WO2000053167A3 - Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs - Google Patents

Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs Download PDF

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Publication number
WO2000053167A3
WO2000053167A3 PCT/US2000/005965 US0005965W WO0053167A3 WO 2000053167 A3 WO2000053167 A3 WO 2000053167A3 US 0005965 W US0005965 W US 0005965W WO 0053167 A3 WO0053167 A3 WO 0053167A3
Authority
WO
WIPO (PCT)
Prior art keywords
long
viral replication
nucleoside analogs
chain hydrocarbons
synergistic inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/005965
Other languages
French (fr)
Other versions
WO2000053167A2 (en
Inventor
John F Marcelletti
Laura E Pope
Mohammed H Khalil
David H Katz
Lee R Katz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avanir Pharmaceuticals Inc
Original Assignee
Avanir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000603656A priority Critical patent/JP2002538200A/en
Priority to PL00350660A priority patent/PL350660A1/en
Priority to HK02101995.1A priority patent/HK1041438B/en
Priority to DE60036862T priority patent/DE60036862T2/en
Priority to KR1020017011487A priority patent/KR20020005615A/en
Priority to AU33962/00A priority patent/AU771510B2/en
Priority to CA002364251A priority patent/CA2364251C/en
Priority to EP00912195A priority patent/EP1156797B1/en
Priority to NZ513849A priority patent/NZ513849A/en
Priority to BR0008829-3A priority patent/BR0008829A/en
Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Priority to IL14518900A priority patent/IL145189A0/en
Publication of WO2000053167A2 publication Critical patent/WO2000053167A2/en
Publication of WO2000053167A3 publication Critical patent/WO2000053167A3/en
Priority to NO20014347A priority patent/NO20014347L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically acceptable carrier. Methods for treating viral infections using such compositions are also disclosed.
PCT/US2000/005965 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs Ceased WO2000053167A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
NZ513849A NZ513849A (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
HK02101995.1A HK1041438B (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
DE60036862T DE60036862T2 (en) 1999-03-10 2000-03-08 SYNERGISTIC INHIBITION OF VIRAL REPLICATION BY LONG-CHAINED HYDROCARBONS AND NUCLEOSIDE ANALOGS
KR1020017011487A KR20020005615A (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
AU33962/00A AU771510B2 (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
CA002364251A CA2364251C (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
EP00912195A EP1156797B1 (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
JP2000603656A JP2002538200A (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogues
PL00350660A PL350660A1 (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long−chain hydrocarbons and nucleoside analogs
BR0008829-3A BR0008829A (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long chain hydrocarbons and nucleoside analogues
IL14518900A IL145189A0 (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
NO20014347A NO20014347L (en) 1999-03-10 2001-09-06 Synergistic inhibition of viral replication by long chain hydrocarbons and nucleoside analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/265,922 US6440980B1 (en) 1996-09-17 1999-03-10 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US09/265,922 1999-03-10

Publications (2)

Publication Number Publication Date
WO2000053167A2 WO2000053167A2 (en) 2000-09-14
WO2000053167A3 true WO2000053167A3 (en) 2001-02-15

Family

ID=23012439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005965 Ceased WO2000053167A2 (en) 1999-03-10 2000-03-08 Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs

Country Status (20)

Country Link
US (2) US6440980B1 (en)
EP (1) EP1156797B1 (en)
JP (1) JP2002538200A (en)
KR (1) KR20020005615A (en)
CN (1) CN1208065C (en)
AT (1) ATE376445T1 (en)
AU (1) AU771510B2 (en)
BR (1) BR0008829A (en)
CA (1) CA2364251C (en)
CZ (1) CZ20013120A3 (en)
DE (1) DE60036862T2 (en)
HK (1) HK1041438B (en)
HU (1) HUP0200294A3 (en)
IL (1) IL145189A0 (en)
NO (1) NO20014347L (en)
NZ (2) NZ513849A (en)
PL (1) PL350660A1 (en)
RU (1) RU2251415C2 (en)
WO (1) WO2000053167A2 (en)
ZA (1) ZA200108283B (en)

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US6440980B1 (en) 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
PL371945A1 (en) * 2001-10-16 2005-07-11 Avanir Pharmacueticals Viral inhibition by n-docosanol
JP2005527499A (en) * 2002-02-13 2005-09-15 メルク　エンド　カムパニー　インコーポレーテッド Methods for inhibiting orthopoxvirus replication using nucleoside compounds
WO2006105216A1 (en) * 2005-03-30 2006-10-05 Novartis Ag Famciclovir for the treatment of recurrent herpes labialis using a one-day treatment
US20070258996A1 (en) * 2005-12-23 2007-11-08 The Sterilex Corporation Antimicrobial compositions
US20080194518A1 (en) * 2005-12-23 2008-08-14 MOOKERJEE Pradip Antimicrobial Compositions
US20090312279A1 (en) * 2005-12-23 2009-12-17 Sterilex Technologies, Llc Antimicrobial compositions
JP2007182398A (en) * 2006-01-06 2007-07-19 Nakajima Kagaku Sangyo Kk Antiviral lubricant
US8236768B2 (en) 2008-10-03 2012-08-07 3B Pharmaceuticals, Inc. Topical antiviral formulations
US8541360B2 (en) * 2008-11-19 2013-09-24 Ben Venue Laboratories, Inc. Parenteral formulations comprising sugar-based esters and ethers
WO2012174535A1 (en) * 2011-06-17 2012-12-20 Constitution Medical, Inc. Solutions for histoprocessing of biological samples
US9125911B2 (en) * 2013-03-14 2015-09-08 Quadex Pharmaceuticals, Llc Combined systemic and topical treatment of disordered tissues
JP6125962B2 (en) * 2013-09-24 2017-05-10 株式会社デンソー Antiviral agent
US11071745B2 (en) * 2014-07-07 2021-07-27 Elian Llc Viral prophylaxis treatment methods and pre-exposure prophylaxis kits
FR3054454B1 (en) 2016-07-26 2020-04-10 IFP Energies Nouvelles CATALYST COMPRISING AN IZM-2 ZEOLITE HAVING AN OPTIMIZED IF / AL MOLAR RATIO FOR THE ISOMERIZATION OF C8 AROMATIC CUTS
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