (1998-02-01), pages 160 - 165, XP000915148, ISSN: 0969-7128 *
ADVANI SUNIL J ET AL: "Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors.", CANCER RESEARCH, vol. 59, no. 9, 1 May 1999 (1999-05-01), pages 2055 - 2058, XP002141883, ISSN: 0008-5472 *
CARPENTER DALE E ET AL: "Sequences of the bovine herpesvirus 1 homologue of herpes simplex virus type-1 alpha-trans-inducing factor (UL48).", GENE (AMSTERDAM), vol. 119, no. 2, 1992, pages 259 - 263, XP002141976, ISSN: 0378-1119 *
CHAMBERS R ET AL: "Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 92, no. 5, 28 February 1995 (1995-02-28), pages 1411 - 1415, XP002090032, ISSN: 0027-8424 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, MEIGNIER B ET AL: "IN-VIVO BEHAVIOR OF GENETICALLY ENGINEERED HERPES SIMPLEX VIRUSES R7017 AND R7020 CONSTRUCTION AND EVALUATION IN RODENTS", XP002141884, Database accession no. PREV198886115148 *
JOURNAL OF INFECTIOUS DISEASES, vol. 158, no. 3, 1988, pages 602 - 614, ISSN: 0022-1899 *
ROIZMAN BERNARD: "The function of herpes simplex virus genes: A primer for genetic engineering of novel vectors.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 21, 1996, 1996, pages 11307 - 11312, XP002141882, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
US8772261B2 (en) 2014-07-08
US8318691B2 (en) 2012-11-27
ATE402713T1 (en) 2008-08-15
EP1695714B1 (en) 2008-07-30
WO2000045853A2 (en) 2000-08-10
DE60039730D1 (en) 2008-09-11
AU2004203458A1 (en) 2004-08-26
DE60027870D1 (en) 2006-06-14
JP2002536347A (en) 2002-10-29
AU2004203458B2 (en) 2007-05-17
AU772471B2 (en) 2004-04-29
US20110002890A1 (en) 2011-01-06
ES2263454T3 (en) 2006-12-16
JP4623832B2 (en) 2011-02-02
US20030207829A9 (en) 2003-11-06
US20020019362A1 (en) 2002-02-14
EP1695714A1 (en) 2006-08-30
ATE325615T1 (en) 2006-06-15
AU2980000A (en) 2000-08-25
DE60027870T2 (en) 2006-12-28
CA2361892A1 (en) 2000-08-10
US20130039890A1 (en) 2013-02-14
EP1150696A2 (en) 2001-11-07
DK1695714T3 (en) 2008-11-10
EP1150696B1 (en) 2006-05-10
CA2361892C (en) 2010-05-25
ES2310382T3 (en) 2009-01-01

Similar Documents

Publication Publication Date Title
WO2000045853A3 (en) Treatment of tumors with genetically engineered herpes virus
AU7380500A (en) Methods for treating tumors using neutron therapy
LU91928I2 (en) Ipilimumab and its pharmaceutically acceptable derivatives (YERVOY®)
AU2001294604A1 (en) Improved radiation therapy treatment method
AU2001282717A1 (en) Cancer treatment by combination therapy
AU2002307749A1 (en) Composition and method for treating cancer using herpes virus
AU3357500A (en) Method for intravascular radiation therapy
AU7031500A (en) Therapeutic quinazoline compounds
MY119375A (en) Treatment of tinnitus using neuroprotective agents
EP1176964B8 (en) Uses of et743 for treating cancer
WO2002066044A3 (en) Method for dendritic cells based immunotherapy of tumors using combination therapy
NZ504938A (en) Tumor antigen peptide derivatives capable of binding to HLA-A24 antigen
AU2001274827A1 (en) Porphyrin-based neutron capture agents for cancer therapy
AU3704800A (en) Co-administration of lucanthone and radiation for treatment of cancer
AU3988099A (en) Combination therapy for treating hypercholesterolemia
AU5300396A (en) Radiation enhanced gene therapy for treatment of tumors
AU5928599A (en) Methods for treating cell proliferative disorders including cancer
AU2180501A (en) Novel DNA polymerase inhibitors, mikanolide and dihydromikanolide
PA8453601A1 (en) FARNESIL TRANSFERASE INHIBITORS COMBINED WITH HMG COA REDUCTASE INHIBITORS FOR CANCER TREATMENT
AU2967700A (en) Combination therapy for lymphoproliferative diseases
WO1998033470A3 (en) Substituted perylenequinones for use in photodynamic therapy
WO2001034197A3 (en) Oncolytic combinations for the treatment of cancer
AU3919001A (en) Use of 2-methyl-thiazolidin-2,4-dicarboxylic acid (2-mtdc) and/or physiologically compatible salts for treating and/or preventing cancers
WO2001034199A3 (en) Oncolytic combinations for the treatment of cancer
NO20016380L (en) Procedure for preventing tumor growth

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2361892

Country of ref document: CA

Ref country code: CA

Ref document number: 2361892

Kind code of ref document: A

Format of ref document f/p: F

Ref country code: JP

Ref document number: 2000 596972

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 29800/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2000908465

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000908465

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 29800/00

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 2000908465

Country of ref document: EP