WO2000049158A3 - Psa and klk-2 splicing variants - Google Patents

Psa and klk-2 splicing variants Download PDF

Info

Publication number
WO2000049158A3
WO2000049158A3 PCT/IL2000/000102 IL0000102W WO0049158A3 WO 2000049158 A3 WO2000049158 A3 WO 2000049158A3 IL 0000102 W IL0000102 W IL 0000102W WO 0049158 A3 WO0049158 A3 WO 0049158A3
Authority
WO
WIPO (PCT)
Prior art keywords
klk
psa
acid sequences
splicing variants
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2000/000102
Other languages
French (fr)
Other versions
WO2000049158A2 (en
Inventor
Kinneret Savitzky
Liat Mintz
Anat David
Idit Azar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Compugen Ltd
Original Assignee
Compugen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12858799A external-priority patent/IL128587A0/en
Priority claimed from IL12943999A external-priority patent/IL129439A0/en
Priority claimed from IL13136399A external-priority patent/IL131363A0/en
Application filed by Compugen Ltd filed Critical Compugen Ltd
Priority to EP00905240A priority Critical patent/EP1159429A2/en
Priority to AU26862/00A priority patent/AU2686200A/en
Publication of WO2000049158A2 publication Critical patent/WO2000049158A2/en
Publication of WO2000049158A3 publication Critical patent/WO2000049158A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention concerns novel nucleic acid sequences, amino acid sequences coded thereby and method of detection using the above. The novel nucleic acid sequences are naturally occurring splice variants of a prostate specific antigen sequence (PSA) or of the KLK-2 gene.
PCT/IL2000/000102 1999-02-18 2000-02-18 Psa and klk-2 splicing variants Ceased WO2000049158A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00905240A EP1159429A2 (en) 1999-02-18 2000-02-18 Psa and klk-2 splicing variants
AU26862/00A AU2686200A (en) 1999-02-18 2000-02-18 Novel nucleic acid and amino acid sequences

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL128587 1999-02-18
IL12858799A IL128587A0 (en) 1999-02-18 1999-02-18 Novel nucleic acid and amino acid sequences
IL129439 1999-04-14
IL12943999A IL129439A0 (en) 1999-04-14 1999-04-14 Novel nucleic acid and amino acid sequences
IL13136399A IL131363A0 (en) 1999-08-11 1999-08-11 Nucleic acid sequences, vectors and host cells containing them polypeptide encoded thereby antibodies reactive with said peptide and pharmaceutical compositions comprising said sequences polypeptide or antibodies
IL131363 1999-08-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09701238 A-371-Of-International 2000-02-18
US09/755,100 Continuation-In-Part US6740516B2 (en) 1999-02-18 2001-01-08 Nucleic acid and amino acid sequences

Publications (2)

Publication Number Publication Date
WO2000049158A2 WO2000049158A2 (en) 2000-08-24
WO2000049158A3 true WO2000049158A3 (en) 2000-12-21

Family

ID=27271903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000102 Ceased WO2000049158A2 (en) 1999-02-18 2000-02-18 Psa and klk-2 splicing variants

Country Status (4)

Country Link
US (2) US6740516B2 (en)
EP (1) EP1159429A2 (en)
AU (1) AU2686200A (en)
WO (1) WO2000049158A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794729B2 (en) * 1994-11-08 2010-09-14 The Trustees Of The University Of Pennsylvania Methods and compositions for immunotherapy of cancer
US7820180B2 (en) * 2004-09-24 2010-10-26 The Trustees Of The University Of Pennsylvania Listeria-based and LLO-based vaccines
EP1151142A2 (en) * 1999-01-28 2001-11-07 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
US20030207808A1 (en) * 1999-02-18 2003-11-06 Kinneret Savitzky Novel nucleic acid and amino acid sequences
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
EP1290032B1 (en) * 2000-05-24 2006-08-09 Roche Diagnostics GmbH Antibodies against particular forms of propsa and use thereof in immunoassays
FR2844278A1 (en) * 2002-09-05 2004-03-12 Exonhit Therapeutics Sa New nucleic acids, useful for diagnosis of cancer and for drug screening, are variants of the kallikrein-2 and prostate-specific antigen genes, also derived polypeptides
AUPS187002A0 (en) * 2002-04-22 2002-05-30 Queensland University Of Technology Condition-specific molecules and uses therefor
FR2848569A1 (en) * 2002-12-17 2004-06-18 Exonhit Therapeutics Sa New nucleic acid encoding variants of human kallikrein-3, useful for diagnosis of prostatic cancer and in screening for therapeutic agents, also related polypeptides and antibodies
US20050136407A1 (en) * 2003-12-19 2005-06-23 Cramer Scott D. Genetic polymorphisms in the prostate-specific antigen gene promoter
AU2005249450A1 (en) * 2004-05-27 2005-12-15 Centocor, Inc. Cynomolgus prostate specific antigen
EP2195015B1 (en) * 2007-10-09 2017-04-12 CureVac AG COMPOSITION FOR TREATING PROSTATE CANCER (PCa)
WO2009046739A1 (en) 2007-10-09 2009-04-16 Curevac Gmbh Composition for treating prostate cancer (pca)
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US20110129499A1 (en) 2008-05-19 2011-06-02 Paulo Maciag Dual delivery system for heterologous antigens
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
WO2012138377A2 (en) 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
CA2829960A1 (en) 2011-03-11 2012-09-20 John Rothman Listeria-based adjuvants
WO2013138337A1 (en) 2012-03-12 2013-09-19 Advaxis Suppressor cell function inhibition following listeria vaccine treatment
WO2015063647A1 (en) 2013-11-01 2015-05-07 Pfizer Inc. Vectors for expression of prostate-associated antigens

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012430A1 (en) * 1991-01-14 1992-07-23 Endorecherche Inc. Prescreening of prostate cancer by serum prostatic specific antigen
WO1998046795A1 (en) * 1997-04-11 1998-10-22 Baylor College Of Medicine Method for detection of recurrent prostate cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889806A (en) * 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5830686A (en) * 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
GB2302874B (en) * 1995-06-29 1999-11-10 Orion Yhtymae Oy Novel proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012430A1 (en) * 1991-01-14 1992-07-23 Endorecherche Inc. Prescreening of prostate cancer by serum prostatic specific antigen
WO1998046795A1 (en) * 1997-04-11 1998-10-22 Baylor College Of Medicine Method for detection of recurrent prostate cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAFFA, R. ET AL.: "A Comparative Analysis of Prostate-Specific Antigen Gene Sequence in Benign and Malignant Prostate Tissue.", UROLOGY, vol. 47, no. 6, June 1996 (1996-06-01), pages 795 - 800, XP000915073 *
RIEGMAN P H J ET AL: "MOLECULAR CLONING AND CHARACTERIZATION OF NOVEL PROSTATE ANTIGEN CDNA'S", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 155, no. 1, 30 August 1988 (1988-08-30), pages 181 - 188, XP002037458, ISSN: 0006-291X *
RIEGMAN, P.H.J. , ET AL.: "Identification of androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species.", MOL. CELL. ENDOCRINOL., vol. 76, 1991, pages 181 - 190, XP000915066 *
RIEGMAN, P.H.J. ET AL.: "Characterization of the Prostate-Specific Antigen Gene: A Novel Human Kallikrein-Like Gene.", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 159, no. 1, 1989, pages 95 - 102, XP002142073 *
See also references of EP1159429A2 *
THIOUNN, N. ET AL.: "Positive Prostate-Specific Antigen Circulating Cells Detected by Reverse Transcriptase-Polymerase Chain Reaction Does Not Imply The Presence of Prostatic Micrometastases", UROLOGY, vol. 50, 1997, pages 245 - 250, XP000915071 *

Also Published As

Publication number Publication date
EP1159429A2 (en) 2001-12-05
US20040219583A1 (en) 2004-11-04
WO2000049158A2 (en) 2000-08-24
AU2686200A (en) 2000-09-04
US20020099189A1 (en) 2002-07-25
US6740516B2 (en) 2004-05-25

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