WO2000052047A3 - Human dickkopf-related protein and nucleic acid molecules and uses therefor - Google Patents

Human dickkopf-related protein and nucleic acid molecules and uses therefor Download PDF

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Publication number
WO2000052047A3
WO2000052047A3 PCT/US2000/005452 US0005452W WO0052047A3 WO 2000052047 A3 WO2000052047 A3 WO 2000052047A3 US 0005452 W US0005452 W US 0005452W WO 0052047 A3 WO0052047 A3 WO 0052047A3
Authority
WO
WIPO (PCT)
Prior art keywords
dkk
nucleic acid
acid molecules
related protein
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/005452
Other languages
French (fr)
Other versions
WO2000052047A9 (en
WO2000052047A2 (en
Inventor
Sean Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to CA2366062A priority Critical patent/CA2366062C/en
Priority to EP00913706A priority patent/EP1161445A2/en
Priority to AU35102/00A priority patent/AU3510200A/en
Publication of WO2000052047A2 publication Critical patent/WO2000052047A2/en
Publication of WO2000052047A3 publication Critical patent/WO2000052047A3/en
Anticipated expiration legal-status Critical
Publication of WO2000052047A9 publication Critical patent/WO2000052047A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4718—Cytokine-induced proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk an Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US2000/005452 1999-03-05 2000-03-03 Human dickkopf-related protein and nucleic acid molecules and uses therefor Ceased WO2000052047A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2366062A CA2366062C (en) 1999-03-05 2000-03-03 Human dickkopf-related protein and nucleic acid molecules and uses therefor
EP00913706A EP1161445A2 (en) 1999-03-05 2000-03-03 Human dickkopf-related protein and nucleic acid molecules and uses therefor
AU35102/00A AU3510200A (en) 1999-03-05 2000-03-03 Human dickkopf-related protein and nucleic acid molecules and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26302299A 1999-03-05 1999-03-05
US09/263,022 1999-03-05

Publications (3)

Publication Number Publication Date
WO2000052047A2 WO2000052047A2 (en) 2000-09-08
WO2000052047A3 true WO2000052047A3 (en) 2001-02-01
WO2000052047A9 WO2000052047A9 (en) 2002-03-14

Family

ID=23000057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005452 Ceased WO2000052047A2 (en) 1999-03-05 2000-03-03 Human dickkopf-related protein and nucleic acid molecules and uses therefor

Country Status (4)

Country Link
EP (1) EP1161445A2 (en)
AU (1) AU3510200A (en)
CA (1) CA2366062C (en)
WO (1) WO2000052047A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459437B2 (en) * 2002-12-05 2008-12-02 University Of Arkansas For Medical Sciences Molecular determinants of myeloma bone disease and uses thereof
US7709611B2 (en) 2004-08-04 2010-05-04 Amgen Inc. Antibodies to Dkk-1
US9644013B2 (en) 2010-07-01 2017-05-09 National University Corporation Okayama University Partial region polypeptide of REIC/Dkk-3 protein

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE255229T1 (en) * 2000-02-24 2003-12-15 Oxford Glycosciences Uk Ltd DPI-6, A THERAPEUTIC BIOMARKER IN NEUROLOGICAL DISEASES
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
HUP0303194A2 (en) * 2001-02-16 2003-12-29 Genentech, Inc. Use of dkk-1 and their antagonists
EP1573024A4 (en) 2001-04-10 2007-08-29 Agensys Inc NUCLEIC ACIDS AND CORRESPONDING PROTEINS USEFUL FOR THE DETECTION AND TREATMENT OF VARIOUS CANCERS
US20040038860A1 (en) 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
EP1395285A4 (en) * 2001-05-17 2005-06-01 Genome Therapeutics Corp REAGENTS AND METHODS FOR MODULATING INDUCED DKK INTERACTIONS
ES2304210B1 (en) * 2002-10-15 2009-09-28 Genentech, Inc USE OF DKK-5, PROCEDURE AND EQUIPMENT FOR DIAGNOSIS OF INSULIN AND HYBRIDOMA RESISTANT DISORDERS AND ANTIBODY AGAINST DKK-5.
US7811750B2 (en) * 2002-12-05 2010-10-12 Board Of Trustees Of The University Of Arkansas Molecular determinants of myeloma bone disease and use thereof
US8124087B2 (en) 2002-12-05 2012-02-28 Board Of Trustees Of The University Of Arkansas Methods of controlling bone loss by inhibiting DKK1
US8637506B2 (en) * 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US7622553B2 (en) 2003-11-17 2009-11-24 Merck & Co., Inc. Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
US7473770B2 (en) 2003-11-17 2009-01-06 Merck & Co., Inc. Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
US8343922B2 (en) * 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
WO2006010534A1 (en) * 2004-07-28 2006-02-02 F.Hoffmann-La Roche Ag Dickkopf homolog 3 as target/marker of beta cell failure
US8252267B2 (en) 2005-03-30 2012-08-28 Sagres Discovery, Inc. DKKL-1 splice product modulators for cancer diagnosis and therapy
WO2007104181A1 (en) * 2006-03-13 2007-09-20 Shanghai Cancer Institute Uses of dkk-1 protein in diagnosis of cancers
KR20130021315A (en) * 2011-08-22 2013-03-05 인하대학교 산학협력단 Composition for preventing or treating erectile dysfunction comprising dkk2 protein or gene therefor and use thereof
WO2020261100A1 (en) * 2019-06-25 2020-12-30 Friedrich Miescher Institute For Biomedical Research Promoter for the specific expression of genes in cells expressing glial fibrillary acidic protein

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027932A2 (en) * 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Cerebellum and embryo specific protein
WO1998046755A1 (en) * 1997-04-16 1998-10-22 Millennium Biotherapeutics, Inc. Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
WO1999022000A1 (en) * 1997-10-27 1999-05-06 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibitor protein of the wnt signal pathway
WO2000018194A1 (en) * 1998-09-18 2000-03-30 Arnold & Richter Cine Technik Gmbh & Co. Betriebs Kg Lighting device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027932A2 (en) * 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Cerebellum and embryo specific protein
WO1998046755A1 (en) * 1997-04-16 1998-10-22 Millennium Biotherapeutics, Inc. Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
WO1999022000A1 (en) * 1997-10-27 1999-05-06 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibitor protein of the wnt signal pathway
WO2000018194A1 (en) * 1998-09-18 2000-03-30 Arnold & Richter Cine Technik Gmbh & Co. Betriebs Kg Lighting device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FINCH P W ET AL.: "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action", PROC. NATL. ACAD. SCI. USA, vol. 94, no. 13, June 1997 (1997-06-01), pages 6770 - 6775, XP002140787 *
GLINKA ET AL: "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction", NATURE, vol. 391, no. 6665, 22 January 1998 (1998-01-22), pages 357 - 362, XP002140766 *
KRUPNIK V E ET AL.: "Functional and structural diversity of the human Dickkopf gene family", GENE, vol. 238, no. 2, 1 October 1999 (1999-10-01), pages 301 - 313, XP002140768 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459437B2 (en) * 2002-12-05 2008-12-02 University Of Arkansas For Medical Sciences Molecular determinants of myeloma bone disease and uses thereof
US7709611B2 (en) 2004-08-04 2010-05-04 Amgen Inc. Antibodies to Dkk-1
US9644013B2 (en) 2010-07-01 2017-05-09 National University Corporation Okayama University Partial region polypeptide of REIC/Dkk-3 protein

Also Published As

Publication number Publication date
EP1161445A2 (en) 2001-12-12
WO2000052047A9 (en) 2002-03-14
CA2366062A1 (en) 2000-09-08
WO2000052047A2 (en) 2000-09-08
AU3510200A (en) 2000-09-21
CA2366062C (en) 2014-06-17

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