WO2000054046A3 - Universal protein array system - Google Patents

Universal protein array system Download PDF

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Publication number
WO2000054046A3
WO2000054046A3 PCT/US2000/006244 US0006244W WO0054046A3 WO 2000054046 A3 WO2000054046 A3 WO 2000054046A3 US 0006244 W US0006244 W US 0006244W WO 0054046 A3 WO0054046 A3 WO 0054046A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
array system
universal protein
protein array
universal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/006244
Other languages
French (fr)
Other versions
WO2000054046A2 (en
Inventor
Hui Ge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
US Department of Health and Human Services
Original Assignee
National Institutes of Health NIH
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH, US Department of Health and Human Services filed Critical National Institutes of Health NIH
Priority to CA002365431A priority Critical patent/CA2365431A1/en
Priority to AU41705/00A priority patent/AU773291B2/en
Priority to EP00921374A priority patent/EP1159615A2/en
Publication of WO2000054046A2 publication Critical patent/WO2000054046A2/en
Publication of WO2000054046A3 publication Critical patent/WO2000054046A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to ordered arrays of molecules, for instance polypeptides or proteins. Such arrays, referred to as universal protein arrays, are described in both macro- and microarray formats. Methods of production and use of such arrays are also described. Also disclosed are kits for the use of such arrays and the preparation of probes for use with them.
PCT/US2000/006244 1999-03-10 2000-03-10 Universal protein array system Ceased WO2000054046A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002365431A CA2365431A1 (en) 1999-03-10 2000-03-10 Universal protein array system
AU41705/00A AU773291B2 (en) 1999-03-10 2000-03-10 UPA, a universal protein array system
EP00921374A EP1159615A2 (en) 1999-03-10 2000-03-10 Universal protein array system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12358699P 1999-03-10 1999-03-10
US60/123,586 1999-03-10

Publications (2)

Publication Number Publication Date
WO2000054046A2 WO2000054046A2 (en) 2000-09-14
WO2000054046A3 true WO2000054046A3 (en) 2000-12-21

Family

ID=22409568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006244 Ceased WO2000054046A2 (en) 1999-03-10 2000-03-10 Universal protein array system

Country Status (4)

Country Link
EP (1) EP1159615A2 (en)
AU (1) AU773291B2 (en)
CA (1) CA2365431A1 (en)
WO (1) WO2000054046A2 (en)

Cited By (4)

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US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US7635572B2 (en) 2003-06-09 2009-12-22 Life Technologies Corporation Methods for conducting assays for enzyme activity on protein microarrays

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US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
AU2001284899A1 (en) * 2000-08-11 2002-02-25 Qianjin Hu Methods and universal monoclonal antibody array
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
AU2001292959A1 (en) 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
DE10054055A1 (en) 2000-10-31 2002-05-23 Nmi Univ Tuebingen Methods for analyzing proteins
EP1397679B1 (en) 2000-11-27 2010-01-20 Intelligent Medical Devices LLC Clinically intelligent diagnostic devices and methods
ATE538380T1 (en) 2001-01-23 2012-01-15 Harvard College NUCLEIC ACID PROGRAMMABLE PROTEIN ARRAYS
US7332286B2 (en) 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
DE10118774A1 (en) * 2001-04-17 2002-10-31 Jerini Ag Method for determining the substrate specificity of an enzymatic activity and device therefor
WO2002090985A1 (en) 2001-05-07 2002-11-14 Kiyoshi Nokihara Peptide-immobilized baseboard and method of assaying target protein using the same
US7981842B2 (en) * 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
EP1279963A1 (en) * 2001-07-27 2003-01-29 Université de Nantes Protein-target screening method using near-infrared fluorescent dyes
US7063946B2 (en) 2001-09-10 2006-06-20 Meso Scale Technologies, Llc. Methods, reagents, kits and apparatus for protein function analysis
EP1451579A4 (en) * 2001-11-19 2005-12-28 Protometrix Inc Method of using a non-antibody protein to detect and measure an analyte
GB0200617D0 (en) * 2002-01-11 2002-02-27 Oxford Glycosciences Uk Ltd Characterisation of analytes
GB0205910D0 (en) * 2002-03-13 2002-04-24 Sense Proteomic Ltd Arrays and methods
GB2402131A (en) * 2003-03-13 2004-12-01 Sense Proteomic Ltd Early entry
US20040209262A1 (en) * 2003-04-21 2004-10-21 Bass Jay K. Biopolymeric arrays comprising test probes for two or more different species and methods for using the same
WO2005059552A1 (en) 2003-12-15 2005-06-30 University Of Pennsylvania Method and devices for running reactions on a target plate for maldi mass spectrometry
KR100690948B1 (en) 2004-06-17 2007-03-09 한국과학기술원 Microbial surface expression method of target protein using outer membrane protein of E. coli
CN1312293C (en) * 2004-11-08 2007-04-25 博奥生物有限公司 High flux biochip and application thereof
KR100784261B1 (en) 2006-01-02 2007-12-11 한국과학기술원 Microbial surface expression method of target protein using spore envelope membrane protein of anthrax
US7855057B2 (en) 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
JP2009543862A (en) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Cancer biomarkers and methods of use thereof
DK3255146T3 (en) 2009-03-16 2019-08-19 Pangu Biopharma Ltd Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities
CN102449143B (en) 2009-03-31 2017-11-14 Atyr医药公司 Compositions and methods comprising aspartyl-tRNA synthetases having unconventional biological activities
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CN103096911B (en) 2010-04-27 2018-05-29 Atyr 医药公司 Treatment relevant with the protein fragments of Isoleucyl-tRNA synthetase, diagnosis and the innovation of antibody compositions are found
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
CN103097524B (en) 2010-04-28 2016-08-03 Atyr医药公司 The innovation for the treatment of, diagnosis and the antibody compositions relevant to the protein fragments of Alanyl-tRNA synthetase finds
WO2011135459A2 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CN103118693B (en) 2010-04-29 2017-05-03 Atyr 医药公司 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
ES2623805T3 (en) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic and antibody compositions related to phenylalanyl-alpha-tRNA synthetase protein fragments
CN103096925A (en) 2010-05-03 2013-05-08 Atyr医药公司 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-tRNA synthetases
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
EP2575857B1 (en) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
CN103118695B (en) 2010-07-12 2016-08-03 Atyr医药公司 Discovery of therapeutic, diagnostic and antibody compositions related to protein fragments of glycyl-tRNA synthetase
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
AU2012265177B2 (en) 2011-06-01 2017-03-02 Medical Prognosis Institute A/S Methods and devices for prognosis of cancer relapse
JP6170077B2 (en) 2012-02-16 2017-07-26 エータイアー ファーマ， インコーポレイテッド Histidyl tRNA synthetase for treating autoimmune and inflammatory diseases
BR112015012239B1 (en) 2012-11-27 2022-07-19 Pontificia Universidad Católica De Chile IN VITRO METHOD OF DIAGNOSIS OF THYROID CANCER
US10392667B2 (en) 2013-06-07 2019-08-27 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
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ES2913294T3 (en) 2015-08-28 2022-06-01 Univ Columbia Systems and procedures for matching cancer signatures
WO2017040315A1 (en) 2015-08-28 2017-03-09 The Trustees Of Columbia University In The City Of New York Virtual inference of protein activity by regulon enrichment analysis
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US7635572B2 (en) 2003-06-09 2009-12-22 Life Technologies Corporation Methods for conducting assays for enzyme activity on protein microarrays

Also Published As

Publication number Publication date
CA2365431A1 (en) 2000-09-14
EP1159615A2 (en) 2001-12-05
AU4170500A (en) 2000-09-28
AU773291B2 (en) 2004-05-20
WO2000054046A2 (en) 2000-09-14

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