WO2000050563A3 - G protein-coupled receptor resembling galanin receptors - Google Patents

G protein-coupled receptor resembling galanin receptors Download PDF

Info

Publication number
WO2000050563A3
WO2000050563A3 PCT/US2000/004416 US0004416W WO0050563A3 WO 2000050563 A3 WO2000050563 A3 WO 2000050563A3 US 0004416 W US0004416 W US 0004416W WO 0050563 A3 WO0050563 A3 WO 0050563A3
Authority
WO
WIPO (PCT)
Prior art keywords
coupled receptor
protein
resembling
galanin receptors
gpr54
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/004416
Other languages
French (fr)
Other versions
WO2000050563A9 (en
WO2000050563A2 (en
Inventor
Andrew D Howard
Gary P O'neill
Brian O'dowd
Susan George
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto
Merck Frosst Canada and Co
Merck and Co Inc
Original Assignee
University of Toronto
Merck Frosst Canada and Co
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto, Merck Frosst Canada and Co, Merck and Co Inc filed Critical University of Toronto
Priority to CA002364988A priority Critical patent/CA2364988A1/en
Priority to JP2000601127A priority patent/JP2002536989A/en
Priority to EP00921344A priority patent/EP1157097A4/en
Publication of WO2000050563A2 publication Critical patent/WO2000050563A2/en
Publication of WO2000050563A3 publication Critical patent/WO2000050563A3/en
Anticipated expiration legal-status Critical
Publication of WO2000050563A9 publication Critical patent/WO2000050563A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Human and rat DNAs encoding a novel G-protein coupled receptor, GPR54, as well as proteins encoded by the DNAs, are provided. Methods of identifying agonists and antagonists of GPR54 are also provided.
PCT/US2000/004416 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors Ceased WO2000050563A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002364988A CA2364988A1 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors
JP2000601127A JP2002536989A (en) 1999-02-24 2000-02-22 G protein-coupled receptor similar to galanin receptor
EP00921344A EP1157097A4 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12165199P 1999-02-24 1999-02-24
US60/121,651 1999-02-24

Publications (3)

Publication Number Publication Date
WO2000050563A2 WO2000050563A2 (en) 2000-08-31
WO2000050563A3 true WO2000050563A3 (en) 2000-12-21
WO2000050563A9 WO2000050563A9 (en) 2001-08-30

Family

ID=22397998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004416 Ceased WO2000050563A2 (en) 1999-02-24 2000-02-22 G protein-coupled receptor resembling galanin receptors

Country Status (4)

Country Link
EP (1) EP1157097A4 (en)
JP (1) JP2002536989A (en)
CA (1) CA2364988A1 (en)
WO (1) WO2000050563A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4486187B2 (en) 1998-10-27 2010-06-23 武田薬品工業株式会社 Novel G protein-coupled receptor protein, its DNA and its ligand
US20020077469A1 (en) * 1999-03-10 2002-06-20 Borowsky Beth E. DNA encoding orphan SNORF11 receptor
CA2404257A1 (en) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Novel protein, dna thereof and process for producing the same
EP1363655A4 (en) * 2000-12-18 2005-04-06 Merck & Co Inc ISOLATED NUCLEIC ACID MOLECULES ENCODING A HUMAN G-GPR54 PROTEIN-COUPLED RECEPTOR AND MURINE, ENCODED PROTEINS, CELLS TRANSFORMED THEREFROM, AND USES THEREOF
WO2002072816A1 (en) * 2001-02-26 2002-09-19 Takeda Chemical Industries, Ltd. Novel mouse type kiss-1 receptor protein and dna thereof
JPWO2003030936A1 (en) * 2001-10-02 2005-01-20 住友製薬株式会社 Life-style related diseases or anorexia remedies and screening methods thereof
WO2004024072A2 (en) * 2002-09-11 2004-03-25 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
GB0304021D0 (en) * 2003-02-21 2003-03-26 Pfizer Ltd Treatment of hypertension
CA2523600A1 (en) * 2003-04-28 2004-11-11 Wyeth Methods utilising g-protein coupled receptor 54
WO2005040833A1 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Regulation of human metastin recognising receptors
JP2008517930A (en) 2004-10-21 2008-05-29 トランス テック ファーマ，インコーポレイテッド Bissulfonamide compounds, compositions, and methods of use as agonists of GalR1
GB0719592D0 (en) 2007-10-08 2007-11-14 Medical Res Council Compound, use and method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003548A1 (en) * 1996-07-19 1998-01-29 Astra Pharma Inc. A novel galanin receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4486187B2 (en) * 1998-10-27 2010-06-23 武田薬品工業株式会社 Novel G protein-coupled receptor protein, its DNA and its ligand

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003548A1 (en) * 1996-07-19 1998-01-29 Astra Pharma Inc. A novel galanin receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEE ET AL.: "Discovery of a receptor related to the galanin receptors", FEBS LETTERS, vol. 446, no. 1, 5 March 1999 (1999-03-05), pages 103 - 107, XP002931209 *
See also references of EP1157097A4 *

Also Published As

Publication number Publication date
JP2002536989A (en) 2002-11-05
EP1157097A2 (en) 2001-11-28
CA2364988A1 (en) 2000-08-31
WO2000050563A9 (en) 2001-08-30
EP1157097A4 (en) 2005-02-16
WO2000050563A2 (en) 2000-08-31

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