WO2000054839A3 - Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses - Google Patents

Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses Download PDF

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Publication number
WO2000054839A3
WO2000054839A3 PCT/US2000/007055 US0007055W WO0054839A3 WO 2000054839 A3 WO2000054839 A3 WO 2000054839A3 US 0007055 W US0007055 W US 0007055W WO 0054839 A3 WO0054839 A3 WO 0054839A3
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WO
WIPO (PCT)
Prior art keywords
pathogen
hyperproliferative
wild
cells
dendritic cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/007055
Other languages
French (fr)
Other versions
WO2000054839A2 (en
Inventor
Dmitry Gabrilovich
David Carbone
Sunil Chada
Abner Mhashilkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Introgen Therapeutics Inc
Vanderbilt University
Original Assignee
Introgen Therapeutics Inc
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Introgen Therapeutics Inc, Vanderbilt University filed Critical Introgen Therapeutics Inc
Priority to AU37558/00A priority Critical patent/AU3755800A/en
Priority to EP00916456A priority patent/EP1165144A2/en
Priority to CA002367692A priority patent/CA2367692A1/en
Publication of WO2000054839A2 publication Critical patent/WO2000054839A2/en
Publication of WO2000054839A3 publication Critical patent/WO2000054839A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4238—Regulators of development
    • A61K40/424—Apoptosis related proteins, e.g. survivin or livin
    • A61K40/4241—Apoptosis related proteins, e.g. survivin or livin p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to immunotherapy methods for treating hyperproliferative disease or pathogen-induced diseases in humans. More specifically, the invention is directed, in one embodiment, to methods for treating a subject with a hyperproliferative disease in which the expression of a self gene is upregulated in hyperproliferative cells. In another embodiment, an adenoviral expression construct comprising a self gene under the control of a promoter operable in eukaryotic cells is intradermally administered to said hyperproliferative cells. In another embodiment of the present invention, a pathogen-induced disease in which the pathogen gene expression is increased or altered, is treated by intradermally administered a pathogen gene under the control of a promoter operable in eukaryotic cells. The present invention thus provides immunotherapies for treating hyperproliferative and pathogen diseases by attenuating the natural immune systems CTL response against hyperproliferative cells or overexpressing mutant p53 antigens.
PCT/US2000/007055 1999-03-15 2000-03-15 Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses Ceased WO2000054839A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU37558/00A AU3755800A (en) 1999-03-15 2000-03-15 Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses
EP00916456A EP1165144A2 (en) 1999-03-15 2000-03-15 Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses
CA002367692A CA2367692A1 (en) 1999-03-15 2000-03-15 Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12438899P 1999-03-15 1999-03-15
US12448299P 1999-03-15 1999-03-15
US60/124,388 1999-03-15
US60/124,482 1999-03-15

Publications (2)

Publication Number Publication Date
WO2000054839A2 WO2000054839A2 (en) 2000-09-21
WO2000054839A3 true WO2000054839A3 (en) 2001-01-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/007055 Ceased WO2000054839A2 (en) 1999-03-15 2000-03-15 Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses

Country Status (5)

Country Link
US (3) US20030045499A1 (en)
EP (1) EP1165144A2 (en)
AU (1) AU3755800A (en)
CA (1) CA2367692A1 (en)
WO (1) WO2000054839A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473247B2 (en) 1999-10-14 2009-01-06 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula

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AU2003231098A1 (en) 2002-04-25 2003-11-10 University Of Connecticut Health Center Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
GB0226717D0 (en) * 2002-11-15 2002-12-24 Collen Res Foundation D DNA vaccination
SE0301109D0 (en) 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
EP1677824A2 (en) * 2003-09-18 2006-07-12 Alexion Pharmaceuticals, Inc. Elicitation of antibodies to self peptides in mice by immunization with dendritic cells
US20050208627A1 (en) * 2003-09-18 2005-09-22 Bowdish Katherine S Elicitation of antibodies to self peptides in mice by immunization with dendritic cells
WO2006124700A2 (en) * 2005-05-12 2006-11-23 Introgen Therapeutics, Inc. P53 vaccines for the treatment of cancers
CA2623867C (en) * 2005-10-13 2015-03-17 Kirin Pharma Kabushiki Kaisha Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures
EP2565201B1 (en) 2005-10-17 2014-11-26 Sloan-Kettering Institute For Cancer Research WT1 HLA class II-binding peptides and compositions and methods comprising same
EP2010209B1 (en) 2006-04-10 2016-06-15 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and methods of use thereof
EP2245464B1 (en) 2008-01-25 2016-12-14 MultiVir Inc. P53 biomarkers
EP3520810A3 (en) 2012-01-13 2019-11-06 Memorial Sloan-Kettering Cancer Center Immunogenic wt1 peptides and use thereof
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
LT2945647T (en) 2013-01-15 2021-02-25 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
CN116535491B (en) * 2022-05-06 2024-03-22 珠海丽凡达生物技术有限公司 Therapeutic nucleic acid molecules, mixtures, drugs and applications in the treatment of solid tumors

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473247B2 (en) 1999-10-14 2009-01-06 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula

Also Published As

Publication number Publication date
CA2367692A1 (en) 2000-09-21
EP1165144A2 (en) 2002-01-02
WO2000054839A2 (en) 2000-09-21
US20050171045A1 (en) 2005-08-04
US20030045499A1 (en) 2003-03-06
US20060063697A1 (en) 2006-03-23
AU3755800A (en) 2000-10-04

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