WO2000050085A3 - Öl-in-wasser-emulsion zur verwendung als arzneimittel bzw. zur herstellung eines arzneimittels - Google Patents

Öl-in-wasser-emulsion zur verwendung als arzneimittel bzw. zur herstellung eines arzneimittels Download PDF

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Publication number
WO2000050085A3
WO2000050085A3 PCT/DE2000/000559 DE0000559W WO0050085A3 WO 2000050085 A3 WO2000050085 A3 WO 2000050085A3 DE 0000559 W DE0000559 W DE 0000559W WO 0050085 A3 WO0050085 A3 WO 0050085A3
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WO
WIPO (PCT)
Prior art keywords
disease
chronic
acute
water emulsion
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2000/000559
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English (en)
French (fr)
Other versions
WO2000050085A2 (de
Inventor
Heinrich Exner
Peter Klose
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Individual
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Individual
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Publication date
Application filed by Individual filed Critical Individual
Priority to DE10080402T priority Critical patent/DE10080402D2/de
Priority to DE50012052T priority patent/DE50012052D1/de
Priority to JP2000600695A priority patent/JP4383678B2/ja
Priority to EP00914043A priority patent/EP1156830B1/de
Priority to CA2364606A priority patent/CA2364606C/en
Priority to AU35504/00A priority patent/AU3550400A/en
Publication of WO2000050085A2 publication Critical patent/WO2000050085A2/de
Publication of WO2000050085A3 publication Critical patent/WO2000050085A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung beruht auf der Feststellung, dass die Öl-in-Wasser-Emulsion in der Zusammensetzung 0,01-30 % Polydimethylsiloxanen, die einen Polymerisationsgrad von n = 20-400 und eine kinematische Viskosität von 20-1300 mm2/s aufweisen, 0,01-15 % hydrophiler Emulgator, 45-99 % biokompatibler Salzlösung, 0,01-10 % Dimethylsulfoxid zur Herstellung eines Arzneimittels gegen SIRS, Intensivmedizin, Viruserkrankungen wie etwa Hepatitis C und AIDS, Colitis ulcerosa, Morbus Crohn, Parkinson, Morbus Alzheimer, MS, infektiösen Hospitalismus und/oder Infektionskrankheiten viraler und/oder bakterieller Genese, Asthma bronchiale, Nieren- und Harnwegsinfektionen, Migräne, rheumatoide Arthritis, Sudeck, akute und chronische Entzündungen, Venen- und Arterienentzündungen, akute und chronische Erschöpfungszustände, Tumorerkrankungen, Muskelschwundkrankheiten, Hämorrhoiden, CIHK, Hypertonie, Alterungsvorgängen, akute und chronische Schmerzzuständen, Spastiken, Polyneuropathien, Prostata Neoplasien, Haarausfall, Impotenz, Neurodermitis, Cervicalsyndrom, Gewebetraumatisierungen bzw. zu deren Behandlung verwendet werden kann.
PCT/DE2000/000559 1999-02-24 2000-02-23 Öl-in-wasser-emulsion zur verwendung als arzneimittel bzw. zur herstellung eines arzneimittels Ceased WO2000050085A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE10080402T DE10080402D2 (de) 1999-02-24 2000-02-23 Öl-in-Wasser-Emulsion zur Verwendung als Arzneimittel bzw. zur Herstellung eines Arzneimittels
DE50012052T DE50012052D1 (de) 1999-02-24 2000-02-23 Verwendung einer öl-in-wasser-emulsion zur herstellung eines arzneimittels
JP2000600695A JP4383678B2 (ja) 1999-02-24 2000-02-23 医薬品としての使用のための水中油型エマルション
EP00914043A EP1156830B1 (de) 1999-02-24 2000-02-23 Verwendung einer öl-in-wasser-emulsion zur herstellung eines arzneimittels
CA2364606A CA2364606C (en) 1999-02-24 2000-02-23 Oil-in-water emulsion for the use as medicament or for producing a medicament
AU35504/00A AU3550400A (en) 1999-02-24 2000-02-23 Oil-in-water emulsion for the use as medicament or for producing a medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19910161 1999-02-24
DE19910161.2 1999-02-24

Publications (2)

Publication Number Publication Date
WO2000050085A2 WO2000050085A2 (de) 2000-08-31
WO2000050085A3 true WO2000050085A3 (de) 2000-12-28

Family

ID=7900130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000559 Ceased WO2000050085A2 (de) 1999-02-24 2000-02-23 Öl-in-wasser-emulsion zur verwendung als arzneimittel bzw. zur herstellung eines arzneimittels

Country Status (10)

Country Link
EP (1) EP1156830B1 (de)
JP (1) JP4383678B2 (de)
AT (1) ATE315408T1 (de)
AU (1) AU3550400A (de)
CA (1) CA2364606C (de)
DE (2) DE50012052D1 (de)
DK (1) DK1156830T3 (de)
ES (1) ES2255988T3 (de)
PT (1) PT1156830E (de)
WO (1) WO2000050085A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10113284A1 (de) 2001-03-16 2002-10-02 Heinrich Exner Adjuvans-Emulsion und Verfahren zu deren Verwendung
DE10313196A1 (de) * 2003-03-19 2004-10-07 Exner, Heinrich, Dr.med.vet. Verwendung einer Emulsion zur Prophylaxe und Therapie von Erkrankungen bei Tieren und Menschen
JP2005075752A (ja) * 2003-08-29 2005-03-24 Nippon Inst For Biological Science 豚繁殖・呼吸障害症候群用ワクチン製剤
DE10353792A1 (de) * 2003-11-13 2005-06-23 Exner, Heinrich, Dr.med.vet. Heil- und Wundsalbe auf der Basis einer wässrigen Emulsion
DE102005009515A1 (de) 2005-02-25 2006-09-07 Exner, Heinrich, Dr. Verfahren zur Herstellung einer Zubereitung einer DMSO-haltigen festen Silikonölemulsion zur Bindung von reaktiven Sauerstoffverbindungen im Körper von Menschen und Tieren
DE102007007698A1 (de) * 2007-02-09 2008-08-21 Exner, Heinrich, Dr. Verwendung einer hochemulgierten Silikonöl-Emulsion (HSE)zur Herstellung eines Medikamentes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445074A1 (de) * 1993-12-09 1995-06-29 Exner Heinrich Dr Med Vet Adjuvans für Antigene, Verfahren zur Herstellung und Verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0732936T3 (da) * 1993-12-09 2000-09-04 Heinrich Exner Adjuvans til antigener, fremgangsmåde til fremstilling og anvendelse

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445074A1 (de) * 1993-12-09 1995-06-29 Exner Heinrich Dr Med Vet Adjuvans für Antigene, Verfahren zur Herstellung und Verwendung

Also Published As

Publication number Publication date
CA2364606C (en) 2012-02-14
ES2255988T3 (es) 2006-07-16
DK1156830T3 (da) 2006-05-29
WO2000050085A2 (de) 2000-08-31
DE10080402D2 (de) 2002-05-08
PT1156830E (pt) 2006-05-31
ATE315408T1 (de) 2006-02-15
JP4383678B2 (ja) 2009-12-16
AU3550400A (en) 2000-09-14
JP2002537359A (ja) 2002-11-05
CA2364606A1 (en) 2000-08-31
EP1156830B1 (de) 2006-01-11
DE50012052D1 (de) 2006-04-06
EP1156830A2 (de) 2001-11-28

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