WO2000053776A3 - Human kallikrein-like genes - Google Patents

Human kallikrein-like genes Download PDF

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Publication number
WO2000053776A3
WO2000053776A3 PCT/CA2000/000258 CA0000258W WO0053776A3 WO 2000053776 A3 WO2000053776 A3 WO 2000053776A3 CA 0000258 W CA0000258 W CA 0000258W WO 0053776 A3 WO0053776 A3 WO 0053776A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
human kallikrein
nucleic acid
acid molecules
kallikrein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000258
Other languages
French (fr)
Other versions
WO2000053776A2 (en
Inventor
George M Yousef
Eleftherios P Diamandis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mount Sinai Hospital
Original Assignee
Mount Sinai Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai Hospital filed Critical Mount Sinai Hospital
Priority to CA002362885A priority Critical patent/CA2362885A1/en
Priority to EP00908878A priority patent/EP1159431A2/en
Priority to JP2000603397A priority patent/JP2002538789A/en
Priority to AU31398/00A priority patent/AU3139800A/en
Priority to US09/936,271 priority patent/US7022497B1/en
Publication of WO2000053776A2 publication Critical patent/WO2000053776A2/en
Publication of WO2000053776A3 publication Critical patent/WO2000053776A3/en
Anticipated expiration legal-status Critical
Priority to US11/319,952 priority patent/US20060134114A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to nucleic acid molecules, kallikrein-like proteins encoded by such nucleic acid molecules; and use of the proteins and nucleic acid molecules
PCT/CA2000/000258 1999-03-11 2000-03-09 Human kallikrein-like genes Ceased WO2000053776A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002362885A CA2362885A1 (en) 1999-03-11 2000-03-09 Human kallikrein-like genes
EP00908878A EP1159431A2 (en) 1999-03-11 2000-03-09 Human kallikrein-like genes
JP2000603397A JP2002538789A (en) 1999-03-11 2000-03-09 Novel human kallikrein-like gene
AU31398/00A AU3139800A (en) 1999-03-11 2000-03-09 Novel human kallikrein-like genes
US09/936,271 US7022497B1 (en) 1999-03-11 2000-03-09 Human kallikrein-like genes
US11/319,952 US20060134114A1 (en) 1999-03-11 2005-12-28 Novel human kallikrein-like genes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12426099P 1999-03-11 1999-03-11
US60/124,260 1999-03-11
US12738699P 1999-04-01 1999-04-01
US60/127,386 1999-04-01
US14491999P 1999-07-21 1999-07-21
US60/144,919 1999-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/319,952 Division US20060134114A1 (en) 1999-03-11 2005-12-28 Novel human kallikrein-like genes

Publications (2)

Publication Number Publication Date
WO2000053776A2 WO2000053776A2 (en) 2000-09-14
WO2000053776A3 true WO2000053776A3 (en) 2000-12-14

Family

ID=27383080

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CA2000/000259 Ceased WO2000053747A1 (en) 1999-03-11 2000-03-09 Sialic acid-binding ig-like lectin (siglec) gene; ob-binding protein like (ob-bpl)
PCT/CA2000/000258 Ceased WO2000053776A2 (en) 1999-03-11 2000-03-09 Human kallikrein-like genes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000259 Ceased WO2000053747A1 (en) 1999-03-11 2000-03-09 Sialic acid-binding ig-like lectin (siglec) gene; ob-binding protein like (ob-bpl)

Country Status (5)

Country Link
EP (1) EP1159431A2 (en)
JP (1) JP2002538789A (en)
AU (2) AU3139900A (en)
CA (2) CA2366087A1 (en)
WO (2) WO2000053747A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364521B2 (en) 2012-06-04 2016-06-14 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943236B2 (en) 1997-02-25 2005-09-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
CA2503475A1 (en) * 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
JP4495349B2 (en) 1999-01-28 2010-07-07 ジェン−プローブ・インコーポレーテッド Nucleic acid sequences for detecting cancer genetic markers in biological samples
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
HK1048495A1 (en) * 1999-10-07 2003-04-04 Schering Aktiengesellschaft Dna encoding prost 07 polypeptide
WO2002037112A2 (en) 2000-11-01 2002-05-10 Mount Sinai Hospital Detection of ovarian cancer
EP1661986A1 (en) * 2000-11-17 2006-05-31 Nuvelo, Inc. Nucleic acids and polypeptides enocoded thereby that are member of the kallikrein gene familyNovel nucleic acids and polypeptides
AUPR402201A0 (en) * 2001-03-27 2001-04-26 Queensland University Of Technology Polynucleotides and polypeptides linked to cancer and/or benign tumours
AU2002360354A1 (en) * 2001-11-07 2003-05-19 Millennium Pharmaceuticals, Inc. Methods of identifying and using modulators of fractalkine receptor
AU2003266038A1 (en) * 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting endocrine cancer using kallikrein 13 (klk13) as a biomarker
EP1664331A2 (en) * 2003-08-30 2006-06-07 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 9 (klk9)
EP1721003A1 (en) * 2004-02-18 2006-11-15 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 5 (klk5)
US20130315891A1 (en) * 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
AU2017207807A1 (en) * 2016-01-12 2018-07-12 Palleon Pharmaceuticals Inc. Use of Siglec-7 or Siglec-9 antibodies for the treatment of cancer
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
CN112480237B (en) * 2019-09-12 2023-10-17 上海津曼特生物科技有限公司 Fusion protein and preparation method and application thereof
CN114414812B (en) * 2020-12-21 2022-09-20 华中科技大学同济医学院附属同济医院 Application of biomarker combination in preparation of reagent for diagnosing fulminant myocarditis and medicine for fulminant myocarditis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020117A1 (en) * 1996-11-05 1998-05-14 Incyte Pharmaceuticals, Inc. Prostate-specific kallikrein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146845A (en) * 1997-04-02 2000-11-14 Smithkline Beecham Corporation Polynucleotides encoding a sialoadhesin family member-2 (SAF-2)
EP0869178A1 (en) * 1997-04-02 1998-10-07 Smithkline Beecham Corporation SAF-3, Sialoadhesin family member-3
NZ510464A (en) * 1998-09-01 2004-05-28 Genentech Inc Further pro polypeptides and sequences thereof
KR100529270B1 (en) * 1998-12-01 2005-11-21 제넨테크, 인크. Promotion or Inhibition of Angiogenesis and Cardiovascularization

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020117A1 (en) * 1996-11-05 1998-05-14 Incyte Pharmaceuticals, Inc. Prostate-specific kallikrein

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
B.R. DUPONT ET AL.: "Assignment of serine protease 17 (PRSS17) to human chromosome bands 19q13.3-q13.4 by in situ hydridization", CYTOGENETICS AND CELL GENETICS, vol. 86, no. 3-4, 22 April 1999 (1999-04-22), pages 212 - 213, XP000911088, Retrieved from the Internet <URL:http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?603767#Reference1> [retrieved on 20000517] *
DIAMANDIS E.P. ET AL: "The new human kallikrein gene family: Implications in carcinogenesis.", TRENDS IN ENDOCRINOLOGY AND METABOLISM, (2000) 11/2 (54-60)., XP000910866 *
GEORGE M. YOUSEF ET AL.: "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4", ANTICANCER RESEARCH, vol. 19, July 1999 (1999-07-01), pages 2343 - 2352, XP000911217 *
GEORGE M. YOUSEF ET AL.: "Prostase/KLK-L1 is a new member of the human Kallikrein gene family, is espressed in prostate and breast tissues, and is hormonally regulated", CANCER RESEARCH, vol. 59, no. 17, 1 September 1999 (1999-09-01), MD US, pages 4252 - 4256, XP002141958 *
J.P. SIMMER ET AL.: "Purification, characterization, and cloning of Enamel Matrix Serine Proteinase 1", JOURNAL OF DENTAL RESEARCH, vol. 77, no. 2, February 1998 (1998-02-01), pages 377 - 386, XP000910876 *
LYNETTE J. SCHEDLICH ET AL.: "Primary structure of a human glandular Kallikrein gene", DNA, vol. 6, no. 5, 1987, pages 429 - 437, XP002044466 *
P.H.J. RIEGMAN ET AL.: "Characterization of the human Kallikrein locus", GENOMICS, vol. 14, 1992, pages 6 - 11, XP002058183 *
P.H.J. RIEGMAN ET AL.: "Characterization of the prostate-specific gene: A novel human Kallikrein-like gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 159, no. 1, 28 February 1989 (1989-02-28), ORLANDO, FL US, pages 95 - 102, XP002141957 *
PETER S. NELSON ET AL.: "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 96, no. 6, 16 March 1999 (1999-03-16), WASHINGTON US, pages 3114 - 3119, XP002141959 *
See also references of EP1159431A2 *
STEPHENSON S A ET AL.: "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene famly cluster on chromosome 19q13.3-13.4", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), MD US, pages 23210 - 23214, XP002141960, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query_old?uid=10438493&form=6&db=m&Dopt=b> [retrieved on 20000517] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364521B2 (en) 2012-06-04 2016-06-14 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms

Also Published As

Publication number Publication date
EP1159431A2 (en) 2001-12-05
WO2000053776A2 (en) 2000-09-14
JP2002538789A (en) 2002-11-19
AU3139800A (en) 2000-09-28
CA2362885A1 (en) 2000-09-14
WO2000053747A1 (en) 2000-09-14
CA2366087A1 (en) 2000-09-14
AU3139900A (en) 2000-09-28

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